메뉴 건너뛰기




Volumn 9, Issue FEB, 2015, Pages

Lactate is always the end product of glycolysis

Author keywords

Aerobic; Anaerobic; Cytosolic lactate shuttle; Lactate dehydrogenase; Mitochondria; NADH; Pyruvate

Indexed keywords

LACTATE DEHYDROGENASE; LACTIC ACID; NICOTINAMIDE ADENINE DINUCLEOTIDE; OXIDOREDUCTASE; OXYGEN; PYRUVIC ACID; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE;

EID: 84949116564     PISSN: 16624548     EISSN: 1662453X     Source Type: Journal    
DOI: 10.3389/fnins.2015.00022     Document Type: Article
Times cited : (274)

References (70)
  • 1
    • 22144434964 scopus 로고    scopus 로고
    • Transcriptional coactivator PGC-1a controls the energy state and contractile function of cardiac muscle
    • Arany, Z., He, H., Lin, J., Hoyer, K., Handschin, C., Toka, O., et al. (2005). Transcriptional coactivator PGC-1a controls the energy state and contractile function of cardiac muscle. Cell Metab. 1, 259-271. doi: 10.1016/j.cmet.2005.03.002
    • (2005) Cell Metab. , vol.1 , pp. 259-271
    • Arany, Z.1    He, H.2    Lin, J.3    Hoyer, K.4    Handschin, C.5    Toka, O.6
  • 2
    • 0021327015 scopus 로고
    • Enzyme activities in normal, dysplastic, and cancerous human breast tissues
    • Balinsky, D., Platz, C. E., and Lewis, J. W. (1984). Enzyme activities in normal, dysplastic, and cancerous human breast tissues. J. Natl. Cancer Inst. 72, 217-224.
    • (1984) J. Natl. Cancer Inst , vol.72 , pp. 217-224
    • Balinsky, D.1    Platz, C.E.2    Lewis, J.W.3
  • 3
    • 25844501539 scopus 로고    scopus 로고
    • A history of research on yeasts 9: regulation of sugar metabolism
    • Barnett, J. A., and Entian, K. D. (2005). A history of research on yeasts 9: regulation of sugar metabolism. Yeast 22, 835-894. doi: 10.1002/yea.1249
    • (2005) Yeast , vol.22 , pp. 835-894
    • Barnett, J.A.1    Entian, K.D.2
  • 4
    • 0033997483 scopus 로고    scopus 로고
    • Intra-and extra-cellular lactate shuttles
    • Brooks, G. A. (2000). Intra-and extra-cellular lactate shuttles. Med. Sci. Sports. Exerc. 32, 790-799. doi: 10.1097/00005768-200004000-00011
    • (2000) Med. Sci. Sports. Exerc. , vol.32 , pp. 790-799
    • Brooks, G.A.1
  • 5
    • 4043113800 scopus 로고    scopus 로고
    • The metabolic systems: anaerobic metabolism (glycolytic and phosphagen)
    • People and Ideas, ed C. M. Tipton (New York, NY: Oxford University Press)
    • Brooks, G. A., and Gladden, L. B. (2003). "The metabolic systems: anaerobic metabolism (glycolytic and phosphagen)," in Exercise Physiology. People and Ideas, ed C. M. Tipton (New York, NY: Oxford University Press), 322-360.
    • (2003) Exercise Physiology , pp. 322-360
    • Brooks, G.A.1    Gladden, L.B.2
  • 6
    • 84924345565 scopus 로고    scopus 로고
    • Cerebral metabolism following traumatic brain injury: new discoveries with implications for treatment
    • Brooks, G. A., and Martin, N. A. (2014). Cerebral metabolism following traumatic brain injury: new discoveries with implications for treatment. Front. Neurosci. 8:408. doi: 10.3389/fnins.2014.00408
    • (2014) Front. Neurosci. , vol.8 , pp. 408
    • Brooks, G.A.1    Martin, N.A.2
  • 7
    • 37049236727 scopus 로고
    • Nature and development of lactic dehydrogenases the two major types of this enzyme form molecular hybrids which change in makeup during development
    • Cahn, R., Zwilling, E., Kaplan, N., and Levine, L. (1962). Nature and development of lactic dehydrogenases the two major types of this enzyme form molecular hybrids which change in makeup during development. Science 136, 962-969. doi: 10.1126/science.136.3520.962
    • (1962) Science , vol.136 , pp. 962-969
    • Cahn, R.1    Zwilling, E.2    Kaplan, N.3    Levine, L.4
  • 8
    • 84986531942 scopus 로고
    • Cytochemical identification of cerebral glycogen and glucose-6-phosphatase activity under normal and experimental conditions: I Neurons and glia.
    • Cataldo, A. M., and Broadwell, R. D. (1986). Cytochemical identification of cerebral glycogen and glucose-6-phosphatase activity under normal and experimental conditions: I. Neurons and glia. J. Electron Microsc. Tech. 3, 413-437. doi: 10.1002/jemt.1060030406
    • (1986) J. Electron Microsc. Tech. , vol.3 , pp. 413-437
    • Cataldo, A.M.1    Broadwell, R.D.2
  • 9
    • 0022462032 scopus 로고
    • Lactate efflux is unrelated to intracellular PO2 in a working red muscle in situ
    • Connett, R., Gayeski, T., and Honig, C. (1986). Lactate efflux is unrelated to intracellular PO2 in a working red muscle in situ. J. Appl. Physiol. 61, 402-408.
    • (1986) J. Appl. Physiol , vol.61 , pp. 402-408
    • Connett, R.1    Gayeski, T.2    Honig, C.3
  • 10
    • 0025216440 scopus 로고
    • Defining hypoxia: a systems view of VO2, glycolysis, energetics, and intracellular PO2
    • Connett, R., Honig, C., Gayeski, T., and Brooks, G. (1990). Defining hypoxia: a systems view of VO2, glycolysis, energetics, and intracellular PO2. J. Appl. Physiol. 68, 833-842.
    • (1990) J. Appl. Physiol , vol.68 , pp. 833-842
    • Connett, R.1    Honig, C.2    Gayeski, T.3    Brooks, G.4
  • 12
    • 0000144989 scopus 로고
    • The carbohydrate metabolism of tumors II. Changes in the sugar, lactic acid, and CO2-Combining Power of Blood Passing through a tumor
    • Cori, C. F., and Cori, G. T. (1925). The carbohydrate metabolism of tumors II. Changes in the sugar, lactic acid, and CO2-Combining Power of Blood Passing through a tumor. J. Biol. Chem. 65, 397-405.
    • (1925) J. Biol. Chem , vol.65 , pp. 397-405
    • Cori, C.F.1    Cori, G.T.2
  • 13
    • 84863539219 scopus 로고    scopus 로고
    • A mitochondrial mystery, solved
    • Divakaruni, A. S., and Murphy, A. N. (2012). A mitochondrial mystery, solved. Science 337, 41-43. doi: 10.1126/science.1225601
    • (2012) Science , vol.337 , pp. 41-43
    • Divakaruni, A.S.1    Murphy, A.N.2
  • 14
    • 0033998388 scopus 로고    scopus 로고
    • Quantitative assessment of pathways for lactate disposal in skeletal muscle fiber types
    • Donovan, C. M., and Pagliassotti, M. J. (2000). Quantitative assessment of pathways for lactate disposal in skeletal muscle fiber types. Med. Sci. Sports Exerc. 32, 772-777. doi: 10.1097/00005768-200004000-00009
    • (2000) Med. Sci. Sports Exerc. , vol.32 , pp. 772-777
    • Donovan, C.M.1    Pagliassotti, M.J.2
  • 15
    • 33646242759 scopus 로고    scopus 로고
    • Incorporating expression data in metabolic modeling: a case study of lactate dehydrogenase
    • Downer, J., Sevinsky, J. R., Ahn, N. G., Resing, K. A., and Betterton, M. (2006). Incorporating expression data in metabolic modeling: a case study of lactate dehydrogenase. J. Theor. Biol. 240, 464-474. doi: 10.1016/j.jtbi.2005.10.007
    • (2006) J. Theor. Biol. , vol.240 , pp. 464-474
    • Downer, J.1    Sevinsky, J.R.2    Ahn, N.G.3    Resing, K.A.4    Betterton, M.5
  • 16
    • 33744783432 scopus 로고    scopus 로고
    • Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance
    • Fantin, V. R., St-Pierre, J., and Leder, P. (2006). Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance. Cancer Cell 9, 425-434. doi: 10.1016/j.ccr.2006.04.023
    • (2006) Cancer Cell , vol.9 , pp. 425-434
    • Fantin, V.R.1    St-Pierre, J.2    Leder, P.3
  • 17
    • 84944488568 scopus 로고
    • Lactic acid in amphibian muscle
    • Fletcher, W. M., and Hopkins, F. G. (1907). Lactic acid in amphibian muscle. J. Physiol. 35, 247-309. doi: 10.1113/jphysiol.1907.sp001194
    • (1907) J. Physiol. , vol.35 , pp. 247-309
    • Fletcher, W.M.1    Hopkins, F.G.2
  • 18
    • 4043110513 scopus 로고    scopus 로고
    • Lactate metabolism: a new paradigm for the third millennium
    • Gladden, L. B. (2004a). Lactate metabolism: a new paradigm for the third millennium. J. Physiol. 558, 5-30. doi: 10.1113/jphysiol.2003.058701
    • (2004) J. Physiol. , vol.558 , pp. 5-30
    • Gladden, L.B.1
  • 19
    • 4043095148 scopus 로고    scopus 로고
    • Lactate metabolism during exercise
    • 3rd Edn., ed J. R. Poortmans (Basel: Karger)
    • Gladden, L. B. (2004b). "Lactate metabolism during exercise," in Principles of Exercise Biochemistry, 3rd Edn., ed J. R. Poortmans (Basel: Karger), 152-196.
    • (2004) Principles of Exercise Biochemistry , pp. 152-196
    • Gladden, L.B.1
  • 20
    • 50349086384 scopus 로고    scopus 로고
    • 200th anniversary of lactate research in muscle
    • Gladden, L. B. (2008). 200th anniversary of lactate research in muscle. Exerc. Sport Sci. Rev. 36, 109-115. doi: 10.1097/JES.0b013e31817c0038
    • (2008) Exerc. Sport Sci. Rev. , vol.36 , pp. 109-115
    • Gladden, L.B.1
  • 21
    • 84919480908 scopus 로고    scopus 로고
    • Modeling alveolar soft part sarcomagenesis in the mouse: a role for lactate in the tumor microenvironment
    • Goodwin, M. L., Jin, H., Straessler, K., Smith-Fry, K., Zhu, J., Monument, M. J., et al. (2014). Modeling alveolar soft part sarcomagenesis in the mouse: a role for lactate in the tumor microenvironment. Cancer Cell 26, 851-862. doi: 10.1016/j.ccell.2014.10.003
    • (2014) Cancer Cell , vol.26 , pp. 851-862
    • Goodwin, M.L.1    Jin, H.2    Straessler, K.3    Smith-Fry, K.4    Zhu, J.5    Monument, M.J.6
  • 22
    • 33744931101 scopus 로고    scopus 로고
    • Colocalization of MCT1, CD147, and LDH in mitochondrial inner membrane of L6 muscle cells: evidence of a mitochondrial lactate oxidation complex
    • Hashimoto, T., Hussien, R., and Brooks, G. A. (2006). Colocalization of MCT1, CD147, and LDH in mitochondrial inner membrane of L6 muscle cells: evidence of a mitochondrial lactate oxidation complex. Am. J. Physiol. Endocrinol. Metab. 290, E1237-E1244. doi: 10.1152/ajpendo.00594.2005
    • (2006) Am. J. Physiol. Endocrinol. Metab. , vol.290 , pp. E1237-E1244
    • Hashimoto, T.1    Hussien, R.2    Brooks, G.A.3
  • 23
    • 0021343295 scopus 로고
    • Adaptations of skeletal muscle to endurance exercise and their metabolic consequences
    • Holloszy, J. O., and Coyle, E. F. (1984). Adaptations of skeletal muscle to endurance exercise and their metabolic consequences. J. Appl. Physiol. 56, 831-838.
    • (1984) J. Appl. Physiol , vol.56 , pp. 831-838
    • Holloszy, J.O.1    Coyle, E.F.2
  • 24
    • 0019142890 scopus 로고
    • Glycolytic enzymes from human autoptic brain cortex: normal aged and demented cases
    • Iwangoff, P., Armbruster, R., Enz, A., and Meier-Ruge, W. (1980). Glycolytic enzymes from human autoptic brain cortex: normal aged and demented cases. Mech. Ageing. Dev. 14, 203-209. doi: 10.1016/0047-6374(80)90120-7
    • (1980) Mech. Ageing. Dev. , vol.14 , pp. 203-209
    • Iwangoff, P.1    Armbruster, R.2    Enz, A.3    Meier-Ruge, W.4
  • 25
    • 0014280928 scopus 로고
    • Oxidation of NADH during contractions of circulated mammalian skeletal muscle
    • Jöbsis, F., and Stainsby, W. (1968). Oxidation of NADH during contractions of circulated mammalian skeletal muscle. Respir. Physiol. 4, 292-300. doi: 10.1016/0034-5687(68)90035-2
    • (1968) Respir. Physiol. , vol.4 , pp. 292-300
    • Jöbsis, F.1    Stainsby, W.2
  • 26
    • 35448984205 scopus 로고    scopus 로고
    • The first demonstration of lactic acid in human blood in shock by Johann Joseph Scherer (1814-1869) in January 1843
    • Kompanje, E., Jansen, T., van der Hoven, B., and Bakker, J. (2007). The first demonstration of lactic acid in human blood in shock by Johann Joseph Scherer (1814-1869) in January 1843. Inten. Care Med. 33, 1967-1971. doi: 10.1007/s00134-007-0788-7
    • (2007) Inten. Care Med. , vol.33 , pp. 1967-1971
    • Kompanje, E.1    Jansen, T.2    van der Hoven, B.3    Bakker, J.4
  • 27
    • 0035982810 scopus 로고    scopus 로고
    • A computational model for glycogenolysis in skeletal muscle
    • Lambeth, M. J., and Kushmerick, M. J. (2002). A computational model for glycogenolysis in skeletal muscle. Ann. Biomed. Eng. 30, 808-827. doi: 10.1114/1.1492813
    • (2002) Ann. Biomed. Eng. , vol.30 , pp. 808-827
    • Lambeth, M.J.1    Kushmerick, M.J.2
  • 28
    • 0018149626 scopus 로고
    • Application of a microchemical technique to the elucidation of enzyme activity profiles within single human mammary tumors
    • Larner, E. H., and Rutherford, C. L. (1978). Application of a microchemical technique to the elucidation of enzyme activity profiles within single human mammary tumors. Cancer 41, 1863-1870.
    • (1978) Cancer , vol.41 , pp. 1863-1870
    • Larner, E.H.1    Rutherford, C.L.2
  • 29
    • 0014030720 scopus 로고
    • Pyruvate inhibition of lactate dehydrogenase activity in human tissue extracts
    • Latner, A., Siddiqui, S., and Skillen, A. (1966). Pyruvate inhibition of lactate dehydrogenase activity in human tissue extracts. Science 154, 527-529.
    • (1966) Science , vol.154 , pp. 527-529
    • Latner, A.1    Siddiqui, S.2    Skillen, A.3
  • 30
    • 80053640489 scopus 로고    scopus 로고
    • CD147 subunit of lactate/H+ symporters MCT1 and hypoxia-inducible MCT4 is critical for energetics and growth of glycolytic tumors
    • Le Floch, R., Chiche, J., Marchiq, I., Naiken, T., Ilc, K., Murray, C. M., et al. (2011). CD147 subunit of lactate/H+ symporters MCT1 and hypoxia-inducible MCT4 is critical for energetics and growth of glycolytic tumors. Proc. Natl. Acad. Sci. U.S.A. 108, 16663-16668. doi: 10.1073/pnas.1106123108
    • (2011) Proc. Natl. Acad. Sci. U.S.A. , vol.108 , pp. 16663-16668
    • Le Floch, R.1    Chiche, J.2    Marchiq, I.3    Naiken, T.4    Ilc, K.5    Murray, C.M.6
  • 31
    • 33751011308 scopus 로고    scopus 로고
    • PGC-1a: a key regulator of energy metabolism
    • Liang, H., and Ward, W. F. (2006). PGC-1a: a key regulator of energy metabolism. Adv. Physiol. Educ. 30, 145-151. doi: 10.1152/advan.00052.2006
    • (2006) Adv. Physiol. Educ. , vol.30 , pp. 145-151
    • Liang, H.1    Ward, W.F.2
  • 32
    • 0021868772 scopus 로고
    • Effect of severe injury and critical illness on high-energy phosphates in human liver and muscle
    • Liaw, K.-Y., Wei, T.-C., Hsu, S.-C., and Lin, J.-K. (1985). Effect of severe injury and critical illness on high-energy phosphates in human liver and muscle. J. Trauma Injury Infect. Crit. Care 25, 628-633. doi: 10.1097/00005373-198507000-00009
    • (1985) J. Trauma Injury Infect. Crit. Care , vol.25 , pp. 628-633
    • Liaw, K.-Y.1    Wei, T.-C.2    Hsu, S.-C.3    Lin, J.-K.4
  • 33
    • 0030042996 scopus 로고    scopus 로고
    • Oxidative capacity of the skeletal muscle and lactic acid kinetics during exercise in normal subjects and in patients with COPD
    • Maltais, F., Simard, A.-A., Simard, C., Jobin, J., Desgagnés, P., and Leblanc, P. (1996). Oxidative capacity of the skeletal muscle and lactic acid kinetics during exercise in normal subjects and in patients with COPD. Am. J. Respir. Crit. Care Med. 153, 288-293. doi: 10.1164/ajrccm.153.1.8542131
    • (1996) Am. J. Respir. Crit. Care Med. , vol.153 , pp. 288-293
    • Maltais, F.1    Simard, A.-A.2    Simard, C.3    Jobin, J.4    Desgagnés, P.5    Leblanc, P.6
  • 34
    • 79960858482 scopus 로고    scopus 로고
    • Metabolism and brain cancer
    • Marie, S. K. N., and Shinjo, S. M. O. (2011). Metabolism and brain cancer. Clinics 66, 33-43. doi: 10.1590/S1807-59322011001300005
    • (2011) Clinics , vol.66 , pp. 33-43
    • Marie, S.K.N.1    Shinjo, S.M.O.2
  • 36
    • 33947424365 scopus 로고    scopus 로고
    • Evidence for a higher glycolytic than oxidative metabolic activity in white matter of rat brain
    • Morland, C., Henjum, S., Iversen, E. G., Skrede, K. K., and Hassel, B. (2007). Evidence for a higher glycolytic than oxidative metabolic activity in white matter of rat brain. Neurochem. Int. 50, 703-709. doi: 10.1016/j.neuint.2007.01.003
    • (2007) Neurochem. Int. , vol.50 , pp. 703-709
    • Morland, C.1    Henjum, S.2    Iversen, E.G.3    Skrede, K.K.4    Hassel, B.5
  • 37
    • 59849113735 scopus 로고    scopus 로고
    • Expression of pyruvate carboxylase in cultured oligodendroglial, microglial and ependymal cells
    • Murin, R., Cesar, M., Kowtharapu, B. S., Verleysdonk, S., and Hamprecht, B. (2009). Expression of pyruvate carboxylase in cultured oligodendroglial, microglial and ependymal cells. Neurochem. Res. 34, 480-489. doi: 10.1007/s11064-008-9806-6
    • (2009) Neurochem. Res. , vol.34 , pp. 480-489
    • Murin, R.1    Cesar, M.2    Kowtharapu, B.S.3    Verleysdonk, S.4    Hamprecht, B.5
  • 38
    • 4043167348 scopus 로고    scopus 로고
    • Enzymes, energy and endurance: some provocative thoughts
    • Medicine and Sport Science, ed J. R. Poortmans (Basel: Karger Medical and Scientific Publishers)
    • Newsholme, E. A. (2004). "Enzymes, energy and endurance: some provocative thoughts," in Principles of Exercise Biochemistrym, 3rd, Rev Edn. Vol. 46, Medicine and Sport Science, ed J. R. Poortmans (Basel: Karger Medical and Scientific Publishers), 1-35.
    • (2004) Principles of Exercise Biochemistrym, 3rd, Rev Edn , vol.46 , pp. 1-35
    • Newsholme, E.A.1
  • 39
  • 40
    • 64749090748 scopus 로고    scopus 로고
    • Hypothesis: using the Warburg effect against cancer by reducing glucose and providing lactate
    • Nijsten, M. W. N., and van Dam, G. M. (2009). Hypothesis: using the Warburg effect against cancer by reducing glucose and providing lactate. Med. Hypotheses 73, 48-51. doi: 10.1016/j.mehy.2009.01.041
    • (2009) Med. Hypotheses , vol.73 , pp. 48-51
    • Nijsten, M.W.N.1    van Dam, G.M.2
  • 41
    • 0030064342 scopus 로고    scopus 로고
    • Muscle glycogen resynthesis after short term, high intensity exercise and resistance exercise
    • Pascoe, D. D., and Gladden, L. B. (1996). Muscle glycogen resynthesis after short term, high intensity exercise and resistance exercise. Sports Med. 21, 98-118. doi: 10.2165/00007256-199621020-00003
    • (1996) Sports Med. , vol.21 , pp. 98-118
    • Pascoe, D.D.1    Gladden, L.B.2
  • 42
    • 0000085046 scopus 로고
    • Memoire sur la fermentation appelée lactique
    • Pasteur, L. (1858). Memoire sur la fermentation appelée lactique. Ann. Chim. Phys. 52, 404-418.
    • (1858) Ann. Chim. Phys. , vol.52 , pp. 404-418
    • Pasteur, L.1
  • 43
    • 0000766945 scopus 로고
    • Expériences et vues nouvelles sur la nature des fermentations
    • Pasteur, L. (1861). Expériences et vues nouvelles sur la nature des fermentations. C. R. Hebd. Seances Acad. Sci. Paris 53, 1260-1264.
    • (1861) C. R. Hebd. Seances Acad. Sci. Paris , vol.53 , pp. 1260-1264
    • Pasteur, L.1
  • 45
    • 0000036984 scopus 로고
    • The electrophoretically distinct forms of mammalian lactic dehydrogenase II. Properties and interrelationships of rabbit and human lactic dehydrogenase isozymes
    • Plagemann, P. G., Gregory, K. F., and Wróblewski, F. (1960). The electrophoretically distinct forms of mammalian lactic dehydrogenase II. Properties and interrelationships of rabbit and human lactic dehydrogenase isozymes. J. Biol. Chem. 235, 2288-2293.
    • (1960) J. Biol. Chem. , vol.235 , pp. 2288-2293
    • Plagemann, P.G.1    Gregory, K.F.2    Wróblewski, F.3
  • 46
    • 0015693104 scopus 로고
    • Optimal freezing conditions for cerebral metabolites in rats
    • Ponten, U., Ratcheson, R., Salford, L., and Siesj, ö, B. (1973). Optimal freezing conditions for cerebral metabolites in rats. J. Neurochem. 21, 1127-1138. doi: 10.1111/j.1471-4159.1973.tb07567.x
    • (1973) J. Neurochem. , vol.21 , pp. 1127-1138
    • Ponten, U.1    Ratcheson, R.2    Salford, L.3    Siesj, O.B.4
  • 47
    • 79952597909 scopus 로고    scopus 로고
    • High brain lactate is not caused by a shift in the lactate dehydrogenase A/B ratio
    • Quistorff, B., and Grunnet, N. (2011a). High brain lactate is not caused by a shift in the lactate dehydrogenase A/B ratio. Proc. Natl. Acad. Sci. U.S.A. 108, E21. doi: 10.1073/pnas.1017750108
    • (2011) Proc. Natl. Acad. Sci. U.S.A. , vol.108 , pp. E21
    • Quistorff, B.1    Grunnet, N.2
  • 49
    • 0034521193 scopus 로고    scopus 로고
    • Intracerebral microdialysis in clinical practice: baseline values for chemical markers during wakefulness, anesthesia, and neurosurgery
    • Reinstrup, P., Ståhl, N., Mellergård, P., Uski, T., Ungerstedt, U., and Nordström, C.-H. (2000). Intracerebral microdialysis in clinical practice: baseline values for chemical markers during wakefulness, anesthesia, and neurosurgery. Neurosurgery 47, 701-709. doi: 10.1097/00006123-200009000-00035
    • (2000) Neurosurgery , vol.47 , pp. 701-709
    • Reinstrup, P.1    Ståhl, N.2    Mellergård, P.3    Uski, T.4    Ungerstedt, U.5    Nordström, C.-H.6
  • 50
    • 0031880556 scopus 로고    scopus 로고
    • Lactate efflux from exercising human skeletal muscle: role of intracellular
    • Richardson, R. S., Noyszewski, E. A., Leigh, J. S., and Wagner, P. D. (1998). Lactate efflux from exercising human skeletal muscle: role of intracellular. J. Appl. Physiol. 85, 627-634.
    • (1998) J. Appl. Physiol. , vol.85 , pp. 627-634
    • Richardson, R.S.1    Noyszewski, E.A.2    Leigh, J.S.3    Wagner, P.D.4
  • 51
    • 0017042973 scopus 로고
    • Lactate content and pH in muscle samples obtained after dynamic exercise
    • Sahlin, K., Harris, R., Nylind, B., and Hultman, E. (1976). Lactate content and pH in muscle samples obtained after dynamic exercise. Pflügers Arch. 367, 143-149. doi: 10.1007/BF00585150
    • (1976) Pflügers Arch. , vol.367 , pp. 143-149
    • Sahlin, K.1    Harris, R.2    Nylind, B.3    Hultman, E.4
  • 52
    • 84904316232 scopus 로고    scopus 로고
    • Lactate and the lactate-to-pyruvate molar ratio cannot be used as independent biomarkers for monitoring brain energetic metabolism: a microdialysis study in patients with traumatic brain injuries
    • Sahuquillo, J., Merino, M.-A., Sánchez-Guerrero, A., Arikan, F., Vidal-Jorge, M., Martínez-Valverde, T., et al. (2014). Lactate and the lactate-to-pyruvate molar ratio cannot be used as independent biomarkers for monitoring brain energetic metabolism: a microdialysis study in patients with traumatic brain injuries. PloS ONE 9:e102540. doi: 10.1371/journal.pone.0102540
    • (2014) PloS ONE , vol.9
    • Sahuquillo, J.1    Merino, M.-A.2    Sánchez-Guerrero, A.3    Arikan, F.4    Vidal-Jorge, M.5    Martínez-Valverde, T.6
  • 53
    • 29144469081 scopus 로고    scopus 로고
    • Lactate: the ultimate cerebral oxidative energy substrate? J
    • Schurr, A. (2006). Lactate: the ultimate cerebral oxidative energy substrate? J. Cereb. Blood Flow Metab. 26, 142-152. doi: 10.1038/sj.jcbfm.9600174
    • (2006) Cereb. Blood Flow Metab. , vol.26 , pp. 142-152
    • Schurr, A.1
  • 54
    • 84865959403 scopus 로고    scopus 로고
    • Aerobic production and utilization of lactate satisfy increased energy demands upon neuronal activation in hippocampal slices and provide neuroprotection against oxidative stress
    • Schurr, A., and Gozal, E. (2012). Aerobic production and utilization of lactate satisfy increased energy demands upon neuronal activation in hippocampal slices and provide neuroprotection against oxidative stress. Front. Pharmacol. 2:96. doi: 10.3389/fphar.2011.00096
    • (2012) Front. Pharmacol. , vol.2 , pp. 96
    • Schurr, A.1    Gozal, E.2
  • 55
    • 34347212817 scopus 로고    scopus 로고
    • Lactate, not pyruvate, is neuronal aerobic glycolysis end product: an in vitro electrophysiological study
    • Schurr, A., and Payne, R. (2007). Lactate, not pyruvate, is neuronal aerobic glycolysis end product: an in vitro electrophysiological study. Neuroscience 147, 613-619. doi: 10.1016/j.neuroscience.2007.05.002
    • (2007) Neuroscience , vol.147 , pp. 613-619
    • Schurr, A.1    Payne, R.2
  • 56
    • 57449115616 scopus 로고    scopus 로고
    • Tumor metabolism: cancer cells give and take lactate
    • Semenza, G. L. (2008). Tumor metabolism: cancer cells give and take lactate. J. Clin. Investig. 118, 3835-3837. doi: 10.1172/JCI37373
    • (2008) J. Clin. Investig. , vol.118 , pp. 3835-3837
    • Semenza, G.L.1
  • 57
    • 0001167981 scopus 로고
    • Enzyme patterns in human tissues I. Methods for the determination of glycolytic enzymes
    • Shonk, C. E., and Boxer, G. E. (1964). Enzyme patterns in human tissues. I. Methods for the determination of glycolytic enzymes. Cancer Res. 24, 709-721.
    • (1964) Cancer Res. , vol.24 , pp. 709-721
    • Shonk, C.E.1    Boxer, G.E.2
  • 58
    • 57449097020 scopus 로고    scopus 로고
    • Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice
    • Sonveaux, P., Végran, F., Schroeder, T., Wergin, M. C., Verrax, J., Rabbani, Z. N., et al. (2008). Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice. J. Clin. Investig. 118, 3930-3942. doi: 10.1172JCI36843
    • (2008) J. Clin. Investig. , vol.118 , pp. 3930-3942
    • Sonveaux, P.1    Végran, F.2    Schroeder, T.3    Wergin, M.C.4    Verrax, J.5    Rabbani, Z.N.6
  • 59
    • 0034004331 scopus 로고    scopus 로고
    • An enzymatic approach to lactate production in human skeletal muscle during exercise
    • Spriet, L. L., Howlett, R. A., and Heigenhauser, G. (2000). An enzymatic approach to lactate production in human skeletal muscle during exercise. Med. Sci. Sports Exerc. 32, 756-763. doi: 10.1097/00005768-200004000-00007
    • (2000) Med. Sci. Sports Exerc. , vol.32 , pp. 756-763
    • Spriet, L.L.1    Howlett, R.A.2    Heigenhauser, G.3
  • 60
    • 0024986689 scopus 로고
    • Control of lactic acid metabolism in contracting muscles and during exercise
    • Stainsby, W. N., and Brooks, G. A. (1990). Control of lactic acid metabolism in contracting muscles and during exercise. Exerc. Sport Sci. Rev. 18, 29-64. doi: 10.1249/00003677-199001000-00005
    • (1990) Exerc. Sport Sci. Rev. , vol.18 , pp. 29-64
    • Stainsby, W.N.1    Brooks, G.A.2
  • 61
    • 0013933873 scopus 로고
    • Lactate metabolism of contracting dog skeletal muscle in situ
    • Stainsby, W. N., and Welch, H. G. (1966). Lactate metabolism of contracting dog skeletal muscle in situ. Am. J. Physiol. 211, 177-183.
    • (1966) Am. J. Physiol. , vol.211 , pp. 177-183
    • Stainsby, W.N.1    Welch, H.G.2
  • 62
    • 0014010441 scopus 로고
    • Substrate and product inhibition of rabbit muscle lactic dehydrogenase heart (H4) and muscle (M4) isozymes
    • Stambaugh, R., and Post, D. (1966). Substrate and product inhibition of rabbit muscle lactic dehydrogenase heart (H4) and muscle (M4) isozymes. J. Biol. Chem. 241, 1462-1467.
    • (1966) J. Biol. Chem. , vol.241 , pp. 1462-1467
    • Stambaugh, R.1    Post, D.2
  • 63
    • 84878162702 scopus 로고    scopus 로고
    • Skeletal muscle PGC-1a controls whole-body lactate homeostasis through estrogen-related receptor a-dependent activation of LDH B and repression of LDH A
    • Summermatter, S., Santos, G., Pérez-Schindler, J., and Handschin, C. (2013). Skeletal muscle PGC-1a controls whole-body lactate homeostasis through estrogen-related receptor a-dependent activation of LDH B and repression of LDH A. Proc. Natl. Acad. Sci. U.S.A. 110, 8738-8743. doi: 10.1073/pnas.1212976110
    • (2013) Proc. Natl. Acad. Sci. U.S.A. , vol.110 , pp. 8738-8743
    • Summermatter, S.1    Santos, G.2    Pérez-Schindler, J.3    Handschin, C.4
  • 65
    • 66249108601 scopus 로고    scopus 로고
    • Understanding the Warburg effect: the metabolic requirements of cell proliferation
    • Vander Heiden, M. G., Cantley, L. C., and Thompson, C. B. (2009). Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science 324, 1029-1033. doi: 10.1126/science.1160809
    • (2009) Science , vol.324 , pp. 1029-1033
    • Vander Heiden, M.G.1    Cantley, L.C.2    Thompson, C.B.3
  • 66
    • 0034033690 scopus 로고    scopus 로고
    • Lactate as a fuel for mitochondrial respiration
    • Van Hall, G. (2000). Lactate as a fuel for mitochondrial respiration. Acta Physiol. Scand. 168, 643-656. doi: 10.1046/j.1365-201x.2000.00716.x
    • (2000) Acta Physiol. Scand. , vol.168 , pp. 643-656
    • Van Hall, G.1
  • 67
    • 2642690674 scopus 로고    scopus 로고
    • Lactate is released and taken up by isolated rabbit vagus nerve during aerobic metabolism
    • Véga, C., Poitry-Yamate, C. L., Jirounek, P., Tsacopoulos, M., and Coles, J. A. (1998). Lactate is released and taken up by isolated rabbit vagus nerve during aerobic metabolism. J. Neurochem. 71, 330-337. doi: 10.1046/j.1471-4159.1998.71010330.x
    • (1998) J. Neurochem. , vol.71 , pp. 330-337
    • Véga, C.1    Poitry-Yamate, C.L.2    Jirounek, P.3    Tsacopoulos, M.4    Coles, J.A.5
  • 68
    • 18944405433 scopus 로고    scopus 로고
    • Metabolic crisis without brain ischemia is common after traumatic brain injury: a combined microdialysis and positron emission tomography study
    • Vespa, P., Bergsneider, M., Hattori, N., Wu, H.-M., Huang, S.-C., Martin, N. A., et al. (2005). Metabolic crisis without brain ischemia is common after traumatic brain injury: a combined microdialysis and positron emission tomography study. J. Cereb. Blood Flow Metab. 25, 763-774. doi: 10.1038/sj.jcbfm.9600073
    • (2005) J. Cereb. Blood Flow Metab. , vol.25 , pp. 763-774
    • Vespa, P.1    Bergsneider, M.2    Hattori, N.3    Wu, H.-M.4    Huang, S.-C.5    Martin, N.A.6
  • 69
    • 85006768050 scopus 로고
    • The metabolism of tumors in the body
    • Warburg, O., Wind, F., and Negelein, E. (1927). The metabolism of tumors in the body. J. Gen. Physiol. 8, 519-530. doi: 10.1085/jgp.8.6.519
    • (1927) J. Gen. Physiol. , vol.8 , pp. 519-530
    • Warburg, O.1    Wind, F.2    Negelein, E.3
  • 70
    • 0033538473 scopus 로고    scopus 로고
    • Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1
    • Wu, Z., Puigserver, P., Andersson, U., Zhang, C., Adelmant, G., Mootha, V., et al. (1999). Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1. Cell 98, 115-124. doi: 10.1016/S0092-8674(00)80611-X
    • (1999) Cell , vol.98 , pp. 115-124
    • Wu, Z.1    Puigserver, P.2    Andersson, U.3    Zhang, C.4    Adelmant, G.5    Mootha, V.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.