Unique lamina propria stromal cells imprint the functional phenotype of mucosal dendritic cells

Mucosal Immunology

Volumn 8, Issue 1, 2015, Pages 141-151

  Vicente Suarez, I ^a   Larange, A ^a   Reardon, C ^a   Matho, M ^a   Feau, S ^a   Chodaczek, G ^a   Park, Y ^a,b   Obata, Y ^c,d   Gold, R ^a   Wang Zhu, Y ^a   Lena, C ^a   Zajonc, D M ^a   Schoenberger, S P ^a   Kronenberg, M ^a   Cheroutre, H ^a  

^a LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY   (United States)

^b Pohang University of Science and Technology (POSTECH)   (South Korea)

^c UNIVERSITY OF TOKYO   (Japan)

^d CHIBA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CD103 ANTIGEN; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; RETINAL DEHYDROGENASE; RETINOIC ACID;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL INTERACTION; CELL MIGRATION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DENDRITIC CELL; ENZYME ACTIVITY; IN VIVO STUDY; INTESTINE FLORA; LAMINA PROPRIA; MOUSE; MUCOSAL DENDRITIC CELL; NONHUMAN; PRIORITY JOURNAL; SPLENIC DENDRITIC CELL; STROMA CELL; ANIMAL; C57BL MOUSE; CELL COMMUNICATION; CELL CULTURE; CELL DIFFERENTIATION; CELL MOTION; DIET; IMMUNOLOGY; IMMUNOMODULATION; KNOCKOUT MOUSE; LYMPHOCYTE ACTIVATION; METABOLISM; MUCOSA; MUCOSAL IMMUNITY; T LYMPHOCYTE;

ANIMALS; CELL COMMUNICATION; CELL DIFFERENTIATION; CELL MOVEMENT; CELLS, CULTURED; DENDRITIC CELLS; DIET; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; IMMUNITY, MUCOSAL; IMMUNOMODULATION; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MUCOUS MEMBRANE; STROMAL CELLS; T-LYMPHOCYTES; TRETINOIN;

EID: 84923633780     PISSN: 19330219     EISSN: 19353456     Source Type: Journal    
DOI: 10.1038/mi.2014.51     Document Type: Article

References (31)

1. Mark, M., Ghyselinck, N. B. & Chambon, P. Function of retinoid nuclear receptors: lessons from genetic and pharmacological dissections of the retinoic acid signaling pathway during mouse embryogenesis. Annu. Rev. Pharmacol. Toxicol. 46, 451-480 (2006)
2. Napoli, J. Interactions of retinoid binding proteins and enzymes in retinoid metabolism. Biochim. Biophys. Acta 1440, 139-162 (1999)
3. Petkovich, M. Regulation of gene expression by vitamin A: the role of nuclear retinoic acid receptors. Annu. Rev. Nutr. 12, 443-471 (1992)
4. Iwata, M. Retinoic acid imprints gut-homing specificity on T Cells. Immunity 21, 527-538 (2004)
5. Mora, J. R. et al. Generation of gut-homing IgA-secreting B cells by intestinal dendritic cells. Science 314, 1157-1160 (2006)
6. Mucida, D. et al. Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid. Science 317, 256-260 (2007)
7. Coombes, J. et al. A functionally specialized population of mucosal CD103 DCs induces Foxp3 regulatory T cells via a TGF-beta and retinoic acid-dependentmechanism. J. Exp. Med. 204, 1757-1764 (2007)
8. Benson, M. J., Pino-Lagos, K., Rosemblatt, M. & Noelle, R. J. All-trans retinoic acid mediates enhanced T reg cell growth, differentiation, and gut homing in the face of high levels of co-stimulation. J. Exp. Med. 204, 1765-1774 (2007)
9. DePaolo, R. W. et al. Co-adjuvant effects of retinoic acid and IL-15 induce inflammatory immunity to dietary antigens. Nature 471, 220-224 (2011)
10. Jaensson, E. et al. Small intestinal CD103 dendritic cells display unique functional properties that are conserved between mice and humans. J. Exp. Med. 205, 2139-2149 (2008)
11. Johansson-Lindbom, B. et al. Functional specialization of gut CD103 dendritic cells in the regulation of tissue-selective T cell homing. J. Exp. Med. 202, 1063-1073 (2005)
12. Agace, W. & Persson, E. How vitamin A metabolizing dendritic cells are generated in the gut mucosa. Trends Immunol. 33, 42-48 (2012)
13. Cassani, B., Villablanca, E., De Calisto, J., Wang, S. & Mora, R. Vitamin A and immune regulation: role of retinoic acid in gut-associated dendritic cell education, immune protection and tolerance. Mol. Aspects Med. 33, 63-76 (2012)
14. Molenaar, R. et al. Expression of retinaldehyde dehydrogenase enzymes in mucosal dendritic cells and gut-draining lymph node stromal cells is controlled by dietary vitamin A. J. Immunol. 186, 1934-1942 (2011)
15. Yokota, A. et al. GM-CSF and IL-4 synergistically trigger dendritic cells to acquire retinoic acid-producing capacity. Int. Immunol. 21, 361-377 (2009)
16. Hammerschmidt, S. I. et al. Retinoic acid induces homing of protective T and B cells to the gut after subcutaneous immunization in mice. J. Clin. Invest. 121, 3051-3061 (2011)
17. Villablanca, E. J. & Mora, J. R. MyD88 and retinoic acid signaling pathways interact to modulate gastrointestinal activities of dendritic cells. Gastroenterology 141, 176-185 (2011)
18. Bhat, P. V. Retinal dehydrogenase gene expression in stomach and small intestine of rats during postnatal development and in vitamin A deficiency. FEBS Lett. 426, 260-262 (1998)
19. Frota-Ruchon, A., Marcinkiewicz, M. & Bhat, P. V. Localization of retinal dehydrogenase type 1 in the stomach and intestine. Cell Tissue Res. 302, 397-400 (2000)
20. Wagner,M., Han, B. & Jessell, T. M. Regional differences in retinoid release from embryonic neural tissue detected by an in vitro reporter assay. Development 116, 55-66 (1992)
21. Kane,M. A., Folias, A. E. & Napoli, J. L. HPLC/UV quantitation of retinal, retinol, and retinyl esters in serum and tissues. Anal. Biochem. 378, 71-79 (2008)
22. Greter, M. et al. GM-CSF controls nonlymphoid tissue dendritic cell homeostasis but is dispensable for the differentiation of inflammatory dendritic cells. Immunity 36, 1031-1046 (2012)
23. Mueller, S. & Germain, R. Stromal cell contributions to the homeostasis and functionality of the immune system. Nat. Rev. Immunol. 9, 618-629 (2009)
24. Roozendaal, R. & Mebius, R. Stromal cell-immune cell interactions. Ann. Rev. Immunol. 29, 23-43 (2011)
25. Hammerschmidt, S. et al. Stromal mesenteric lymph node cells are essential for the generation of gut-homing Tcells in vivo. J. Exp. Med. 205, 2483-2490 (2008)
26. Molenaar, R. et al. Lymph node stromal cells support dendritic cell-induced gut-homing of T Cells. J. Immunol. 183, 6395-6402 (2009)
27. Iliev, I. D., Mileti, E., Matteoli, G., Chieppa, M. & Rescigno, M. Intestinal epithelial cells promote colitis-protective regulatory T-cell differentiation through dendritic cell conditioning. Mucosal Immunol. 2, 340-350 (2009)
28. Wang, S. et al. MyD88-dependent TLR1/2 signals educate dendritic cells with gut-specific imprinting properties. J. Immunol. 187, 141-150 (2011)
29. Agace, W. W. IRF4 transcription-factor-dependent CD103CD11b dendritic cells drive mucosal T helper 17 cell differentiation. Immunity 38, 958-969 (2013)
30. van de Laar, L., Coffer, P. J. & Woltman, A. M. Regulation of dendritic cell development by GM-CSF: molecular control and implications for immune homeostasis and therapy. Blood 119, 3383-3393 (2012)
31. Wagner,M. A. Use of reporter cells to study endogenous retinoid sources in embryonic tissues. Methods Enzymol. 282, 98-107 (1997).