Dietary and commensal derived nutrients: Shaping mucosal and systemic immunity

Current Opinion in Immunology

Volumn 24, Issue 4, 2012, Pages 379-384

  Spencer, Sean P ^a,b   Belkaid, Yasmine ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AROMATIC HYDROCARBON RECEPTOR; GPR43 RECEPTOR; IMMUNOGLOBULIN A; RECEPTOR; RETINALDEHYDE DEHYDROGENASE 2; RETINOIC ACID; RETINOL; SHORT CHAIN FATTY ACID; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 5; TRACE ELEMENT; UNCLASSIFIED DRUG; VACCINE; VITAMIN D; VITAMIN D RECEPTOR;

COMMENSAL; DENDRITIC CELL; DIET; FOXP3+ REGULATORY T CELL; GASTROINTESTINAL TRACT; HUMAN; INFECTION SENSITIVITY; INTESTINE FLORA; LIPID DIET; MALNUTRITION; MUCOSAL IMMUNITY; NONHUMAN; NUTRITION; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE; RETINOL DEFICIENCY; REVIEW; SIGNAL TRANSDUCTION; TH17 CELL; VACCINATION; VITAMIN METABOLISM;

ANIMALS; DIET; HUMANS; IMMUNITY, MUCOSAL; INTESTINAL MUCOSA; NUTRITIONAL PHYSIOLOGICAL PHENOMENA;

EID: 84865297479     PISSN: 09527915     EISSN: 18790372     Source Type: Journal    
DOI: 10.1016/j.coi.2012.07.006     Document Type: Review

References (55)

1. Mowat A.M., Viney J.L. The anatomical basis of intestinal immunity. Immunol Rev 1997, 156:145-166.
2. Hooper L.V., Littman D.R., Macpherson A.J. Interactions between the microbiota and the immune system. Science 2012, 336:1268-1273.
3. Maslowski K.M., Mackay C.R. Diet, gut microbiota and immune responses. Nat Immunol 2011, 12:5-9.
4. Hall J.A., Grainger J.R., Spencer S.P., Belkaid Y. The role of retinoic acid in tolerance and immunity. Immunity 2011, 35:13-22.
5. Sommer A. Vitamin A deficiency and clinical disease: an historical overview. J Nutr 2008, 138:1835-1839.
6. Underwood B.A. Vitamin A deficiency disorders: international efforts to control a preventable " pox" . J Nutr 2004, 134:231S-236S.
7. Rahmathullah L., Underwood B.A., Thulasiraj R.D., Milton R.C., Ramaswamy K., Rahmathullah R., Babu G. Reduced mortality among children in southern India receiving a small weekly dose of vitamin A. N Engl J Med 1990, 323:929-935.
8. Harrison E.H. Mechanisms of digestion and absorption of dietary vitamin A. Annu Rev Nutr 2005, 25:87-103.
9. Kane M.A., Folias A.E., Wang C., Napoli J.L. Quantitative profiling of endogenous retinoic acid in vivo and in vitro by tandem mass spectrometry. Anal Chem 2008, 80:1702-1708.
10. Jaensson E., Uronen-Hansson H., Pabst O., Eksteen B., Tian J., Coombes J.L., Berg P.L., Davidsson T., Powrie F., Johansson-Lindbom B., et al. Small intestinal CD103+ dendritic cells display unique functional properties that are conserved between mice and humans. J Exp Med 2008, 205:2139-2149.
11. Schulz O., Jaensson E., Persson E.K., Liu X., Worbs T., Agace W.W., Pabst O. Intestinal CD103+, but not CX3CR1+, antigen sampling cells migrate in lymph and serve classical dendritic cell functions. J Exp Med 2009, 206:3101-3114.
12. Iwata M., Hirakiyama A., Eshima Y., Kagechika H., Kato C., Song S.Y. Retinoic acid imprints gut-homing specificity on T cells. Immunity 2004, 21:527-538.
13. Yokota A., Takeuchi H., Maeda N., Ohoka Y., Kato C., Song S.Y., Iwata M. GM-CSF and IL-4 synergistically trigger dendritic cells to acquire retinoic acid-producing capacity. Int Immunol 2009, 21:361-377.
14. Wang S., Villablanca E.J., De Calisto J., Gomes D.C., Nguyen D.D., Mizoguchi E., Kagan J.C., Reinecker H.C., Hacohen N., Nagler C., et al. MyD88-dependent TLR1/2 signals educate dendritic cells with gut-specific imprinting properties. J Immunol 2011, 187:141-150.
15. Manicassamy S., Reizis B., Ravindran R., Nakaya H., Salazar-Gonzalez R.M., Wang Y.C., Pulendran B. Activation of beta-catenin in dendritic cells regulates immunity versus tolerance in the intestine. Science 2010, 329:849-853.
16. Villablanca E.J., Wang S., de Calisto J., Gomes D.C., Kane M.A., Napoli J.L., Blaner W.S., Kagechika H., Blomhoff R., Rosemblatt M., et al. MyD88 and retinoic acid signaling pathways interact to modulate gastrointestinal activities of dendritic cells. Gastroenterology 2011, 141:176-185.
17. Feng T., Cong Y., Qin H., Benveniste E.N., Elson C.O. Generation of mucosal dendritic cells from bone marrow reveals a critical role of retinoic acid. J Immunol 2010, 185:5915-5925.
18. Mora J.R., Iwata M., Eksteen B., Song S.Y., Junt T., Senman B., Otipoby K.L., Yokota A., Takeuchi H., Ricciardi-Castagnoli P., et al. Generation of gut-homing IgA-secreting B cells by intestinal dendritic cells. Science 2006, 314:1157-1160.
19. Suzuki K., Maruya M., Kawamoto S., Sitnik K., Kitamura H., Agace W.W., Fagarasan S. The sensing of environmental stimuli by follicular dendritic cells promotes immunoglobulin A generation in the gut. Immunity 2010, 33:71-83.
20. Josefowicz S.Z., Niec R.E., Kim H.Y., Treuting P., Chinen T., Zheng Y., Umetsu D.T., Rudensky A.Y. Extrathymically generated regulatory T cells control mucosal TH2 inflammation. Nature 2012, 482:395-399.
21. Mucida D., Kutchukhidze N., Erazo A., Russo M., Lafaille J.J., Curotto de Lafaille M.A. Oral tolerance in the absence of naturally occurring Tregs. J Clin Invest 2005, 115:1923-1933.
22. Travis M.A., Reizis B., Melton A.C., Masteller E., Tang Q., Proctor J.M., Wang Y., Bernstein X., Huang X., Reichardt L.F., et al. Loss of integrin alpha(v)beta8 on dendritic cells causes autoimmunity and colitis in mice. Nature 2007, 449:361-365.
23. Denning T.L., Wang Y.C., Patel S.R., Williams I.R., Pulendran B. Lamina propria macrophages and dendritic cells differentially induce regulatory and interleukin 17-producing T cell responses. Nat Immunol 2007, 8:1086-1094.
24. Sun C.M., Hall J.A., Blank R.B., Bouladoux N., Oukka M., Mora J.R., Belkaid Y. Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid. J Exp Med 2007, 204:1775-1785.
25. Coombes J.L., Siddiqui K.R., Arancibia-Carcamo C.V., Hall J., Sun C.M., Belkaid Y., Powrie F. A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-beta and retinoic acid-dependent mechanism. J Exp Med 2007, 204:1757-1764.
26. Cha H.R., Chang S.Y., Chang J.H., Kim J.O., Yang J.Y., Kim C.H., Kweon M.N. Downregulation of Th17 cells in the small intestine by disruption of gut flora in the absence of retinoic acid. J Immunol 2010, 184:6799-6806.
27. Wang C., Kang S.G., HogenEsch H., Love P.E., Kim C.H. Retinoic acid determines the precise tissue tropism of inflammatory Th17 cells in the intestine. J Immunol 2010, 184:5519-5526.
28. Takahashi H., Kanno T., Nakayamada S., Hirahara K., Sciume G., Muljo S.A., Kuchen S., Casellas R., Wei L., Kanno Y., et al. TGF-beta and retinoic acid induce the microRNA miR-10a, which targets Bcl-6 and constrains the plasticity of helper T cells. Nat Immunol 2012, 13:587-595.
29. Hall J.A., Cannons J.L., Grainger J.R., Dos Santos L.M., Hand T.W., Naik S., Wohlfert E.A., Chou D.B., Oldenhove G., Robinson M., et al. Essential role for retinoic acid in the promotion of CD4(+) T cell effector responses via retinoic acid receptor alpha. Immunity 2011, 34:435-447.
30. Pino-Lagos K., Guo Y., Brown C., Alexander M.P., Elgueta R., Bennett K.A., De Vries V., Nowak E., Blomhoff R., Sockanathan S., et al. A retinoic acid-dependent checkpoint in the development of CD4+ T cell-mediated immunity. J Exp Med 2011, 208:1767-1775.
31. Hammerschmidt S.I., Friedrichsen M., Boelter J., Lyszkiewicz M., Kremmer E., Pabst O., Forster R. Retinoic acid induces homing of protective T and B cells to the gut after subcutaneous immunization in mice. J Clin Invest 2011, 121:3051-3061.
32. DePaolo R.W., Abadie V., Tang F., Fehlner-Peach H., Hall J.A., Wang W., Marietta E.V., Kasarda D.D., Waldmann T.A., Murray J.A., et al. Co-adjuvant effects of retinoic acid and IL-15 induce inflammatory immunity to dietary antigens. Nature 2011, 471:220-224.
33. Mora J.R., Iwata M., von Andrian U.H. Vitamin effects on the immune system: vitamins A and D take centre stage. Nat Rev Immunol 2008, 8:685-698.
34. Savy M., Edmond K., Fine P.E., Hall A., Hennig B.J., Moore S.E., Mulholland K., Schaible U., Prentice A.M. Landscape analysis of interactions between nutrition and vaccine responses in children. J Nutr 2009, 139:2154S-2218S.
35. von Essen M.R., Kongsbak M., Schjerling P., Olgaard K., Odum N., Geisler C. Vitamin D controls T cell antigen receptor signaling and activation of human T cells. Nat Immunol 2010, 11:344-349.
36. Bruce D., Cantorna M.T. Intrinsic requirement for the vitamin D receptor in the development of CD8alphaalpha-expressing T cells. J Immunol 2011, 186:2819-2825.
37. Sun J. Vitamin D and mucosal immune function. Curr Opin Gastroenterol 2010, 26:591-595.
38. Yamaguchi T., Hirota K., Nagahama K., Ohkawa K., Takahashi T., Nomura T., Sakaguchi S. Control of immune responses by antigen-specific regulatory T cells expressing the folate receptor. Immunity 2007, 27:145-159.
39. Li Y., Innocentin S., Withers D.R., Roberts N.A., Gallagher A.R., Grigorieva E.F., Wilhelm C., Veldhoen M. Exogenous stimuli maintain intraepithelial lymphocytes via aryl hydrocarbon receptor activation. Cell 2011, 147:629-640.
40. Kiss E.A., Vonarbourg C., Kopfmann S., Hobeika E., Finke D., Esser C., Diefenbach A. Natural aryl hydrocarbon receptor ligands control organogenesis of intestinal lymphoid follicles. Science 2011, 334:1561-1565.
41. Maslowski K.M., Vieira A.T., Ng A., Kranich J., Sierro F., Yu D., Schilter H.C., Rolph M.S., Mackay F., Artis D., et al. Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43. Nature 2009, 461:1282-1286.
42. Devkota S., Wang Y., Musch M.W., Leone V., Fehlner-Peach H., Nadimpalli A., Antonopoulos D.A., Jabri B., Chang E.B. Dietary-fat-induced taurocholic acid promotes pathobiont expansion and colitis in Il10(-/-) mice. Nature 2012, 487:104-108.
43. Ley R.E., Turnbaugh P.J., Klein S., Gordon J.I. Microbial ecology: human gut microbes associated with obesity. Nature 2006, 444:1022-1023.
44. Monira S., Nakamura S., Gotoh K., Izutsu K., Watanabe H., Alam N.H., Endtz H.P., Cravioto A., Ali S.I., Nakaya T., et al. Gut microbiota of healthy and malnourished children in Bangladesh. Front Microbiol 2011, 2:228.
45. Shulzhenko N., Morgun A., Hsiao W., Battle M., Yao M., Gavrilova O., Orandle M., Mayer L., Macpherson A.J., McCoy K.D., et al. Crosstalk between B lymphocytes, microbiota and the intestinal epithelium governs immunity versus metabolism in the gut. Nat Med 2011, 17:1585-1593.
46. Vijay-Kumar M., Aitken J.D., Carvalho F.A., Cullender T.C., Mwangi S., Srinivasan S., Sitaraman S.V., Knight R., Ley R.E., Gewirtz A.T. Metabolic syndrome and altered gut microbiota in mice lacking Toll-like receptor 5. Science 2010, 328:228-231.
47. Gordon J.I., Dewey K.G., Mills D.A., Medzhitov R.M. The human gut microbiota and undernutrition. Sci Transl Med 2012, 4:112.
48. Yatsunenko T., Rey F.E., Manary M.J., Trehan I., Dominguez-Bello M.G., Contreras M., Magris M., Hidalgo G., Baldassano R.N., Anokhin A.P., et al. Human gut microbiome viewed across age and geography. Nature 2012, 486:222-227.
49. Nicholson J.K., Holmes E., Kinross J., Burcelin R., Gibson G., Jia W., Pettersson S. Host-gut microbiota metabolic interactions. Science 2012, 336:1262-1267.
50. Yuk J.M., Shin D.M., Lee H.M., Yang C.S., Jin H.S., Kim K.K., Lee Z.W., Lee S.H., Kim J.M., Jo E.K. Vitamin D3 induces autophagy in human monocytes/macrophages via cathelicidin. Cell Host Microbe 2009, 6:231-243.
51. Vaishnava S., Yamamoto M., Severson K.M., Ruhn K.A., Yu X., Koren O., Ley R., Wakeland E.K., Hooper L.V. The antibacterial lectin RegIIIgamma promotes the spatial segregation of microbiota and host in the intestine. Science 2011, 334:255-258.
52. Sonnenberg G.F., Monticelli L.A., Alenghat T., Fung T.C., Hutnick N.A., Kunisawa J., Shibata N., Grunberg S., Sinha R., Zahm A.M., et al. Innate lymphoid cells promote anatomical containment of lymphoid-resident commensal bacteria. Science 2012, 336:1321-1325.
53. Kawamoto S., Tran T.H., Maruya M., Suzuki K., Doi Y., Tsutsui Y., Kato L.M., Fagarasan S. The inhibitory receptor PD-1 regulates IgA selection and bacterial composition in the gut. Science 2012, 336:485-489.
54. Suzuki K., Meek B., Doi Y., Muramatsu M., Chiba T., Honjo T., Fagarasan S. Aberrant expansion of segmented filamentous bacteria in IgA-deficient gut. Proc Natl Acad Sci U S A 2004, 101:1981-1986.
55. Salzman N.H., Hung K., Haribhai D., Chu H., Karlsson-Sjoberg J., Amir E., Teggatz P., Barman M., Hayward M., Eastwood D., et al. Enteric defensins are essential regulators of intestinal microbial ecology. Nat Immunol 2010, 11:76-83.