Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells

Chemical Research in Toxicology

Volumn 28, Issue 10, 2015, Pages 1903-1913

  Ravindra, Kodihalli C ^a   Ho, Wanxing Eugene ^b,c   Cheng, Chang ^d,e   Godoy, Luiz C ^a   Wishnok, John S ^a   Ong, Choon Nam ^b   Wong, W S Fred ^e   Wogan, Gerald N ^a   Tannenbaum, Steven R ^a,c  

^a Massachusetts Institute of Technology Cambridge   (United States)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^c SINGAPORE MIT ALLIANCE FOR RESEARCH AND TECHNOLOGY   (Singapore)

^d SINGAPORE GENERAL HOSPITAL   (Singapore)

^e NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

ARTESUNATE; CELL PROTEIN; DIHYDROARTEMISININ; GLUCOSE; KELCH LIKE ECH ASSOCIATED PROTEIN 1; MITOCHONDRIAL ENZYME; STRUCTURAL PROTEIN; TRANSCRIPTION FACTOR NRF2; ANTIMALARIAL AGENT; ARTEMISININ DERIVATIVE; KEAP1 PROTEIN, HUMAN; SIGNAL PEPTIDE;

ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; BRONCHUS MUCOSA; CONTROLLED STUDY; DRUG MECHANISM; ENERGY METABOLISM; EPITHELIUM CELL; GENE EXPRESSION; HUMAN; HUMAN CELL; INFLAMMATORY DISEASE; LUNG DISEASE; MOLECULAR INTERACTION; PROTEOMICS; STRESS; BRONCHUS; CELL LINE; CELL PROLIFERATION; CYTOLOGY; DRUG EFFECTS; ELECTROSPRAY MASS SPECTROMETRY; GLYCOLYSIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; METABOLISM; UPREGULATION;

ANTIMALARIALS; ARTEMISININS; BRONCHI; CELL LINE; CELL PROLIFERATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; EPITHELIAL CELLS; GLYCOLYSIS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; NF-E2-RELATED FACTOR 2; PROTEOMICS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; UP-REGULATION;

EID: 84944790442     PISSN: 0893228X     EISSN: 15205010     Source Type: Journal    
DOI: 10.1021/acs.chemrestox.5b00105     Document Type: Article

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