Anti-malarial drug artesunate ameliorates oxidative lung damage in experimental allergic asthma

Free Radical Biology and Medicine

Volumn 53, Issue 3, 2012, Pages 498-507

  Ho, Wanxing Eugene ^a,b,c   Cheng, Chang ^c,d   Peh, Hong Yong ^c,d   Xu, Fengguo ^a   Tannenbaum, Steven R ^b,e   Ong, Choon Nam ^a   Wong, W S Fred ^c,d  

^a NATIONAL UNIVERSITY HEALTH SYSTEM   (Singapore)

^b SINGAPORE MIT ALLIANCE FOR RESEARCH AND TECHNOLOGY   (Singapore)

^c NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^d NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^e MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

Allergy; Artemisinin; Free radicals; Lipid peroxidation; Nitric oxide; Nrf2; Oxidative DNA damage; Protein nitration

Indexed keywords

3 NITROTYROSINE; 8 HYDROXYDEOXYGUANOSINE; 8 ISOPROSTANE; ARTESUNATE; CATALASE; DEXAMETHASONE; INOSINATE DEHYDROGENASE; OVALBUMIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 1; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 4; SUPEROXIDE DISMUTASE; TRANSCRIPTION FACTOR NRF2; TUMOR NECROSIS FACTOR ALPHA;

ALLERGIC AIRWAY INFLAMMATION; ALLERGIC ASTHMA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTHMA; CONTROLLED STUDY; EOSINOPHIL COUNT; EPITHELIUM CELL; FEMALE; GENE EXPRESSION; LUNG INJURY; MOUSE; NEUTROPHIL COUNT; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SENSITIZATION;

ANIMALS; ANTI-ASTHMATIC AGENTS; ANTI-INFLAMMATORY AGENTS; ANTIMALARIALS; ANTIOXIDANTS; ARTEMISININS; ASTHMA; BRONCHIOLES; BRONCHOALVEOLAR LAVAGE FLUID; CELL NUCLEUS; CELLS, CULTURED; DEXAMETHASONE; EPITHELIAL CELLS; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; LEUKOCYTES; LUNG INJURY; MACROPHAGES; MICE; MICE, INBRED BALB C; NEUTROPHIL INFILTRATION; NF-E2-RELATED FACTOR 2; OVALBUMIN; OXIDOREDUCTASES; REACTIVE OXYGEN SPECIES; RESPIRATORY MUCOSA;

ARTESUNATE; MURINAE; MUS;

EID: 84863457529     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2012.05.021     Document Type: Article

References (45)

1. T. Hoshino, M. Okamoto, S. Takei, Y. Sakazaki, T. Iwanaga, and H. Aizawa Redox-regulated mechanisms in asthma Antioxid. Redox Signaling 10 2008 769 783 (Pubitemid 351225896)
2. H. Sugiura, and M. Ichinose Oxidative and nitrative stress in bronchial asthma Antioxid. Redox Signaling 10 2008 785 797 (Pubitemid 351225897)
3. R. Do, K.H. Bartlett, H. Dilmich-Ward, W. Chu, and S.M. Kennedy Biomarkers of airway acidity and oxidative stress in exhaled breath condensate from grain workers Am. J. Respir. Crit. Care Med. 178 2008 1048 1054
4. I. Romieu, A. Barraza-Villarreal, C. Escamilla-Nunez, A.C. Almstrand, D. Diaz-Sanchez, P.D. Sly, and A.C. Olin Exhaled breath malondialdehyde as a marker of effect of exposure to air pollution in children with asthma J. Allergy Clin. Immunol. 121 2008 903 909
5. L.G. Wood, M.L. Garg, J.L. Simpson, T.A. Mori, K.D. Croft, P.A. Wark, and P.G. Gibson Induced sputum 8-isoprostane concentrations in inflammatory airway diseases Am. J. Respir. Crit. Care Med. 171 2005 426 430 (Pubitemid 40444241)
6. T. Chiba, H. Uchi, G. Tsuji, H. Gondo, Y. Moroi, and M. Furue Arylhydrocarbon (AhR) activation in airway epithelial cells induces MUC5AC via reactive oxygen species (ROS) production Pulm. Pharmacol. Ther. 24 2011 133 140
7. 2 handling and Rho/ROCK signaling Am. J. Physiol. Lung C 291 2006 L1177 L1184
8. Y.S. Cho, J. Lee, T.H. Lee, E.Y. Lee, K.U. Lee, J.Y. Park, and H.B. Moon α-Lipoic acid inhibits airway inflammation and hyperresponsiveness in a mouse model of asthma J. Allergy Clin. Immunol. 114 2004 429 435 (Pubitemid 39119048)
9. J.G. Wagner, Q. Jiang, J.R. Harkema, B.N. Ames, B. Illek, R.A. Roubey, and D.B. Peden γ-Tocopherol prevents airway eosinophilia and mucous cell hyperplasia in experimentally induced allergic rhinitis and asthma Clin. Exp. Allergy 38 2008 501 511 (Pubitemid 351208073)
10. T. Gordi, and E.-I. Lepist Artemisinin derivatives: toxic for laboratory animals, safe for humans? Toxicol. Lett. 147 2004 99 107 (Pubitemid 38130178)
11. H. Xu, Y. He, X. Yang, L. Liang, Z. Zhan, Y. Ye, F. Lian, and L. Sun Anti-malarial agent artesunate inhibits TNF-α-induced production of proinflammatory cytokines via inhibition of NF-κB and PI3 kinase/Akt signal pathway in human rheumatoid arthritis fibroblast-like synoviocytes Rheumatology 46 2007 920 926 (Pubitemid 47062496)
12. O. Jin, H. Zhang, Z. Gu, S. Zhao, T. Xu, K. Zhou, B. Jiang, J. Wang, X. Zeng, and L. Sun A pilot study of the therapeutic efficacy and mechanism of artesunate in the MRL/lpr murine model of systemic lupus erythematosus Cell. Mol. Immunol. 6 2009 461 467
13. B. Li, J. Li, X. Pan, G. Ding, H. Cao, W. Jiang, J. Zheng, and H. Zhou Artesunate protects sepsis model mice challenged with Staphylococcus aureus by decreasing TNF-α release via inhibition of TLR2 and Nod2 mRNA expressions and transcription factor NF-κB activation Int. Immunopharmacol. 10 2010 344 350
14. C. Cheng, W.E. Ho, F.Y. Goh, S.P. Guan, L.R. Kong, W.Q. Lai, B.P. Leung, and W.S. Wong Anti-malarial drug artesunate attenuates experimental allergic asthma via inhibition of the phosphoinositide 3-kinase/Akt pathway PLoS One 6 e20932 2011
15. A. Duguet, H. Iijima, S.Y. Eum, Q. Hamid, and D.H. Eidelman Eosinophil peroxidase mediates protein nitration in allergic airway inflammation in mice Am. J. Respir. Crit. Care Med. 164 2001 1119 1126 (Pubitemid 33052237)
16. F.Y. Goh, N. Upton, S.P. Guan, C. Cheng, M.K. Shanmugam, G. Sethi, and W.S.F. Wong Fisetin, a bioactive flavonol, attenuates allergic airway inflammation through negative regulation of NF-κB Eur. J. Pharmacol. 679 2012 109 116
17. A.A. Andreadis, S.L. Hazen, and S.A. Comhair Erzurum, S. C. Oxidative and nitrosative events in asthma Free Radic. Biol. Med. 35 2003 213 225 (Pubitemid 37288922)
18. D. Giustarini, I. Dalle-Donne, D. Tsikas, and R. Rossi Oxidative stress and human diseases: origin, link, measurement, mechanisms, and biomarkers Crit. Rev. Clin. Lab. Sci. 46 2009 241 281
19. L.G. Wood, P.G. Gibson, and M.L. Garg Biomarkers of lipid peroxidation, airway inflammation and asthma Eur. Respir. J. 21 2003 177 186 (Pubitemid 36150317)
20. S. Ghosh, A.J. Janocha, M.A. Aronica, S. Swaidani, S.A. Comhair, W. Xu, L. Zheng, S. Kaveti, M. Kinter, S.L. Hazen, and S.C. Erzurum Nitrotyrosine proteome survey in asthma identifies oxidative mechanism of catalase inactivation J. Immunol. 176 2006 5587 5597
21. H. Abdala-Valencia, J. Earwood, S. Bansal, M. Jansen, G. Babcock, B. Garvy, M. Wills-Karp, J.M. Cook-Mills, and N.A.D.P.H. Nonhematopoietic oxidase regulation of lung eosinophilia and airway hyperresponsiveness in experimentally induced asthma Am. J. Physiol. Lung Cell Mol. Physiol 292 2007 L1111 1125
22. I. Rahman, S.K. Biswas, and A. Kode Oxidant and antioxidant balance in the airways and airway diseases Eur. J. Pharmacol. 533 2006 222 239 (Pubitemid 43340015)
23. A. Nadeem, S.K. Chhabra, A. Masood, and H.G. Raj Increased oxidative stress and altered levels of antioxidants in asthma J. Allergy Clin. Immunol. 111 2003 72 78 (Pubitemid 36143294)
24. J.K. Moon, and T. Shibamoto Antioxidant assays for plant and food components J. Agric. Food Chem. 57 2009 1655 1666
25. A. Boutten, D. Goven, J. Boczkowski, and M. Bonay Oxidative stress targets in pulmonary emphysema: focus on the Nrf2 pathway Expert Opin. Ther. Targets 14 2010 329 346
26. H.Y. Cho, S.P. Reddy, A. DeBiase, M. Yamamoto, and S.R. Kleeberger Gene expression profiling of NRF2-mediated protection against oxidative injury Free Radic. Biol. Med. 38 2005 325 343 (Pubitemid 40081112)
27. P.J. Barnes Corticosteroid resistance in airway disease Proc. Am. Thorac. Soc 1 2004 264 268
28. B. Vagaggini, M.L. Bartoli, S. Cianchetti, F. Costa, E. Bacci, F.L. Dente, A. Di Franco, L. Malagrino, and P. Paggiaro Increase in markers of airway inflammation after ozone exposure can be observed also in stable treated asthmatics with minimal functional response to ozone Respir. Res. 11 2010 5
29. L.G. Wood, and P.G. Gibson Reduced circulating antioxidant defences are associated with airway hyper-responsiveness, poor control and severe disease pattern in asthma Br. J. Nutr 103 2010 735 741
30. W. MacNee Oxidative stress and lung inflammation in airways disease Eur. J. Pharmacol. 429 2001 195 207 (Pubitemid 33043996)
31. G. Caramori, and A. Papi Oxidants and asthma Thorax 59 2004 170 173 (Pubitemid 38228419)
32. P. Montuschi, M. Corradi, G. Ciabattoni, J. Nightingale, S.A. Kharitonov, and P.J. Barnes Increased 8-isoprostane, a marker of oxidative stress, in exhaled condensate of asthma patients Am. J. Respir. Crit. Care Med. 160 1999 216 220 (Pubitemid 29326091)
33. S. Caballero Balanza, A. Martorell Aragones, J.C. Cerda Mir, J. Belda Ramirez, R. Navarro Ivanez, A. Navarro Soriano, R. Felix Toledo, and A. Escribano Montaner Leukotriene B4 and 8-isoprostane in exhaled breath condensate of children with episodic and persistent asthma J. Invest. Allergol. Clin. Immunol. 20 2010 237 243
34. P.J. Barnes, K. Maneechotesuwan, S. Essilfie-Quaye, S.A. Kharitonov, and I.M. Adcock Loss of control of asthma following inhaled corticosteroid withdrawal is associated with increased sputum interleukin-8 and neutrophils Chest 132 2007 98 105 (Pubitemid 47068209)
35. K. Ito, C. Herbert, J.S. Siegle, C. Vuppusetty, N. Hansbro, P.S. Thomas, P.S. Foster, P.J. Barnes, and R.K. Kumar Steroid-resistant neutrophilic inflammation in a mouse model of an acute exacerbation of asthma Am. J. Respir. Cell Mol. Biol. 39 2008 543 550
36. P.C. Dedon, and S.R. Tannenbaum Reactive nitrogen species in the chemical biology of inflammation Arch. Biochem. Biophys. 423 2004 12 22 (Pubitemid 38202218)
37. T. Hanazawa, S.A. Kharitonov, and P.J. Barnes Increased nitrotyrosine in exhaled breath condensate of patients with asthma Am. J. Respir. Crit. Care Med. 162 2000 1273 1276
38. R. Radi Nitric oxide, oxidants, and protein tyrosine nitration Proc. Natl. Acad. Sci. USA 101 2004 4003 4008 (Pubitemid 38405874)
39. L.J. Roberts, P. Montuschi, and P.J. Barnes Isoprostanes: markers and mediators of oxidative stress FASEB J 18 2004 1791 1800 (Pubitemid 39602265)
40. E. Baraldi, S. Carraro, R. Alinovi, A. Pesci, L. Ghiro, A. Bodini, G. Piacentini, F. Zacchello, and S. Zanconato Cysteinyl leukotrienes and 8-isoprostane in exhaled breath condensate of children with asthma exacerbations Thorax 58 2003 505 509 (Pubitemid 36714012)
41. P.G. Van Hoydonck, W.A. Wuyts, B.M. Vanaudenaerde, E.G. Schouten, L.J. Dupont, and E.H. Temme Quantitative analysis of 8-isoprostane and hydrogen peroxide in exhaled breath condensate Eur. Respir. J. 23 2004 189 192 (Pubitemid 38195500)
42. A.M. Fitzpatrick, W.G. Teague, L. Burwell, M.S. Brown, L.A.S. Brown, and N.N.S.A. Res Glutathione oxidation is associated with airway macrophage functional impairment in children with severe asthma Pediatr. Res. 69 2011 154 159
43. E.P. Carter, C. Garat, and M. Imamura Continual emerging roles of HO-1: protection against airway inflammation Am. J. Physiol. Lung Cell. Mol. Physiol 287 2004 L24 25
44. N. Li, J. Alam, M.I. Venkatesan, A. Eiguren-Fernandez, D. Schmitz, E. Di Stefano, N. Slaughter, E. Killeen, X. Wang, A. Huang, M. Wang, A.H. Miguel, A. Cho, C. Sioutas, and A.E. Nel Nrf2 is a key transcription factor that regulates antioxidant defense in macrophages and epithelial cells: protecting against the proinflammatory and oxidizing effects of diesel exhaust chemicals J. Immunol. 173 2004 3467 3481 (Pubitemid 39142058)
45. T. Rangasamy, J. Guo, W.A. Mitzner, J. Roman, A. Singh, A.D. Fryer, M. Yamamoto, T.W. Kensler, R.M. Tuder, S.N. Georas, and S. Biswal Disruption of Nrf2 enhances susceptibility to severe airway inflammation and asthma in mice J. Exp. Med. 202 2005 47 59 (Pubitemid 41002909)