The antimalarial drug artesunate inhibits primary human cultured airway smooth muscle cell proliferation

American Journal of Respiratory Cell and Molecular Biology

Volumn 50, Issue 2, 2014, Pages 451-458

  Tan, Sheryl S L ^a   Ong, Benjamin ^a   Cheng, Chang ^a   Eugene Ho, Wanxing ^b   Tam, John K C ^a   Stewart, Alastair G ^c   Harris, Trudi ^c   Wong, W S Fred ^a   Tran, Thai ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b NATIONAL UNIVERSITY HEALTH SYSTEM   (Singapore)

^c UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Airway wall remodeling; Asthma; Cyclin D1; P70S6K; PI3K

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; ARTESUNATE; CYCLIN D1; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B;

ADOLESCENT; ADULT; AGED; AIRWAY SMOOTH MUSCLE CELL; ALLERGIC ASTHMA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CELL CULTURE; CELL HYPERPLASIA; CELL PROLIFERATION; CONTROLLED STUDY; DRUG EFFECT; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MALE; MIDDLE AGED; MOUSE; MURINE MODEL; NONHUMAN; PROTEIN PHOSPHORYLATION; SMOOTH MUSCLE FIBER; YOUNG ADULT;

AIRWAY REMODELING; ANIMALS; ANTIMALARIALS; ARTEMISININS; ASTHMA; CELL PROLIFERATION; CELLS, CULTURED; CYCLIN D1; DEXAMETHASONE; FEMALE; GLUCOCORTICOIDS; HUMANS; MICE; MUSCLE, SMOOTH; MYOCYTES, SMOOTH MUSCLE; PHOSPHATIDYLINOSITOL 3-KINASES; RESPIRATORY SYSTEM;

EID: 84893234807     PISSN: 10441549     EISSN: 15354989     Source Type: Journal    
DOI: 10.1165/rcmb.2013-0273OC     Document Type: Article

References (35)

1. Ebina M, Takahashi T, Chiba T, Motomiya M. Cellular hypertrophy and hyperplasia of airway smooth muscles underlying bronchial asthma: a 3-D morphometric study. Am Rev Respir Dis 1993;148:720-726.
2. Lambert RK, Wiggs BR, Kuwano K, Hogg JC, Paré PD. Functional significance of increased airway smooth muscle in asthma and COPD. J Appl Physiol 1993;74:2771-2781.
3. Hirst SJ, Lee TH. Airway smooth muscle as a target of glucocorticoid action in the treatment of asthma. Am J Respir Crit Care Med 1998; 158:S201-S206.
4. Stewart AG, Tomlinson PR, Wilson JW. Regulation of airway wall remodeling: prospects for the development of novel antiasthma drugs. Adv Pharmacol 1995;33:209-253.
5. Sotomayor H, Badier M, Vervloet D, Orehek J. Seasonal increase of carbachol airway responsiveness in patients allergic to grass pollen: reversal by corticosteroids. Am Rev Respir Dis 1984;130: 56-58.
6. Jeffery PK, Godfrey RW, Adelroth E, Nelson F, Rogers A, Johansson SA. Effects of treatment on airway inflammation and thickening of basement membrane reticular collagen in asthma: a quantitative light and electron microscopic study. Am Rev Respir Dis 1992;145: 890-899.
7. Nash JJ, Nash AG, Leach ME, Poetker DM. Medical malpractice and corticosteroid use. Otolaryngol Head Neck Surg 2011;144:10-15.
8. Poetker DM, Reh DD. A comprehensive review of the adverse effects of systemic corticosteroids. Otolaryngol Clin North Am 2010;43: 753-768.
9. Krishna S, Bustamante L, Haynes RK, Staines HM. Artemisinins: their growing importance in medicine. Trends Pharmacol Sci 2008;29:520-527.
10. Efferth T, Kaina B. Toxicity of the antimalarial artemisinin and its dervatives. Crit Rev Toxicol 2010;40:405-421.
11. Xu Q, Li ZX, Peng HQ, Sun ZW, Cheng RL, Ye ZM, Li WX. Artesunate inhibits growth and induces apoptosis in human osteosarcoma HOS cell line in vitro and in vivo. J Zhejiang Univ Sci B 2011;12: 247-255.
12. Li S, Xue F, Cheng Z, Yang X, Wang S, Geng F, Pan L. Effect of artesunate on inhibiting proliferation and inducing apoptosis of SP2/0 myeloma cells through affecting NFkappaB p65. Int J Hematol 2009;90:513-521.
13. Cheng C, Ho WE, Goh FY, Guan SP, Kong LR, Lai WQ, Leung BP, Wong WS. Anti-malarial drug artesunate attenuates experimental allergic asthma via inhibition of the phosphoinositide 3-kinase/Akt pathway. PLoS ONE 2011;6:e20932.
14. Tran T, Stewart AG. Protease-activated receptor (PAR)-independent growth and pro-inflammatory actions of thrombin on human cultured airway smooth muscle. Br J Pharmacol 2003;138:865-875.
15. Fernandes D, Guida E, Koutsoubos V, Harris T, Vadiveloo P, Wilson JW, Stewart AG. Glucocorticoids inhibit proliferation, cyclin D1 expression, and retinoblastoma protein phosphorylation, but not activity of the extracellular-regulated kinases in human cultured airway smooth muscle. Am J Respir Cell Mol Biol 1999;21:77-88.
16. Tran T, Teoh CM, Tam JK, Qiao Y, Chin CY, Chong OK, Stewart AG, Harris T, Wong WS, Guan SP, et al. Laminin drives survival signals to promote a contractile smooth muscle phenotype and airway hyperreactivity. FASEB J 2013;27:3991-4003.
17. Bao Z, Guan S, Cheng C, Wu S, Wong SH, Kemeny DM, Leung BP, Wong WS. A novel antiinflammatory role for andrographolide in asthma via inhibition of the nuclear factor-kappaB pathway. Am J Respir Crit Care Med 2009;179:657-665.
18. Robinson PJ, Hegele RG, Schellenberg RR. Increased airway reactivity in human RSV bronchiolitis in the guinea pig is not due to increased wall thickness. Pediatr Pulmonol 1996;22:248-254.
19. Vlahos R, Lee KS, Guida E, Fernandes DJ, Wilson JW, Stewart AG. Differential inhibition of thrombin- and EGF-stimulated human cultured airway smooth muscle proliferation by glucocorticoids. Pulm Pharmacol Ther 2003;16:171-180.
20. Ravenhall C, Guida E, Harris T, Koutsoubos V, Stewart A. The importance of ERK activity in the regulation of cyclin D1 levels and DNA synthesis in human cultured airway smooth muscle. Br J Pharmacol 2000;131:17-28.
21. Maddika S, Ande SR, Wiechec E, Hansen LL, Wesselborg S, Los M. Akt-mediated phosphorylation of CDK2 regulates its dual role in cell cycle progression and apoptosis. J Cell Sci 2008;121: 979-988.
22. Stewart AG, Harris T, Fernandes DJ, Schachte LC, Koutsoubos V, Guida E, Ravenhall CE, Vadiveloo P, Wilson JW. Beta2- adrenergic receptor agonists and cAMP arrest human cultured airway smooth muscle cells in the G(1) phase of the cell cycle: role of proteasome degradation of cyclin D1. Mol Pharmacol 1999;56:1079-1086.
23. Orsini MJ, Krymskaya VP, Eszterhas AJ, Benovic JL, Panettieri RA Jr, Penn RB. MAPK superfamily activation in human airway smooth muscle: mitogenesis requires prolonged p42/p44 activation. Am J Physiol 1999;277:L479-L488.
24. Burgess JK, Lee JH, Ge Q, Ramsay EE, Poniris MH, Parmentier J, Roth M, Johnson PR, Hunt NH, Black JL, et al. Dual ERK and phosphatidylinositol 3-kinase pathways control airway smooth muscle proliferation: differences in asthma. J Cell Physiol 2008;216:673-679.
25. Page K, Li J, Wang Y, Kartha S, Pestell RG, Hershenson MB. Regulation of cyclin D(1) expression and DNA synthesis by phosphatidylinositol 3-kinase in airway smooth muscle cells. Am J Respir Cell Mol Biol 2000;23:436-443.
26. Krymskaya VP, Penn RB, Orsini MJ, Scott PH, Plevin RJ, Walker TR, Eszterhas AJ, Amrani Y, Chilvers ER, Panettieri RA Jr. Phosphatidylinositol 3-kinase mediates mitogen-induced human airway smooth muscle cell proliferation. Am J Physiol 1999;277:L65-L78.
27. Scott PH, Belham CM, al-Hafidh J, Chilvers ER, Peacock AJ, Gould GW, Plevin R. A regulatory role for cAMP in phosphatidylinositol 3-kinase/p70 ribosomal S6 kinase-mediated DNA synthesis in platelet-derived-growth-factor- stimulated bovine airway smoothmuscle cells. Biochem J 1996;318:965-971.
28. Hashemolhosseini S, Nagamine Y, Morley SJ, Desriviè res S, Mercep L, Ferrari S. Rapamycin inhibition of the G1 to S transition is mediated by effects on cyclin D1 mRNA and protein stability. J Biol Chem 1998;273:14424-14429.
29. Haake SM, Dinh CT, Chen S, Eshraghi AA, Van De Water TR. Dexamethasone protects auditory hair cells against TNFalphainitiated apoptosis via activation of PI3K/Akt and NFkappaB signaling. Hear Res 2009;255:22-32.
30. Cheng C, Ng DS, Chan TK, Guan SP, Ho WE, Koh AH, Bian JS, Lau HY, Wong WS. Anti-allergic action of anti-malarial drug artesunate in experimental mast cell-mediated anaphylactic models. Allergy 2013; 68:195-203.
31. Chen H, Sun B, Wang S, Pan S, Gao Y, Bai X, Xue D. Growth inhibitory effects of dihydroartemisinin on pancreatic cancer cells: involvement of cell cycle arrest and inactivation of nuclear factor-kappaB. J Cancer Res Clin Oncol 2010;136:897-903.
32. He Y, Fan J, Lin H, Yang X, Ye Y, Liang L, Zhan Z, Dong X, Sun L, Xu H. The anti-malaria agent artesunate inhibits expression of vascular endothelial growth factor and hypoxia-inducible factor-1a in human rheumatoid arthritis fibroblast-like synoviocyte. Rheumatol Int 2011; 31:53-60.
33. Marwick JA, Adcock IM, Chung KF. Overcoming reduced glucocorticoid sensitivity in airway disease: molecular mechanisms and therapeutic approaches. Drugs 2010;70:929-948.
34. Chung KF, Godard P, Adelroth E, Ayres J, Barnes N, Barnes P, Bel E, Burney P, Chanez P, Connett G, et al.; European Respiratory Society. Difficult/therapy-resistant asthma: the need for an integrated approach to define clinical phenotypes, evaluate risk factors, understand pathophysiology and find novel therapies. ERS Task Force on Difficult/Therapy-Resistant Asthma. Eur Respir J 1999;13:1198-1208.
35. Gordi T, Lepist EI. Artemisinin derivatives: toxic for laboratory animals, safe for humans? Toxicol Lett 2004;147:99-107.