메뉴 건너뛰기




Volumn 8, Issue , 2015, Pages 2989-3001

Luteolin decreases invasiveness, deactivates STAT3 signaling, and reverses interleukin-6 induced epithelial–mesenchymal transition and matrix metalloproteinase secretion of pancreatic cancer cells

Author keywords

Epithelial mesenchymal transition; Luteolin; Matrix metalloproteinase; STAT3

Indexed keywords

GELATINASE A; GELATINASE B; INTERLEUKIN 6; LUTEOLIN; MATRILYSIN; STAT3 PROTEIN;

EID: 84944744981     PISSN: 11786930     EISSN: 11786930     Source Type: Journal    
DOI: 10.2147/OTT.S91511     Document Type: Article
Times cited : (79)

References (50)
  • 2
    • 0036400016 scopus 로고    scopus 로고
    • Dietary flavonoids: Bioavailability, metabolic effects, and safety
    • Ross JA, Kasum CM. Dietary flavonoids: bioavailability, metabolic effects, and safety. Annu Rev Nutr. 2002;22:19-34.
    • (2002) Annu Rev Nutr. , vol.22 , pp. 19-34
    • Ross, J.A.1    Kasum, C.M.2
  • 3
    • 0033637140 scopus 로고    scopus 로고
    • The effects of plant flavonoids on mammalian cells: Implications for inflammation, heart disease, and cancer
    • Middleton E Jr, Kandaswami C, Theoharides TC. The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer. Pharmacol Rev. 2000;52(4):673-751.
    • (2000) Pharmacol Rev. , vol.52 , Issue.4 , pp. 673-751
    • Middleton, E.1    Kandaswami, C.2    Theoharides, T.C.3
  • 4
    • 34250362760 scopus 로고    scopus 로고
    • Comparison of antioxidative and antitumor activities of six flavonoids from Epimedium koreanum
    • Wang T, Zhang JC, Chen Y, Huang F, Yang MS, Xiao PG. Comparison of antioxidative and antitumor activities of six flavonoids from Epimedium koreanum. Zhongguo Zhong Yao Za Zhi. 2007;32(8):715-718.
    • (2007) Zhongguo Zhong Yao Za Zhi. , vol.32 , Issue.8 , pp. 715-718
    • Wang, T.1    Zhang, J.C.2    Chen, Y.3    Huang, F.4    Yang, M.S.5    Xiao, P.G.6
  • 5
    • 23044455268 scopus 로고    scopus 로고
    • The antitumor activities of flavonoids
    • Kandaswami C, Lee LT, Lee PP, et al. The antitumor activities of flavonoids. In Vivo. 2005;19(5):895-909.
    • (2005) In Vivo. , vol.19 , Issue.5 , pp. 895-909
    • Kandaswami, C.1    Lee, L.T.2    Lee, P.P.3
  • 6
    • 84927696925 scopus 로고    scopus 로고
    • Luteolin protects against vascular inflammation in mice and TNF-alpha-induced monocyte adhesion to endothelial cells via suppressing IκBα/NF-κB signaling pathway
    • Jia Z, Nallasamy P, Liu D, et al. Luteolin protects against vascular inflammation in mice and TNF-alpha-induced monocyte adhesion to endothelial cells via suppressing IκBα/NF-κB signaling pathway. J Nutr Biochem. 2015;26(3):293-302.
    • (2015) J Nutr Biochem. , vol.26 , Issue.3 , pp. 293-302
    • Jia, Z.1    Nallasamy, P.2    Liu, D.3
  • 7
    • 84896393412 scopus 로고    scopus 로고
    • Brain inflammation, neuropsychiatric disorders, and immunoendocrine effects of luteolin
    • Theoharides TC, Conti P, Economu M. Brain inflammation, neuropsychiatric disorders, and immunoendocrine effects of luteolin. J Clin Psychopharmacol. 2014;34(2):187-189.
    • (2014) J Clin Psychopharmacol. , vol.34 , Issue.2 , pp. 187-189
    • Theoharides, T.C.1    Conti, P.2    Economu, M.3
  • 8
    • 84895174074 scopus 로고    scopus 로고
    • Luteolin enhances paclitaxel-induced apoptosis in human breast cancer MDA-MB-231 cells by blocking STAT3
    • Yang MY, Wang CJ, Chen NF, Ho WH, Lu FJ, Tseng TH. Luteolin enhances paclitaxel-induced apoptosis in human breast cancer MDA-MB-231 cells by blocking STAT3. Chem Biol Interact. 2014;213:60-68.
    • (2014) Chem Biol Interact. , vol.213 , pp. 60-68
    • Yang, M.Y.1    Wang, C.J.2    Chen, N.F.3    Ho, W.H.4    Lu, F.J.5    Tseng, T.H.6
  • 9
    • 7044236785 scopus 로고    scopus 로고
    • Luteolin sensitizes tumor necrosis factor-alpha-induced apoptosis in human tumor cells
    • Shi RX, Ong CN, Shen HM. Luteolin sensitizes tumor necrosis factor-alpha-induced apoptosis in human tumor cells. Oncogene. 2004;23(46):7712-7721.
    • (2004) Oncogene. , vol.23 , Issue.46 , pp. 7712-7721
    • Shi, R.X.1    Ong, C.N.2    Shen, H.M.3
  • 10
    • 84900532045 scopus 로고    scopus 로고
    • Luteolin is effective in the non-small cell lung cancer model with L858R/T790M EGF receptor mutation and erlotinib resistance
    • Hong Z, Cao X, Li N, et al. Luteolin is effective in the non-small cell lung cancer model with L858R/T790M EGF receptor mutation and erlotinib resistance. Br J Pharmacol. 2014;171(11):2842-2853.
    • (2014) Br J Pharmacol. , vol.171 , Issue.11 , pp. 2842-2853
    • Hong, Z.1    Cao, X.2    Li, N.3
  • 11
    • 84860408601 scopus 로고    scopus 로고
    • Luteolin induced G2 phase cell cycle arrest and apoptosis on non-small cell lung cancer cells
    • Cai X, Ye T, Liu C, et al. Luteolin induced G2 phase cell cycle arrest and apoptosis on non-small cell lung cancer cells. Toxicol In Vitro. 2011;25(7):1385-1391.
    • (2011) Toxicol In Vitro. , vol.25 , Issue.7 , pp. 1385-1391
    • Cai, X.1    Ye, T.2    Liu, C.3
  • 12
    • 77956338212 scopus 로고    scopus 로고
    • Luteolin suppresses IL-1beta-induced cytokines and MMPs production via p38 MAPK, JNK, NF-kappaB and AP-1 activation in human synovial sarcoma cell line, SW982
    • Choi EM, Lee YS. Luteolin suppresses IL-1beta-induced cytokines and MMPs production via p38 MAPK, JNK, NF-kappaB and AP-1 activation in human synovial sarcoma cell line, SW982. Food Chem Toxicol. 2010;48(10):2607-2611.
    • (2010) Food Chem Toxicol. , vol.48 , Issue.10 , pp. 2607-2611
    • Choi, E.M.1    Lee, Y.S.2
  • 13
    • 7444272077 scopus 로고    scopus 로고
    • Luteolin inhibits vascular endothelial growth factor-induced angiogenesis; inhibition of endothelial cell survival and proliferation by targeting phosphatidylinositol 3′-kinase activity
    • Bagli E, Stefaniotou M, Morbidelli L, et al. Luteolin inhibits vascular endothelial growth factor-induced angiogenesis; inhibition of endothelial cell survival and proliferation by targeting phosphatidylinositol 3′-kinase activity. Cancer Res. 2004;64(21):7936-7946.
    • (2004) Cancer Res. , vol.64 , Issue.21 , pp. 7936-7946
    • Bagli, E.1    Stefaniotou, M.2    Morbidelli, L.3
  • 14
    • 84930176620 scopus 로고    scopus 로고
    • The contribution of TGF-beta in Epithelial-Mesenchymal Transition (EMT): Down-regulation of E-cadherin via snail
    • Yu H, Shen Y, Hong J, Xia Q, Zhou F, Liu X. The contribution of TGF-beta in Epithelial-Mesenchymal Transition (EMT): down-regulation of E-cadherin via snail. Neoplasma. 2015;62(1):1-15.
    • (2015) Neoplasma. , vol.62 , Issue.1 , pp. 1-15
    • Yu, H.1    Shen, Y.2    Hong, J.3    Xia, Q.4    Zhou, F.5    Liu, X.6
  • 15
    • 3042618951 scopus 로고    scopus 로고
    • N-cadherin expression and epithelial-mesenchymal transition in pancreatic carcinoma
    • Nakajima S, Doi R, Toyoda E, et al. N-cadherin expression and epithelial-mesenchymal transition in pancreatic carcinoma. Clin Cancer Res. 2004;10(12 Pt 1):4125-4133.
    • (2004) Clin Cancer Res. , vol.10 , Issue.12 , pp. 4125-4133
    • Nakajima, S.1    Doi, R.2    Toyoda, E.3
  • 16
    • 84907302546 scopus 로고    scopus 로고
    • Dihydropyrimidine accumulation is required for the epithelial-mesenchymal transition
    • Shaul YD, Freinkman E, Comb WC, et al. Dihydropyrimidine accumulation is required for the epithelial-mesenchymal transition. Cell. 2014;158(5):1094-1109.
    • (2014) Cell. , vol.158 , Issue.5 , pp. 1094-1109
    • Shaul, Y.D.1    Freinkman, E.2    Comb, W.C.3
  • 17
    • 40349116206 scopus 로고    scopus 로고
    • Fra-1 regulates vimentin during Ha-RAS-induced epithelial mesenchymal transition in human colon carcinoma cells
    • Andreolas C, Kalogeropoulou M, Voulgari A, Pintzas A. Fra-1 regulates vimentin during Ha-RAS-induced epithelial mesenchymal transition in human colon carcinoma cells. Int J Cancer. 2008;122(8): 1745-1756.
    • (2008) Int J Cancer. , vol.122 , Issue.8 , pp. 1745-1756
    • Andreolas, C.1    Kalogeropoulou, M.2    Voulgari, A.3    Pintzas, A.4
  • 18
    • 84866325625 scopus 로고    scopus 로고
    • The epithelial-mesenchymal transition under control: Global programs to regulate epithelial plasticity
    • Nieto MA, Cano A. The epithelial-mesenchymal transition under control: global programs to regulate epithelial plasticity. Semin Cancer Biol. 2012;22(5-6):361-368.
    • (2012) Semin Cancer Biol. , vol.22 , Issue.5-6 , pp. 361-368
    • Nieto, M.A.1    Cano, A.2
  • 19
    • 0036554937 scopus 로고    scopus 로고
    • Radiation-induced increase in invasive potential of human pancreatic cancer cells and its blockade by a matrix metalloproteinase inhibitor, CGS27023
    • Qian LW, Mizumoto K, Urashima T, et al. Radiation-induced increase in invasive potential of human pancreatic cancer cells and its blockade by a matrix metalloproteinase inhibitor, CGS27023. Clin Cancer Res. 2002;8(4):1223-1227.
    • (2002) Clin Cancer Res. , vol.8 , Issue.4 , pp. 1223-1227
    • Qian, L.W.1    Mizumoto, K.2    Urashima, T.3
  • 20
    • 79953761842 scopus 로고    scopus 로고
    • Stat3 and MMP7 contribute to pancreatic ductal adenocarcinoma initiation and progression
    • Fukuda A, Wang SC, Morris JP, et al. Stat3 and MMP7 contribute to pancreatic ductal adenocarcinoma initiation and progression. Cancer Cell. 2011;19(4):441-455.
    • (2011) Cancer Cell. , vol.19 , Issue.4 , pp. 441-455
    • Fukuda, A.1    Wang, S.C.2    Morris, J.P.3
  • 21
    • 5644220189 scopus 로고    scopus 로고
    • Prostaglandin E2 enhances pancreatic cancer invasiveness through an Ets-1-dependent induction of matrix metalloproteinase-2
    • Ito H, Duxbury M, Benoit E, et al. Prostaglandin E2 enhances pancreatic cancer invasiveness through an Ets-1-dependent induction of matrix metalloproteinase-2. Cancer Res. 2004;64(20):7439-7446.
    • (2004) Cancer Res. , vol.64 , Issue.20 , pp. 7439-7446
    • Ito, H.1    Duxbury, M.2    Benoit, E.3
  • 22
    • 0036177290 scopus 로고    scopus 로고
    • Histologic features of venous invasion, expression of vascular endothelial growth factor and matrix metalloproteinase-2 and matrix metalloproteinase-9, and the relation with liver metastasis in pancreatic cancer
    • Nagakawa Y, Aoki T, Kasuya K, Tsuchida A, Koyanagi Y. Histologic features of venous invasion, expression of vascular endothelial growth factor and matrix metalloproteinase-2 and matrix metalloproteinase-9, and the relation with liver metastasis in pancreatic cancer. Pancreas. 2002;24(2):169-178.
    • (2002) Pancreas. , vol.24 , Issue.2 , pp. 169-178
    • Nagakawa, Y.1    Aoki, T.2    Kasuya, K.3    Tsuchida, A.4    Koyanagi, Y.5
  • 23
    • 84922273516 scopus 로고    scopus 로고
    • Enhanced invasion of lung adenocarcinoma cells after co-culture with THP-1-derived macrophages via the induction of EMT by IL-6
    • Dehai C, Bo P, Qiang T, et al. Enhanced invasion of lung adenocarcinoma cells after co-culture with THP-1-derived macrophages via the induction of EMT by IL-6. Immunol Lett. 2014;160(1):1-10.
    • (2014) Immunol Lett. , vol.160 , Issue.1 , pp. 1-10
    • Dehai, C.1    Bo, P.2    Qiang, T.3
  • 24
    • 69249221254 scopus 로고    scopus 로고
    • Interleukin-6 induces an epithelial-mesenchymal transition phenotype in human breast cancer cells
    • Sullivan NJ, Sasser AK, Axel AE, et al. Interleukin-6 induces an epithelial-mesenchymal transition phenotype in human breast cancer cells. Oncogene. 2009;28(33):2940-2947.
    • (2009) Oncogene. , vol.28 , Issue.33 , pp. 2940-2947
    • Sullivan, N.J.1    Sasser, A.K.2    Axel, A.E.3
  • 25
    • 80052903715 scopus 로고    scopus 로고
    • The effects and mechanisms of blockage of STAT3 signaling pathway on IL-6 inducing EMT in human pancreatic cancer cells in vitro
    • Huang C, Yang G, Jiang T, Zhu G, Li H, Qiu Z. The effects and mechanisms of blockage of STAT3 signaling pathway on IL-6 inducing EMT in human pancreatic cancer cells in vitro. Neoplasma. 2011;58(5):396-405.
    • (2011) Neoplasma. , vol.58 , Issue.5 , pp. 396-405
    • Huang, C.1    Yang, G.2    Jiang, T.3    Zhu, G.4    Li, H.5    Qiu, Z.6
  • 26
    • 78449304323 scopus 로고    scopus 로고
    • Gprc5a deletion enhances the transformed phenotype in normal and malignant lung epithelial cells by eliciting persistent Stat3 signaling induced by autocrine leukemia inhibitory factor
    • Chen Y, Deng J, Fujimoto J, et al. Gprc5a deletion enhances the transformed phenotype in normal and malignant lung epithelial cells by eliciting persistent Stat3 signaling induced by autocrine leukemia inhibitory factor. Cancer Res. 2010;70(21):8917-8926.
    • (2010) Cancer Res. , vol.70 , Issue.21 , pp. 8917-8926
    • Chen, Y.1    Deng, J.2    Fujimoto, J.3
  • 27
    • 82055208627 scopus 로고    scopus 로고
    • An interleukin-21-interleukin-10-STAT3 pathway is critical for functional maturation of memory CD8+ T cells
    • Cui W, Liu Y, Weinstein JS, Craft J, Kaech SM. An interleukin-21-interleukin-10-STAT3 pathway is critical for functional maturation of memory CD8+ T cells. Immunity. 2011;35(5):792-805.
    • (2011) Immunity. , vol.35 , Issue.5 , pp. 792-805
    • Cui, W.1    Liu, Y.2    Weinstein, J.S.3    Craft, J.4    Kaech, S.M.5
  • 28
    • 84857636386 scopus 로고    scopus 로고
    • Reciprocal activation between PLK1 and Stat3 contributes to survival and proliferation of esophageal cancer cells
    • Zhang Y, Du XL, Wang CJ, et al. Reciprocal activation between PLK1 and Stat3 contributes to survival and proliferation of esophageal cancer cells. Gastroenterology. 2012;142(3):521-530; e523.
    • (2012) Gastroenterology. , vol.142 , Issue.3
    • Zhang, Y.1    Du, X.L.2    Wang, C.J.3
  • 29
    • 84907286255 scopus 로고    scopus 로고
    • Activation of the mTORC1 and STAT3 pathways promotes the malignant transformation of colitis in mice
    • He Z, He X, Chen Z, et al. Activation of the mTORC1 and STAT3 pathways promotes the malignant transformation of colitis in mice. Oncol Rep. 2014;32(5):1873-1880.
    • (2014) Oncol Rep. , vol.32 , Issue.5 , pp. 1873-1880
    • He, Z.1    He, X.2    Chen, Z.3
  • 30
    • 84904046340 scopus 로고    scopus 로고
    • Inflammation-induced NFATc1-STAT3 transcription complex promotes pancreatic cancer initiation by KrasG12D
    • Baumgart S, Chen NM, Siveke JT, et al. Inflammation-induced NFATc1-STAT3 transcription complex promotes pancreatic cancer initiation by KrasG12D. Cancer Discov. 2014;4(6):688-701.
    • (2014) Cancer Discov. , vol.4 , Issue.6 , pp. 688-701
    • Baumgart, S.1    Chen, N.M.2    Siveke, J.T.3
  • 31
    • 79960383874 scopus 로고    scopus 로고
    • STAT3 plays a critical role in KRAS-induced pancreatic tumorigenesis
    • Corcoran RB, Contino G, Deshpande V, et al. STAT3 plays a critical role in KRAS-induced pancreatic tumorigenesis. Cancer Res. 2011;71(14):5020-5029.
    • (2011) Cancer Res. , vol.71 , Issue.14 , pp. 5020-5029
    • Corcoran, R.B.1    Contino, G.2    Deshpande, V.3
  • 32
    • 68049115773 scopus 로고    scopus 로고
    • SMAD4 gene mutations are associated with poor prognosis in pancreatic cancer
    • Blackford A, Serrano OK, Wolfgang CL, et al. SMAD4 gene mutations are associated with poor prognosis in pancreatic cancer. Clin Cancer Res. 2009;15(14):4674-4679.
    • (2009) Clin Cancer Res. , vol.15 , Issue.14 , pp. 4674-4679
    • Blackford, A.1    Serrano, O.K.2    Wolfgang, C.L.3
  • 33
    • 77953916705 scopus 로고    scopus 로고
    • K-ras mutational status predicts poor prognosis in unresectable pancreatic cancer
    • Chen H, Tu H, Meng ZQ, Chen Z, Wang P, Liu LM. K-ras mutational status predicts poor prognosis in unresectable pancreatic cancer. Eur J Surg Oncol. 2010;36(7):657-662.
    • (2010) Eur J Surg Oncol. , vol.36 , Issue.7 , pp. 657-662
    • Chen, H.1    Tu, H.2    Meng, Z.Q.3    Chen, Z.4    Wang, P.5    Liu, L.M.6
  • 34
    • 77958553912 scopus 로고    scopus 로고
    • Estimating prognosis and palliation based on tumour marker CA 19-9 and quality of life indicators in patients with advanced pancreatic cancer receiving chemotherapy
    • Bernhard J, Dietrich D, Glimelius B, et al. Estimating prognosis and palliation based on tumour marker CA 19-9 and quality of life indicators in patients with advanced pancreatic cancer receiving chemotherapy. Br J Cancer. 2010;103(9):1318-1324.
    • (2010) Br J Cancer. , vol.103 , Issue.9 , pp. 1318-1324
    • Bernhard, J.1    Dietrich, D.2    Glimelius, B.3
  • 35
    • 84913554641 scopus 로고    scopus 로고
    • Luteolin and gemcitabine protect against pancreatic cancer in an orthotopic mouse model
    • Johnson JL, Dia VP, Wallig M, Gonzalez de Mejia E. Luteolin and gemcitabine protect against pancreatic cancer in an orthotopic mouse model. Pancreas. 2015;44(1):144-151.
    • (2015) Pancreas. , vol.44 , Issue.1 , pp. 144-151
    • Johnson, J.L.1    Dia, V.P.2    Wallig, M.3    Gonzalez de Mejia, E.4
  • 36
    • 84866462314 scopus 로고    scopus 로고
    • The molecular mechanism of luteolin-induced apoptosis is potentially related to inhibition of angiogenesis in human pancreatic carcinoma cells
    • Cai X, Lu W, Ye T, et al. The molecular mechanism of luteolin-induced apoptosis is potentially related to inhibition of angiogenesis in human pancreatic carcinoma cells. Oncol Rep. 2012;28(4):1353-1361.
    • (2012) Oncol Rep. , vol.28 , Issue.4 , pp. 1353-1361
    • Cai, X.1    Lu, W.2    Ye, T.3
  • 37
    • 0036327836 scopus 로고    scopus 로고
    • Blockade of the epidermal growth factor receptor tyrosine kinase activity by quercetin and luteolin leads to growth inhibition and apoptosis of pancreatic tumor cells
    • Lee LT, Huang YT, Hwang JJ, et al. Blockade of the epidermal growth factor receptor tyrosine kinase activity by quercetin and luteolin leads to growth inhibition and apoptosis of pancreatic tumor cells. Anticancer Res. 2002;22(3):1615-1627.
    • (2002) Anticancer Res. , vol.22 , Issue.3 , pp. 1615-1627
    • Lee, L.T.1    Huang, Y.T.2    Hwang, J.J.3
  • 38
    • 84942097649 scopus 로고    scopus 로고
    • Effect of MSX2 interference on epithelial-mesenchymal transitions of pancreatic cancer cell line PANC-1
    • Zhang D, Ma X, Wu B, Cui P, Liu H, Lu Z. Effect of MSX2 interference on epithelial-mesenchymal transitions of pancreatic cancer cell line PANC-1. Nan Fang Yi Ke Da Xue Xue Bao. 2015;35(2):179-184.
    • (2015) Nan Fang Yi Ke Da Xue Xue Bao. , vol.35 , Issue.2 , pp. 179-184
    • Zhang, D.1    Ma, X.2    Wu, B.3    Cui, P.4    Liu, H.5    Lu, Z.6
  • 39
    • 17044448378 scopus 로고    scopus 로고
    • Mechanisms in LPA-induced tumor cell migration: Critical role of phosphorylated ERK
    • Stahle M, Veit C, Bachfischer U, et al. Mechanisms in LPA-induced tumor cell migration: critical role of phosphorylated ERK. J Cell Sci. 2003;116(Pt 18):3835-3846.
    • (2003) J Cell Sci. , vol.116 , pp. 3835-3846
    • Stahle, M.1    Veit, C.2    Bachfischer, U.3
  • 40
    • 80755159105 scopus 로고    scopus 로고
    • Gadd45a sensitizes medulloblastoma cells to irradiation and suppresses MMP-9-mediated EMT
    • Asuthkar S, Nalla AK, Gondi CS, et al. Gadd45a sensitizes medulloblastoma cells to irradiation and suppresses MMP-9-mediated EMT. Neuro Oncol. 2011;13(10):1059-1073.
    • (2011) Neuro Oncol. , vol.13 , Issue.10 , pp. 1059-1073
    • Asuthkar, S.1    Nalla, A.K.2    Gondi, C.S.3
  • 41
    • 21844432918 scopus 로고    scopus 로고
    • Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability
    • Radisky DC, Levy DD, Littlepage LE, et al. Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability. Nature. 2005;436(7047):123-127.
    • (2005) Nature. , vol.436 , Issue.7047 , pp. 123-127
    • Radisky, D.C.1    Levy, D.D.2    Littlepage, L.E.3
  • 42
    • 84891666772 scopus 로고    scopus 로고
    • p21-activated kinase 4 regulation of endometrial cancer cell migration and invasion involves the ERK1/2 pathway mediated MMP-2 secretion
    • Lu W, Xia YH, Qu JJ, et al. p21-activated kinase 4 regulation of endometrial cancer cell migration and invasion involves the ERK1/2 pathway mediated MMP-2 secretion. Neoplasma. 2013;60(5):493-503.
    • (2013) Neoplasma. , vol.60 , Issue.5 , pp. 493-503
    • Lu, W.1    Xia, Y.H.2    Qu, J.J.3
  • 43
    • 84890434612 scopus 로고    scopus 로고
    • eEF1A2 promotes cell migration, invasion and metastasis in pancreatic cancer by upregulating MMP-9 expression through Akt activation
    • Xu C, Hu DM, Zhu Q. eEF1A2 promotes cell migration, invasion and metastasis in pancreatic cancer by upregulating MMP-9 expression through Akt activation. Clin Exp Metastasis. 2013;30(7):933-944.
    • (2013) Clin Exp Metastasis. , vol.30 , Issue.7 , pp. 933-944
    • Xu, C.1    Hu, D.M.2    Zhu, Q.3
  • 44
    • 84880078474 scopus 로고    scopus 로고
    • Epithelial to mesenchymal transition promotes breast cancer progression via a fibronectin-dependent STAT3 signaling pathway
    • Balanis N, Wendt MK, Schiemann BJ, Wang Z, Schiemann WP, Carlin CR. Epithelial to mesenchymal transition promotes breast cancer progression via a fibronectin-dependent STAT3 signaling pathway. J Biol Chem. 2013;288(25):17954-17967.
    • (2013) J Biol Chem. , vol.288 , Issue.25 , pp. 17954-17967
    • Balanis, N.1    Wendt, M.K.2    Schiemann, B.J.3    Wang, Z.4    Schiemann, W.P.5    Carlin, C.R.6
  • 45
    • 84881303278 scopus 로고    scopus 로고
    • Stat3-coordinated Lin-28-let-7-HMGA2 and miR-200-ZEB1 circuits initiate and maintain oncostatin M-driven epithelial-mesenchymal transition
    • Guo L, Chen C, Shi M, et al. Stat3-coordinated Lin-28-let-7-HMGA2 and miR-200-ZEB1 circuits initiate and maintain oncostatin M-driven epithelial-mesenchymal transition. Oncogene. 2013;32(45): 5272-5282.
    • (2013) Oncogene. , vol.32 , Issue.45 , pp. 5272-5282
    • Guo, L.1    Chen, C.2    Shi, M.3
  • 46
    • 84910066394 scopus 로고    scopus 로고
    • A noncanonical Frizzled2 pathway regulates epithelial-mesenchymal transition and metastasis
    • Gujral TS, Chan M, Peshkin L, Sorger PK, Kirschner MW, MacBeath G. A noncanonical Frizzled2 pathway regulates epithelial-mesenchymal transition and metastasis. Cell. 2014;159(4):844-856.
    • (2014) Cell. , vol.159 , Issue.4 , pp. 844-856
    • Gujral, T.S.1    Chan, M.2    Peshkin, L.3    Sorger, P.K.4    Kirschner, M.W.5    McBeath, G.6
  • 47
    • 84929940184 scopus 로고    scopus 로고
    • FTY720 inhibits proliferation and epithelial-mesenchymal transition in cholangiocarcinoma by deactivating STAT3 signaling
    • Lu Z, Wang J, Zheng T, et al. FTY720 inhibits proliferation and epithelial-mesenchymal transition in cholangiocarcinoma by deactivating STAT3 signaling. BMC Cancer. 2014;14:783.
    • (2014) BMC Cancer. , vol.14 , pp. 783
    • Lu, Z.1    Wang, J.2    Zheng, T.3
  • 48
    • 79953756112 scopus 로고    scopus 로고
    • Stat3/Socs3 activation by IL-6 transsignaling promotes progression of pancreatic intraepithelial neoplasia and development of pancreatic cancer
    • Lesina M, Kurkowski MU, Ludes K, et al. Stat3/Socs3 activation by IL-6 transsignaling promotes progression of pancreatic intraepithelial neoplasia and development of pancreatic cancer. Cancer Cell. 2011; 19(4):456-469.
    • (2011) Cancer Cell. , vol.19 , Issue.4 , pp. 456-469
    • Lesina, M.1    Kurkowski, M.U.2    Ludes, K.3
  • 49
    • 84890769381 scopus 로고    scopus 로고
    • Type I interferon-mediated pathway interacts with peroxisome proliferator activated receptor-γ (PPAR-γ): At the cross-road of pancreatic cancer cell proliferation
    • Dicitore A, Caraglia M, Gaudenzi G, et al. Type I interferon-mediated pathway interacts with peroxisome proliferator activated receptor-γ (PPAR-γ): at the cross-road of pancreatic cancer cell proliferation. Biochim Biophys Acta. 2014;1845(1):42-52.
    • (2014) Biochim Biophys Acta. , vol.1845 , Issue.1 , pp. 42-52
    • Dicitore, A.1    Caraglia, M.2    Gaudenzi, G.3
  • 50
    • 84855746824 scopus 로고    scopus 로고
    • The PPAR-γ agonist troglitazone antagonizes survival pathways induced by STAT-3 in recombinant interferon-β treated pancreatic cancer cells
    • Vitale G, Zappavigna S, Marra M, et al. The PPAR-γ agonist troglitazone antagonizes survival pathways induced by STAT-3 in recombinant interferon-β treated pancreatic cancer cells. Biotechnol Adv. 2012; 30(1):169-184.
    • (2012) Biotechnol Adv. , vol.30 , Issue.1 , pp. 169-184
    • Vitale, G.1    Zappavigna, S.2    Marra, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.