EEF1A2 promotes cell migration, invasion and metastasis in pancreatic cancer by upregulating MMP-9 expression through Akt activation

Clinical and Experimental Metastasis

Volumn 30, Issue 7, 2013, Pages 933-944

  Xu, Chao ^a   Hu, Duan Min ^a,b   Zhu, Qi ^a  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b THE SECOND AFFILIATED HOSPITAL OF SOOCHOW UNIVERSITY   (China)

Author keywords

eEF1A2; Invasion; Metastasis; MMP 9; Pancreatic cancer

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; ELONGATION FACTOR 1ALPHA; GELATINASE B; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; SMALL INTERFERING RNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL INVASION; CELL LINE; CELL MIGRATION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; GENE SILENCING; GREATER OMENTUM; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MALE; MESENTERY; MOUSE; NONHUMAN; PANCREAS CANCER; PERITONEAL CAVITY; PERITONEUM; PERITONEUM METASTASIS; PHENOTYPE; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; UPREGULATION;

BASE SEQUENCE; CELL MOVEMENT; DNA PRIMERS; ENZYME ACTIVATION; HUMANS; MATRIX METALLOPROTEINASE 9; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS; PANCREATIC NEOPLASMS; PEPTIDE ELONGATION FACTOR 1; PROTO-ONCOGENE PROTEINS C-AKT; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA INTERFERENCE; UP-REGULATION;

EID: 84890434612     PISSN: 02620898     EISSN: 15737276     Source Type: Journal    
DOI: 10.1007/s10585-013-9593-6     Document Type: Article

References (39)

1. Siegel R, Naishadham D, Jemal A et al (2012) Cancer statistics, 2012. CA Cancer J Clin 62(1):10-29
2. Hidalgo M (2010) Pancreatic cancer. N Engl J Med 362(17):1605-1617
3. Rhim AD, Mirek ET, Aiello NM et al (2012) EMT and dissemination even precede pancreatic tumor formation. Cell 148(1-2):349-361
4. Neoptolemos JP, Stocken DD, Friess H et al (2004) A randomized trial of chemoradiotherapy and chemotherapy after resection of pancreatic cancer. N Engl J Med 350(12):1200-1210
5. Browne GJ, Proud CG (2002) Regulation of peptide-chain elongation in mammalian cells. Eur J Biochem 269(22):5360-5368
6. Soares DC, Barlow PN, Newbery HJ et al (2009) Structural models of human eEF1A1 and eEF1A2 reveal two distinct surface clusters of sequence variation and potential differences in phosphorylation. PLoS One 4(7):e6315
7. Knudsen SM, Frydenberg J, Clark BF et al (1993) Tissue-dependent variation in the expression of elongation factor-1 alpha isoforms: isolation and characterisation of a cDNA encoding a novel variant of human elongation-factor 1 alpha. Eur J Biochem 215(3):549-554
8. Lee S, Francoeur AM, Liu S et al (1992) Tissue-specific expression in mammalian brain, heart, and muscle of S1, a member of the elongation factor-1 alpha gene family. J Biol Chem 267(33):24064-24068
9. Bektas M, Nurten R, Gurel Z et al (1994) Interactions of eukaryotic elongation factor 2 with actin: a possible link between protein synthetic machinery and cytoskeleton. FEBS Lett 356(1):89-93
10. Gross SR, Kinzy TG (2005) Translation elongation factor 1A is essential for regulation of the actin cytoskeleton and cell morphology. Nat Struct Mol Biol 12(9):772-778
11. Chung CM, Man C, Jin Y et al (2005) Amplification and overexpression of aurora kinase A (AURKA) in immortalized human ovarian epithelial (HOSE) cells. Mol Carcinog 43(3):165-174
12. Shamovsky I, Ivannikov M, Kandel ES et al (2006) RNA-mediated response to heat shock in mammalian cells. Nature 440(7083):556-560
13. Chang R, Wang E (2007) Mouse translation elongation factor eEF1A-2 interacts with Prdx-I to protect cells against apoptotic death induced by oxidative stress. J Cell Biochem 100(2):267-278
14. Amiri A, Noei F, Jeganatham S et al (2007) eEF1A2 activates Akt and stimulates Akt-dependent actin remodelling, invasion and migration. Oncogene 26(21):3027-3040
15. Li Z, Qi CF, Shin DM et al (2010) Eef1a2 promotes cell growth, inhibits apoptosis and activates JAK/STAT and AKT signaling in mouse plasmacytomas. PLoS One 5(5):e10755
16. Anand N, Murthy S, Amann G et al (2002) Protein elongation factor EEF1A2 is a putative oncogene in ovarian cancer. Nat Genet 31(3):301-305
17. Tomlinson VA, Newbery HJ, Wray NR et al (2005) Translation elongation factor eEF1A2 is a potential oncoprotein that is overexpressed in two-thirds of breast tumours. BMC Cancer 5:113
18. Li R, Wang H, Bekele BN et al (2006) Identification of putative oncogenes in lung adenocarcinoma by a comprehensive functional genomic approach. Oncogene 25(18):2628-2635
19. Scaggiante B, Dapas B, Bonin S et al (2012) Dissecting the expression of EEF1A1/2 genes in human prostate cancer cells: the potential of EEF1A2 as a hallmark for prostate transformation and progression. Br J Cancer 106(1):166-173
20. Grassi G, Scaggiante B, Farra R et al (2007) The expression levels of the translational factors eEF1A 1/2 correlate with cell growth but not apoptosis in hepatocellular carcinoma cell lines with different differentiation grade. Biochimie 89(12):1544-1552
21. Cao HX, Zhu Q, Huang J et al (2009) Regulation and functional role of eEF1A2 in pancreatic carcinoma. Biochem Biophys Res Commun 380(1):11-16
22. Hu DM, Xu C, Zhu Q (2013) eEF1A2 protein expression correlates with lymph node metastasis and decreased survival in pancreatic ductal adenocarcinoma. Hepatogastroenterology 60(124):222-227
23. Pencil SD, Toh Y, Nicolson GL (1993) Candidate metastasis-associated genes of the rat 13762NF mammary adenocarcinoma. Breast Cancer Res Treat 25(2):165-174
24. Edmonds BT, Wyckoff J, Yeung YG et al (1996) Elongation factor-1 alpha is an overexpressed actin binding protein in metastatic rat mammary adenocarcinoma. J Cell Sci 109(Pt 11):2705-2714
25. Pecorari L, Marin O, Silvestri C et al (2009) Elongation factor 1 alpha interacts with phospho-Akt in breast cancer cells and regulates their proliferation, survival and motility. Mol Cancer 8:58
26. Li Y, Aoki T, Mori Y et al (2004) Cleavage of lumican by membrane-type matrix metalloproteinase-1 abrogates this proteoglycan-mediated suppression of tumor cell colony formation in soft agar. Cancer Res 64(19):7058-7064
27. Ozaki H, Matsuzaki H, Ando H et al (2012) Enhancement of metastatic ability by ectopic expression of ST6GalNAcI on a gastric cancer cell line in a mouse model. Clin Exp Metastasis 29(3):229-238
28. Pryczynicz A, Guzińska-Ustymowicz K, Dymicka-Piekarska V et al (2007) Expression of matrix metalloproteinase 9 in pancreatic ductal carcinoma is associated with tumor metastasis formation. Folia Histochem Cytobiol 45(1):37-40
29. Itoh Y, Nagase H (2002) Matrix metalloproteinases in cancer. Essays Biochem 38:21-36
30. Bernhard EJ, Gruber SB, Muschel RJ (1994) Direct evidence linking expression of matrix metalloproteinase 9 (92-kDa gelatinase/collagenase) to the metastatic phenotype in transformed rat embryo cells. Proc Natl Acad Sci USA 91(10):4293-4297
31. Gress TM, Müller-Pillasch F, Lerch MM et al (1995) Expression and in situ localization of genes coding for extracellular matrix proteins and extracellular matrix degrading proteases in pancreatic cancer. Int J Cancer 62(4):407-413
32. Shi WD, Meng ZQ, Chen Z et al (2009) Identification of liver metastasis-related genes in a novel human pancreatic carcinoma cell model by microarray analysis. Cancer Lett 283(1):84-91
33. Chin YR, Toker A (2009) Function of Akt/PKB signaling to cell motility, invasion and the tumor stroma in cancer. Cell Signal 21(4):470-476
34. Meng Q, Xia C, Fang J et al (2006) Role of PI3 K and AKT specific isoforms in ovarian cancer cell migration, invasion and proliferation through the p70S6K1 pathway. Cell Signal 18(12):2262-2271
35. Grille SJ, Bellacosa A, Upson J et al (2003) The protein kinase Akt induces epithelial mesenchymal transition and promotes enhanced motility and invasiveness of squamous cell carcinoma line. Cancer Res 63(9):2172-2178
36. Mohi MG, Neel BG (2007) The role of Shp2 (PTPN11) in cancer. Curr Opin Genet Dev 17(1):23-30
37. Panasyuk G, Nemazanyy I, Filonenko V et al (2008) A2 isoform of mammalian translation factor eEF1A displays increased tyrosine phosphorylation and ability to interact with different signalling molecules. Int J Biochem Cell Biol 40(1):63-71
38. Zhu X, Wang L, Zhang B et al (2011) TGF-beta 1-induced PI3 K/Akt/NF-kappa B/MMP9 signalling pathway is activated in Philadelphia chromosome-positive chronic myeloid leukaemia hemangioblasts. J Biochem 149(4):405-414
39. Kim D, Kim S, Koh H et al (2001) Akt/PKB promotes cancer cell invasion via increased motility and metalloproteinase production. FASEB J 15(11):1953-1962