Integrating High-Dimensional Transcriptomics and Image Analysis Tools into Early Safety Screening: Proof of Concept for a New Early Drug Development Strategy

Chemical Research in Toxicology

Volumn 28, Issue 10, 2015, Pages 1914-1925

  Verbist, Bie M P ^a   Verheyen, Geert R ^a,b   Vervoort, Liesbet ^a,c   Crabbe, Marjolein ^a   Beerens, Dominiek ^a   Bosmans, Cindy ^a   Jaensch, Steffen ^a   Osselaer, Steven ^a   Talloen, Willem ^a   Van Den Wyngaert, Ilse ^a   Van Hecke, Geert ^a   Wuyts, Dirk ^a   Van Goethem, Freddy ^a   Göhlmann, Hinrich W H ^a  

^a JANSSEN RESEARCH AND DEVELOPMENT   (Belgium)

^b Thomas More University College   (Belgium)

^c HistoGeneX NV   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

COLCHICINE; DOCETAXEL; GRISEOFULVIN; NOCODAZOLE; QUINAZOLINE; QUINOLINE; QUINOXALINE; TUBULIN; VINBLASTINE; PDE10A PROTEIN, HUMAN; PHOSPHODIESTERASE; PHOSPHODIESTERASE INHIBITOR; PYRROLIDINE DERIVATIVE; TRANSCRIPTOME;

ARTICLE; CONTROLLED STUDY; DOWN REGULATION; DRUG DEVELOPMENT; DRUG SAFETY; DRUG STRUCTURE; GENE EXPRESSION PROFILING; GENOTOXICITY; HIGH CONTENT IMAGING; HUMAN; HUMAN CELL; IMAGE ANALYSIS; IMAGING; IN VITRO STUDY; MALE; MICRONUCLEUS TEST; POLYPHARMACOLOGY; STRUCTURE ACTIVITY RELATION; TOXICITY ASSAY; TRANSCRIPTOMICS; ANIMAL; CHEMISTRY; CONFOCAL MICROSCOPY; DRUG EFFECTS; HEK293 CELL LINE; METABOLISM; TUMOR CELL LINE;

ANIMALS; CELL LINE, TUMOR; DRUG DISCOVERY; GENE EXPRESSION PROFILING; HEK293 CELLS; HUMANS; MICROSCOPY, CONFOCAL; PHOSPHODIESTERASE INHIBITORS; PHOSPHORIC DIESTER HYDROLASES; PYRROLIDINES; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSCRIPTOME; TUBULIN;

EID: 84944722935     PISSN: 0893228X     EISSN: 15205010     Source Type: Journal    
DOI: 10.1021/acs.chemrestox.5b00103     Document Type: Article

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