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Volumn 15, Issue 13-14, 2010, Pages 561-569

Overcoming psychological barriers to good discovery decisions

Author keywords

[No Author keywords available]

Indexed keywords

COGNITION; DECISION MAKING; DRUG RESEARCH; EVIDENCE BASED MEDICINE; PSYCHOLOGICAL ASPECT; REVIEW;

EID: 77954316269     PISSN: 13596446     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.drudis.2010.05.007     Document Type: Review
Times cited : (31)

References (42)
  • 1
    • 73449101512 scopus 로고    scopus 로고
    • Lessons from 60 years of pharmaceutical innovation
    • Munos B. Lessons from 60 years of pharmaceutical innovation. Nat. Rev. Drug Discov. 2009, 8:959-968.
    • (2009) Nat. Rev. Drug Discov. , vol.8 , pp. 959-968
    • Munos, B.1
  • 2
    • 77649234756 scopus 로고    scopus 로고
    • How to improve R&D productivity: the pharmaceutical industry's grand challenge
    • Paul S.M., et al. How to improve R&D productivity: the pharmaceutical industry's grand challenge. Nat. Rev. Drug Discov. 2010, 9:203-214.
    • (2010) Nat. Rev. Drug Discov. , vol.9 , pp. 203-214
    • Paul, S.M.1
  • 3
    • 33847045218 scopus 로고    scopus 로고
    • Why pharma must go Hollywood
    • Bernal L. Why pharma must go Hollywood. Scientist 2007, 21:42.
    • (2007) Scientist , vol.21 , pp. 42
    • Bernal, L.1
  • 4
    • 67349164247 scopus 로고    scopus 로고
    • Making medicinal chemistry more effective - application of Lean Sigma to improve processes, speed and quality
    • Andersson S., et al. Making medicinal chemistry more effective - application of Lean Sigma to improve processes, speed and quality. Drug Discov. Today 2009, 14:598-604.
    • (2009) Drug Discov. Today , vol.14 , pp. 598-604
    • Andersson, S.1
  • 5
    • 70350526933 scopus 로고    scopus 로고
    • The productivity dilemma revisited: inherent conflicts between process management and exploration. In Adler, P.S et al Perspectives on the Productivity Dilemma
    • Tushman M.L., Benner M. The productivity dilemma revisited: inherent conflicts between process management and exploration. In Adler, P.S et al Perspectives on the Productivity Dilemma. J. Ops Manage. 2009, 27:99-113.
    • (2009) J. Ops Manage. , vol.27 , pp. 99-113
    • Tushman, M.L.1    Benner, M.2
  • 7
    • 33947691728 scopus 로고    scopus 로고
    • Driving earlier clinical attrition: if you want to find the needle, burn down the haystack
    • Peck R.W. Driving earlier clinical attrition: if you want to find the needle, burn down the haystack. Drug Discov. Today 2007, 12:289-294.
    • (2007) Drug Discov. Today , vol.12 , pp. 289-294
    • Peck, R.W.1
  • 8
    • 0032160634 scopus 로고    scopus 로고
    • The hidden traps in decision making
    • Hammond J.S., et al. The hidden traps in decision making. Harv. Bus. Rev. 1998, 76:47-50.
    • (1998) Harv. Bus. Rev. , vol.76 , pp. 47-50
    • Hammond, J.S.1
  • 10
    • 0003672777 scopus 로고
    • Bias in human reasoning: causes and consequences
    • Lawrence Erlbaum Associates
    • Evans J.St.B.T. Bias in human reasoning: causes and consequences. Essays in Cognitive Psychology 1990, Lawrence Erlbaum Associates.
    • (1990) Essays in Cognitive Psychology
    • Evans, J.1
  • 11
    • 77958116450 scopus 로고    scopus 로고
    • Why is it still drug discovery?
    • Spring issue
    • Segall M.D. Why is it still drug discovery?. Eur. Biopharmaceut. Rev. 2008, Spring issue.
    • (2008) Eur. Biopharmaceut. Rev.
    • Segall, M.D.1
  • 12
    • 33750579770 scopus 로고    scopus 로고
    • Drug discovery in jeopardy
    • Cuatrecasas P. Drug discovery in jeopardy. J. Clin. Invest. 2006, 116:2837-2842.
    • (2006) J. Clin. Invest. , vol.116 , pp. 2837-2842
    • Cuatrecasas, P.1
  • 14
    • 84855627833 scopus 로고    scopus 로고
    • Bad Science, Fourth Estate, additional chapter available free of charge through
    • Goldacre, B. (2008) Bad Science, Fourth Estate, additional chapter available free of charge through http://www.amazon.co.uk/Bad-Science-Ben-Goldacre/dp/000728487X/?tag=bs0b-21.
    • (2008)
    • Goldacre, B.1
  • 15
    • 0002731826 scopus 로고
    • Timid choices and bold forecasts: a cognitive perspective on risk taking
    • Kahneman D., Lovallo D. Timid choices and bold forecasts: a cognitive perspective on risk taking. Manage. Sci. 1993, 39:17-31.
    • (1993) Manage. Sci. , vol.39 , pp. 17-31
    • Kahneman, D.1    Lovallo, D.2
  • 16
    • 33751221287 scopus 로고    scopus 로고
    • Positive psychotherapy
    • Seligman M.E.P., et al. Positive psychotherapy. Am. Psychol. 2006, 61:774-788.
    • (2006) Am. Psychol. , vol.61 , pp. 774-788
    • Seligman, M.E.P.1
  • 17
    • 33846020720 scopus 로고    scopus 로고
    • Focus on success: using in silico optimisation to achieve an optimal balance of properties
    • Segall M.D., et al. Focus on success: using in silico optimisation to achieve an optimal balance of properties. Expert Opin. Drug Metab. Toxicol. 2006, 2:325-337.
    • (2006) Expert Opin. Drug Metab. Toxicol. , vol.2 , pp. 325-337
    • Segall, M.D.1
  • 18
    • 23044450704 scopus 로고    scopus 로고
    • Diagnostic error in internal medicine
    • Graber M.L., et al. Diagnostic error in internal medicine. Arch. Intern. Med. 2005, 165:1493-1499.
    • (2005) Arch. Intern. Med. , vol.165 , pp. 1493-1499
    • Graber, M.L.1
  • 19
    • 0004201621 scopus 로고    scopus 로고
    • Cambridge University Press
    • Baron J. Thinking and Deciding 2000, Cambridge University Press, pp. 127. 3rd edn.
    • (2000) Thinking and Deciding , pp. 127
    • Baron, J.1
  • 20
    • 40949162504 scopus 로고    scopus 로고
    • A more rational approach to new-product development
    • Bonabeau E., et al. A more rational approach to new-product development. Harv. Bus. Rev. 2008, 86:96-102.
    • (2008) Harv. Bus. Rev. , vol.86 , pp. 96-102
    • Bonabeau, E.1
  • 21
    • 62949129784 scopus 로고    scopus 로고
    • Translational medicine for stroke drug discovery: the pharmaceutical industry perspective
    • Feuerstein G.Z., Chavez J. Translational medicine for stroke drug discovery: the pharmaceutical industry perspective. Stroke 2009, 40:S121-S125.
    • (2009) Stroke , vol.40
    • Feuerstein, G.Z.1    Chavez, J.2
  • 22
    • 0036330007 scopus 로고    scopus 로고
    • Toward wisdom from failure: lessons learned from neuroprotective stroke trials and new therapeutic directions
    • Gladstone D.J., et al. Toward wisdom from failure: lessons learned from neuroprotective stroke trials and new therapeutic directions. Stroke 2002, 33:2123-2136.
    • (2002) Stroke , vol.33 , pp. 2123-2136
    • Gladstone, D.J.1
  • 23
    • 77950572352 scopus 로고    scopus 로고
    • Publication bias in reports of animal stroke studies leads to major overstatement of efficacy
    • Sena E.S., et al. Publication bias in reports of animal stroke studies leads to major overstatement of efficacy. PLoS Biol. 2010, 8:e1000344.
    • (2010) PLoS Biol. , vol.8
    • Sena, E.S.1
  • 24
    • 37549068172 scopus 로고    scopus 로고
    • Missing steps in the STAIR case: a translational medicine perspective on the development of NXY-059 for treatment of acute ischemic stroke
    • Feuerstein G.Z., et al. Missing steps in the STAIR case: a translational medicine perspective on the development of NXY-059 for treatment of acute ischemic stroke. J. Cereb. Blood Flow Metab. 2008, 28:217-219.
    • (2008) J. Cereb. Blood Flow Metab. , vol.28 , pp. 217-219
    • Feuerstein, G.Z.1
  • 25
    • 0036141160 scopus 로고    scopus 로고
    • Neuroprotection is unlikely to be effective in humans using current trial designs
    • Grotta J. Neuroprotection is unlikely to be effective in humans using current trial designs. Stroke 2002, 33:306-307.
    • (2002) Stroke , vol.33 , pp. 306-307
    • Grotta, J.1
  • 26
    • 0037160918 scopus 로고    scopus 로고
    • Clinical problem solving and diagnostic decision making: selective review of the cognitive literature
    • Elstein A.S., Schwarz A. Clinical problem solving and diagnostic decision making: selective review of the cognitive literature. BMJ 2002, 324:729-732.
    • (2002) BMJ , vol.324 , pp. 729-732
    • Elstein, A.S.1    Schwarz, A.2
  • 27
    • 16444379263 scopus 로고    scopus 로고
    • Can we avoid bias?
    • Bradley C.P. Can we avoid bias?. BMJ 2005, 330:784.
    • (2005) BMJ , vol.330 , pp. 784
    • Bradley, C.P.1
  • 28
    • 0037029126 scopus 로고    scopus 로고
    • Improving the accuracy of mammography: volume and outcome relationships
    • Esserman L., et al. Improving the accuracy of mammography: volume and outcome relationships. J. Natl. Cancer Inst. 2002, 94:369-375.
    • (2002) J. Natl. Cancer Inst. , vol.94 , pp. 369-375
    • Esserman, L.1
  • 31
    • 84855626005 scopus 로고    scopus 로고
    • The answer is (c), approximately 10%. Of 1000 compounds, 108 (990×0.1+10×0.9) would be reported as toxic by the test, of which only 9 really are toxic.
    • The answer is (c), approximately 10%. Of 1000 compounds, 108 (990×0.1+10×0.9) would be reported as toxic by the test, of which only 9 really are toxic.
  • 32
    • 0141596114 scopus 로고    scopus 로고
    • Simple tools for understanding risks: from innumeracy to insight
    • Gigerenzer G., Edwards A. Simple tools for understanding risks: from innumeracy to insight. BMJ 2003, 327:741-744.
    • (2003) BMJ , vol.327 , pp. 741-744
    • Gigerenzer, G.1    Edwards, A.2
  • 33
    • 0036213151 scopus 로고    scopus 로고
    • On experimental design in drug discovery
    • DeWitte R.S. On experimental design in drug discovery. Curr. Drug Disc. 2002, 2:19-22.
    • (2002) Curr. Drug Disc. , vol.2 , pp. 19-22
    • DeWitte, R.S.1
  • 36
    • 0029885129 scopus 로고    scopus 로고
    • Quantitative methods in the planning of pharmaceutical research
    • Gittins J. Quantitative methods in the planning of pharmaceutical research. Drug Inf. J. 1996, 30:479-487.
    • (1996) Drug Inf. J. , vol.30 , pp. 479-487
    • Gittins, J.1
  • 37
    • 72449144842 scopus 로고    scopus 로고
    • Beyond profiling: using ADMET models to guide decisions
    • Segall M., et al. Beyond profiling: using ADMET models to guide decisions. Chem. Biodivers. 2009, 6:2144-2151.
    • (2009) Chem. Biodivers. , vol.6 , pp. 2144-2151
    • Segall, M.1
  • 38
    • 77954309458 scopus 로고    scopus 로고
    • Guiding the decision-making process to identify high quality compounds
    • (Abstract 244)
    • Segall M.D., et al. Guiding the decision-making process to identify high quality compounds. Drug Metab. Rev. 2009, 41(s3):7-186. (Abstract 244).
    • (2009) Drug Metab. Rev. , vol.41 , Issue.3 S , pp. 7-186
    • Segall, M.D.1
  • 39
    • 57349189389 scopus 로고    scopus 로고
    • Multiparameter evidence synthesis in epidemiology and medical decision making
    • Ades A.E., et al. Multiparameter evidence synthesis in epidemiology and medical decision making. J. Health Serv. Res. Policy 2008, 13:12-22.
    • (2008) J. Health Serv. Res. Policy , vol.13 , pp. 12-22
    • Ades, A.E.1
  • 40
    • 67649369260 scopus 로고    scopus 로고
    • Smart planner: radically accelerating R&D to combat a biothreat
    • Chadwick A.T., Edwards R.A. Smart planner: radically accelerating R&D to combat a biothreat. Drug Dev. Res. 2009, 70:335-348.
    • (2009) Drug Dev. Res. , vol.70 , pp. 335-348
    • Chadwick, A.T.1    Edwards, R.A.2
  • 41
    • 0036231765 scopus 로고    scopus 로고
    • Evidence-based practice for mere mortals: the role of informatics and health services research
    • Sim I., et al. Evidence-based practice for mere mortals: the role of informatics and health services research. J. Gen. Intern. Med. 2002, 17:302-308.
    • (2002) J. Gen. Intern. Med. , vol.17 , pp. 302-308
    • Sim, I.1
  • 42
    • 0000505675 scopus 로고
    • On the failure to eliminate hypotheses in a conceptual task
    • Wason P.C. On the failure to eliminate hypotheses in a conceptual task. Q. J. Exp. Psychol. 1960, 12:129-140.
    • (1960) Q. J. Exp. Psychol. , vol.12 , pp. 129-140
    • Wason, P.C.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.