In vitro transcriptomic prediction of hepatotoxicity for early drug discovery

Journal of Theoretical Biology

Volumn 290, Issue 1, 2011, Pages 27-36

  Cheng, Feng ^a   Theodorescu, Dan ^b,c   Schulman, Ira G ^d   Lee, Jae K ^a  

^a UNIVERSITY OF VIRGINIA   (United States)

^b UNIVERSITY OF COLORADO   (United States)

^c UNIVERSITY OF COLORADO CANCER CENTER   (United States)

^d UNIVERSITY OF VIRGINIA   (United States)

Author keywords

Co expression extrapolation; Drug hepatocellular toxicity; Multi gene expression based predictor

Indexed keywords

1,4 DICHLOROBENZENE; ALANINE AMINOTRANSFERASE; MYCLOBUTANIL; PARACETAMOL; PROPICONAZOLE; TRIADIMEFON;

DRUG; GENE EXPRESSION; PREDICTION; TOXICITY;

ACUTE TOXICITY; ARTICLE; CLUSTER ANALYSIS; DRUG SCREENING; GENE EXPRESSION; GENE IDENTIFICATION; HUMAN; IN VITRO STUDY; LIVER CELL; LIVER FAILURE; LIVER TOXICITY; NONHUMAN; PREDICTION; PREDICTIVE VALUE; PRIORITY JOURNAL; SENSITIVITY AND SPECIFICITY; TOXICITY TESTING; TRANSCRIPTOMICS;

ALGORITHMS; ANIMALS; BIOLOGICAL MARKERS; DISEASE MODELS, ANIMAL; DRUG EVALUATION, PRECLINICAL; DRUG-INDUCED LIVER INJURY; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HEPATOCYTES; HUMANS; LIVER; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PREDICTIVE VALUE OF TESTS; RATS; TOXICITY TESTS; TOXICOGENETICS;

ANIMALIA; RODENTIA;

EID: 80052827182     PISSN: 00225193     EISSN: 10958541     Source Type: Journal    
DOI: 10.1016/j.jtbi.2011.08.009     Document Type: Article

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