Reversal of the drug binding pocket defects of the AcrB multidrug efflux pump protein of Escherichia coli

Journal of Bacteriology

Volumn 197, Issue 20, 2015, Pages 3255-3264

  Soparkar, Ketaki ^a,b   Kinana, Alfred D ^d   Weeks, Jon W ^a,c   Morrison, Keith D ^e   Nikaido, Hiroshi ^d   Misra, Rajeev ^a  

^a ARIZONA STATE UNIVERSITY   (United States)

^b CoValence Laboratories ^*  (United States)

^c UNIVERSITY OF OKLAHOMA   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e ARIZONA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACRB PROTEIN; BACTERIAL PROTEIN; CEFALOTIN; CEPHALOSPORIN DERIVATIVE; CIPROFLOXACIN; DODECYL SULFATE SODIUM; DOXORUBICIN; ERYTHROMYCIN; MINOCYCLINE; NALIDIXIC ACID; NITROCEFIN; NOVOBIOCIN; OXACILLIN; UNCLASSIFIED DRUG; ACRB PROTEIN, E COLI; ANTIINFECTIVE AGENT; ESCHERICHIA COLI PROTEIN; MULTIDRUG RESISTANCE PROTEIN;

AMINO ACID SUBSTITUTION; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL MUTATION; BACTERIAL STRAIN; BACTERIUM CULTURE; BINDING AFFINITY; DRUG BINDING; DRUG BINDING POCKET; DRUG CONFORMATION; DRUG PURIFICATION; ESCHERICHIA COLI; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; SALMONELLA ENTERICA; SITE DIRECTED MUTAGENESIS; ANTAGONISTS AND INHIBITORS; BINDING SITE; BIOLOGY; DRUG EFFECTS; GENETICS; METABOLISM; MULTIDRUG RESISTANCE; MUTATION; PROTEIN CONFORMATION;

AMINO ACID SUBSTITUTION; ANTI-BACTERIAL AGENTS; BINDING SITES; CEPHALOSPORINS; COMPUTATIONAL BIOLOGY; DRUG RESISTANCE, MULTIPLE, BACTERIAL; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; MUTATION; PROTEIN CONFORMATION;

EID: 84944522936     PISSN: 00219193     EISSN: 10985530     Source Type: Journal    
DOI: 10.1128/JB.00547-15     Document Type: Article

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