Overexpression of GRß in colonic mucosal cell line partly reflects altered gene expression in colonic mucosa of patients with inflammatory bowel disease

Journal of Steroid Biochemistry and Molecular Biology

Volumn 155, Issue , 2016, Pages 76-84

  Nagy, Zsolt ^a   Acs, Bence ^a   Butz, Henriett ^a   Feldman, Karolina ^a   Marta, Alexa ^a   Szabo, Peter M ^a   Baghy, Kornelia ^a   Pazmany, Tamas ^b   Racz, Karoly ^a   Liko, Istvan ^a,b   Patocs, Attila ^a  

^a SEMMELWEIS UNIVERSITY   (Hungary)

^b GEDEON RICHTER LTD   (Hungary)

Author keywords

Gene expression; Glucocorticoid receptor beta; Glucocorticoid resistance; Inflammation; Inflammatory bowel disease

Indexed keywords

DEXAMETHASONE; GLUCOCORTICOID RECEPTOR BETA; TRANSCRIPTOME; GLUCOCORTICOID RECEPTOR;

ARTICLE; CACO 2 CELL LINE; CELL ADHESION; CELL PROLIFERATION; COLON MUCOSA; COMPUTER MODEL; CONTROLLED STUDY; GENE EXPRESSION PROFILING; GENE IDENTIFICATION; GENE OVEREXPRESSION; GENOME; HUMAN; HUMAN CELL; IN VITRO STUDY; INFLAMMATORY BOWEL DISEASE; INTESTINE CELL; INTESTINE EPITHELIUM; INTESTINE MUCOSA; META ANALYSIS (TOPIC); MICROARRAY ANALYSIS; MUCOSA CELL; UPREGULATION; CELL MOTION; CELL NUCLEUS; COLON; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PATHOPHYSIOLOGY;

CACO-2 CELLS; CELL ADHESION; CELL MOVEMENT; CELL NUCLEUS; CELL PROLIFERATION; COLON; DEXAMETHASONE; GENE EXPRESSION REGULATION; HUMANS; INFLAMMATORY BOWEL DISEASES; INTESTINAL MUCOSA; RECEPTORS, GLUCOCORTICOID; TRANSCRIPTOME;

EID: 84944388825     PISSN: 09600760     EISSN: 18791220     Source Type: Journal    
DOI: 10.1016/j.jsbmb.2015.10.006     Document Type: Article

References (37)

1. R. Grose, S. Werner, D. Kessler, J. Tuckermann, K. Huggel, S. Durka, and et al. A role for endogenous glucocorticoids in wound repair EMBO Rep. 3 2002 575 582
2. Á. Szappanos, Z. Nagy, B. Kovács, G. Poór, M. Tóth, K. Rácz, and et al. Tissue-specific glucocorticoid signaling may determine the resistance against glucocorticoids in autoimmune diseases Curr. Med. Chem. 2015 1126 1135
3. C.M. Bamberger, A.M. Bamberger, M. de Castro, and G.P. Chrousos Glucocorticoid receptor beta, a potential endogenous inhibitor of glucocorticoid action in humans J. Clin. Invest. 95 1995 2435 2441
4. R.H. Oakley, C.M. Jewell, M.R. Yudt, D.M. Bofetiado, and J.A. Cidlowski The dominant negative activity of the human glucocorticoid receptor beta isoform. Specificity and mechanisms of action J. Biol. Chem. 274 1999 27857 27866
5. M. De Castro, S. Elliot, T. Kino, C. Bamberger, M. Karl, E. Webster, and et al. The non-ligand binding β-Isoform of the human glucocorticoid receptor (hGRß): tissue levels, mechanism of action, and potential physiologic role Mol. Med. 2 1996 597 607
6. H. Kelly, Bowen, N. Jee, C. Mahfiche, T. Lee, and et al. The glucocorticoid receptor beta isoform can mediate transcriptional repression by recruiting histone deacetylases J. Allergy Clin. Immunol. 121 2008 203 208
7. T. Kino, I. Manoli, S. Kelkar, Y. Wang, and Y.A. Su Glucocorticoid receptor (GR) beta has intrinsic, GRalpha-independent transcriptional activity Biochem. Biophys. Res. Commun. 381 2009 671 675
8. LJ, C.M. Lewis-Tuffin, R.J. Jewell, J.B. Bienstock, Collins, and J.A. Cidlowski Human glucocorticoid receptor beta binds RU-486 and is transcriptionally active Mol. Cell. Biol. 27 2007 2266 2282
9. N. Auphan, J.A. DiDonato, C. Rosette, A. Helmberg, and M. Karin Immunosuppression by glucocorticoids: inhibition of NF-kappa B activity through induction of I kappa B synthesis Science 270 1995 286 290
10. J.C. Webster, R.H. Oakley, C.M. Jewell, and J.A. Cidlowski Proinflammatory cytokines regulate human glucocorticoid receptor gene expression and lead to the accumulation of the dominant negative beta isoform: a mechanism for the generation of glucocorticoid resistance Proc. Natl. Acad. Sci. U. S. A. 98 2001 6865 6870
11. S. Fujishima, H. Takeda, S. Kawata, and M. Yamakawa The relationship between the expression of the glucocorticoid receptor in biopsied colonic mucosa and the glucocorticoid responsiveness of ulcerative colitis patients Clin. Immunol. 133 2009 208 217
12. T. Towers, G. Naftali, M. Gabay, A. Carlebach, and B. Klein High levels of glucocorticoid receptors in patients with active Crohn's disease may predict steroid resistance Clin. Exp. Immunol. 141 2005 357 362
13. H. Zhang, Q. Ouyang, Z.-H. Wen, C. Fiocchi, W.-P. Liu, D.-Y. Chen, and et al. Significance of glucocorticoid receptor expression in colonic mucosal cells of patients with ulcerative colitis World J. Gastroenterol. 11 2005 1775 1778
14. A.V.B. Granlund, A. Flatberg, A.E. Østvik, I. Drozdov, B.I. Gustafsson, M. Kidd, and et al. Whole genome gene expression meta-analysis of inflammatory bowel disease colon mucosa demonstrates lack of major differences between Crohn's disease and ulcerative colitis PLoS One. 8 2013 e56818
15. I. Arijs, G. De Hertogh, K. Lemaire, R. Quintens, L. Van Lommel, K. Van Steen, and et al. Mucosal gene expression of antimicrobial peptides in inflammatory bowel disease before and after first infliximab treatment PLoS One 4 2009 e7984
16. J.T. Bjerrum, M. Hansen, J. Olsen, and O.H. Nielsen Genome-wide gene expression analysis of mucosal colonic biopsies and isolated colonocytes suggests a continuous inflammatory state in the lamina propria of patients with quiescent ulcerative colitis Inflamm. Bowel Dis. 16 2010 999 1007
17. O.H. Csillag, R. Nielsen, F.C. Borup, and J. Nielsen Clinical phenotype and gene expression profile in Crohn's disease Am. J. Physiol. Gastrointest. Liver Physiol. 292 2007 G298 G304
18. G. Toedter, K. Li, S. Sague, K. Ma, C. Marano, M. Macoritto, and et al. Genes associated with intestinal permeability in ulcerative colitis: changes in expression following infliximab therapy Inflamm. Bowel Dis. 18 2012 1399 1410
19. B. Boyle, H. Butz, I. Liko, A. Zalatnai, M. Toth, K. Feldman, and et al. Expression of glucocorticoid receptor isoforms in human adrenocortical adenomas Steroids 75 2010 695 700
20. G.P. Charmandari, T. Chrousos, N. Ichijo, A. Bhattacharyya, E. Vottero, and et al. The human glucocorticoid receptor (hGR) beta isoform suppresses the transcriptional activity of hGRalpha by interfering with formation of active coactivator complexes Mol. Endocrinol. 19 2005 52 64
21. T. Kino, Y.A. Su, and G.P. Chrousos Human glucocorticoid receptor isoform beta: recent understanding of its potential implications in physiology and pathophysiology Cell. Mol. Life Sci. 66 2009 3435 3448
22. A.-M.G. Psarra, S. Solakidi, I.P. Trougakos, L.H. Margaritis, G. Spyrou, and C.E. Sekeris Glucocorticoid receptor isoforms in human hepatocarcinoma HepG2 and SaOS-2 osteosarcoma cells: presence of glucocorticoid receptor alpha in mitochondria and of glucocorticoid receptor beta in nucleoli Int. J. Biochem. Cell Biol. 37 2005 2544 2558
23. L.-B. Li, D.Y.M. Leung, R.J. Martin, and E. Goleva Inhibition of histone deacetylase 2 expression by elevated glucocorticoid receptor beta in steroid-resistant asthma Am. J. Respir. Crit. Care Med. 182 2010 877 883
24. K. Strickland, P.J. Kisich, A. Hauk, G.P. Vottero, D.J. Chrousos, and et al. High constitutive glucocorticoid receptor beta in human neutrophils enables them to reduce their spontaneous rate of cell death in response to corticosteroids J. Exp. Med. 193 2001 585 593
25. X. Zhang, A.F. Clark, and T. Yorio FK506-binding protein 51 regulates nuclear transport of the glucocorticoid receptor beta and glucocorticoid responsiveness Invest. Ophthalmol. Vis. Sci. 49 2008 1037 1047
26. L.C. Matthews, A.A. Berry, D.J. Morgan, T.M. Poolman, K. Bauer, F. Kramer, and et al. Glucocorticoid receptor regulates accurate chromosome segregation and is associated with malignancy Proc. Natl. Acad. Sci. U. S. A. 2015
27. Thomas-Chollier M, L.C. Watson, S.B. Cooper, M.A. Pufall, J.S. Liu, K. Borzym, and et al. A naturally occurring insertion of a single amino acid rewires transcriptional regulation by glucocorticoid receptor isoforms Proc. Natl. Acad. Sci. U. S. A. 110 2013 17826 17831
28. E. Shimshoni, D. Yablecovitch, L. Baram, I. Dotan, and I. Sagi ECM remodelling in IBD: innocent bystander or partner in crime? The emerging role of extracellular molecular events in sustaining intestinal inflammation Gut 64 2015 367 372
29. K. Heilmann, U. Hoffmann, E. Witte, C. Loddenkemper, C. Sina, S. Schreiber, and et al. Osteopontin as two-sided mediator of intestinal inflammation J. Cell. Mol. Med. 13 2009 1162 1174
30. M. Mor-Vaknin, Y. Legendre, C.H.C. Yu, S.K. Serezani, A. Garg, and et al. Murine colitis is mediated by vimentin Sci. Rep. 3 2013 1045
31. Y.-L. Ng, B. Klopcic, F. Lloyd, C. Forrest, W. Greene, and I.C. Lawrance Secreted protein acidic and rich in cysteine (SPARC) exacerbates colonic inflammatory symptoms in dextran sodium sulphate-induced murine colitis PLoS One 8 2013 e77575
32. F. Wu, and S. Chakravarti Differential expression of inflammatory and fibrogenic genes and their regulation by NF-kappaB inhibition in a mouse model of chronic colitis J. Immunol. 179 2007 6988 7000
33. R. Ahrens, A. Waddell, L. Seidu, C. Blanchard, R. Carey, E. Forbes, and et al. Intestinal macrophage/epithelial cell-derived CCL11/eotaxin-1 mediates eosinophil recruitment and function in pediatric ulcerative colitis J. Immunol. 181 2008 7390 7399
34. R. Carey, I. Jurickova, E. Ballard, E. Bonkowski, X. Han, H. Xu, and et al. Activation of an IL-6: STAT3-dependent transcriptome in pediatric-onset inflammatory bowel disease Inflamm. Bowel Dis. 14 2008 446 457
35. B. Funke, F. Lasitschka, W. Roth, R. Penzel, S. Meuer, M. Saile, and et al. Selective downregulation of retinoic acid-inducible gene I within the intestinal epithelial compartment in Crohn's disease Inflamm. Bowel Dis. 17 2011 1943 1954
36. S. Kugathasan, R.N. Baldassano, J.P. Bradfield, P.M.A. Sleiman, M. Imielinski, S.L. Guthery, and et al. Loci on 20q13 and 21q22 are associated with pediatric-onset inflammatory bowel disease Nat. Genet. 40 2008 1211 1215
37. J. Olsen, T.A. Gerds, J.B. Seidelin, C. Csillag, J.T. Bjerrum, J.T. Troelsen, and et al. Diagnosis of ulcerative colitis before onset of inflammation by multivariate modeling of genome-wide gene expression data Inflamm. Bowel Dis. 15 2009 1032 1038