Glucocorticoid receptor regulates accurate chromosome segregation and is associated with malignancy

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 17, 2015, Pages 5479-5484

  Matthews, Laura C ^a   Berry, Andrew A ^a   Morgan, David J ^a   Poolman, Toryn M ^a   Bauer, Kerstin ^b   Kramer, Frederike ^c   Spiller, David G ^d   Richardson, Rachel V ^e   Chapman, Karen E ^e   Farrow, Stuart N ^a,f   Norman, Michael R ^g   Williamson, Andrew J K ^d   Whetton, Anthony D ^d   Taylor, Stephen S ^d   Tuckermann, Jan P ^b,c   White, Michael R H ^d   Ray, David W ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b UNIVERSITY OF ULM   (Germany)

^c FRITZ LIPMANN INSTITUTE   (Germany)

^d UNIVERSITY OF MANCHESTER   (United Kingdom)

^e UNIVERSITY OF EDINBURGH   (United Kingdom)

^f GLAXOSMITHKLINE   (United Kingdom)

^g UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

Aneuploidy; Cancer; DNA damage; Glucocorticoid receptor; Mitosis

Indexed keywords

AURORA A KINASE; GLUCOCORTICOID RECEPTOR; TUMOR SUPPRESSOR PROTEIN;

ACCURACY; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BREAST CANCER; CARCINOGENESIS; CELL CYCLE; CELL TRANSFORMATION; CHROMOSOME SEGREGATION; COLON CANCER; CONTROLLED STUDY; EMBRYO; GENETIC COMPLEMENTATION; HUMAN; HUMAN CELL; INCIDENCE; LIGAND BINDING; LIVER CANCER; LUNG CANCER; MITOSIS; MITOSIS SPINDLE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; TUMOR SUPPRESSOR GENE; ANIMAL; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MUTANT MOUSE STRAIN; NEOPLASM; PATHOLOGY; PROTEIN TERTIARY STRUCTURE; TUMOR CELL CULTURE;

MUS;

ANIMALS; CELL TRANSFORMATION, NEOPLASTIC; CHROMOSOME SEGREGATION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MICE; MICE, MUTANT STRAINS; MITOSIS; NEOPLASMS; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, GLUCOCORTICOID; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEINS;

EID: 84928691391     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1411356112     Document Type: Article

References (50)

1. Payvar F, et al. (1981) Purified glucocorticoid receptors bind selectively in vitro to a cloned DNA fragment whose transcription is regulated by glucocorticoids in vivo. Proc Natl Acad Sci USA 78(11):6628-6632.
2. Hollenberg SM, et al. (1985) Primary structure and expression of a functional human glucocorticoid receptor cDNA. Nature 318(6047):635-641.
3. Evans RM (2005) The nuclear receptor superfamily: A rosetta stone for physiology. Mol Endocrinol 19(6):1429-1438.
4. Rhen T, Cidlowski JA (2005) Antiinflammatory action of glucocorticoids - New mechanisms for old drugs. N Engl J Med 353(16):1711-1723.
5. Davies TH, Ning YM, Sánchez ER (2002) A new first step in activation of steroid receptors: Hormone-induced switching of FKBP51 and FKBP52 immunophilins. J Biol Chem 277(7):4597-4600.
6. Harrell JM, et al. (2004) Evidence for glucocorticoid receptor transport on microtubules by dynein. J Biol Chem 279(52):54647-54654.
7. John S, et al. (2008) Interaction of the glucocorticoid receptor with the chromatin landscape. Mol Cell 29(5):611-624.
8. John S, et al. (2011) Chromatin accessibility pre-determines glucocorticoid receptor binding patterns. Nat Genet 43(3):264-268.
9. Biddie SC, et al. (2011) Transcription factor AP1 potentiates chromatin accessibility and glucocorticoid receptor binding. Mol Cell 43(1):145-155.
10. Uhlenhaut NH, et al. (2013) Insights into negative regulation by the glucocorticoid receptor from genome-wide profiling of inflammatory cistromes. Mol Cell 49(1):158-171.
11. Matthews L, et al. (2011) Cell cycle phase regulates glucocorticoid receptor function. PLoS ONE 6(7):e22289.
12. Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R (2006) Phosphoproteome analysis of the human mitotic spindle. Proc Natl Acad Sci USA 103(14):5391-5396.
13. Hsu SC, Qi M, DeFranco DB (1992) Cell cycle regulation of glucocorticoid receptor function. EMBO J 11(9):3457-3468.
14. Abel GA, et al. (2002) Activity of the GR in G2 and mitosis. Mol Endocrinol 16(6):1352-1366.
15. Tissing WJ, Meijerink JP, den Boer ML, Pieters R (2003) Molecular determinants of glucocorticoid sensitivity and resistance in acute lymphoblastic leukemia. Leukemia 17(1):17-25.
16. Rogatsky I, Trowbridge JM, Garabedian MJ (1997) Glucocorticoid receptor-mediated cell cycle arrest is achieved through distinct cell-specific transcriptional regulatory mechanisms. Mol Cell Biol 17(6):3181-3193.
17. Sauer G, et al. (2005) Proteome analysis of the human mitotic spindle. Mol Cell Proteomics 4(1):35-43.
18. Abrieu A, Kahana JA, Wood KW, Cleveland DW (2000) CENP-E as an essential component of the mitotic checkpoint in vitro. Cell 102(6):817-826.
19. Kalitsis P, Earle E, Fowler KJ, Choo KH (2000) Bub3 gene disruption in mice reveals essential mitotic spindle checkpoint function during early embryogenesis. Genes Dev 14(18):2277-2282.
20. Wang Z, Frederick J, Garabedian MJ (2002) Deciphering the phosphorylation "code" of the glucocorticoid receptor in vivo. J Biol Chem 277(29):26573-26580.
21. Wiese C, Zheng Y (1999) Gamma-tubulin complexes and their interaction with microtubule-organizing centers. Curr Opin Struct Biol 9(2):250-259.
22. Mole-Bajer J, Bajer AS, Zinkowski RP, Balczon RD, Brinkley BR (1990) Autoantibodies from a patient with scleroderma CREST recognized kinetochores of the higher plant Haemanthus. Proc Natl Acad Sci USA 87(9):3599-3603.
23. Rice L, et al. (2008) Identification and functional analysis of SKA2 interaction with the glucocorticoid receptor. J Endocrinol 198(3):499-509.
24. Hanisch A, Silljé HH, Nigg EA (2006) Timely anaphase onset requires a novel spindle and kinetochore complex comprising Ska1 and Ska2. EMBO J 25(23):5504-5515.
25. Janssen A, van der Burg M, Szuhai K, Kops GJ, Medema RH (2011) Chromosome segregation errors as a cause of DNA damage and structural chromosome aberrations. Science 333(6051):1895-1898.
26. Burma S, Chen BP, Murphy M, Kurimasa A, Chen DJ (2001) ATM phosphorylates histone H2AX in response to DNA double-strand breaks. J Biol Chem 276(45):42462-42467.
27. Trebble P, et al. (2010) Familial glucocorticoid resistance caused by a novel frameshift glucocorticoid receptor mutation. J Clin Endocrinol Metab 95(12):E490-E499.
28. Musacchio A, Salmon ED (2007) The spindle-assembly checkpoint in space and time. Nat Rev Mol Cell Biol 8(5):379-393.
29. Walczak CE, Cai S, Khodjakov A (2010) Mechanisms of chromosome behaviour during mitosis. Nat Rev Mol Cell Biol 11(2):91-102.
30. Rieder CL, Faruki S, Khodjakov A (2001) The centrosome in vertebrates: More than a microtubule-organizing center. Trends Cell Biol 11(10):413-419.
31. Sampath SC, et al. (2004) The chromosomal passenger complex is required for chromatin-induced microtubule stabilization and spindle assembly. Cell 118(2):187-202.
32. Ma HT, Poon RY (2011) How protein kinases co-ordinate mitosis in animal cells. Biochem J 435(1):17-31.
33. Marumoto T, et al. (2003) Aurora-A kinase maintains the fidelity of early and late mitotic events in HeLa cells. J Biol Chem 278(51):51786-51795.
34. Vader G, Medema RH, Lens SM (2006) The chromosomal passenger complex: Guiding Aurora-B through mitosis. J Cell Biol 173(6):833-837.
35. Maiato H, Logarinho E (2014) Mitotic spindle multipolarity without centrosome amplification. Nat Cell Biol 16(5):386-394.
36. Akner G, Wikström AC, Mossberg K, Sundqvist KG, Gustafsson JA (1994) Morphometric studies of the localization of the glucocorticoid receptor in mammalian cells and of glucocorticoid hormone-induced effects. J Histochem Cytochem 42(5):645-657.
37. Jensen AØ, et al. (2009) Use of oral glucocorticoids and risk of skin cancer and non-Hodgkin's lymphoma: A population-based case-control study. Br J Cancer 100(1): 200-205.
38. Weaver BA, Silk AD, Montagna C, Verdier-Pinard P, Cleveland DW (2007) Aneuploidy acts both oncogenically and as a tumor suppressor. Cancer Cell 11(1):25-36.
39. Dietrich K, et al. (2009) Glucocorticoid therapy and risk of bladder cancer. Br J Cancer 101(8):1316-1320.
40. Kay P, et al. (2011) Loss of glucocorticoid receptor expression by DNA methylation prevents glucocorticoid induced apoptosis in human small cell lung cancer cells. PLoS ONE 6(10):e24839.
41. Sommer P, et al. (2007) Glucocorticoid receptor overexpression exerts an antisurvival effect on human small cell lung cancer cells. Oncogene 26(50):7111-7121.
42. Sommer P, et al. (2010) Glucocorticoid receptor over-expression promotes human small cell lung cancer apoptosis in vivo and thereby slows tumor growth. Endocr Relat Cancer 17(1):203-213.
43. Lind GE, et al. (2006) ADAMTS1, CRABP1, and NR3C1 identified as epigenetically deregulated genes in colorectal tumorigenesis. Cell Oncol 28(5-6):259-272.
44. Nesset KA, Perri AM, Mueller CR (2014) Frequent promoter hypermethylation and expression reduction of the glucocorticoid receptor gene in breast tumors. Epigenetics 9(6):851-859.
45. Shah SP, et al. (2012) The clonal and mutational evolution spectrum of primary triplenegative breast cancers. Nature 486(7403):395-399.
46. Pan D, Kocherginsky M, Conzen SD (2011) Activation of the glucocorticoid receptor is associated with poor prognosis in estrogen receptor-negative breast cancer. Cancer Res 71(20):6360-6370.
47. Grunberg SM (2007) Antiemetic activity of corticosteroids in patients receiving cancer chemotherapy: Dosing, efficacy, and tolerability analysis. Ann Oncol 18(2):233-240.
48. Keith BD (2008) Systematic review of the clinical effect of glucocorticoids on non-hematologic malignancy. BMC Cancer 8:84.
49. Trebble PJ, et al. (2013) A ligand-specific kinetic switch regulates glucocorticoid receptor trafficking and function. J Cell Sci 126(Pt 14):3159-3169.
50. Poolman TM, Farrow SN, Matthews L, Loudon AS, Ray DW (2013) Pin1 promotes GR transactivation by enhancing recruitment to target genes. Nucleic Acids Res 41(18):8515-8525.