메뉴 건너뛰기




Volumn 34, Issue 6, 2015, Pages 2821-2826

Role of the LKB1/AMPK pathway in tumor invasion and metastasis of cancer cells (Review)

Author keywords

AMP activated protein kinase; Liver kinase B1; Metastasis; TGF signal transduction; Tumor invasion

Indexed keywords

ADENYLATE KINASE; MAMMALIAN TARGET OF RAPAMYCIN; PROTEIN KINASE LKB1; TRANSFORMING GROWTH FACTOR BETA; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; PROTEIN SERINE THREONINE KINASE; STK11 PROTEIN, HUMAN;

EID: 84943792809     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2015.4288     Document Type: Review
Times cited : (74)

References (79)
  • 3
    • 84893395020 scopus 로고    scopus 로고
    • Integrative genomic analysis reveals a high frequency of LKB1 genetic alteration in Chinese lung adenocarcinomas
    • Fang R, Zheng C, Sun Y, Han X, Gao B, Li C, Liu H, Wong KK, Liu XY, Chen H, et al: Integrative genomic analysis reveals a high frequency of LKB1 genetic alteration in Chinese lung adenocarcinomas. J Thorac Oncol 9: 254-258, 2014.
    • (2014) J Thorac Oncol , vol.9 , pp. 254-258
    • Fang, R.1    Zheng, C.2    Sun, Y.3    Han, X.4    Gao, B.5    Li, C.6    Liu, H.7    Wong, K.K.8    Liu, X.Y.9    Chen, H.10
  • 7
    • 72949115493 scopus 로고    scopus 로고
    • Structure of the LKB1-STRAD-MO25 complex reveals an allosteric mechanism of kinase activation
    • Zeqiraj E, Filippi BM, Deak M, Alessi DR and van Aalten DM: Structure of the LKB1-STRAD-MO25 complex reveals an allosteric mechanism of kinase activation. Science 326: 1707-1711, 2009.
    • (2009) Science , vol.326 , pp. 1707-1711
    • Zeqiraj, E.1    Filippi, B.M.2    Deak, M.3    Alessi, D.R.4    Van Aalten, D.M.5
  • 10
    • 84884479862 scopus 로고    scopus 로고
    • Breaking the epithelial polarity barrier in cancer: The strange case of LKB1/PAR-4
    • Partanen JI, Tervonen TA and Klefström J: Breaking the epithelial polarity barrier in cancer: The strange case of LKB1/PAR-4. Philos Trans R Soc Lond BBiol Sci 368: 20130111, 2013.
    • (2013) Philos Trans R Soc Lond BBiol Sci , vol.368 , pp. 20130111
    • Partanen, J.I.1    Tervonen, T.A.2    Klefström, J.3
  • 11
    • 84907915831 scopus 로고    scopus 로고
    • Loss of LKB1 disrupts breast epithelial cell polarity and promotes breast cancer metastasis and invasion
    • Li J, Liu J, Li P, Mao X, Li W, Yang J and Liu P: Loss of LKB1 disrupts breast epithelial cell polarity and promotes breast cancer metastasis and invasion. J Exp Clin Cancer Res 33: 70, 2014.
    • (2014) J Exp Clin Cancer Res , vol.33 , pp. 70
    • Li, J.1    Liu, J.2    Li, P.3    Mao, X.4    Li, W.5    Yang, J.6    Liu, P.7
  • 12
    • 84893844482 scopus 로고    scopus 로고
    • Exogenous activation of LKB1/AMPK signaling induces G1 arrest in cells with endogenous LKB1 expression
    • Liang X, Wang P, Gao Q and Tao X: Exogenous activation of LKB1/AMPK signaling induces G1 arrest in cells with endogenous LKB1 expression. Mol Med Rep 9: 1019-1024, 2014.
    • (2014) Mol Med Rep , vol.9 , pp. 1019-1024
    • Liang, X.1    Wang, P.2    Gao, Q.3    Tao, X.4
  • 13
    • 84868450290 scopus 로고    scopus 로고
    • ATM and LKB1 dependent activation of AMPK sensitizes cancer cells to etoposide-induced apoptosis
    • Luo L, Huang W, Tao R, Hu N, Xiao ZX and Luo Z: ATM and LKB1 dependent activation of AMPK sensitizes cancer cells to etoposide-induced apoptosis. Cancer Lett 328: 114-119, 2013.
    • (2013) Cancer Lett , vol.328 , pp. 114-119
    • Luo, L.1    Huang, W.2    Tao, R.3    Hu, N.4    Xiao, Z.X.5    Luo, Z.6
  • 14
    • 84876320551 scopus 로고    scopus 로고
    • LKB1 and AMPK and the cancer-metabolism link-ten years after
    • Hardie DG and Alessi DR: LKB1 and AMPK and the cancer-metabolism link-ten years after. BMC Biol 11: 36, 2013.
    • (2013) BMC Biol , vol.11 , pp. 36
    • Hardie, D.G.1    Alessi, D.R.2
  • 16
    • 84873608350 scopus 로고    scopus 로고
    • The LKB1-AMPK pathway-friend or foe in cancer
    • Hardie DG: The LKB1-AMPK pathway-friend or foe in cancer? Cancer Cell 23: 131-132, 2013.
    • (2013) Cancer Cell , vol.23 , pp. 131-132
    • Hardie, D.G.1
  • 17
    • 84868005485 scopus 로고    scopus 로고
    • AMP-activated protein kinase: A target for drugs both ancient and modern
    • Hardie DG, Ross FA and Hawley SA: AMP-activated protein kinase: A target for drugs both ancient and modern. Chem Biol 19: 1222-1236, 2012.
    • (2012) Chem Biol , vol.19 , pp. 1222-1236
    • Hardie, D.G.1    Ross, F.A.2    Hawley, S.A.3
  • 18
    • 84881614717 scopus 로고    scopus 로고
    • Molecular mechanism of action of metformin: Old or new insights
    • Rena G, Pearson ER and Sakamoto K: Molecular mechanism of action of metformin: Old or new insights? Diabetologia 56: 1898-1906, 2013.
    • (2013) Diabetologia , vol.56 , pp. 1898-1906
    • Rena, G.1    Pearson, E.R.2    Sakamoto, K.3
  • 19
    • 80052511813 scopus 로고    scopus 로고
    • The AMPK signalling pathway coordinates cell growth, autophagy and metabolism
    • Mihaylova MM and Shaw RJ: The AMPK signalling pathway coordinates cell growth, autophagy and metabolism. Nat Cell Biol 13: 1016-1023, 2011.
    • (2011) Nat Cell Biol , vol.13 , pp. 1016-1023
    • Mihaylova, M.M.1    Shaw, R.J.2
  • 21
    • 84920135306 scopus 로고    scopus 로고
    • The Warburg effect in tumor progression: Mitochondrial oxidative metabolism as an anti-metastasis mechanism
    • Lu J, Tan M and Cai Q: The Warburg effect in tumor progression: Mitochondrial oxidative metabolism as an anti-metastasis mechanism. Cancer Lett 356: 156-164, 2015.
    • (2015) Cancer Lett , vol.356 , pp. 156-164
    • Lu, J.1    Tan, M.2    Cai, Q.3
  • 23
    • 84871870815 scopus 로고    scopus 로고
    • AMP kinase activation improves angiogenesis in pulmonary artery endothelial cells with in utero pulmonary hypertension
    • Teng RJ, Du J, Afolayan AJ, Eis A, Shi Y and Konduri GG: AMP kinase activation improves angiogenesis in pulmonary artery endothelial cells with in utero pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol 304: L29-L42, 2013.
    • (2013) Am J Physiol Lung Cell Mol Physiol , vol.304 , pp. L29-L42
    • Teng, R.J.1    Du, J.2    Afolayan, A.J.3    Eis, A.4    Shi, Y.5    Konduri, G.G.6
  • 24
    • 28244466264 scopus 로고    scopus 로고
    • 5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside inhibits cancer cell proliferation in vitro and in vivo via AMP-activated protein kinase
    • Rattan R, Giri S, Singh AK and Singh I: 5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside inhibits cancer cell proliferation in vitro and in vivo via AMP-activated protein kinase. J Biol Chem 280: 39582-39593, 2005.
    • (2005) J Biol Chem , vol.280 , pp. 39582-39593
    • Rattan, R.1    Giri, S.2    Singh, A.K.3    Singh, I.4
  • 25
    • 79956088595 scopus 로고    scopus 로고
    • The long and winding road to rational treatment of cancer associated with LKB1/AMPK/TSC/mTORC1 signaling
    • van Veelen W, Korsse SE, van de Laar L and Peppelenbosch MP: The long and winding road to rational treatment of cancer associated with LKB1/AMPK/TSC/mTORC1 signaling. Oncogene 30: 2289-2303, 2011.
    • (2011) Oncogene , vol.30 , pp. 2289-2303
    • Van Veelen, W.1    Korsse, S.E.2    Van De Laar, L.3    Peppelenbosch, M.P.4
  • 26
    • 84912528393 scopus 로고    scopus 로고
    • MTOR and autophagy: A dynamic relationship governed by nutrients and energy
    • Dunlop EA and Tee AR: mTOR and autophagy: A dynamic relationship governed by nutrients and energy. Semin Cell Dev Biol 36: 121-129, 2014.
    • (2014) Semin Cell Dev Biol , vol.36 , pp. 121-129
    • Dunlop, E.A.1    Tee, A.R.2
  • 28
    • 79961118336 scopus 로고    scopus 로고
    • AMPK and mTOR coordinate the regulation of Ulk1 and mammalian autophagy initiation
    • Shang L and Wang X: AMPK and mTOR coordinate the regulation of Ulk1 and mammalian autophagy initiation. Autophagy 7: 924-926, 2011.
    • (2011) Autophagy , vol.7 , pp. 924-926
    • Shang, L.1    Wang, X.2
  • 29
    • 84866061320 scopus 로고    scopus 로고
    • AMPK-dependent phosphorylation of ULK1 regulates ATG9 localization
    • Mack HI, Zheng B, Asara JM and Thomas SM: AMPK-dependent phosphorylation of ULK1 regulates ATG9 localization. Autophagy 8: 1197-1214, 2012.
    • (2012) Autophagy , vol.8 , pp. 1197-1214
    • Mack, H.I.1    Zheng, B.2    Asara, J.M.3    Thomas, S.M.4
  • 30
    • 84864080019 scopus 로고    scopus 로고
    • The epithelial-mesenchymal transition (EMT) regulatory factor SLUG (SNAI2) is a downstream target of SPARC and AKT in promoting melanoma cell invasion
    • Fenouille N, Tichet M, Dufies M, Pottier A, Mogha A, Soo JK, Rocchi S, Mallavialle A, Galibert MD, Khammari A, et al: The epithelial-mesenchymal transition (EMT) regulatory factor SLUG (SNAI2) is a downstream target of SPARC and AKT in promoting melanoma cell invasion. PLoS One 7: e40378, 2012.
    • (2012) PLoS One , vol.7 , pp. e40378
    • Fenouille, N.1    Tichet, M.2    Dufies, M.3    Pottier, A.4    Mogha, A.5    Soo, J.K.6    Rocchi, S.7    Mallavialle, A.8    Galibert, M.D.9    Khammari, A.10
  • 31
    • 84875227932 scopus 로고    scopus 로고
    • Matricellular proteins: Priming the tumour microenvironment for cancer development and metastasis
    • Wong GS and Rustgi AK: Matricellular proteins: Priming the tumour microenvironment for cancer development and metastasis. Br J Cancer 108: 755-761, 2013.
    • (2013) Br J Cancer , vol.108 , pp. 755-761
    • Wong, G.S.1    Rustgi, A.K.2
  • 32
    • 84923115145 scopus 로고    scopus 로고
    • Hepatocyte nuclear factor 4 alpha promotes the invasion, metastasis and angiogenesis of neuroblastoma cells via targeting matrix metalloproteinase 14
    • Xiang X, Zhao X, Qu H, Li D, Yang D, Pu J, Mei H, Zhao J, Huang K, Zheng L, et al: Hepatocyte nuclear factor 4 alpha promotes the invasion, metastasis and angiogenesis of neuroblastoma cells via targeting matrix metalloproteinase 14. Cancer Lett 359: 187-197, 2015.
    • (2015) Cancer Lett , vol.359 , pp. 187-197
    • Xiang, X.1    Zhao, X.2    Qu, H.3    Li, D.4    Yang, D.5    Pu, J.6    Mei, H.7    Zhao, J.8    Huang, K.9    Zheng, L.10
  • 33
    • 84895077403 scopus 로고    scopus 로고
    • Daidzein, R-(+)equol and S-(-)equol inhibit the invasion of MDA-MB-231 breast cancer cells potentially via the down-regulation of matrix metalloproteinase-2
    • Magee PJ, Allsopp P, Samaletdin A and Rowland IR: Daidzein, R-(+)equol and S-(-)equol inhibit the invasion of MDA-MB-231 breast cancer cells potentially via the down-regulation of matrix metalloproteinase-2. Eur J Nutr 53: 345-350, 2014.
    • (2014) Eur J Nutr , vol.53 , pp. 345-350
    • Magee, P.J.1    Allsopp, P.2    Samaletdin, A.3    Rowland, I.R.4
  • 35
    • 84903140339 scopus 로고    scopus 로고
    • Blocking PI3K/Akt signaling attenuates metastasis of nasopharyngeal carcinoma cells through induction of mesenchymal-epithelial reverting transition
    • Jiang H, Gao M, Shen Z, Luo B, Li R, Jiang X, Ding R, Ha Y, Wang Z and Jie W: Blocking PI3K/Akt signaling attenuates metastasis of nasopharyngeal carcinoma cells through induction of mesenchymal-epithelial reverting transition. Oncol Rep 32: 559-566, 2014.
    • (2014) Oncol Rep , vol.32 , pp. 559-566
    • Jiang, H.1    Gao, M.2    Shen, Z.3    Luo, B.4    Li, R.5    Jiang, X.6    Ding, R.7    Ha, Y.8    Wang, Z.9    Jie, W.10
  • 36
    • 84880616839 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition and cell invasion
    • Son H and Moon A: Epithelial-mesenchymal transition and cell invasion. Toxicol Res 26: 245-252, 2010.
    • (2010) Toxicol Res , vol.26 , pp. 245-252
    • Son, H.1    Moon, A.2
  • 37
    • 80053074082 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition in breast cancer progression and metastasis
    • Wang Y and Zhou BP: Epithelial-mesenchymal transition in breast cancer progression and metastasis. Chin J Cancer 30: 603-611, 2011.
    • (2011) Chin J Cancer , vol.30 , pp. 603-611
    • Wang, Y.1    Zhou, B.P.2
  • 38
    • 84860389952 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition and cancer stem cells: A dangerously dynamic duo in breast cancer progression
    • May CD, Sphyris N, Evans KW, Werden SJ, Guo W and Mani SA: Epithelial-mesenchymal transition and cancer stem cells: A dangerously dynamic duo in breast cancer progression. Breast Cancer Res 13: 202, 2011.
    • (2011) Breast Cancer Res , vol.13 , pp. 202
    • May, C.D.1    Sphyris, N.2    Evans, K.W.3    Werden, S.J.4    Guo, W.5    Mani, S.A.6
  • 39
    • 59449090107 scopus 로고    scopus 로고
    • TGF-beta-induced epithelial to mesenchymal transition
    • Xu J, Lamouille S and Derynck R: TGF-beta-induced epithelial to mesenchymal transition. Cell Res 19: 156-172, 2009.
    • (2009) Cell Res , vol.19 , pp. 156-172
    • Xu, J.1    Lamouille, S.2    Derynck, R.3
  • 41
    • 84871948755 scopus 로고    scopus 로고
    • TGF-β signaling and epithelial-mesenchymal transition in cancer progression
    • Katsuno Y, Lamouille S and Derynck R: TGF-β signaling and epithelial-mesenchymal transition in cancer progression. Curr Opin Oncol 25: 76-84, 2013.
    • (2013) Curr Opin Oncol , vol.25 , pp. 76-84
    • Katsuno, Y.1    Lamouille, S.2    Derynck, R.3
  • 42
    • 84884208384 scopus 로고    scopus 로고
    • Efficient TGFβ-induced epithelial-mesenchymal transition depends on hyaluronan synthase HAS2
    • Porsch H, Bernert B, Mehić M, Theocharis AD, Heldin CH and Heldin P: Efficient TGFβ-induced epithelial-mesenchymal transition depends on hyaluronan synthase HAS2. Oncogene 32: 4355-4365, 2013.
    • (2013) Oncogene , vol.32 , pp. 4355-4365
    • Porsch, H.1    Bernert, B.2    Mehić, M.3    Theocharis, A.D.4    Heldin, C.H.5    Heldin, P.6
  • 43
    • 79960838436 scopus 로고    scopus 로고
    • The TGF-β/Smad pathway induces breast cancer cell invasion through the up-regulation of matrix metalloproteinase 2 and 9 in a spheroid invasion model system
    • Wiercinska E, Naber HP, Pardali E, van der Pluijm G, van Dam H and ten Dijke P: The TGF-β/Smad pathway induces breast cancer cell invasion through the up-regulation of matrix metalloproteinase 2 and 9 in a spheroid invasion model system. Breast Cancer Res Treat 128: 657-666, 2011.
    • (2011) Breast Cancer Res Treat , vol.128 , pp. 657-666
    • Wiercinska, E.1    Naber, H.P.2    Pardali, E.3    Van Der Pluijm, G.4    Van Dam, H.5    Ten Dijke, P.6
  • 44
    • 34547587877 scopus 로고    scopus 로고
    • Cell size and invasion in TGF-beta-induced epithelial to mesenchymal transition is regulated by activation of the mTOR pathway
    • Lamouille S and Derynck R: Cell size and invasion in TGF-beta-induced epithelial to mesenchymal transition is regulated by activation of the mTOR pathway. J Cell Biol 178: 437-451, 2007.
    • (2007) J Cell Biol , vol.178 , pp. 437-451
    • Lamouille, S.1    Derynck, R.2
  • 45
    • 84861448736 scopus 로고    scopus 로고
    • TGF-β-induced activation of mTOR complex 2 drives epithelial-mesenchymal transition and cell invasion
    • Lamouille S, Connolly E, Smyth JW, Akhurst RJ and Derynck R: TGF-β-induced activation of mTOR complex 2 drives epithelial-mesenchymal transition and cell invasion. J Cell Sci 125: 1259-1273, 2012.
    • (2012) J Cell Sci , vol.125 , pp. 1259-1273
    • Lamouille, S.1    Connolly, E.2    Smyth, J.W.3    Akhurst, R.J.4    Derynck, R.5
  • 46
    • 84905899881 scopus 로고    scopus 로고
    • TGFβ-induced invasion of prostate cancer cells is promoted by c-Jun-dependent transcriptional activation of Snail1
    • Thakur N, Gudey SK, Marcusson A, Fu JY, Bergh A, Heldin CH and Landström M: TGFβ-induced invasion of prostate cancer cells is promoted by c-Jun-dependent transcriptional activation of Snail1. Cell Cycle 13: 2400-2414, 2014.
    • (2014) Cell Cycle , vol.13 , pp. 2400-2414
    • Thakur, N.1    Gudey, S.K.2    Marcusson, A.3    Fu, J.Y.4    Bergh, A.5    Heldin, C.H.6    Landström, M.7
  • 48
    • 84856750556 scopus 로고    scopus 로고
    • Antimetastatic effects of norcantharidin on hepatocellular carcinoma by transcriptional inhibition of MMP-9 through modulation of NF-κB activity
    • Yeh CB, Hsieh MJ, Hsieh YH, Chien MH, Chiou HL and Yang SF: Antimetastatic effects of norcantharidin on hepatocellular carcinoma by transcriptional inhibition of MMP-9 through modulation of NF-κB activity. PLoS One 7: e31055, 2012.
    • (2012) PLoS One , vol.7 , pp. e31055
    • Yeh, C.B.1    Hsieh, M.J.2    Hsieh, Y.H.3    Chien, M.H.4    Chiou, H.L.5    Yang, S.F.6
  • 49
    • 84902174063 scopus 로고    scopus 로고
    • S100A4 promotes squamous cell laryngeal cancer Hep-2 cell invasion via NF-κB/MMP-9 signal
    • Zhang W, Liu Y and Wang CW: S100A4 promotes squamous cell laryngeal cancer Hep-2 cell invasion via NF-κB/MMP-9 signal. Eur Rev Med Pharmacol Sci 18: 1361-1367, 2014.
    • (2014) Eur Rev Med Pharmacol Sci , vol.18 , pp. 1361-1367
    • Zhang, W.1    Liu, Y.2    Wang, C.W.3
  • 50
    • 84860709668 scopus 로고    scopus 로고
    • Hedgehog signaling pathway mediates invasion and metastasis of hepatocellular carcinoma via ERK pathway
    • Lu JT, Zhao WD, He W and Wei W: Hedgehog signaling pathway mediates invasion and metastasis of hepatocellular carcinoma via ERK pathway. Acta Pharmacol Sin 33: 691-700, 2012.
    • (2012) Acta Pharmacol Sin , vol.33 , pp. 691-700
    • Lu, J.T.1    Zhao, W.D.2    He, W.3    Wei, W.4
  • 51
    • 84916225729 scopus 로고    scopus 로고
    • Upregulation of MAPK/Erk and PI3K/Akt pathways in ulcerative colitis-associated colon cancer
    • Setia S, Nehru B and Sanyal SN: Upregulation of MAPK/Erk and PI3K/Akt pathways in ulcerative colitis-associated colon cancer. Biomed Pharmacother 68: 1023-1029, 2014.
    • (2014) Biomed Pharmacother , vol.68 , pp. 1023-1029
    • Setia, S.1    Nehru, B.2    Sanyal, S.N.3
  • 53
    • 84905705835 scopus 로고    scopus 로고
    • Fibulin-3 suppresses Wnt/β-catenin signaling and lung cancer invasion
    • Chen X, Meng J, Yue W, Yu J, Yang J, Yao Z and Zhang L: Fibulin-3 suppresses Wnt/β-catenin signaling and lung cancer invasion. Carcinogenesis 35: 1707-1716, 2014.
    • (2014) Carcinogenesis , vol.35 , pp. 1707-1716
    • Chen, X.1    Meng, J.2    Yue, W.3    Yu, J.4    Yang, J.5    Yao, Z.6    Zhang, L.7
  • 55
    • 84873085769 scopus 로고    scopus 로고
    • Identifying the regulative role of NF-κB binding sites within promoter region of human matrix metalloproteinase 9 (mmp-9) by TNF-α induction
    • Wu HT, Sie SS, Kuan TC and Lin CS: Identifying the regulative role of NF-κB binding sites within promoter region of human matrix metalloproteinase 9 (mmp-9) by TNF-α induction. Appl Biochem Biotechnol 169: 438-449, 2013.
    • (2013) Appl Biochem Biotechnol , vol.169 , pp. 438-449
    • Wu, H.T.1    Sie, S.S.2    Kuan, T.C.3    Lin, C.S.4
  • 56
    • 84886094157 scopus 로고    scopus 로고
    • Hedgehog signal inhibitors suppress the invasion of human rhabdomyosarcoma cells
    • Oue T, Uehara S, Yamanaka H, Nomura M and Usui N: Hedgehog signal inhibitors suppress the invasion of human rhabdomyosarcoma cells. Pediatr Surg Int 29: 1153-1158, 2013.
    • (2013) Pediatr Surg Int , vol.29 , pp. 1153-1158
    • Oue, T.1    Uehara, S.2    Yamanaka, H.3    Nomura, M.4    Usui, N.5
  • 57
    • 84905568827 scopus 로고    scopus 로고
    • An AMPK-independent signaling pathway downstream of the LKB1 tumor suppressor controls Snail1 and metastatic potential
    • Goodwin JM, Svensson RU, Lou HJ, Winslow MM, Turk BE and Shaw RJ: An AMPK-independent signaling pathway downstream of the LKB1 tumor suppressor controls Snail1 and metastatic potential. Mol Cell 55: 436-450, 2014.
    • (2014) Mol Cell , vol.55 , pp. 436-450
    • Goodwin, J.M.1    Svensson, R.U.2    Lou, H.J.3    Winslow, M.M.4    Turk, B.E.5    Shaw, R.J.6
  • 59
    • 79251614530 scopus 로고    scopus 로고
    • Lkb1 and Pten synergise to suppress mTOR-mediated tumorigenesis and epithelial-mesenchymal transition in the mouse bladder
    • Shorning BY, Griffiths D and Clarke AR: Lkb1 and Pten synergise to suppress mTOR-mediated tumorigenesis and epithelial-mesenchymal transition in the mouse bladder. PLoS One 6: e16209, 2011.
    • (2011) PLoS One , vol.6 , pp. e16209
    • Shorning, B.Y.1    Griffiths, D.2    Clarke, A.R.3
  • 60
    • 79959903575 scopus 로고    scopus 로고
    • Activation of AMP-activated protein kinase is essential for lysophosphatidic acid-induced cell migration in ovarian cancer cells
    • Kim EK, Park JM, Lim S, Choi JW, Kim HS, Seok H, Seo JK, Oh K, Lee DS, Kim KT, et al: Activation of AMP-activated protein kinase is essential for lysophosphatidic acid-induced cell migration in ovarian cancer cells. J Biol Chem 286: 24036-24045, 2011.
    • (2011) J Biol Chem , vol.286 , pp. 24036-24045
    • Kim, E.K.1    Park, J.M.2    Lim, S.3    Choi, J.W.4    Kim, H.S.5    Seok, H.6    Seo, J.K.7    Oh, K.8    Lee, D.S.9    Kim, K.T.10
  • 62
    • 84858268243 scopus 로고    scopus 로고
    • Effect of metformin on the proliferation, migration, and MMP-2 and-9 expression of human umbilical vein endothelial cells
    • Esfahanian N, Shakiba Y, Nikbin B, Soraya H, Maleki-Dizaji N, Ghazi-Khansari M and Garjani A: Effect of metformin on the proliferation, migration, and MMP-2 and-9 expression of human umbilical vein endothelial cells. Mol Med Rep 5: 1068-1074, 2012.
    • (2012) Mol Med Rep , vol.5 , pp. 1068-1074
    • Esfahanian, N.1    Shakiba, Y.2    Nikbin, B.3    Soraya, H.4    Maleki-Dizaji, N.5    Ghazi-Khansari, M.6    Garjani, A.7
  • 63
    • 84884197563 scopus 로고    scopus 로고
    • AMP-activated protein kinase activation mediates CCL3-induced cell migration and matrix metalloproteinase-2 expression in human chondrosarcoma
    • Hsu CJ, Wu MH, Chen CY, Tsai CH, Hsu HC and Tang CH: AMP-activated protein kinase activation mediates CCL3-induced cell migration and matrix metalloproteinase-2 expression in human chondrosarcoma. Cell Commun Signal 11: 68, 2013.
    • (2013) Cell Commun Signal , vol.11 , pp. 68
    • Hsu, C.J.1    Wu, M.H.2    Chen, C.Y.3    Tsai, C.H.4    Hsu, H.C.5    Tang, C.H.6
  • 64
    • 84455208086 scopus 로고    scopus 로고
    • Berberine-induced AMPK activation inhibits the metastatic potential of melanoma cells via reduction of ERK activity and COX-2 protein expression
    • Kim HS, Kim MJ, Kim EJ, Yang Y, Lee MS and Lim JS: Berberine-induced AMPK activation inhibits the metastatic potential of melanoma cells via reduction of ERK activity and COX-2 protein expression. Biochem Pharmacol 83: 385-394, 2012.
    • (2012) Biochem Pharmacol , vol.83 , pp. 385-394
    • Kim, H.S.1    Kim, M.J.2    Kim, E.J.3    Yang, Y.4    Lee, M.S.5    Lim, J.S.6
  • 65
    • 84907048181 scopus 로고    scopus 로고
    • AMPK reverses the mesenchymal phenotype of cancer cells by targeting the Akt-MDM2-Foxo3a signaling axis
    • Chou CC, Lee KH, Lai IL, Wang D, Mo X, Kulp SK, Shapiro CL and Chen CS: AMPK reverses the mesenchymal phenotype of cancer cells by targeting the Akt-MDM2-Foxo3a signaling axis. Cancer Res 74: 4783-4795, 2014.
    • (2014) Cancer Res , vol.74 , pp. 4783-4795
    • Chou, C.C.1    Lee, K.H.2    Lai, I.L.3    Wang, D.4    Mo, X.5    Kulp, S.K.6    Shapiro, C.L.7    Chen, C.S.8
  • 66
    • 84921348845 scopus 로고    scopus 로고
    • AMP-activated protein kinase (AMPK) as a potential therapeutic target independent of PI3K/Akt signaling in prostate cancer
    • Choudhury Y, Yang Z, Ahmad I, Nixon C, Salt IP and Leung HY: AMP-activated protein kinase (AMPK) as a potential therapeutic target independent of PI3K/Akt signaling in prostate cancer. Oncoscience 1: 446-456, 2014.
    • (2014) Oncoscience , vol.1 , pp. 446-456
    • Choudhury, Y.1    Yang, Z.2    Ahmad, I.3    Nixon, C.4    Salt, I.P.5    Leung, H.Y.6
  • 67
    • 84880369307 scopus 로고    scopus 로고
    • Linked decreases in liver kinase B1 and AMP-activated protein kinase activity modulate matrix catabolic responses to biomechanical injury in chondrocytes
    • Petursson F, Husa M, June R, Lotz M, Terkeltaub R and Liu-Bryan R: Linked decreases in liver kinase B1 and AMP-activated protein kinase activity modulate matrix catabolic responses to biomechanical injury in chondrocytes. Arthritis Res Ther 15: R77, 2013.
    • (2013) Arthritis Res Ther , vol.15 , pp. R77
    • Petursson, F.1    Husa, M.2    June, R.3    Lotz, M.4    Terkeltaub, R.5    Liu-Bryan, R.6
  • 68
    • 75949097288 scopus 로고    scopus 로고
    • The regulation of AMPK signaling in a natural state of profound metabolic rate depression
    • Ramnanan CJ, McMullen DC, Groom AG and Storey KB: The regulation of AMPK signaling in a natural state of profound metabolic rate depression. Mol Cell Biochem 335: 91-105, 2010.
    • (2010) Mol Cell Biochem , vol.335 , pp. 91-105
    • Ramnanan, C.J.1    McMullen, D.C.2    Groom, A.G.3    Storey, K.B.4
  • 69
    • 84877928942 scopus 로고    scopus 로고
    • AMP-activated protein kinase inhibits TGF-β-, angiotensin II-, aldosterone-, high glucose-, and albumin-induced epithelial-mesenchymal transition
    • Lee JH, Kim JH, Kim JS, Chang JW, Kim SB, Park JS and Lee SK: AMP-activated protein kinase inhibits TGF-β-, angiotensin II-, aldosterone-, high glucose-, and albumin-induced epithelial-mesenchymal transition. Am J Physiol Renal Physiol 304: F686-F697, 2013.
    • (2013) Am J Physiol Renal Physiol , vol.304 , pp. F686-F697
    • Lee, J.H.1    Kim, J.H.2    Kim, J.S.3    Chang, J.W.4    Kim, S.B.5    Park, J.S.6    Lee, S.K.7
  • 70
    • 84155184239 scopus 로고    scopus 로고
    • AMP-activated protein kinase inhibits TGF-β-induced fibrogenic responses of hepatic stellate cells by targeting transcriptional coactivator p300
    • Lim JY, Oh MA, Kim WH, Sohn HY and Park SI: AMP-activated protein kinase inhibits TGF-β-induced fibrogenic responses of hepatic stellate cells by targeting transcriptional coactivator p300. J Cell Physiol 227: 1081-1089, 2012.
    • (2012) J Cell Physiol , vol.227 , pp. 1081-1089
    • Lim, J.Y.1    Oh, M.A.2    Kim, W.H.3    Sohn, H.Y.4    Park, S.I.5
  • 72
    • 79955463156 scopus 로고    scopus 로고
    • LITAF and TNFSF15, two downstream targets of AMPK, exert inhibitory effects on tumor growth
    • Zhou J, Yang Z, Tsuji T, Gong J, Xie J, Chen C, Li W, Amar S and Luo Z: LITAF and TNFSF15, two downstream targets of AMPK, exert inhibitory effects on tumor growth. Oncogene 30: 1892-1900, 2011.
    • (2011) Oncogene , vol.30 , pp. 1892-1900
    • Zhou, J.1    Yang, Z.2    Tsuji, T.3    Gong, J.4    Xie, J.5    Chen, C.6    Li, W.7    Amar, S.8    Luo, Z.9
  • 75
    • 84916929215 scopus 로고    scopus 로고
    • Capsaicin suppresses the migration of cholangiocarcinoma cells by down-regulating matrix metalloproteinase-9 expression via the AMPK-NF-κB signaling pathway
    • Lee GR, Jang SH, Kim CJ, Kim AR, Yoon DJ, Park NH and Han IS: Capsaicin suppresses the migration of cholangiocarcinoma cells by down-regulating matrix metalloproteinase-9 expression via the AMPK-NF-κB signaling pathway. Clin Exp Metastasis 31: 897-907, 2014.
    • (2014) Clin Exp Metastasis , vol.31 , pp. 897-907
    • Lee, G.R.1    Jang, S.H.2    Kim, C.J.3    Kim, A.R.4    Yoon, D.J.5    Park, N.H.6    Han, I.S.7
  • 76
    • 84863286242 scopus 로고    scopus 로고
    • Acrp30 inhibits leptin-induced metastasis by downregulating the JAK/STAT3 pathway via AMPK activation in aggressive SPEC-2 endometrial cancer cells
    • Wu X, Yan Q, Zhang Z, Du G and Wan X: Acrp30 inhibits leptin-induced metastasis by downregulating the JAK/STAT3 pathway via AMPK activation in aggressive SPEC-2 endometrial cancer cells. Oncol Rep 27: 1488-1496, 2012.
    • (2012) Oncol Rep , vol.27 , pp. 1488-1496
    • Wu, X.1    Yan, Q.2    Zhang, Z.3    Du, G.4    Wan, X.5
  • 77
    • 84897473060 scopus 로고    scopus 로고
    • The involvement of AMPK/GSK3-beta signals in the control of metastasis and proliferation in hepato-carcinoma cells treated with anthocyanins extracted from Korea wild berry Meoru
    • Park SY, Lee YK, Lee WS, Park OJ and Kim YM: The involvement of AMPK/GSK3-beta signals in the control of metastasis and proliferation in hepato-carcinoma cells treated with anthocyanins extracted from Korea wild berry Meoru. BMC Complement Altern Med 14: 109, 2014.
    • (2014) BMC Complement Altern Med , vol.14 , pp. 109
    • Park, S.Y.1    Lee, Y.K.2    Lee, W.S.3    Park, O.J.4    Kim, Y.M.5
  • 78
    • 1842505299 scopus 로고    scopus 로고
    • ARK5 is a tumor invasion-associated factor downstream of Akt signaling
    • Suzuki A, Lu J, Kusakai G, Kishimoto A, Ogura T and Esumi H: ARK5 is a tumor invasion-associated factor downstream of Akt signaling. Mol Cell Biol 24: 3526-3535, 2004.
    • (2004) Mol Cell Biol , vol.24 , pp. 3526-3535
    • Suzuki, A.1    Lu, J.2    Kusakai, G.3    Kishimoto, A.4    Ogura, T.5    Esumi, H.6
  • 79
    • 84872698668 scopus 로고    scopus 로고
    • High NUAK1 expression correlates with poor prognosis and involved in NSCLC cells migration and invasion
    • Chen P, Li K, Liang Y, Li L and Zhu X: High NUAK1 expression correlates with poor prognosis and involved in NSCLC cells migration and invasion. Exp Lung Res 39: 9-17, 2013.
    • (2013) Exp Lung Res , vol.39 , pp. 9-17
    • Chen, P.1    Li, K.2    Liang, Y.3    Li, L.4    Zhu, X.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.