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Volumn 100, Issue 10, 2015, Pages E1308-E1318

α-klotho expression in human tissues

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA KLOTHO PROTEIN; KLOTHO PROTEIN; UNCLASSIFIED DRUG; BETA GLUCURONIDASE;

EID: 84943750798     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jc.2015-1800     Document Type: Article
Times cited : (160)

References (41)
  • 1
    • 0030724491 scopus 로고    scopus 로고
    • Mutation of the mouse klotho gene leads to a syndrome resembling ageing
    • Kuro-o M, Matsumura Y, Aizawa H, et al. Mutation of the mouse klotho gene leads to a syndrome resembling ageing. Nature. 1997; 390:45-51.
    • (1997) Nature. , vol.390 , pp. 45-51
    • Kuro-O, M.1    Matsumura, Y.2    Aizawa, H.3
  • 2
    • 24944481544 scopus 로고    scopus 로고
    • Suppression of aging in mice by the hormone Klotho
    • Kurosu H, Yamamoto M, Clark JD, et al. Suppression of aging in mice by the hormone Klotho. Science 2005;309:1829-1833.
    • (2005) Science , vol.309 , pp. 1829-1833
    • Kurosu, H.1    Yamamoto, M.2    Clark, J.D.3
  • 3
    • 77950200010 scopus 로고    scopus 로고
    • The genetics of ageing
    • Kenyon CJ. The genetics of ageing. Nature. 2010;464:504-512.
    • (2010) Nature. , vol.464 , pp. 504-512
    • Kenyon, C.J.1
  • 4
    • 84880579414 scopus 로고    scopus 로고
    • Chronic kidney disease: A clinical model of premature aging
    • Stenvinkel P, Larsson TE. Chronic kidney disease: A clinical model of premature aging. Am J Kidney Dis. 2013;62:339-351.
    • (2013) Am J Kidney Dis. , vol.62 , pp. 339-351
    • Stenvinkel, P.1    Larsson, T.E.2
  • 5
    • 84898949273 scopus 로고    scopus 로고
    • Association of Klotho polymorphisms with healthy aging: A systematic review and meta-analysis
    • Di Bona D, Accardi G, Virruso C, Candore G, Caruso C. Association of Klotho polymorphisms with healthy aging: A systematic review and meta-analysis. Rejuvenation Res. 2014;17:212-216.
    • (2014) Rejuvenation Res. , vol.17 , pp. 212-216
    • Di Bona, D.1    Accardi, G.2    Virruso, C.3    Candore, G.4    Caruso, C.5
  • 6
    • 27844561111 scopus 로고    scopus 로고
    • Regulation of oxidative stress by the anti-aging hormone klotho
    • Yamamoto M, Clark JD, Pastor JV, et al. Regulation of oxidative stress by the anti-aging hormone klotho. J Biol Chem 2005;280: 38029-38034.
    • (2005) J Biol Chem , vol.280 , pp. 38029-38034
    • Yamamoto, M.1    Clark, J.D.2    Pastor, J.V.3
  • 7
    • 28844474827 scopus 로고    scopus 로고
    • Anti-apoptotic and antisenescence effects of Klotho on vascular endothelial cells
    • Ikushima M, Rakugi H, Ishikawa K, et al. Anti-apoptotic and antisenescence effects of Klotho on vascular endothelial cells. Biochem Biophys Res Comm. 2006;339:827-832.
    • (2006) Biochem Biophys Res Comm. , vol.339 , pp. 827-832
    • Ikushima, M.1    Rakugi, H.2    Ishikawa, K.3
  • 8
    • 79953138206 scopus 로고    scopus 로고
    • Klotho inhibits transforming growth factor-1 (TGF-1) signaling and suppresses renal fibrosis and cancer metastasis in mice
    • Doi S, Zou Y, Togao O, et al. Klotho inhibits transforming growth factor-1 (TGF-1) signaling and suppresses renal fibrosis and cancer metastasis in mice. J Biol Chem. 2011;286:8655-8665.
    • (2011) J Biol Chem. , vol.286 , pp. 8655-8665
    • Doi, S.1    Zou, Y.2    Togao, O.3
  • 9
    • 0036295211 scopus 로고    scopus 로고
    • Regulation of angiogenesis by the aging suppressor gene klotho
    • Fukino K, Suzuki T, Saito Y, et al. Regulation of angiogenesis by the aging suppressor gene klotho. Biochem Biophys Res Commun. 2002;293:332-337.
    • (2002) Biochem Biophys Res Commun. , vol.293 , pp. 332-337
    • Fukino, K.1    Suzuki, T.2    Saito, Y.3
  • 10
    • 0035986324 scopus 로고    scopus 로고
    • Production of nitric oxide, but not prostacyclin, is reduced in klotho mice
    • Nakamura T, Saito Y, Ohyama Y, et al. Production of nitric oxide, but not prostacyclin, is reduced in klotho mice. Jpn J Pharmacol. 2002;89:149-156.
    • (2002) Jpn J Pharmacol. , vol.89 , pp. 149-156
    • Nakamura, T.1    Saito, Y.2    Ohyama, Y.3
  • 11
    • 84860778116 scopus 로고    scopus 로고
    • Vascular Klotho deficiency potentiates the development of human artery calcification and mediates resistance to fibroblast growth factor 23
    • Lim K, Lu TS, Molostvov G, et al. Vascular Klotho deficiency potentiates the development of human artery calcification and mediates resistance to fibroblast growth factor 23. Circulation. 2012; 125:2243-2255.
    • (2012) Circulation. , vol.125 , pp. 2243-2255
    • Lim, K.1    Lu, T.S.2    Molostvov, G.3
  • 12
    • 34547908461 scopus 로고    scopus 로고
    • Augmented Wnt signaling in a mammalian model of accelerated aging
    • Liu H, Fergusson MM, Castilho RM, et al. Augmented Wnt signaling in a mammalian model of accelerated aging. Science. 2007;317: 803-806.
    • (2007) Science. , vol.317 , pp. 803-806
    • Liu, H.1    Fergusson, M.M.2    Castilho, R.M.3
  • 13
    • 77956642900 scopus 로고    scopus 로고
    • Klotho: A novel phosphaturic substance acting as an autocrine enzyme in the renal proximal tubule
    • Hu MC, Shi M, Zhang J, et al. Klotho: A novel phosphaturic substance acting as an autocrine enzyme in the renal proximal tubule. FASEB J. 2010;24:3438-3450.
    • (2010) FASEB J. , vol.24 , pp. 3438-3450
    • Hu, M.C.1    Shi, M.2    Zhang, J.3
  • 14
    • 78049481921 scopus 로고    scopus 로고
    • Parathyroid Klotho and FGF-receptor 1 expression decline with renal function in hyperparathyroid patients with chronic kidney disease and kidney transplant recipients
    • Krajisnik T, Olauson H, Mirza MA, et al. Parathyroid Klotho and FGF-receptor 1 expression decline with renal function in hyperparathyroid patients with chronic kidney disease and kidney transplant recipients. Kidney Int. 2010;78:1024-1032.
    • (2010) Kidney Int. , vol.78 , pp. 1024-1032
    • Krajisnik, T.1    Olauson, H.2    Mirza, M.A.3
  • 15
    • 84930273524 scopus 로고    scopus 로고
    • Differential expression and regulation of Klotho by paricalcitol in the kidney, parathyroid, and aorta of uremic rats
    • Ritter CS, Zhang S, Delmez J, Finch JL, Slatopolsky E. Differential expression and regulation of Klotho by paricalcitol in the kidney, parathyroid, and aorta of uremic rats. Kidney Int. 2015;87:1141-1152.
    • (2015) Kidney Int. , vol.87 , pp. 1141-1152
    • Ritter, C.S.1    Zhang, S.2    Delmez, J.3    Finch, J.L.4    Slatopolsky, E.5
  • 16
    • 84896728556 scopus 로고    scopus 로고
    • Cardiovascular risk factors and chronic kidney disease-FGF23: A key molecule in the cardiovascular disease
    • Jimbo R, Shimosawa T. Cardiovascular risk factors and chronic kidney disease-FGF23: A key molecule in the cardiovascular disease. Int J Hypertens. 2014;2014:381082.
    • (2014) Int J Hypertens. , vol.2014 , pp. 381082
    • Jimbo, R.1    Shimosawa, T.2
  • 17
    • 78651408919 scopus 로고    scopus 로고
    • Klotho deficiency causes vascular calcification in chronic kidney disease
    • Hu MC, Shi M, Zhang J, et al. Klotho deficiency causes vascular calcification in chronic kidney disease. J Am Soc Nephrol. 2011; 22:124-136.
    • (2011) J Am Soc Nephrol. , vol.22 , pp. 124-136
    • Hu, M.C.1    Shi, M.2    Zhang, J.3
  • 18
    • 77957122891 scopus 로고    scopus 로고
    • Association of carotid atherosclerosis with genetic polymorphisms of the klotho gene in patients with hypertension
    • Oguro R, Kamide K, Kokubo Y, et al. Association of carotid atherosclerosis with genetic polymorphisms of the klotho gene in patients with hypertension. Geriatr Gerontol Int. 2010;10:311-318.
    • (2010) Geriatr Gerontol Int. , vol.10 , pp. 311-318
    • Oguro, R.1    Kamide, K.2    Kokubo, Y.3
  • 19
    • 84920555876 scopus 로고    scopus 로고
    • The changes of serum sKlotho and NGAL levels and their correlation in type 2 diabetes mellitus patients with different stages of urinary albumin
    • Wu C, Wang Q, Lv C, et al. The changes of serum sKlotho and NGAL levels and their correlation in type 2 diabetes mellitus patients with different stages of urinary albumin. Diabetes Res Clin Pract. 2014;106:343-350.
    • (2014) Diabetes Res Clin Pract. , vol.106 , pp. 343-350
    • Wu, C.1    Wang, Q.2    Lv, C.3
  • 20
    • 84924170646 scopus 로고    scopus 로고
    • Klotho gene deficiency causes saltsensitive hypertension via monocyte chemotactic protein-1/CC chemokine receptor 2-mediated inflammation
    • Zhou X, Chen K, Lei H, Sun Z. Klotho gene deficiency causes saltsensitive hypertension via monocyte chemotactic protein-1/CC chemokine receptor 2-mediated inflammation. J Am Soc Nephrol. 2015;26(1):121-132.
    • (2015) J Am Soc Nephrol. , vol.26 , Issue.1 , pp. 121-132
    • Zhou, X.1    Chen, K.2    Lei, H.3    Sun, Z.4
  • 21
    • 0034810211 scopus 로고    scopus 로고
    • Severely reduced production of klotho in human chronic renal failure kidney
    • Koh N, Fujimori T, Nishiguchi S, et al. Severely reduced production of klotho in human chronic renal failure kidney. Biochem Biophys Res Commun. 2001;280:1015-1020.
    • (2001) Biochem Biophys Res Commun. , vol.280 , pp. 1015-1020
    • Koh, N.1    Fujimori, T.2    Nishiguchi, S.3
  • 22
    • 33947622052 scopus 로고    scopus 로고
    • Association of theF352V variant of the Klotho gene with bone mineral density
    • Riancho JA, Valero C, Hernández JL, et al. Association of theF352V variant of the Klotho gene with bone mineral density. Biogerontology. 2007;8:121-127.
    • (2007) Biogerontology. , vol.8 , pp. 121-127
    • Riancho, J.A.1    Valero, C.2    Hernández, J.L.3
  • 23
    • 19944430732 scopus 로고    scopus 로고
    • Association of single nucleotide polymorphisms in klotho with priapism in sickle cell anaemia
    • Nolan VG, Baldwin C, Ma Q, et al. Association of single nucleotide polymorphisms in klotho with priapism in sickle cell anaemia. Br J Haematol. 2005;128:266-272.
    • (2005) Br J Haematol. , vol.128 , pp. 266-272
    • Nolan, V.G.1    Baldwin, C.2    Ma, Q.3
  • 24
    • 84876461971 scopus 로고    scopus 로고
    • Restoration of klotho expression induces apoptosis and autophagy in hepatocellular carcinoma cells
    • Shu G, Xie B, Ren F, et al. Restoration of klotho expression induces apoptosis and autophagy in hepatocellular carcinoma cells. CellOncol (Dordr). 2013;36:121-129.
    • (2013) CellOncol (Dordr). , vol.36 , pp. 121-129
    • Shu, G.1    Xie, B.2    Ren, F.3
  • 25
    • 58149229326 scopus 로고    scopus 로고
    • Klotho: A tumor suppressor and a modulator of the IGF-1 and FGF pathways in human breast cancer
    • Wolf I, Levanon-Cohen S, Bose S, et al. Klotho: A tumor suppressor and a modulator of the IGF-1 and FGF pathways in human breast cancer. Oncogene. 2008;27:7094-7105.
    • (2008) Oncogene. , vol.27 , pp. 7094-7105
    • Wolf, I.1    Levanon-Cohen, S.2    Bose, S.3
  • 26
    • 84874016733 scopus 로고    scopus 로고
    • Restoration of klotho gene expression induces apoptosis and autophagy in gastric cancer cells: Tumor suppressive role of klotho in gastric cancer
    • Xie B, Zhou J, Shu G, et al. Restoration of klotho gene expression induces apoptosis and autophagy in gastric cancer cells: tumor suppressive role of klotho in gastric cancer. Cancer Cell Int. 2013;13: 18.
    • (2013) Cancer Cell Int. , vol.13 , pp. 18
    • Xie, B.1    Zhou, J.2    Shu, G.3
  • 27
    • 84878201990 scopus 로고    scopus 로고
    • Klotho suppresses tumor progression via inhibiting PI3K/Akt/GSK3/Snail signaling in renal cell carcinoma
    • Zhu Y, Xu L, Zhang J, et al. Klotho suppresses tumor progression via inhibiting PI3K/Akt/GSK3/Snail signaling in renal cell carcinoma. Cancer Sci. 2013;104:663-671.
    • (2013) Cancer Sci. , vol.104 , pp. 663-671
    • Zhu, Y.1    Xu, L.2    Zhang, J.3
  • 29
    • 78650179845 scopus 로고    scopus 로고
    • Association of the functional KL-VS variant of Klotho gene with early-onset ischemic stroke
    • Majumdar V, Nagaraja D, Christopher R. Association of the functional KL-VS variant of Klotho gene with early-onset ischemic stroke. Biochem Biophys Res Commun. 2010;403:412-416.
    • (2010) Biochem Biophys Res Commun. , vol.403 , pp. 412-416
    • Majumdar, V.1    Nagaraja, D.2    Christopher, R.3
  • 30
    • 85018177161 scopus 로고    scopus 로고
    • Oxidative stress inhibits Klotho activation ofTRPV5andTRPV6in intestinal epithelial cells
    • Maruggi M, Nguyen AT, Resta S. Oxidative stress inhibits Klotho activation ofTRPV5andTRPV6in intestinal epithelial cells.FASEB J. 2010;24:1013.2.
    • (2010) FASEB J. , vol.24 , pp. 10132
    • Maruggi, M.1    Nguyen, A.T.2    Resta, S.3
  • 32
    • 84867029524 scopus 로고    scopus 로고
    • Targeted deletion of Klotho in kidney distal tubule disrupts mineral metabolism
    • Olauson H, Lindberg K, Amin R, et al. Targeted deletion of Klotho in kidney distal tubule disrupts mineral metabolism. JAmSoc Nephrol. 2012;23:1641-1651.
    • (2012) JAmSoc Nephrol. , vol.23 , pp. 1641-1651
    • Olauson, H.1    Lindberg, K.2    Amin, R.3
  • 33
  • 34
    • 84911867793 scopus 로고    scopus 로고
    • Testosterone increases renal anti-aging klotho gene expression via the androgen receptor-mediated pathway
    • Hsu SC, Huang SM, Lin SH, et al. Testosterone increases renal anti-aging klotho gene expression via the androgen receptor-mediated pathway. Biochem J. 2014;464:221-229.
    • (2014) Biochem J. , vol.464 , pp. 221-229
    • Hsu, S.C.1    Huang, S.M.2    Lin, S.H.3
  • 35
    • 79952201520 scopus 로고    scopus 로고
    • Klotho interferes with a novel FGF-signalling pathway and insulin/Igf-like signalling to improve longevity and stress resistance in Caenorhabditis elegans
    • Château MT, Araiz C, Descamps S, Galas S. Klotho interferes with a novel FGF-signalling pathway and insulin/Igf-like signalling to improve longevity and stress resistance in Caenorhabditis elegans. Aging. 2010;2:567-581.
    • (2010) Aging. , vol.2 , pp. 567-581
    • Château, M.T.1    Araiz, C.2    Descamps, S.3    Galas, S.4
  • 36
    • 84862820335 scopus 로고    scopus 로고
    • Nuclear localization of Klotho in brain: An anti-aging protein
    • German DC, Khobahy I, Pastor J, Kuro-O M, Liu X. Nuclear localization of Klotho in brain: an anti-aging protein. Neurobiol Aging 2012;33:1483.e25-e30.
    • (2012) Neurobiol Aging , vol.33 , pp. 1483e25-1483e30
    • German, D.C.1    Khobahy, I.2    Pastor, J.3    Kuro-O, M.4    Liu, X.5
  • 37
    • 2342610541 scopus 로고    scopus 로고
    • Secreted Klotho protein in sera and CSF: Implication for post-translational cleavage in release of Klotho protein from cell membrane
    • Imura A, Iwano A, Tohyama O, et al. Secreted Klotho protein in sera and CSF: implication for post-translational cleavage in release of Klotho protein from cell membrane.FEBSLett. 2004;565:143-147.
    • (2004) FEBSLett. , vol.565 , pp. 143-147
    • Imura, A.1    Iwano, A.2    Tohyama, O.3
  • 38
    • 84888403692 scopus 로고    scopus 로고
    • Klotho in the cerebrospinal fluid of adults with and without Alzheimer's disease
    • Semba RD, Moghekar AR, Hu J, et al. Klotho in the cerebrospinal fluid of adults with and without Alzheimer's disease. Neurosci Lett. 2014;558:37-40.
    • (2014) Neurosci Lett. , vol.558 , pp. 37-40
    • Semba, R.D.1    Moghekar, A.R.2    Hu, J.3
  • 39
    • 84901267951 scopus 로고    scopus 로고
    • Life extension factor klotho enhances cognition
    • Dubal DB, Yokoyama JS, Zhu L, et al. Life extension factor klotho enhances cognition. Cell Rep. 2014;7:1065-1076.
    • (2014) Cell Rep. , vol.7 , pp. 1065-1076
    • Dubal, D.B.1    Yokoyama, J.S.2    Zhu, L.3
  • 40
    • 84874868426 scopus 로고    scopus 로고
    • Klotho endows hepatoma cells with resistance to anoikis viaVEGFR2/PAK1activation in hepatocellular carcinoma
    • Chen L, Liu H, Liu J, et al. Klotho endows hepatoma cells with resistance to anoikis viaVEGFR2/PAK1activation in hepatocellular carcinoma. PLoS One. 2013;8:e58413.
    • (2013) PLoS One. , vol.8 , pp. e58413
    • Chen, L.1    Liu, H.2    Liu, J.3
  • 41
    • 34848869695 scopus 로고    scopus 로고
    • Tissue-specific expression of Klotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity ofFGF19and FGF21
    • Kurosu H, Choi M, Ogawa Y, et al. Tissue-specific expression of Klotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity ofFGF19and FGF21. J BiolChem2007; 282:26687-26695.
    • (2007) J BiolChem , vol.282 , pp. 26687-26695
    • Kurosu, H.1    Choi, M.2    Ogawa, Y.3


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