The changes of serum sKlotho and NGAL levels and their correlation in type 2 diabetes mellitus patients with different stages of urinary albumin

Diabetes Research and Clinical Practice

Volumn 106, Issue 2, 2014, Pages 343-350

  Wu, Can ^a   Wang, Qiuyue ^a   Lv, Chuan ^a   Qin, Ningning ^a   Lei, Sha ^a   Yuan, Qin ^a   Wang, Guan ^a  

^a CHINA MEDICAL UNIVERSITY   (China)

Author keywords

Anti aging protein Klotho; Diabetes mellitus; Diabetic kidney disease; Neutrophil gelatinase associated lipocalin; Urinary albumin

Indexed keywords

8 ISOPROSTAGLANDIN F2 ALPHA; ALBUMIN; CHOLESTEROL; CREATININE; HEMOGLOBIN A1C; HIGH DENSITY LIPOPROTEIN; KLOTHO PROTEIN; LOW DENSITY LIPOPROTEIN; MONOCYTE CHEMOTACTIC PROTEIN 1; NEUTROPHIL GELATINASE ASSOCIATED LIPOCALIN; NITROGEN; TRANSFORMING GROWTH FACTOR BETA1; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR ALPHA; UREA; 8-EPI-PROSTAGLANDIN F2ALPHA; ACUTE PHASE PROTEIN; BETA GLUCURONIDASE; BIOLOGICAL MARKER; LCN2 PROTEIN, HUMAN; LIPOCALIN; ONCOPROTEIN; PROSTAGLANDIN F2 ALPHA; SERUM ALBUMIN;

ADULT; ARTICLE; COLORIMETRY; CONTROLLED STUDY; CREATININE BLOOD LEVEL; CREATININE URINE LEVEL; DIABETIC NEPHROPATHY; EARLY DIAGNOSIS; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; MACROALBUMINURIA; MAJOR CLINICAL STUDY; MALE; MICROALBUMINURIA; NON INSULIN DEPENDENT DIABETES MELLITUS; PROTEIN BLOOD LEVEL; UREA NITROGEN BLOOD LEVEL; ALBUMINURIA; ANALOGS AND DERIVATIVES; BLOOD; CASE CONTROL STUDY; COMPLICATION; DIABETIC NEPHROPATHIES; DISEASE COURSE; METABOLISM; MIDDLE AGED; URINE;

ACUTE-PHASE PROTEINS; ADULT; ALBUMINURIA; BIOLOGICAL MARKERS; CASE-CONTROL STUDIES; CHEMOKINE CCL2; DIABETES MELLITUS, TYPE 2; DIABETIC NEPHROPATHIES; DINOPROST; DISEASE PROGRESSION; EARLY DIAGNOSIS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; GLUCURONIDASE; HUMANS; LIPOCALINS; MALE; MIDDLE AGED; PROTO-ONCOGENE PROTEINS; SERUM ALBUMIN; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84920555876     PISSN: 01688227     EISSN: 18728227     Source Type: Journal    
DOI: 10.1016/j.diabres.2014.08.026     Document Type: Article

References (26)

1. Saha S.A., Tuttle K.R. Influence of glycemic control on the development of diabetic cardiovascular and kidney disease. Cardiol Clin 2010, 28(3):497-516.
2. Foley R.N., Collins A.J. The growing economic burden of diabetic kidney disease. Curr Diab Rep 2009, 9(6):460-465.
3. American Diabetes Association Standards of medical care in diabetes-2011. Diabetes Care 2011, 34(Suppl 1):S11-S61.
4. Wang Y., Kuro-o M., Sun Z. Klotho gene delivery suppresses Nox2 expression and attenuates oxidative stress in rat aortic smooth muscle cells via the cAMP-PKA pathway. Aging Cell 2012, 11(3):410-417.
5. Zhao Y., Banerjee S., Dey N., et al. Klotho depletion contributes to increased inflammation in kidney of the db/db mouse model of diabetes via RelA (Serine)536 phosphorylation. Diabetes 2011, 60(7):1907-1916.
6. Roberts L.J., Morrow J.D. Measurement of F(2)-isoprostanes as an index of oxidative stress in vivo. Free Radical Biol Med 2000, 28(4):505-513.
7. Halliwell B., Lee C.Y. Using isoprostanes as biomarkers of oxidative stress: some rarely considered issues. Antioxid Redox Signal 2010, 13:145-156.
8. Kim J.Y., Lee J.W., Youn Y.J., et al. Urinary levels of 8-iso-prostaglandin F2α and 8-hydroxydeoxyguanine as markers of oxidative stress in patients with coronary artery disease. Korean Circ J 2012, 42(Sep (9)):614-617.
9. Yamamoto M., Clark J.D., Pastor J.V., et al. Regulation of oxidative stress by the anti-aging hormone Klotho. J Biol Chem 2005, 280(45):38029-38034.
10. Doi S., Zou Y., Toqao O., et al. Klotho inhibits transforming growth factor-β1 (TGF-β1) signaling and suppresses renal fibrosis and cancer metastasis in mice. J Biol Chem 2011, 286(10):8655-8665. 11.
11. Masashi K., Hitoshi S., Hiroshi M., et al. A decreased level of serum soluble Klotho is an independent biomarker associated with arterial stiffness in patients with chronic kidney disease. PLoS One 2013, 8(2):e56695.
12. Shimamura Y., Hamada K., Inoue K., et al. Serum levels of soluble secreted α-Klotho are decreased in the early stages of chronic kidney disease, making it a probable novel biomarker for early diagnosis. Clin Exp Nephrol 2012, 16(5):722-729.
13. Kuei-Mei C., Chin-Chan Lee, Chih-Huang C., et al. Clinical value of NGAL, L-FABP and albuminuria in predicting GFR decline in type 2 diabetes mellitus patients. PLoS One 2013, 8(1):e54863.
14. Fu W.J., Xiong S.L., Fang Y.G., et al. Urinary tubular biomarkers in short-term type 2 diabetes mellitus patients: a cross-sectional study. Endocrine 2012, 41(1):82-88.
15. Fu W.J., Li B.L., Wang S.B., et al. Changes of the tubular markers in type 2 diabetes mellitus with glomerular hyperfiltration. Diabetes Res Clin Pract 2012, 95:105-109.
16. Hu M.C., Shi M., Zhang J.N., et al. Klotho deficiency is an early biomarker of renal ischemia-reperfusion injury and its replacement is protective. Kidney Int 2010, 78:1240-1251.
17. Kuro-o M., Matsumura Y., Aizawa H., et al. Mutation of the mouse Klotho gene leads to a syndrome resembling ageing. Nature 1997, 390(6655):45-51.
18. Kurosu H., Yamamoto M., Clark J.D., et al. Suppression of aging in mice by the hormone Klotho. Science 2005, 309(5742):1829-1833.
19. Hu M.C., Shi M., Zhang J., et al. Klotho: a novel phosphaturic substance acting as an autocrine enzyme in the renal proximal tubule. FASEB J 2010, 24(9):3438-3450.
20. Yamazaki Y., Imura A., Urakawa I., et al. Establishment of sandwich ELISA for soluble alpha-Klotho measurement: age-dependent change of soluble alpha-Klotho levels in healthy subjects. Biochem Biophys Res Commun 2010, 398(3):513-518.
21. Lin Y., Sun Z. Thyroid hormone potentiates insulin signaling and attenuates hyperglycemia and insulin resistance in a mouse model of type 2 diabetes. Br J Pharmacol 2011, 162(3):597-610.
22. Devaraj S., Syed B., Chien A., et al. Validation of an immunoassay for soluble Klotho protein: decreased levels in diabetes and increased levels in chronic kidney disease. Am J Clin Pathol 2012, 137(3):479-485.
23. Kim S.S., Song S.H., Kim I.J., et al. Clinical implication of urinary tubular markers in the early stage of nephropathy with type 2 diabetic patients. Diabetes Res Clin Pract 2012, 97(2):251-257.
24. Vaidya V.S., Niewczas M.A., Ficociello L.H., et al. Regression of microalbuminuria in type 1 diabetes is associated with lower levels of urinary tubular injury biomarkers, kidney injury molecule-1, and N-acetyl-beta-d-glucosaminidase. Kidney Int 2011, 79(4):464-470.
25. Nishida Y., Oda H., Yorioka N. Effect of lipoproteins on mesangial cell proliferation. Kidney Int 1999, 71(Suppl):S51-S53.
26. Law I.K., Xu A., Lam K.S., et al. Lipocalin-2 deficiency attenuates insulin resistance associated with aging and obesity. Diabetes 2010, 59(4):872-882.