NOX4-dependent Hydrogen peroxide promotes shear stress-induced SHP2 sulfenylation and eNOS activation

Free Radical Biology and Medicine

Volumn 89, Issue , 2015, Pages 419-430

  Sánchez Gómez, Francisco J ^a   Calvo, Enrique ^b   Bretón Romero, Rosa ^a   Fierro Fernández, Marta ^a   Anilkumar, Narayana ^c   Shah, Ajay M ^c   Schröder, Katrin ^d   Brandes, Ralf P ^d   Vázquez, Jesús ^b   Lamas, Santiago ^a  

^a UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

^b CENTRO NACIONAL DE INVESTIGACIONES CARDIOVASCULARES CNIC   (Spain)

^c KING'S COLLEGE LONDON   (United Kingdom)

^d GOETHE UNIVERSITY   (Germany)

Author keywords

Endothelium; Free radicals; Hydrogen peroxide; Laminar shear stress; Redox signaling; Sulfenylation; Vasodilation

Indexed keywords

5,5 DIMETHYL 1,3 CYCLOHEXANEDIONE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; HYDROGEN PEROXIDE; PROTEIN TYROSINE PHOSPHATASE SHP 2; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 4; NITRIC OXIDE; NOS3 PROTEIN, MOUSE; NOX4 PROTEIN, MOUSE; OXIDIZING AGENT; PTPN11 PROTEIN, MOUSE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SULFENIC ACID DERIVATIVE; SUPEROXIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; EMBRYO; ENDOTHELIUM CELL; ENZYME ACTIVATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LUNG ENDOTHELIUM; MASS SPECTROMETRY; MOUSE; NONHUMAN; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REACTION ANALYSIS; SHEAR STRESS; SIGNAL TRANSDUCTION; SULFENYLATION; VASODILATATION; ANIMAL; AORTA; BOVINE; C57BL MOUSE; CELL CULTURE; CHEMISTRY; DRUG EFFECTS; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; KNOCKOUT MOUSE; MALE; MECHANICAL STRESS; METABOLISM; PATHOLOGY; PHOSPHORYLATION; PHYSIOLOGY; VASCULAR ENDOTHELIUM; WESTERN BLOTTING;

ANIMALS; AORTA; BLOTTING, WESTERN; CATTLE; CELLS, CULTURED; ENDOTHELIUM, VASCULAR; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; HYDROGEN PEROXIDE; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NADPH OXIDASE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE III; OXIDANTS; OXIDATION-REDUCTION; PHOSPHORYLATION; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 11; SIGNAL TRANSDUCTION; STRESS, MECHANICAL; SULFENIC ACIDS; SUPEROXIDES;

EID: 84943625887     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2015.08.014     Document Type: Article

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