SHP-2 binds to caveolin-1 and regulates Src activity via competitive inhibition of CSK in response to H2O2 in astrocytes

PLoS ONE

Volumn 9, Issue 3, 2014, Pages

  Jo, Ara ^a   Park, Hyunju ^a   Lee, Sung Hee ^a   Ahn, So Hee ^a   Kim, Hee Ja ^a   Park, Eun Mi ^a   Choi, Youn Hee ^a  

^a Ewha Womans University School of Medicine   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

C SRC TYROSINE KINASE; CAVEOLIN 1; FOCAL ADHESION KINASE; HYDROGEN PEROXIDE; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHOTYROSINE; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE PHOSPHATASE SHP 2; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; CSK TYROSINE-PROTEIN KINASE; PROTEIN BINDING; PROTEIN KINASE P60; PTPN11 PROTEIN, HUMAN; REACTIVE OXYGEN METABOLITE;

ARTICLE; ASTROCYTE; ASTROCYTOMA CELL; BINDING AFFINITY; COMPETITIVE INHIBITION; COMPLEX FORMATION; CONTROLLED STUDY; HUMAN; HUMAN CELL; OXIDATIVE STRESS; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; ANTAGONISTS AND INHIBITORS; ASTROCYTOMA; CELL LINE; DRUG EFFECTS; ENZYME ACTIVATION; GENETICS; METABOLISM; PHOSPHORYLATION; RNA INTERFERENCE;

ASTROCYTES; ASTROCYTOMA; CAVEOLIN 1; CELL LINE; ENZYME ACTIVATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FOCAL ADHESION PROTEIN-TYROSINE KINASES; HUMANS; HYDROGEN PEROXIDE; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 11; PROTO-ONCOGENE PROTEINS PP60(C-SRC); REACTIVE OXYGEN SPECIES; RNA INTERFERENCE; RNA, SMALL INTERFERING; SRC-FAMILY KINASES;

EID: 84898402136     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0091582     Document Type: Article

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