Role of Nox4 in murine models of kidney disease

Free Radical Biology and Medicine

Volumn 53, Issue 4, 2012, Pages 842-853

  Babelova, Andrea ^a   Avaniadi, Despina ^a   Jung, Oliver ^a   Fork, Christian ^a   Beckmann, Janet ^a   Kosowski, Judith ^a   Weissmann, Norbert ^b   Anilkumar, Narayana ^c   Shah, Ajay M ^c   Schaefer, Liliana ^a   Schröder, Katrin ^a   Brandes, Ralf P ^a  

^a GOETHE UNIVERSITY   (Germany)

^b JUSTUS LIEBIG UNIVERSITY   (Germany)

^c KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Diabetes; Fibrosis; NADPH oxidase; Oxidative stress; Redox regulation; Renal failure

Indexed keywords

CONNECTIVE TISSUE GROWTH FACTOR; FIBRONECTIN; HYDROGEN PEROXIDE; INTERCELLULAR ADHESION MOLECULE 1; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 1; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 4; TAMOXIFEN;

ALBUMINURIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASSAY; CONTROLLED STUDY; DISEASE COURSE; HYPERTENSION; KIDNEY DISEASE; KIDNEY INJURY; KIDNEY TUBULE; KNOCKOUT MOUSE; MALE; MOUSE; NEPHRECTOMY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; STREPTOZOCIN DIABETES; UPREGULATION; URETER LIGATION; WILD TYPE;

ALBUMINURIA; ANIMALS; CONNECTIVE TISSUE GROWTH FACTOR; DIABETES MELLITUS, EXPERIMENTAL; DIABETIC NEPHROPATHIES; DISEASE MODELS, ANIMAL; FIBROSIS; GENE DELETION; GLOMERULAR FILTRATION RATE; HYDROGEN PEROXIDE; INTERCELLULAR ADHESION MOLECULE-1; KIDNEY; KIDNEY TUBULES; MALE; MICE; MICE, 129 STRAIN; MICE, TRANSGENIC; NADPH OXIDASE; NEPHRECTOMY; RENAL INSUFFICIENCY; URETERAL OBSTRUCTION;

ANIMALIA; MURINAE; MUS;

EID: 84864414285     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2012.06.027     Document Type: Article

References (40)

1. A.A. Eddy Molecular insights into renal interstitial fibrosis J. Am. Soc. Nephrol. 7 1996 2495 2508
2. Y. Liu Epithelial to mesenchymal transition in renal fibrogenesis: pathologic significance, molecular mechanism, and therapeutic intervention J. Am. Soc. Nephrol. 15 2004 1 12
3. E.J. Wright, T.A. McCaffrey, A.P. Robertson, E.D. Vaughan Jr., and D. Felsen Chronic unilateral ureteral obstruction is associated with interstitial fibrosis and tubular expression of transforming growth factor-beta Lab. Invest 74 1996 528 537
4. K.J. Davies The broad spectrum of responses to oxidants in proliferating cells: a new paradigm for oxidative stress IUBMB Life 48 1999 41 47
5. M.R. Abid, Z. Kachra, K.C. Spokes, and W.C. Aird NADPH oxidase activity is required for endothelial cell proliferation and migration FEBS Lett 486 2000 252 256
6. N. Hogg, J. Browning, T. Howard, C. Winterford, D. Fitzpatrick, and G. Gobe Apoptosis in vascular endothelial cells caused by serum deprivation, oxidative stress and transforming growth factor-beta Endothelium 7 1999 35 49
7. A.C. Bulua, A. Simon, R. Maddipati, M. Pelletier, H. Park, K.Y. Kim, M.N. Sack, D.L. Kastner, and R.M. Siegel Mitochondrial reactive oxygen species promote production of proinflammatory cytokines and are elevated in TNFR1-associated periodic syndrome (TRAPS) J. Exp. Med. 208 2011 519 533
8. K. Bedard, and K.H. Krause The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology Physiol. Rev. 87 2007 245 313
9. L. Serrander, L. Cartier, K. Bedard, B. Banfi, B. Lardy, O. Plastre, A. Sienkiewicz, L. Forro, W. Schlegel, and K.H. Krause NOX4 activity is determined by mRNA levels and reveals a unique pattern of ROS generation Biochem. J. 406 2007 105 114
10. K. Schroder, I. Helmcke, K. Palfi, K.H. Krause, R. Busse, and R.P. Brandes Nox1 mediates basic fibroblast growth factor-induced migration of vascular smooth muscle cells Arterioscler.Thromb.Vasc. Biol. 27 2007 1736 1743
11. P.S. Gill, and C.S. Wilcox NADPH oxidases in the kidney Antioxid. Redox Signal. 8 2006 1597 1607
12. Y. Gorin, K. Block, J. Hernandez, B. Bhandari, B. Wagner, J.L. Barnes, and H.E. Abboud Nox4 NAD(P)H oxidase mediates hypertrophy and fibronectin expression in the diabetic kidney J. Biol. Chem. 280 2005 39616 39626
13. K. Asaba, A. Tojo, M.L. Onozato, A. Goto, M.T. Quinn, T. Fujita, and C.S. Wilcox Effects of NADPH oxidase inhibitor in diabetic nephropathy Kidney Int. 67 2005 1890 1898
14. C.D. Bondi, N. Manickam, D.Y. Lee, K. Block, Y. Gorin, H.E. Abboud, and J.L. Barnes NAD(P)H oxidase mediates TGF-beta1-induced activation of kidney myofibroblasts J. Am. Soc. Nephrol. 21 2010 93 102
15. M. Zhang, A.C. Brewer, K. Schroder, C.X. Santos, D.J. Grieve, M. Wang, N. Anilkumar, B. Yu, X. Dong, S.J. Walker, R.P. Brandes, and A.M. Shah NADPH oxidase-4 mediates protection against chronic load-induced stress in mouse hearts by enhancing angiogenesis Proc. Natl. Acad. Sci. USA 107 2010 18121 18126
16. K. Schroder, M. Zhang, S. Benkhoff, A. Mieth, R. Pliquett, J. Kosowski, C. Kruse, P. Luedike, U.R. Michaelis, N. Weissmann, S. Dimmeler, A.M. Shah, and R.P. Brandes Nox4 is a protective reactive oxygen species generating vascular NADPH oxidase Circ. Res. 110 2012 1217 1225
17. L.J. Ma, and A.B. Fogo Model of robust induction of glomerulosclerosis in mice: importance of genetic background Kidney Int. 64 2003 350 355
18. N. Anilkumar, R. Weber, M. Zhang, A. Brewer, and A.M. Shah Nox4 and nox2 NADPH oxidases mediate distinct cellular redox signaling responses to agonist stimulation Arterioscler.Thromb. Vasc. Biol. 28 2008 1347 1354
19. P. Goyal, N. Weissmann, F. Rose, F. Grimminger, H.J. Schafers, W. Seeger, and J. Hanze Identification of novel Nox4 splice variants with impact on ROS levels in A549 cells Biochem. Biophys. Res. Commun. 329 2005 32 39
20. M. Geiszt, J.B. Kopp, P. Varnai, and T.L. Leto Identification of renox, an NAD(P)H oxidase in kidney Proc. Natl. Acad. Sci. USA 97 2000 8010 8014
21. 2-generating NADH oxidase in human lung fibroblasts by transforming growth factor beta 1 J. Biol. Chem 270 1995 30334 30338
22. J.M. Larios, R. Budhiraja, B.L. Fanburg, and V.J. Thannickal Oxidative protein cross-linking reactions involving L-tyrosine in transforming growth factor-beta1-stimulated fibroblasts J. Biol. Chem 276 2001 17437 17441
23. S. Carnesecchi, C. Deffert, Y. Donati, O. Basset, B. Hinz, O. Preynat-Seauve, C. Guichard, J.L. Arbiser, B. Banfi, J.C. Pache, C. Barazzone-Argiroffo, and K.H. Krause A key role for NOX4 in epithelial cell death during development of lung fibrosis Antioxid. Redox Signal 15 2011 607 619
24. L. Hecker, R. Vittal, T. Jones, R. Jagirdar, T.R. Luckhardt, J.C. Horowitz, S. Pennathur, F.J. Martinez, and V.J. Thannickal NADPH oxidase-4 mediates myofibroblast activation and fibrogenic responses to lung injury Nat. Med 15 2009 1077 1081
25. J.L. Barnes, and Y. Gorin Myofibroblast differentiation during fibrosis: role of NAD(P)H oxidases Kidney Int. 79 2011 944 956
26. J. Kuroda, T. Ago, S. Matsushima, P. Zhai, M.D. Schneider, and J. Sadoshima NADPH oxidase 4 (Nox4) is a major source of oxidative stress in the failing heart Proc. Natl. Acad. Sci. USA 107 2010 15565 15570
27. S.M. Craige, K. Chen, Y. Pei, C. Li, X. Huang, C. Chen, R. Shibata, K. Sato, K. Walsh, and J.F. Keaney Jr. NADPH oxidase 4 promotes endothelial angiogenesis through endothelial nitric oxide synthase activation Circulation 124 2011 731 740
28. R. Ray, C.E. Murdoch, M. Wang, C.X. Santos, M. Zhang, S. Alom-Ruiz, N. Anilkumar, A. Ouattara, A.C. Cave, S.J. Walker, D.J. Grieve, R.L. Charles, P. Eaton, A.C. Brewer, and A.M. Shah Endothelial Nox4 NADPH oxidase enhances vasodilatation and reduces blood pressure in vivo Arterioscler. Thromb. Vasc. Biol. 31 2011 1368 1376
29. R.P. Brandes, I. Takac, and K. Schroder No superoxide - no stress?: Nox4, the good NADPH oxidase! Arterioscler.Thromb.Vasc. Biol. 31 2011 1255 1257
30. A.C. Brewer, T.V. Murray, M. Arno, M. Zhang, N.P. Anilkumar, G.E. Mann, and A.M. Shah Nox4 regulates Nrf2 and glutathione redox in cardiomyocytes in vivo Free Radic. Biol. Med. 51 2011 205 215
31. S.G. Rhee, and H.A. Woo Multiple functions of peroxiredoxins: peroxidases, sensors and regulators of the intracellular messenger HO, and protein chaperones Antioxid. Redox Signal. 15 2011 781 794
32. Y. Fu, Y. Zhang, Z. Wang, L. Wang, X. Wei, B. Zhang, Z. Wen, H. Fang, Q. Pang, and F. Yi Regulation of NADPH oxidase activity is associated with miRNA-25-mediated NOX4 expression in experimental diabetic nephropathy Am. J. Nephrol 32 2010 581 589
33. T. Etoh, T. Inoguchi, M. Kakimoto, N. Sonoda, K. Kobayashi, J. Kuroda, H. Sumimoto, and H. Nawata Increased expression of NAD(P)H oxidase subunits, NOX4 and p22phox, in the kidney of streptozotocin-induced diabetic rats and its reversibity by interventive insulin treatment Diabetologia 46 2003 1428 1437
34. M. Sedeek, G. Callera, A. Montezano, A. Gutsol, F. Heitz, C. Szyndralewiez, P. Page, C.R. Kennedy, K.D. Burns, R.M. Touyz, and R.L. Hebert Critical role of Nox4-based NADPH oxidase in glucose-induced oxidative stress in the kidney: implications in type 2 diabetic nephropathy Am. J. Physiol. Renal Physiol 299 2010 F1348 F1358
35. K. Block, A. Eid, K.K. Griendling, D.Y. Lee, Y. Wittrant, and Y. Gorin Nox4 NAD(P)H oxidase mediates Src-dependent tyrosine phosphorylation of PDK-1 in response to angiotensin II: role in mesangial cell hypertrophy and fibronectin expression J. Biol. Chem 283 2008 24061 24076
36. G.R. Drummond, S. Selemidis, K.K. Griendling, and C.G. Sobey Combating oxidative stress in vascular disease: NADPH oxidases as therapeutic targets Nat. Rev. Drug Discov. 10 2011 453 471
37. F. Gaggini, B. Laleu, M. Orchard, L. Fioraso-Cartier, L. Cagnon, S. Houngninou-Molango, A. Gradia, G. Duboux, C. Merlot, F. Heitz, C. Szyndralewiez, and P. Page Design, synthesis and biological activity of original pyrazolo-pyrido-diazepine, -pyrazine and -oxazine dione derivatives as novel dual Nox4/Nox1 inhibitors Bioorg. Med. Chem 19 2011 6989 6999
38. B. Laleu, F. Gaggini, M. Orchard, L. Fioraso-Cartier, L. Cagnon, S. Houngninou-Molango, A. Gradia, G. Duboux, C. Merlot, F. Heitz, C. Szyndralewiez, and P. Page First in class, potent, and orally bioavailable NADPH oxidase isoform 4 (Nox4) inhibitors for the treatment of idiopathic pulmonary fibrosis J. Med. Chem 53 2010 7715 7730
39. S. Garrido-Urbani, S. Jemelin, C. Deffert, S. Carnesecchi, O. Basset, C. Szyndralewiez, F. Heitz, P. Page, X. Montet, L. Michalik, J. Arbiser, C. Ruegg, K.H. Krause, and B.A. Imhof Targeting vascular NADPH oxidase 1 blocks tumor angiogenesis through a PPARalpha mediated mechanism PLoS.One 6 2011 e14665
40. C. Kleinschnitz, H. Grund, K. Wingler, M.E. Armitage, E. Jones, M. Mittal, D. Barit, T. Schwarz, C. Geis, P. Kraft, K. Barthel, M.K. Schuhmann, A.M. Herrmann, S.G. Meuth, G. Stoll, S. Meurer, A. Schrewe, L. Becker, V. Gailus-Durner, H. Fuchs, T. Klopstock, M.H. de Angelis, K. Jandeleit-Dahm, A.M. Shah, N. Weissmann, and H.H. Schmidt Post-stroke inhibition of induced NADPH oxidase type 4 prevents oxidative stress and neurodegeneration PLoS.Biol. 8 2010