Ca2+-independent activation of the endothelial nitric oxide synthase in response to tyrosine phosphatase inhibitors and fluid shear stress

Circulation Research

Volumn 82, Issue 6, 1998, Pages 686-695

  Fleming, Ingrid ^a   Bauersachs, Johann ^a   Fisslthaler, Beate ^a   Busse, Rudi ^a  

^a UNIVERSITY HOSPITAL FRANKFURT   (Germany)

Author keywords

Cytoskeleton; Nitric oxide; Shear stress; Tyrosine kinase

Indexed keywords

ARSENOSOBENZENE; CALCIUM ION; CALMIDAZOLIUM; CALMODULIN; CYCLIC GMP; CYTOSKELETON PROTEIN; ERBSTATIN; GELDANAMYCIN; GENISTEIN; HERBIMYCIN A; MITOGEN ACTIVATED PROTEIN KINASE; N(G) NITROARGININE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; PAXILLIN; PHOSPHOLIPASE C; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE INHIBITOR; PROTEIN TYROSINE PHOSPHATASE; 1,2-BIS(2-AMINOPHENOXY)ETHANE-N,N,N',N'-TETRAACETIC ACID; CALCIUM; DRUG DERIVATIVE; EGTAZIC ACID; ENZYME INHIBITOR; ETHYLENE GLYCOL 1,2 BIS(2 AMINOPHENYL) ETHER N,N,N',N' TETRAACETIC ACID; IMIDAZOLE DERIVATIVE; ORGANOARSENIC DERIVATIVE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CYTOSKELETON; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SHEAR STRESS; SWINE; VASCULAR ENDOTHELIUM; ANALYSIS OF VARIANCE; ANIMAL; CAROTID ARTERY; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; FEMALE; IN VITRO STUDY; MALE; MECHANICAL STRESS; METABOLISM; MUSCLE RELAXATION; PHOSPHORYLATION; PHYSIOLOGY; RABBIT; VASODILATATION;

ANALYSIS OF VARIANCE; ANIMALS; ARSENICALS; CALCIUM; CALMODULIN; CAROTID ARTERIES; EGTAZIC ACID; ENDOTHELIUM, VASCULAR; ENZYME ACTIVATION; ENZYME INHIBITORS; FEMALE; IMIDAZOLES; MALE; MUSCLE RELAXATION; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PHOSPHORYLATION; PROTEIN-TYROSINE KINASES; PROTEIN-TYROSINE-PHOSPHATASE; RABBITS; STRESS, MECHANICAL; VASODILATION;

EID: 0032489676     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.82.6.686     Document Type: Article

References (40)

1. Busse R, Mülsch A. Calcium-dependent nitric oxide synthesis in endothelial cytosol is mediated by calmodulin. FEBS Lett. 1990;265:133-136.
2. Busse R, Fleming I. Regulation and functional consequences of endothelial nitric oxide formation. Ann Med. 1995;27:331-340.
3. Singer AH, Peach MJ. Calcium- and endothelial-mediated vascular smooth muscle relaxation in rabbit aorta. Hypertension. 1982;4(suppl II):II-19-II-25.
4. Lückhoff A, Pohl U, Mülsch A, Busse R. Differential role of extra- and intracellular calcium in the release of EDRF and prostacyclin from cultured endothelial cells. Br J Pharmacol. 1988;95:189-196.
5. Mülsch A, Bassenge E, Busse R. Nitric oxide synthesis in endothelial cytosol: evidence for a calcium-dependent and a calcium-independent mechanism. Naunyn Schmiedebergs Arch Pharmacol. 1989;340:767-770.
6. Nishida K, Harrison DG, Navas JP, Fisher AA, Dockery SP, Uematsu M, Nerem RM, Alexander RW, Murphy TJ. Molecular cloning and characterization of the constitutive bovine aortic endothelial cell nitric oxide synthase. J Clin Invest. 1992;90:2092-2096.
7. Bredt DS, Huang PM, Glatt CE, Lowenstein C, Reed RR, Snyder SH. Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase. Nature. 1991;351:714-718.
8. Marsden PA, Schappert KT, Chen HS, Flowers M, Sundell CL, Wilcox JN, Lamas S, Michel T, Molecular cloning and characterization of human endothelial nitric oxide synthase. FEBS Lett. 1992;307:287-293.
9. Ayajiki K, Kindermann M, Hecker M, Fleming I, Busse R. Intracellular pH and tyrosine phosphorylation but not calcium determine shear stress-induced nitric oxide production in native endothelial cells. Circ Res. 1996;78:750-758.
10. 2+ signaling of vascular endothelial cells: effect of shear stress and ATP. Am J Physiol. 1991;260:H1698-H1707.
11. Shen J, Luscinskas FW, Connolly A, Dewey CF Jr, Gimbronc MA Jr. Fluid shear stress modulates cytosolic free calcium in vascular endothelial cells. Am J Physiol. 1992;262:C384-C390.
12. Schwarz G, Droogmans G, Nilius B. Shear stress induced membrane currents and calcium transients in human vascular endothelial cells. Pflugers Arch. 1992;421:394-396.
13. Kuchan MJ, Frangos JA. Role of calcium and calmodulin in flow-induced nitric oxide production in endothelial cells. Am J Physiol. 1994;266:C628-C636.
14. 2+. Am J Physiol. 1995;269:C863-C869.
15. Fleming I, Hecker M, Busse R. Intracellular alkalinization induced by bradykinin sustains activation of the constitutive nitric oxide synthase in endothelial cells. Cric Res. 1994;74:1220-1226.
16. García-Cardena G, Fan G, Stern DF, Liu J, Sessa WC. Endothelial nitric oxide synthase is regulated by tyrosine phosphorylation and interacts with caveolin-1. J Biol Chem. 1996;271:27237-27240.
17. García-Cardena G, Martasek P, Masters BS, Skidd PM, Couet J, Li SW, Lisanti MP, Sessa WC. Dissecting the interaction between nitric oxide synthase (NOS) and caveolin: functional significance of the NOS caveolin binding domain in vivo. J Biol Chem. 1997;272:25437-25440.
18. 2+-calmodulin and caveolin. J Biol Chem. 1997;272:15583-15586.
19. Venema VJ, Zou R, Ju H, Marrero MB, Venema RC. Caveolin-1 detergent solubility and association with endothelial nitric oxide synthase is modulated by tyrosine phosphorylation. Biochem Biophys Res Commun. 1997;236:155-161.
20. Busse R, Lamontagne D. Endothelium-derived bradykinin is responsible for the increase in calcium produced by angiotensin-converting enzyme inhibitors in human endothelial cells. Naunyn Schmiedebergs Arch Pharmacol. 1991;344:126-129.
21. Fleming I, Fisslthaler B, Busse R. Calcium signaling in endothelial cells involves activation of tyrosine kinases and leads to activation of MAP kinase. Circ Res. 1995;76:522-529.
22. Smart EJ, Ying YS, Mineo C, Anderson RGW. A detergent-free method for purifying caveolae membrane from tissue culture cells. Proc Natl Acad Sci USA. 1995;92:10104-10108.
23. Mülsch A, Bohme E, Busse R. Stimulation of soluble guanylate cyclase by endothelium-derived relaxing factor from cultured endothelial cells. Eur J Pharmacol. 1987;135:247-250.
24. Cooper JA, Sefton BM, Hunter T. Detection and quantification of phosphotyrosine in proteins. Methods Enzymol. 1983;99:387-402.
25. Fleming I, Fisslthaler B, Busse R. Interdependence of calcium signaling and protein tyrosine phosphorylation in human endothelial cells. J Biol Chem. 1996;271:11009-11015.
26. 2+ influx and protein tyrosine phosphorylation in endothelial cells is inhibited by herbimycin A. Biochem Biophys Res Commun. 1994;202: 1651-1656.
27. Fleming I, Bara A, Busse R. Calcium signalling and autacoid production in endothelial cells are modulated by changes in tyrosine kinase and phosphatase activity. J Vasc Res. 1996;33:225-234.
28. Venema VJ, Marrero MB, Venema RC. Bradykinin-stimulated protein syrosine phosphorylation promotes endothelial nitric oxide synthase translocation to the cytoskeleton. Biochem Biophys Res Commun. 1996; 226:703-710.
29. Takahashi M, Berk BC. Mitogen-activated protein kinase (ERK1/2) activation by shear stress and adhesion in endothelial cells. J Clin Invest. 1996;98:2623-2631.
30. Takahashi M, Ishida T, Traub O, Corson MA, Berk BC. Mechanotransduction in endothelial cells: temporal signaling events in response to shear stress. J Vasc Res. 1997;34:212-219.
31. Robinson LJ, Busconi L, Michel T. Agonist-modulated palmitoylation of endothelial nitric oxide synthase. J Biol Chem. 1995;270:995-998.
32. Michel T, Li GK, Busconi L. Phosphorylation and subcellular translocation of endothelial nitric oxide synthase. Proc Natl Acad Sci U S A. 1993;90:6252-6256.
33. Corson MA, James NL, Latta SE, Nerem RM, Berk BC, Harrison DG. Phosphorylation of endothelial nitric oxide synthase in response to fluid shear stress. Circ Res. 1996;79:984-991.
34. Shaul PW, Smart EJ, Robinson LJ, German Z, Yuhanna IS, Ying YS, Anderson RGW, Michel T. Acylation targets endothelial nitric oxide synthase to plasmalemmal caveolae. J Biol Chem. 1996;271:6518-6522.
35. Feron O, Belhassen L, Kobzik L, Smith TW, Kelly RA, Michel T. Endothelial nitric oxide synthase targeting to caveolae: specific interactions with caveolin isoforms in cardiac myocytes and endothelial cells. J Biol Chem. 1996;271:22810-22814.
36. Lisanti MP, Scherer PE, Vidugiriene J, Tang Z, Hermanowski-Vosatka A, Tu Y-H, Cook RF, Sargiacomo M. Characterization of caveolin-rich membrane domains isolated from an endothelial-rich source: implications for human disease. J Cell Biol 1994;126:111-126.
37. fgr in human neutrophils adherent to fibrinogen. J Leukoc Biol. 1995;58:595-606.
38. Chao DS, Gorospe JRM, Brenman JE, Rafael JA, Peters MF, Froehner SC, Hoffman EP, Chamberlain JS. Bredt DS. Selective loss of sarcolemmal nitric oxide synthase in Becker muscular dystrophy. J Exp Med. 1996;184:609-618.
39. Brenman JE, Chao DS, Gee SH, McGee AW, Craven SE, Santillano DR, Wu ZQ, Huang F, Xia HH, Peters MF, Froehner SC, Bredt DS. Interaction of nitric oxide synthase with the postsynaptic density protein PSD-95 and α1-syntrophin mediated by PDZ domains. Cell. 1996;84:757-767.
40. Jaffrey SR, Snyder SH. PIN: an associated protein inhibitor of neuronal nitric oxide synthase. Science. 1996;274:774-777.