-
1
-
-
0028892429
-
Proteolytic processing mechanisms in the biosynthesis of neuroendocrine peptides: The subtilisinlike proprotein convertases
-
Rouillé Y, Duguay SJ, Lund K, et al. Proteolytic processing mechanisms in the biosynthesis of neuroendocrine peptides: the subtilisinlike proprotein convertases. Front Neuroendocrinol. 1995;16:322-361.
-
(1995)
Front Neuroendocrinol.
, vol.16
, pp. 322-361
-
-
Rouillé, Y.1
Duguay, S.J.2
Lund, K.3
-
2
-
-
84873809815
-
Prohormone convertases 1/3 and 2
-
Fricker LD, Devi L, eds., Princeton, NJ: Morgan& Claypool Life Sciences Publishers
-
Hoshino A, Lindberg I. Prohormone convertases 1/3 and 2. In: Fricker LD, Devi L, eds. Peptide Biosynthesis. Princeton, NJ: Morgan& Claypool Life Sciences Publishers; 2012.
-
(2012)
Peptide Biosynthesis
-
-
Hoshino, A.1
Lindberg, I.2
-
3
-
-
0030949271
-
Obesity and impaired prohormone processing associated with mutations in the human prohormone convertase 1 gene
-
Jackson RS, Creemers JW, Ohagi S, et al. Obesity and impaired prohormone processing associated with mutations in the human prohormone convertase 1 gene. Nat Genet. 1997;16:303-306.
-
(1997)
Nat Genet.
, vol.16
, pp. 303-306
-
-
Jackson, R.S.1
Creemers, J.W.2
Ohagi, S.3
-
4
-
-
0346096721
-
Small-intestinal dysfunction accompanies the complex endocrinopathy of human proprotein convertase 1 deficiency
-
Jackson RS, Creemers JW, Farooqi IS, et al. Small-intestinal dysfunction accompanies the complex endocrinopathy of human proprotein convertase 1 deficiency. J Clin Invest. 2003;112:1550-1560.
-
(2003)
J Clin Invest.
, vol.112
, pp. 1550-1560
-
-
Jackson, R.S.1
Creemers, J.W.2
Farooqi, I.S.3
-
5
-
-
34548765134
-
Hyperphagia and earlyonset obesity due to a novel homozygous missense mutation in prohormone convertase 1/3
-
Farooqi IS, Volders K, Stanhope R, et al. Hyperphagia and earlyonset obesity due to a novel homozygous missense mutation in prohormone convertase 1/3. J Clin Endocrinol Metab. 2007;92:3369-3373.
-
(2007)
J Clin Endocrinol Metab.
, vol.92
, pp. 3369-3373
-
-
Farooqi, I.S.1
Volders, K.2
Stanhope, R.3
-
6
-
-
84879480364
-
Congenital proprotein convertase 1/3 deficiency causes malabsorptive diarrhea and other endocrinopathies in a pediatric cohort
-
Martn MG, Lindberg I, Solorzano-Vargas RS, et al. Congenital proprotein convertase 1/3 deficiency causes malabsorptive diarrhea and other endocrinopathies in a pediatric cohort. Gastroenterology. 2013;145:138-148.
-
(2013)
Gastroenterology.
, vol.145
, pp. 138-148
-
-
Martn, M.G.1
Lindberg, I.2
Solorzano-Vargas, R.S.3
-
7
-
-
84922657340
-
A nonsense loss-of-function mutation in PCSK1 contributes to dominantly inherited human obesity
-
Philippe J, Stijnen P, Meyre D, et al. A nonsense loss-of-function mutation in PCSK1 contributes to dominantly inherited human obesity. Int J Obes (Lond). 2015;39:295-302.
-
(2015)
Int J Obes (Lond).
, vol.39
, pp. 295-302
-
-
Philippe, J.1
Stijnen, P.2
Meyre, D.3
-
8
-
-
84907486842
-
Anovel familial mutation in thePCSK1gene that alters the oxyanion hole residue of proprotein convertase 1/3 and impairs its enzymatic activity
-
Wilschanski M, Abbasi M, Blanco E, et al.Anovel familial mutation in thePCSK1gene that alters the oxyanion hole residue of proprotein convertase 1/3 and impairs its enzymatic activity. PLoS One. 2014; 9:e108878.
-
(2014)
PLoS One
, vol.9
, pp. e108878
-
-
Wilschanski, M.1
Abbasi, M.2
Blanco, E.3
-
9
-
-
33744763342
-
Obesity, hyperphagia and increased metabolic efficiency in Pc1 mutant mice
-
Lloyd DJ, Bohan S, Gekakis N. Obesity, hyperphagia and increased metabolic efficiency in Pc1 mutant mice. Hum Mol Genet. 2006; 15:1884-1893.
-
(2006)
Hum Mol Genet.
, vol.15
, pp. 1884-1893
-
-
Lloyd, D.J.1
Bohan, S.2
Gekakis, N.3
-
10
-
-
80052829855
-
The effect of PCSK1 variants on waist, waist-hip ratio and glucose metabolism is modified by sex and glucose tolerance status
-
Gjesing AP, Vestmar MA, Jorgensen T, et al. The effect of PCSK1 variants on waist, waist-hip ratio and glucose metabolism is modified by sex and glucose tolerance status. PLoSOne. 2011;6:e23907.
-
(2011)
PLoSOne.
, vol.6
, pp. e23907
-
-
Gjesing, A.P.1
Vestmar, M.A.2
Jorgensen, T.3
-
11
-
-
84925222316
-
The association of common variants in PCSK1 with obesity: A HuGE review and meta-analysis
-
Stijnen P, Tuand K, Varga TV, Franks PW, Aertgeerts B, Creemers JW. The association of common variants in PCSK1 with obesity: a HuGE review and meta-analysis.AmJ Epidemiol. 2014;180:1051-1065.
-
(2014)
Am J Epidemiol.
, vol.180
, pp. 1051-1065
-
-
Stijnen, P.1
Tuand, K.2
Varga, T.V.3
Franks, P.W.4
Aertgeerts, B.5
Creemers, J.W.6
-
12
-
-
48349113289
-
Common nonsynonymous variants in PCSK1 confer risk of obesity
-
Benzinou M, Creemers JW, Choquet H, et al. Common nonsynonymous variants in PCSK1 confer risk of obesity. Nat Genet. 2008; 40:943-945.
-
(2008)
Nat Genet.
, vol.40
, pp. 943-945
-
-
Benzinou, M.1
Creemers, J.W.2
Choquet, H.3
-
13
-
-
84874375410
-
Contribution ofcommonPCSK1 genetic variants to obesity in 8,359 subjects from multi-ethnic American population
-
Choquet H, Kasberger J, Hamidovic A, Jorgenson E. Contribution ofcommonPCSK1 genetic variants to obesity in 8,359 subjects from multi-ethnic American population. PLoS One. 2013;8:e57857.
-
(2013)
PLoS One
, vol.8
, pp. e57857
-
-
Choquet, H.1
Kasberger, J.2
Hamidovic, A.3
Jorgenson, E.4
-
14
-
-
82355191718
-
Effects of rs6234/rs6235 and rs6232/rs6234/rs6235 PCSK1 single-nucleotide polymorphism clusters on proprotein convertase 1/3 biosynthesis and activity
-
Mbikay M, Sirois F, Nkongolo KK, Basak A, Chrétien M. Effects of rs6234/rs6235 and rs6232/rs6234/rs6235 PCSK1 single-nucleotide polymorphism clusters on proprotein convertase 1/3 biosynthesis and activity. Mol Genet Metab. 2011;104:682-687.
-
(2011)
Mol Genet Metab.
, vol.104
, pp. 682-687
-
-
Mbikay, M.1
Sirois, F.2
Nkongolo, K.K.3
Basak, A.4
Chrétien, M.5
-
15
-
-
84856523505
-
Heterozygous mutations causing partial prohormone convertase 1 deficiency contribute to human obesity
-
Creemers JW, Choquet H, Stijnen P, et al. Heterozygous mutations causing partial prohormone convertase 1 deficiency contribute to human obesity. Diabetes. 2012;61:383-390.
-
(2012)
Diabetes.
, vol.61
, pp. 383-390
-
-
Creemers, J.W.1
Choquet, H.2
Stijnen, P.3
-
16
-
-
84873801109
-
Functional consequences of a novel variant of PCSK1
-
Pickett LA, Yourshaw M, Albornoz V, et al. Functional consequences of a novel variant of PCSK1. PLoS One. 2013;8:e55065.
-
(2013)
PLoS One
, vol.8
, pp. e55065
-
-
Pickett, L.A.1
Yourshaw, M.2
Albornoz, V.3
-
17
-
-
0026503049
-
Expression in human lung tumor cells of the proprotein processing enzyme PC1/PC3. Cloning and primary sequence of a 5 kb cDNA
-
Creemers JW, Roebroek AJ, Van de Ven WJ. Expression in human lung tumor cells of the proprotein processing enzyme PC1/PC3. Cloning and primary sequence of a 5 kb cDNA. FEBS Lett. 1992; 300:82-88.
-
(1992)
FEBS Lett.
, vol.300
, pp. 82-88
-
-
Creemers, J.W.1
Roebroek, A.J.2
Van De Ven, W.J.3
-
18
-
-
84907059375
-
Biochemical and cell biological properties of the human prohormone convertase 1/3 Ser357Gly mutation: A PC1/3 hypermorph
-
Blanco EH, Peinado JR, Martn MG, Lindberg I. Biochemical and cell biological properties of the human prohormone convertase 1/3 Ser357Gly mutation: a PC1/3 hypermorph. Endocrinology. 2014; 155:3434-3447.
-
(2014)
Endocrinology
, vol.155
, pp. 3434-3447
-
-
Blanco, E.H.1
Peinado, J.R.2
Martn, M.G.3
Lindberg, I.4
-
19
-
-
0028238009
-
Evidence for cleavage of the PC1/PC3 pro-segment in the endoplasmic reticulum
-
Lindberg I. Evidence for cleavage of the PC1/PC3 pro-segment in the endoplasmic reticulum. Mol Cell Neurosci. 1994;5:263-268.
-
(1994)
Mol Cell Neurosci.
, vol.5
, pp. 263-268
-
-
Lindberg, I.1
-
20
-
-
0028337442
-
Enzymatic properties of carboxyl-terminally truncated prohormone convertase 1 (PC1/SPC3) and evidence for autocatalytic conversion
-
Zhou Y, Lindberg I. Enzymatic properties of carboxyl-terminally truncated prohormone convertase 1 (PC1/SPC3) and evidence for autocatalytic conversion. J Biol Chem. 1994;269:18408-18413.
-
(1994)
J Biol Chem.
, vol.269
, pp. 18408-18413
-
-
Zhou, Y.1
Lindberg, I.2
-
21
-
-
66149088834
-
Functional and structural characterization of a dense core secretory granule sorting domain from the PC1/3 protease
-
Dikeakos JD, Di Lello P, Lacombe MJ, et al. Functional and structural characterization of a dense core secretory granule sorting domain from the PC1/3 protease. Proc Natl Acad Sci USA. 2009;106: 7408-7413.
-
(2009)
Proc Natl Acad Sci USA.
, vol.106
, pp. 7408-7413
-
-
Dikeakos, J.D.1
Di Lello, P.2
Lacombe, M.J.3
-
22
-
-
0034088234
-
Proinsulin endoproteolysis confers enhanced targeting of processed insulin to the regulated secretory pathway
-
Kuliawat R, Prabakaran D, Arvan P. Proinsulin endoproteolysis confers enhanced targeting of processed insulin to the regulated secretory pathway. Mol Biol Cell. 2000;11:1959-1972.
-
(2000)
Mol Biol Cell.
, vol.11
, pp. 1959-1972
-
-
Kuliawat, R.1
Prabakaran, D.2
Arvan, P.3
-
23
-
-
28844478947
-
Prohormone-convertase 1 processing enhances post-Golgi sorting of prothyrotropin-releasing hormone-derived peptides
-
Mulcahy LR, Vaslet CA, Nillni EA. Prohormone-convertase 1 processing enhances post-Golgi sorting of prothyrotropin-releasing hormone-derived peptides. J Biol Chem. 2005;280:39818-39826.
-
(2005)
J Biol Chem.
, vol.280
, pp. 39818-39826
-
-
Mulcahy, L.R.1
Vaslet, C.A.2
Nillni, E.A.3
-
24
-
-
1342326470
-
Dense-core granules: A specific hallmark of the neuronal/neurosecretory cell phenotype
-
Malosio ML, Giordano T, Laslop A, Meldolesi J. Dense-core granules: a specific hallmark of the neuronal/neurosecretory cell phenotype. J Cell Sci. 2004;117:743-749.
-
(2004)
J Cell Sci.
, vol.117
, pp. 743-749
-
-
Malosio, M.L.1
Giordano, T.2
Laslop, A.3
Meldolesi, J.4
-
25
-
-
0032918044
-
Amutation in the insulin 2 gene induces diabetes with severe pancreatic β-cell dysfunction in the Mody mouse
-
WangJ, Takeuchi T, Tanaka S, et al.Amutation in the insulin 2 gene induces diabetes with severe pancreatic β-cell dysfunction in the Mody mouse. J Clin Invest. 1999;103:27-37.
-
(1999)
J Clin Invest.
, vol.103
, pp. 27-37
-
-
Wang, J.1
Takeuchi, T.2
Tanaka, S.3
-
26
-
-
0034465474
-
Autosomal dominant growth hormone (GH) deficiency type II: The Del32-71-GH deletion mutant suppresses secretion of wild-type GH
-
Lee MS, Wajnrajch MP, Kim SS, et al. Autosomal dominant growth hormone (GH) deficiency type II: the Del32-71-GH deletion mutant suppresses secretion of wild-type GH. Endocrinology. 2000;141: 883-890.
-
(2000)
Endocrinology
, vol.141
, pp. 883-890
-
-
Lee, M.S.1
Wajnrajch, M.P.2
Kim, S.S.3
-
27
-
-
0033605653
-
Mutant vasopressin precursors that cause autosomal dominant neurohypophyseal diabetes insipidus retain dimerization and impair the secretion of wild-type proteins
-
Ito M, Yu RN, Jameson JL. Mutant vasopressin precursors that cause autosomal dominant neurohypophyseal diabetes insipidus retain dimerization and impair the secretion of wild-type proteins. J Biol Chem. 1999;274:9029-9037.
-
(1999)
J Biol Chem.
, vol.274
, pp. 9029-9037
-
-
Ito, M.1
Yu, R.N.2
Jameson, J.L.3
-
28
-
-
84879658402
-
Dominant protein interactions that influence the pathogenesis of conformational diseases
-
Wright J, Wang X, Haataja L, et al. Dominant protein interactions that influence the pathogenesis of conformational diseases. J Clin Invest. 2013;123:3124-3134.
-
(2013)
J Clin Invest.
, vol.123
, pp. 3124-3134
-
-
Wright, J.1
Wang, X.2
Haataja, L.3
-
29
-
-
84903280912
-
Defective transport of the obesity mutant PC1/3 N222D contributes to loss of function
-
Prabhu Y, Blanco EH, LiuM,et al. Defective transport of the obesity mutant PC1/3 N222D contributes to loss of function. Endocrinology. 2014;155:2391-2401.
-
(2014)
Endocrinology
, vol.155
, pp. 2391-2401
-
-
Prabhu, Y.1
Blanco, E.H.2
Liu, M.3
-
30
-
-
79960846307
-
Corticotropin-releasing factor binding protein enters the regulated secretory pathway in neuroendocrine cells and cortical neurons
-
Blanco EH, Zñiga JP, Andrés ME, Alvarez AR, Gysling K. Corticotropin-releasing factor binding protein enters the regulated secretory pathway in neuroendocrine cells and cortical neurons. Neuropeptides. 2011;45:273-279.
-
(2011)
Neuropeptides.
, vol.45
, pp. 273-279
-
-
Blanco, E.H.1
Zñiga, J.P.2
Andrés, M.E.3
Alvarez, A.R.4
Gysling, K.5
-
31
-
-
0036175128
-
Targeted disruption of the Chop gene delays endoplasmic reticulum stress-mediated diabetes
-
Oyadomari S, Koizumi A, Takeda K, et al. Targeted disruption of the Chop gene delays endoplasmic reticulum stress-mediated diabetes. J Clin Invest. 2002;109:525-532.
-
(2002)
J Clin Invest.
, vol.109
, pp. 525-532
-
-
Oyadomari, S.1
Koizumi, A.2
Takeda, K.3
-
32
-
-
77349112160
-
In vitro processing and secretion of mutant insulin proteins that cause permanent neonatal diabetes
-
Rajan S, Eames SC, Park SY, et al. In vitro processing and secretion of mutant insulin proteins that cause permanent neonatal diabetes. Am J Physiol Endocrinol Metab. 2010;298:E403-E410.
-
(2010)
Am J Physiol Endocrinol Metab.
, vol.298
, pp. E403-E410
-
-
Rajan, S.1
Eames, S.C.2
Park, S.Y.3
-
33
-
-
84875115035
-
Anamphipathicβ-helix in the prodomain of cocaine and amphetamine regulated transcript peptide precursor serves as its sorting signal to the regulated secretory pathway
-
Blanco EH, Lagos CF, AndresME,Gysling K.Anamphipathicβ-helix in the prodomain of cocaine and amphetamine regulated transcript peptide precursor serves as its sorting signal to the regulated secretory pathway. PLoS One. 2013;8:e59695.
-
(2013)
PLoS One
, vol.8
, pp. e59695
-
-
Blanco, E.H.1
Lagos, C.F.2
Andres, M.E.3
Gysling, K.4
-
34
-
-
33845764296
-
Aguided tour into subcellular colocalization analysis in light microscopy
-
Bolte S, Cordelières FP.Aguided tour into subcellular colocalization analysis in light microscopy. J Microsc. 2006;224:213-232.
-
(2006)
J Microsc.
, vol.224
, pp. 213-232
-
-
Bolte, S.1
Cordelières, F.P.2
-
35
-
-
0027104001
-
Dynamics of three-dimensional replication patterns during the S-phase, analysed by double labelling of DNA and confocal microscopy
-
Manders EM, Stap J, Brakenhoff GJ, van Driel R, Aten JA. Dynamics of three-dimensional replication patterns during the S-phase, analysed by double labelling of DNA and confocal microscopy. J Cell Sci. 1992;103(pt 3):857-862.
-
(1992)
J Cell Sci.
, vol.103
, pp. 857-862
-
-
Manders, E.M.1
Stap, J.2
Brakenhoff, G.J.3
Van Driel, R.4
Aten, J.A.5
-
36
-
-
0029935163
-
Partial colocalization of glucocorticoid and mineralocorticoid receptors in discrete compartments in nuclei of rat hippocampus neurons
-
van Steensel B, van Binnendijk EP, Hornsby CD, et al. Partial colocalization of glucocorticoid and mineralocorticoid receptors in discrete compartments in nuclei of rat hippocampus neurons. J Cell Sci. 1996;109(pt 4):787-792.
-
(1996)
J Cell Sci.
, vol.109
, pp. 787-792
-
-
Van Steensel, B.1
Van Binnendijk, E.P.2
Hornsby, C.D.3
-
37
-
-
84869129268
-
Allelic clustering and ancestry-dependent frequencies of rs6232, rs6234, and rs6235 PCSK1 SNPs in a Northern Ontario population sample
-
Sirois F, Kaefer N, Currie KA, Chrétien M, Nkongolo KK, Mbikay M. Allelic clustering and ancestry-dependent frequencies of rs6232, rs6234, and rs6235 PCSK1 SNPs in a Northern Ontario population sample. J Community Genet. 2012;3:319-322.
-
(2012)
J Community Genet.
, vol.3
, pp. 319-322
-
-
Sirois, F.1
Kaefer, N.2
Currie, K.A.3
Chrétien, M.4
Nkongolo, K.K.5
Mbikay, M.6
-
38
-
-
0029075455
-
7B2 facilitates the maturation of proPC2 in neuroendocrine cells and is required for the expression of enzymatic activity
-
Zhu X, Lindberg I. 7B2 facilitates the maturation of proPC2 in neuroendocrine cells and is required for the expression of enzymatic activity. J Cell Biol. 1995;129:1641-1650.
-
(1995)
J Cell Biol.
, vol.129
, pp. 1641-1650
-
-
Zhu, X.1
Lindberg, I.2
-
39
-
-
79953176286
-
Modulation of PC1/3 activity by self-interaction and substrate binding
-
Hoshino A, Kowalska D, Jean F, Lazure C, Lindberg I. Modulation of PC1/3 activity by self-interaction and substrate binding. Endocrinology. 2011;152:1402-1411.
-
(2011)
Endocrinology
, vol.152
, pp. 1402-1411
-
-
Hoshino, A.1
Kowalska, D.2
Jean, F.3
Lazure, C.4
Lindberg, I.5
-
40
-
-
84884182501
-
Alteration of endoplasmic reticulum lipid rafts contributes to lipotoxicity in pancreatic β-cells
-
Boslem E, Weir JM, MacIntosh G, et al. Alteration of endoplasmic reticulum lipid rafts contributes to lipotoxicity in pancreatic β-cells. J Biol Chem. 2013;288:26569-26582.
-
(2013)
J Biol Chem.
, vol.288
, pp. 26569-26582
-
-
Boslem, E.1
Weir, J.M.2
MacIntosh, G.3
-
41
-
-
0028203583
-
Differential effects of temperature blockade on the proteolytic processing of three secretory granule-associated proteins
-
Milgram SL, Mains RE. Differential effects of temperature blockade on the proteolytic processing of three secretory granule-associated proteins. J Cell Sci. 1994;107(pt 3):737-745.
-
(1994)
J Cell Sci.
, vol.107
, pp. 737-745
-
-
Milgram, S.L.1
Mains, R.E.2
-
42
-
-
47949099916
-
From endoplasmic-reticulum stress to the inflammatory response
-
Zhang K, Kaufman RJ. From endoplasmic-reticulum stress to the inflammatory response. Nature. 2008;454:455-462.
-
(2008)
Nature.
, vol.454
, pp. 455-462
-
-
Zhang, K.1
Kaufman, R.J.2
-
43
-
-
35648957233
-
Proinsulin maturation, misfolding, and proteotoxicity
-
Liu M, Hodish I, Rhodes CJ, Arvan P. Proinsulin maturation, misfolding, and proteotoxicity. Proc Natl Acad Sci USA. 2007;104: 15841-15846.
-
(2007)
Proc Natl Acad Sci USA.
, vol.104
, pp. 15841-15846
-
-
Liu, M.1
Hodish, I.2
Rhodes, C.J.3
Arvan, P.4
-
44
-
-
0037312881
-
Dominant negative pathogenesis by mutant proinsulin in the Akita diabetic mouse
-
Izumi T, Yokota-Hashimoto H, Zhao S, Wang J, Halban PA, Takeuchi T. Dominant negative pathogenesis by mutant proinsulin in the Akita diabetic mouse. Diabetes. 2003;52:409-416.
-
(2003)
Diabetes.
, vol.52
, pp. 409-416
-
-
Izumi, T.1
Yokota-Hashimoto, H.2
Zhao, S.3
Wang, J.4
Halban, P.A.5
Takeuchi, T.6
-
45
-
-
0033782015
-
Dynamic interaction of BiP and ER stress transducers in the unfoldedprotein response
-
Bertolotti A, Zhang Y, Hendershot LM, Harding HP, Ron D. Dynamic interaction of BiP and ER stress transducers in the unfoldedprotein response. Nat Cell Biol. 2000;2:326-332.
-
(2000)
Nat Cell Biol.
, vol.2
, pp. 326-332
-
-
Bertolotti, A.1
Zhang, Y.2
Hendershot, L.M.3
Harding, H.P.4
Ron, D.5
-
46
-
-
0035966269
-
XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor
-
Yoshida H, Matsui T, Yamamoto A, Okada T, Mori K. XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor. Cell. 2001; 107:881-891.
-
(2001)
Cell.
, vol.107
, pp. 881-891
-
-
Yoshida, H.1
Matsui, T.2
Yamamoto, A.3
Okada, T.4
Mori, K.5
|