Dense-core granules: A specific hallmark of the neuronal/neurosecretory cell phenotype

Journal of Cell Science

Volumn 117, Issue 5, 2004, Pages 743-749

  Malosio, Maria Luisa ^a,b   Giordano, Tiziana ^a,b   Laslop, Andrea ^a,c   Meldolesi, Jacopo ^a  

^a VITA SALUTE SAN RAFFAELE UNIVERSITY   (Italy)

^b SAN RAFFAELE HOSPITAL   (Italy)

^c INNSBRUCK MEDICAL UNIVERSITY   (Austria)

Author keywords

Chromogranin A; Chromogranin B; Dense core granules; Neurosecretory cells; Regulated exocytoxis

Indexed keywords

CHROMOGRANIN A; CHROMOGRANIN B; CYCLOHEXIMIDE; SECRETORY PROTEIN;

ADENOCARCINOMA; ANIMAL CELL; ARTICLE; CELL CLONE; CELL GRANULE; CELL ORGANELLE; CONTROLLED STUDY; EXOCYTOSIS; FIBROBLAST; GENE EXPRESSION; GENE SEQUENCE; GENETIC TRANSFECTION; GOLGI COMPLEX; IMMUNOFLUORESCENCE; LYSOSOME; NERVE CELL; NEUROSECRETORY CELL; NONHUMAN; ON OFF PHENOMENON; PHENOTYPE; PRIORITY JOURNAL; PROTEIN METABOLISM; RAT; TRANS GOLGI NETWORK;

ANIMALS; BREAST NEOPLASMS; CELL LINE; CHROMOGRANIN A; CHROMOGRANINS; FIBROBLASTS; HAPLORHINI; HUMANS; MICE; MICROSCOPY, CONFOCAL; MICROSCOPY, FLUORESCENCE; NEURONS; NEUROSECRETORY SYSTEMS; PC12 CELLS; PHENOTYPE; RATS; SECRETORY VESICLES; TRANSFECTION;

ANIMALIA;

EID: 1342326470     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: 10.1242/jcs.00934     Document Type: Article

References (28)

1. Bauer, R., Hoflehner, J., Doblinger, A., Kapeller, I. and Laslop, A. (2000). Regulation of the biosynthesis and processing of chromogranins in organotypic slices: influence of depolarization, forskolin and differentiating factors. Eur. J. Neurosci. 12, 2746-2756.
2. Bitler, C. M., Zhang, M. B. and Howard, B. D. (1986). PC12 variants deficient in catecholamine transport. J. Neurochem. 47, 1286-1293.
3. Borgonovo, B., Cocucci, E., Racchetti, G., Podini, P., Bachi, A. and Meldolesi, J. (2002). Regulated exocytosis: a novel, widely expressed system. Nat. Cell Biol. 4, 955-962.
4. Chanat, E. and Huttner, W. B. (1991). Milieu-induced, selective aggregation of regulated secretory proteins in the trans-Golgi network. J. Cell Biol. 115, 1505-1519.
5. Chanat, E., Weiss, U., Huttner, W. B. and Tooze, S. A. (1993). Reduction of the disulfide bond of chromogranin B (secretogranin I) in the trans-Golgi network causes its missorting to the constitutive secretory pathways. EMBO J. 12, 2159-2168.
6. Clementi, E., Racchetti, G., Zacchetti, D., Panzeri, M. C. and Meldolesi, J. (1992). Differential expression of markers and activities in a group of PC12 nerve cell clones. Eur. J. Neurosci. 4, 944-953.
7. Colombo, B., Curnis, E., Foglieni, C., Monno, A., Arrigoni, G. and Corti, A. (2002). Chromogranin A expression in neoplastic cells affects tumor growth and morphogenesis in mouse models. Cancer Res. 62, 941-946.
8. Cowley, D. J., Moore, Y. R., Darling, D. S., Joyce, P. B. and Gorr, S. U. (2000). N- and C-terminal domains direct cell type-specific sorting of chromogranin A to secretory granules. J. Biol. Chem. 275, 7743-7748.
9. Dannies, P. S. (1999). Protein hormone storage in secretory granules: mechanisms for concentration and sorting. Endocr. Rev. 20, 3-21.
10. Day, R. and Gorr, S. U. (2002). Secretory granule biogenesis and chromogranin A: master gene, on/off switch or assembly factor? Trends Endocrinol. Metab. 14, 10-13.
11. Gatti, G., Podini, P. and Meldolesi, J. (1997). Overexpression of calsequestrin in L6 myoblasts: formation of endoplasmic reticulum subdomains and their evolution into discrete vacuoles where aggregates of the protein are specifically accumulated. Mol. Biol. Cell 8, 1789-1803.
12. Gerdes, H. H., Rosa, P., Phillips, E., Baeuerle, P. A., Frank, R., Argos, P. and Huttner, W. B. (1989). The primary structure of human secretogranin II, a widespread tyrosine-sulfated secretory granule protein that exhibits low pH- and calcium-induced aggregation. J. Biol. Chem. 264, 12009-12015.
13. Gorr, S. U., Shioi, J. and Cohn, D. V. (1989). Interaction of calcium with porcine adrenal chromogranin A (secretory protein-I) and chromogranin B (secretogranin I). Am. J. Physiol. 257, E247-E254.
14. Grumolato, L., Louiset, E., Alexandre, D., Ait-Ali, D., Turquier, V., Fournier, A., Fasolo, A., Vaudry, H. and Anouar, Y. (2003). PACAP and NGF regulate common and distinct traits of the sympathoadrenal lineage: effects on electrical properties, gene markers and transcription factors in differentiating PC12 cells. Eur. J. Neurosci. 17, 71-82.
15. Grundschober, C., Malosio, M. L., Astolfi, L., Giordano, T., Nef, P. and Meldolesi, J. (2002). Neurosecretion competence. A comprehensive gene expression program identified in PC12 cells. J. Biol. Chem. 277, 36715-36724.
16. Huh, Y. H., Jeon, S. H. and Yoo, S. H. (2003). Chromogranin B-induced secretory granule biogenesis: comparison with the similar role of chromogranin A. J. Biol. Chem. 278, 40581-40589.
17. Jaiswal, J. K., Andrews, N. W. and Simon, S. M. (2002). Membrane proximal lysosomes are the major vesicles responsible for calcium-dependent exocytosis in nonsecretory cells. J. Cell Biol. 159, 625-635.
18. Kim, T., Tao-Cheng, J. H., Eiden, L. E. and Loh, Y. P. (2001). Chromogranin A, an 'on/off' switch controlling dense-core secretory granule biogenesis. Cell 106, 499-509.
19. Kroesen, S., Marksteiner, J., Leitner, B., Hogue-Angeletti, R., Fischer-Colbrie, R. and Winkler, H. (1996). Rat brain: distribution of immunoreactivity of PE-11, a peptide derived from chromogranin B. Eur. J. Neurosci. 8, 2679-2689.
20. Malosio, M. L., Benfante, R., Racchetti, G., Borgonovo, B., Rosa, P. and Meldolesi, J. (1999). Neurosecretory cells without neurosecretion: evidence of an independently regulated trait of the cell phenotype. J. Physiol. 520 Pt 1, 43-52.
21. Pance, A., Morgan, K., Guest, P. C., Bowers, K., Dean, G. E., Cutler, D. F. and Jackson, A. P. (1999). A PC12 variant lacking regulated secretory organelles: aberrant protein targeting and evidence for a factor inhibiting neuroendocrine gene expression. J. Neurochem. 73, 21-30.
22. Reddy, A., Caler, E. V. and Andrews, N. W. (2001). Plasma membrane repair is mediated by Ca(2+)-regulated exocytosis of lysosomes. Cell 106, 157-169.
23. Rustom, A., Bajohrs, M., Kaether, C., Keller, P., Toomre, D., Corbeil, D. and Gerdes, H. H. (2002). Selective delivery of secretory cargo in Golgi-derived carriers of nonepithelial cells. Traffic 3, 279-288.
24. Schafer, M. K., Nohr, D., Romeo, H., Eiden, L. E. and Weihe, E. (1994). Pan-neuronal expression of chromogranin A in rat nervous system. Peptides 15, 263-279.
25. Shoji-Kasai, Y., Yoshida, A., Sato, K., Hoshino, T., Ogura, A., Kondo, S., Fujimoto, Y., Kuwahara, R., Kato, R. and Takahashi, M. (1992). Neurotransmitter release from synaptotagmin-deficient clonal variants of PC12 cells. Science 256, 1821-1823.
26. Thiele, C., Gerdes, H. H. and Huttner, W. B. (1997). Protein secretion: puzzling receptors. Curr. Biol. 7, R496-R500.
27. Tooze, S. A. (1998). Biogenesis of secretory granules in the trans-Golgi network of neuroendocrine and endocrine cells. Biochim. Biophys. Acta 1404, 231-244.
28. Weibel, E. R., Staubli, W., Gnagi, H. R. and Hess, F. A. (1969). Correlated morphometric and biochemical studies on the liver cell. I. Morphometric model, stereologic methods, and normal morphometric data for rat liver. J. Cell Biol. 42, 68-91. f