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Volumn 36, Issue , 2015, Pages 189-198

Screening and modular design for metabolic pathway optimization

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL FUELS; METABOLISM; PRODUCT DESIGN;

EID: 84943574477     PISSN: 09581669     EISSN: 18790429     Source Type: Journal    
DOI: 10.1016/j.copbio.2015.08.013     Document Type: Review
Times cited : (22)

References (60)
  • 1
    • 84925494179 scopus 로고    scopus 로고
    • Metabolic engineering of strains: from industrial-scale to lab-scale chemical production
    • Sun J., Alper H.S. Metabolic engineering of strains: from industrial-scale to lab-scale chemical production. J Ind Microbiol Biotechnol 2015, 42:423-436.
    • (2015) J Ind Microbiol Biotechnol , vol.42 , pp. 423-436
    • Sun, J.1    Alper, H.S.2
  • 2
    • 77953642931 scopus 로고    scopus 로고
    • High-throughput metabolic engineering: advances in small-molecule screening and selection
    • Dietrich J.A., McKee A.E., Keasling J.D. High-throughput metabolic engineering: advances in small-molecule screening and selection. Annu Rev Biochem 2010, 79:563-590.
    • (2010) Annu Rev Biochem , vol.79 , pp. 563-590
    • Dietrich, J.A.1    McKee, A.E.2    Keasling, J.D.3
  • 4
    • 84925538255 scopus 로고    scopus 로고
    • Combinatorial and high-throughput screening approaches for strain engineering
    • Liu W., Jiang R. Combinatorial and high-throughput screening approaches for strain engineering. Appl Microbiol Biotechnol 2015, 99:2093-2104.
    • (2015) Appl Microbiol Biotechnol , vol.99 , pp. 2093-2104
    • Liu, W.1    Jiang, R.2
  • 5
    • 84855863085 scopus 로고    scopus 로고
    • Isolation of improved free fatty acid overproducing strains of Escherichia coli via nile red based high-throughput screening
    • Hoover S.W., Youngquist J.T., Angart P.A., Withers S.T., Lennen R.M., Pfleger B.F. Isolation of improved free fatty acid overproducing strains of Escherichia coli via nile red based high-throughput screening. Environ Prog Sust Energy 2012, 31:17-23.
    • (2012) Environ Prog Sust Energy , vol.31 , pp. 17-23
    • Hoover, S.W.1    Youngquist, J.T.2    Angart, P.A.3    Withers, S.T.4    Lennen, R.M.5    Pfleger, B.F.6
  • 6
    • 84877804801 scopus 로고    scopus 로고
    • Modular optimization of multi-gene pathways for fatty acids production in E. coli
    • Xu P., Gu Q., Wang W., Wong L., Bower A.G., Collins C.H., Koffas M.A. Modular optimization of multi-gene pathways for fatty acids production in E. coli. Nat Commun 2013, 4:1409.
    • (2013) Nat Commun , vol.4 , pp. 1409
    • Xu, P.1    Gu, Q.2    Wang, W.3    Wong, L.4    Bower, A.G.5    Collins, C.H.6    Koffas, M.A.7
  • 7
    • 84876397731 scopus 로고    scopus 로고
    • New options to engineer biofuel microbes: development and application of a high-throughput screening system
    • Scheel M., Lutke-Eversloh T. New options to engineer biofuel microbes: development and application of a high-throughput screening system. Metab Eng 2013, 17:51-58.
    • (2013) Metab Eng , vol.17 , pp. 51-58
    • Scheel, M.1    Lutke-Eversloh, T.2
  • 8
    • 79955164750 scopus 로고    scopus 로고
    • Engineered ketol-acid reductoisomerase and alcohol dehydrogenase enable anaerobic 2-methylpropan-1-ol production at theoretical yield in Escherichia coli
    • Bastian S., Liu X., Meyerowitz J.T., Snow C.D., Chen M.M., Arnold F.H. Engineered ketol-acid reductoisomerase and alcohol dehydrogenase enable anaerobic 2-methylpropan-1-ol production at theoretical yield in Escherichia coli. Metab Eng 2011, 13:345-352.
    • (2011) Metab Eng , vol.13 , pp. 345-352
    • Bastian, S.1    Liu, X.2    Meyerowitz, J.T.3    Snow, C.D.4    Chen, M.M.5    Arnold, F.H.6
  • 9
    • 84866839540 scopus 로고    scopus 로고
    • Structure-guided engineering of Lactococcus lactis alcohol dehydrogenase LlAdhA for improved conversion of isobutyraldehyde to isobutanol
    • Liu X., Bastian S., Snow C.D., Brustad E.M., Saleski T.E., Xu J.H., Meinhold P., Arnold F.H. Structure-guided engineering of Lactococcus lactis alcohol dehydrogenase LlAdhA for improved conversion of isobutyraldehyde to isobutanol. J Biotechnol 2012, 164:188-195.
    • (2012) J Biotechnol , vol.164 , pp. 188-195
    • Liu, X.1    Bastian, S.2    Snow, C.D.3    Brustad, E.M.4    Saleski, T.E.5    Xu, J.H.6    Meinhold, P.7    Arnold, F.H.8
  • 10
    • 84872665471 scopus 로고    scopus 로고
    • Thiolase engineering for enhanced butanol production in Clostridium acetobutylicum
    • Mann M.S., Lutke-Eversloh T. Thiolase engineering for enhanced butanol production in Clostridium acetobutylicum. Biotechnol Bioeng 2013, 110:887-897.
    • (2013) Biotechnol Bioeng , vol.110 , pp. 887-897
    • Mann, M.S.1    Lutke-Eversloh, T.2
  • 11
    • 84859633048 scopus 로고    scopus 로고
    • Design of a dynamic sensor-regulator system for production of chemicals and fuels derived from fatty acids
    • Zhang F., Carothers J.M., Keasling J.D. Design of a dynamic sensor-regulator system for production of chemicals and fuels derived from fatty acids. Nat Biotechnol 2012, 30:354-359.
    • (2012) Nat Biotechnol , vol.30 , pp. 354-359
    • Zhang, F.1    Carothers, J.M.2    Keasling, J.D.3
  • 12
    • 84905668376 scopus 로고    scopus 로고
    • Improving fatty acids production by engineering dynamic pathway regulation and metabolic control
    • Xu P., Li L., Zhang F., Stephanopoulos G., Koffas M. Improving fatty acids production by engineering dynamic pathway regulation and metabolic control. Proc Natl Acad Sci U S A 2014, 111:11299-11304.
    • (2014) Proc Natl Acad Sci U S A , vol.111 , pp. 11299-11304
    • Xu, P.1    Li, L.2    Zhang, F.3    Stephanopoulos, G.4    Koffas, M.5
  • 13
    • 85032942314 scopus 로고    scopus 로고
    • A sense of balance: experimental investigation and modeling of a malonyl-CoA sensor in Escherichia coli
    • Feher T., Libis V., Carbonell P., Faulon J.L. A sense of balance: experimental investigation and modeling of a malonyl-CoA sensor in Escherichia coli. Front Bioeng Biotechnol 2015, 3:46.
    • (2015) Front Bioeng Biotechnol , vol.3 , pp. 46
    • Feher, T.1    Libis, V.2    Carbonell, P.3    Faulon, J.L.4
  • 14
    • 84875515904 scopus 로고    scopus 로고
    • Transcription factor-based screens and synthetic selections for microbial small-molecule biosynthesis
    • Dietrich J.A., Shis D.L., Alikhani A., Keasling J.D. Transcription factor-based screens and synthetic selections for microbial small-molecule biosynthesis. ACS Synth Biol 2013, 2:47-58.
    • (2013) ACS Synth Biol , vol.2 , pp. 47-58
    • Dietrich, J.A.1    Shis, D.L.2    Alikhani, A.3    Keasling, J.D.4
  • 16
    • 84862167101 scopus 로고    scopus 로고
    • High-throughput enzyme evolution in Saccharomyces cerevisiae using a synthetic RNA switch
    • Michener J.K., Smolke C.D. High-throughput enzyme evolution in Saccharomyces cerevisiae using a synthetic RNA switch. Metab Eng 2012, 14:306-316.
    • (2012) Metab Eng , vol.14 , pp. 306-316
    • Michener, J.K.1    Smolke, C.D.2
  • 17
    • 84921476371 scopus 로고    scopus 로고
    • A synthetic suicide riboswitch for the high-throughput screening of metabolite production in Saccharomyces cerevisiae
    • Lee S.W., Oh M.K. A synthetic suicide riboswitch for the high-throughput screening of metabolite production in Saccharomyces cerevisiae. Metab Eng 2015, 28:143-150.
    • (2015) Metab Eng , vol.28 , pp. 143-150
    • Lee, S.W.1    Oh, M.K.2
  • 18
    • 84879999713 scopus 로고    scopus 로고
    • Screening for enhanced triacetic acid lactone production by recombinant Escherichia coli expressing a designed triacetic acid lactone reporter
    • Tang S.Y., Qian S., Akinterinwa O., Frei C.S., Gredell J.A., Cirino P.C. Screening for enhanced triacetic acid lactone production by recombinant Escherichia coli expressing a designed triacetic acid lactone reporter. J Am Chem Soc 2013, 135:10099-10103.
    • (2013) J Am Chem Soc , vol.135 , pp. 10099-10103
    • Tang, S.Y.1    Qian, S.2    Akinterinwa, O.3    Frei, C.S.4    Gredell, J.A.5    Cirino, P.C.6
  • 19
    • 84873455663 scopus 로고    scopus 로고
    • Engineering allosteric control to an unregulated enzyme by transfer of a regulatory domain
    • Cross P.J., Allison T.M., Dobson R.C., Jameson G.B., Parker E.J. Engineering allosteric control to an unregulated enzyme by transfer of a regulatory domain. Proc Natl Acad Sci U S A 2013, 110:2111-2116.
    • (2013) Proc Natl Acad Sci U S A , vol.110 , pp. 2111-2116
    • Cross, P.J.1    Allison, T.M.2    Dobson, R.C.3    Jameson, G.B.4    Parker, E.J.5
  • 20
    • 84879454382 scopus 로고    scopus 로고
    • Directed evolution of a cellobiose utilization pathway in Saccharomyces cerevisiae by simultaneously engineering multiple proteins
    • Eriksen D.T., Hsieh P.C., Lynn P., Zhao H. Directed evolution of a cellobiose utilization pathway in Saccharomyces cerevisiae by simultaneously engineering multiple proteins. Microb Cell Fact 2013, 12:61.
    • (2013) Microb Cell Fact , vol.12 , pp. 61
    • Eriksen, D.T.1    Hsieh, P.C.2    Lynn, P.3    Zhao, H.4
  • 21
    • 84873843576 scopus 로고    scopus 로고
    • Combinatorial design of a highly efficient xylose-utilizing pathway in Saccharomyces cerevisiae for the production of cellulosic biofuels
    • Kim B., Du J., Eriksen D.T., Zhao H. Combinatorial design of a highly efficient xylose-utilizing pathway in Saccharomyces cerevisiae for the production of cellulosic biofuels. Appl Environ Microbiol 2013, 79:931-941.
    • (2013) Appl Environ Microbiol , vol.79 , pp. 931-941
    • Kim, B.1    Du, J.2    Eriksen, D.T.3    Zhao, H.4
  • 22
    • 84874816614 scopus 로고    scopus 로고
    • Engineering improved ethanol production in Escherichia coli with a genome-wide approach
    • Woodruff L.B., Boyle N.R., Gill R.T. Engineering improved ethanol production in Escherichia coli with a genome-wide approach. Metab Eng 2013, 17:1-11.
    • (2013) Metab Eng , vol.17 , pp. 1-11
    • Woodruff, L.B.1    Boyle, N.R.2    Gill, R.T.3
  • 23
    • 33845442201 scopus 로고    scopus 로고
    • Engineering yeast transcription machinery for improved ethanol tolerance and production
    • Alper H., Moxley J., Nevoigt E., Fink G.R., Stephanopoulos G. Engineering yeast transcription machinery for improved ethanol tolerance and production. Science 2006, 314:1565-1568.
    • (2006) Science , vol.314 , pp. 1565-1568
    • Alper, H.1    Moxley, J.2    Nevoigt, E.3    Fink, G.R.4    Stephanopoulos, G.5
  • 24
    • 84893352171 scopus 로고    scopus 로고
    • Rewiring global regulator cAMP receptor protein (CRP) to improve E. coli tolerance towards low PH
    • Basak S., Geng H., Jiang R. Rewiring global regulator cAMP receptor protein (CRP) to improve E. coli tolerance towards low PH. J Biotechnol 2014, 173:68-75.
    • (2014) J Biotechnol , vol.173 , pp. 68-75
    • Basak, S.1    Geng, H.2    Jiang, R.3
  • 25
    • 33845624857 scopus 로고    scopus 로고
    • Microbial sensors for small molecules: development of a mevalonate biosensor
    • Pfleger B.F., Pitera D.J., Newman J.D., Martin V.J., Keasling J.D. Microbial sensors for small molecules: development of a mevalonate biosensor. Metab Eng 2007, 9:30-38.
    • (2007) Metab Eng , vol.9 , pp. 30-38
    • Pfleger, B.F.1    Pitera, D.J.2    Newman, J.D.3    Martin, V.J.4    Keasling, J.D.5
  • 26
    • 79251610629 scopus 로고    scopus 로고
    • Computational design of auxotrophy-dependent microbial biosensors for combinatorial metabolic engineering experiments
    • Tepper N., Shlomi T. Computational design of auxotrophy-dependent microbial biosensors for combinatorial metabolic engineering experiments. PLoS One 2011, 6:e16274.
    • (2011) PLoS One , vol.6 , pp. e16274
    • Tepper, N.1    Shlomi, T.2
  • 27
    • 77955795752 scopus 로고    scopus 로고
    • Screening of a thiamine-auxotrophic yeast for alpha-ketoglutaric acid overproduction
    • Zhou J., Zhou H., Du G., Liu L., Chen J. Screening of a thiamine-auxotrophic yeast for alpha-ketoglutaric acid overproduction. Lett Appl Microbiol 2010, 51:264-271.
    • (2010) Lett Appl Microbiol , vol.51 , pp. 264-271
    • Zhou, J.1    Zhou, H.2    Du, G.3    Liu, L.4    Chen, J.5
  • 28
    • 84900315204 scopus 로고    scopus 로고
    • Microfluidic high-throughput culturing of single cells for selection based on extracellular metabolite production or consumption
    • Wang B.L., Ghaderi A., Zhou H., Agresti J., Weitz D.A., Fink G.R., Stephanopoulos G. Microfluidic high-throughput culturing of single cells for selection based on extracellular metabolite production or consumption. Nat Biotechnol 2014, 32:473-478.
    • (2014) Nat Biotechnol , vol.32 , pp. 473-478
    • Wang, B.L.1    Ghaderi, A.2    Zhou, H.3    Agresti, J.4    Weitz, D.A.5    Fink, G.R.6    Stephanopoulos, G.7
  • 29
    • 84903164690 scopus 로고    scopus 로고
    • A novel platform for automated high-throughput fluxome profiling of metabolic variants
    • Heux S., Poinot J., Massou S., Sokol S., Portais J.C. A novel platform for automated high-throughput fluxome profiling of metabolic variants. Metab Eng 2014, 25:8-19.
    • (2014) Metab Eng , vol.25 , pp. 8-19
    • Heux, S.1    Poinot, J.2    Massou, S.3    Sokol, S.4    Portais, J.C.5
  • 31
    • 84859776222 scopus 로고    scopus 로고
    • The future of metabolic engineering and synthetic biology: towards a systematic practice
    • Yadav V.G., De Mey M., Lim C.G., Ajikumar P.K., Stephanopoulos G. The future of metabolic engineering and synthetic biology: towards a systematic practice. Metab Eng 2012, 14:233-241.
    • (2012) Metab Eng , vol.14 , pp. 233-241
    • Yadav, V.G.1    De Mey, M.2    Lim, C.G.3    Ajikumar, P.K.4    Stephanopoulos, G.5
  • 32
    • 84911920717 scopus 로고    scopus 로고
    • Metabolic pathway balancing and its role in the production of biofuels and chemicals
    • Jones J.A., Toparlak O.D., Koffas M.A. Metabolic pathway balancing and its role in the production of biofuels and chemicals. Curr Opin Biotechnol 2014, 33:52-59.
    • (2014) Curr Opin Biotechnol , vol.33 , pp. 52-59
    • Jones, J.A.1    Toparlak, O.D.2    Koffas, M.A.3
  • 34
    • 84923921660 scopus 로고    scopus 로고
    • Metabolic engineering strategies for microbial synthesis of oleochemicals
    • Pfleger B.F., Gossing M., Nielsen J. Metabolic engineering strategies for microbial synthesis of oleochemicals. Metab Eng 2015, 29:1-11.
    • (2015) Metab Eng , vol.29 , pp. 1-11
    • Pfleger, B.F.1    Gossing, M.2    Nielsen, J.3
  • 36
    • 80051941601 scopus 로고    scopus 로고
    • Engineered reversal of the beta-oxidation cycle for the synthesis of fuels and chemicals
    • Dellomonaco C., Clomburg J.M., Miller E.N., Gonzalez R. Engineered reversal of the beta-oxidation cycle for the synthesis of fuels and chemicals. Nature 2011, 476:355-359.
    • (2011) Nature , vol.476 , pp. 355-359
    • Dellomonaco, C.1    Clomburg, J.M.2    Miller, E.N.3    Gonzalez, R.4
  • 37
    • 84868098920 scopus 로고    scopus 로고
    • Controlled biosynthesis of odd-chain fuels and chemicals via engineered modular metabolic pathways
    • Tseng H.C., Prather K.L. Controlled biosynthesis of odd-chain fuels and chemicals via engineered modular metabolic pathways. Proc Natl Acad Sci U S A 2012, 109:17925-17930.
    • (2012) Proc Natl Acad Sci U S A , vol.109 , pp. 17925-17930
    • Tseng, H.C.1    Prather, K.L.2
  • 39
    • 38049001166 scopus 로고    scopus 로고
    • Non-fermentative pathways for synthesis of branched-chain higher alcohols as biofuels
    • Atsumi S., Hanai T., Liao J.C. Non-fermentative pathways for synthesis of branched-chain higher alcohols as biofuels. Nature 2008, 451:86-89.
    • (2008) Nature , vol.451 , pp. 86-89
    • Atsumi, S.1    Hanai, T.2    Liao, J.C.3
  • 42
    • 84923320438 scopus 로고    scopus 로고
    • Retro-biosynthetic screening of a modular pathway design achieves selective route for microbial synthesis of 4-methyl-pentanol
    • Sheppard M.J., Kunjapur A.M., Wenck S.J., Prather K.L. Retro-biosynthetic screening of a modular pathway design achieves selective route for microbial synthesis of 4-methyl-pentanol. Nat Commun 2014, 5:5031.
    • (2014) Nat Commun , vol.5 , pp. 5031
    • Sheppard, M.J.1    Kunjapur, A.M.2    Wenck, S.J.3    Prather, K.L.4
  • 43
    • 84868481932 scopus 로고    scopus 로고
    • Improved 2-methyl-1-propanol production in an engineered Bacillus subtilis by constructing inducible pathways
    • Li S., Jia X., Wen J. Improved 2-methyl-1-propanol production in an engineered Bacillus subtilis by constructing inducible pathways. Biotechnol Lett 2012, 34:2253-2258.
    • (2012) Biotechnol Lett , vol.34 , pp. 2253-2258
    • Li, S.1    Jia, X.2    Wen, J.3
  • 46
    • 84922980443 scopus 로고    scopus 로고
    • Integrated engineering of beta-oxidation reversal and omega-oxidation pathways for the synthesis of medium chain omega-functionalized carboxylic acids
    • Clomburg J.M., Blankschien M.D., Vick J.E., Chou A., Kim S., Gonzalez R. Integrated engineering of beta-oxidation reversal and omega-oxidation pathways for the synthesis of medium chain omega-functionalized carboxylic acids. Metab Eng 2015, 28:202-212.
    • (2015) Metab Eng , vol.28 , pp. 202-212
    • Clomburg, J.M.1    Blankschien, M.D.2    Vick, J.E.3    Chou, A.4    Kim, S.5    Gonzalez, R.6
  • 47
    • 84893503533 scopus 로고    scopus 로고
    • Metabolic engineering of Escherichia coli for production of fatty acid short-chain esters through combination of the fatty acid and 2-keto acid pathways
    • Guo D., Zhu J., Deng Z., Liu T. Metabolic engineering of Escherichia coli for production of fatty acid short-chain esters through combination of the fatty acid and 2-keto acid pathways. Metab Eng 2014, 22:69-75.
    • (2014) Metab Eng , vol.22 , pp. 69-75
    • Guo, D.1    Zhu, J.2    Deng, Z.3    Liu, T.4
  • 48
    • 84865278391 scopus 로고    scopus 로고
    • Successes and failures in modular genetic engineering
    • Kittleson J.T., Wu G.C., Anderson J.C. Successes and failures in modular genetic engineering. Curr Opin Chem Biol 2012, 16:329-336.
    • (2012) Curr Opin Chem Biol , vol.16 , pp. 329-336
    • Kittleson, J.T.1    Wu, G.C.2    Anderson, J.C.3
  • 49
    • 84866953925 scopus 로고    scopus 로고
    • Modular control of multiple pathways using engineered orthogonal T7 polymerases
    • Temme K., Hill R., Segall-Shapiro T.H., Moser F., Voigt C.A. Modular control of multiple pathways using engineered orthogonal T7 polymerases. Nucleic Acids Res 2012, 40:8773-8781.
    • (2012) Nucleic Acids Res , vol.40 , pp. 8773-8781
    • Temme, K.1    Hill, R.2    Segall-Shapiro, T.H.3    Moser, F.4    Voigt, C.A.5
  • 50
    • 84964240931 scopus 로고    scopus 로고
    • Autonomous production of 1,4-butanediol via a de novo biosynthesis pathway in engineered Escherichia coli
    • Liu H., Lu T. Autonomous production of 1,4-butanediol via a de novo biosynthesis pathway in engineered Escherichia coli. Metab Eng 2015, 29:135-141.
    • (2015) Metab Eng , vol.29 , pp. 135-141
    • Liu, H.1    Lu, T.2
  • 51
    • 8544223537 scopus 로고    scopus 로고
    • Hierarchical thinking in network biology: the unbiased modularization of biochemical networks
    • Papin J.A., Reed J.L., Palsson B.O. Hierarchical thinking in network biology: the unbiased modularization of biochemical networks. Trends Biochem Sci 2004, 29:641-647.
    • (2004) Trends Biochem Sci , vol.29 , pp. 641-647
    • Papin, J.A.1    Reed, J.L.2    Palsson, B.O.3
  • 53
  • 54
    • 84890395226 scopus 로고    scopus 로고
    • Expression-level optimization of a multi-enzyme pathway in the absence of a high-throughput assay
    • Lee M.E., Aswani A., Han A.S., Tomlin C.J., Dueber J.E. Expression-level optimization of a multi-enzyme pathway in the absence of a high-throughput assay. Nucleic Acids Res 2013, 41:10668-10678.
    • (2013) Nucleic Acids Res , vol.41 , pp. 10668-10678
    • Lee, M.E.1    Aswani, A.2    Han, A.S.3    Tomlin, C.J.4    Dueber, J.E.5
  • 55
    • 84874796954 scopus 로고    scopus 로고
    • Synergy as design principle for metabolic engineering of 1-propanol production in Escherichia coli
    • Shen C.R., Liao J.C. Synergy as design principle for metabolic engineering of 1-propanol production in Escherichia coli. Metab Eng 2013, 17:12-22.
    • (2013) Metab Eng , vol.17 , pp. 12-22
    • Shen, C.R.1    Liao, J.C.2
  • 57
    • 84879830242 scopus 로고    scopus 로고
    • Investigating host dependence of xylose utilization in recombinant Saccharomyces cerevisiae strains using RNA-seq analysis
    • Feng X., Zhao H. Investigating host dependence of xylose utilization in recombinant Saccharomyces cerevisiae strains using RNA-seq analysis. Biotechnol Biofuels 2013, 6:96.
    • (2013) Biotechnol Biofuels , vol.6 , pp. 96
    • Feng, X.1    Zhao, H.2
  • 59
    • 84899555105 scopus 로고    scopus 로고
    • Isobutanol production at elevated temperatures in thermophilic Geobacillus thermoglucosidasius
    • Lin P.P., Rabe K.S., Takasumi J.L., Kadisch M., Arnold F.H., Liao J.C. Isobutanol production at elevated temperatures in thermophilic Geobacillus thermoglucosidasius. Metab Eng 2014, 24:1-8.
    • (2014) Metab Eng , vol.24 , pp. 1-8
    • Lin, P.P.1    Rabe, K.S.2    Takasumi, J.L.3    Kadisch, M.4    Arnold, F.H.5    Liao, J.C.6


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