Engineering allosteric control to an unregulated enzyme by transfer of a regulatory domain

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 6, 2013, Pages 2111-2116

  Cross, Penelope J ^a   Allison, Timothy M ^a   Dobson, Renwick C J ^a,b   Jameson, Geoffrey B ^c   Parker, Emily J ^a  

^a UNIVERSITY OF CANTERBURY   (New Zealand)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c MASSEY UNIVERSITY   (New Zealand)

Author keywords

ACT domain; Shikimate

Indexed keywords

3 DEOXY 7 PHOSPHOHEPTULONATE SYNTHASE; CHAPERONIN; CHIMERIC PROTEIN; HYBRID PROTEIN; SHIKIMIC ACID;

ALLOSTERISM; ARTICLE; BIOSYNTHESIS; GENE FUSION; MOLECULAR CLONING; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN CONFORMATION; PROTEIN EXPRESSION; X RAY CRYSTALLOGRAPHY;

3-DEOXY-7-PHOSPHOHEPTULONATE SYNTHASE; ALLOSTERIC REGULATION; ALLOSTERIC SITE; AMINO ACID SEQUENCE; AMINO ACIDS, AROMATIC; BACTERIAL PROTEINS; CRYSTALLOGRAPHY, X-RAY; EVOLUTION, MOLECULAR; GENE FUSION; GENES, BACTERIAL; KINETICS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN CONFORMATION; PROTEIN ENGINEERING; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, TERTIARY; PROTEIN SUBUNITS; PYROCOCCUS FURIOSUS; RECOMBINANT FUSION PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; THERMOTOGA MARITIMA; TYROSINE;

EID: 84873455663     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1217923110     Document Type: Article

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