Metabolic flux elucidation for large-scale models using 13C labeled isotopes

Metabolic Engineering

Volumn 9, Issue 5-6, 2007, Pages 387-405

  Suthers, Patrick F ^a   Burgard, Anthony P ^b   Dasika, Madhukar S ^a   Nowroozi, Farnaz ^c   Van Dien, Stephen ^b   Keasling, Jay D ^c   Maranas, Costas D ^a  

^a The Pennsylvania State University   (United States)

^b GENOMATICA INC   (United States)

^c University of California   (United States)

Author keywords

Constraint based modeling; Isotope labeling; Metabolic flux analysis; Nonlinear optimization; Statistical analysis

Indexed keywords

AMINO ACIDS; CELLS; COMPUTATIONAL METHODS; ESCHERICHIA COLI; ISOTOPES; MATHEMATICAL MODELS; METABOLITES; OPTIMIZATION; STATISTICAL METHODS;

CONSTRAINT BASED MODELINGS; ISOTOPE LABELINGS; METABOLIC FLUX ANALYSIS; NONLINEAR OPTIMIZATIONS;

METABOLISM;

ADENOSINE TRIPHOSPHATE; ARTEMISIN; CARBON 13; GLUCOSE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE;

ARTICLE; ESCHERICHIA COLI; ISOTOPE LABELING; METABOLIC ENGINEERING; METABOLIC REGULATION; METABOLITE; NONHUMAN; NONLINEAR SYSTEM; PRIORITY JOURNAL; PROCESS OPTIMIZATION; STATISTICAL ANALYSIS;

ADENOSINE TRIPHOSPHATE; BIOREACTORS; CARBON ISOTOPES; CELLS, CULTURED; ENERGY METABOLISM; ESCHERICHIA COLI; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; ISOTOPE LABELING; MATHEMATICS; MODELS, BIOLOGICAL; NAD; NADP; SESQUITERPENES;

ESCHERICHIA COLI;

EID: 35548947590     PISSN: 10967176     EISSN: 10967184     Source Type: Journal    
DOI: 10.1016/j.ymben.2007.05.005     Document Type: Article

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