AMG 837: A potent, orally bioavailable GPR40 agonist

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 2, 2012, Pages 1267-1270

  Houze, Jonathan B ^a   Zhu, Liusheng ^a   Sun, Ying ^a   Akerman, Michelle ^a   Qiu, Wei ^a   Zhang, Alex J ^a   Sharma, Rajiv ^a   Schmitt, Michael ^a   Wang, Yingcai ^a   Liu, Jiwen ^a   Liu, Jinqian ^a   Medina, Julio C ^a   Reagan, Jeff D ^a   Luo, Jian ^a   Tonn, George ^a   Zhang, Jane ^a   Lu, Jenny Ying Lin ^a   Chen, Michael ^a   Lopez, Edwin ^a   Nguyen, Kathy ^a   Yang, Li ^a   Tang, Liang ^a   Tian, Hui ^a   Shuttleworth, Steven J ^a   Lin, Daniel C H ^a   more..

^a AMGEN INC   (United States)

Author keywords

Agonist; Anti diabetic; FFA1; GPCR; GPR40; Insulin; Secretagogue

Indexed keywords

3 [4 [[40 (TRIFLUOROMETHYL)BIPHENYL 3 YL]METHOXY]PHENYL]HEX 4 YNOIC ACID; AMG 837; ANTIDIABETIC AGENT; G PROTEIN COUPLED RECEPTOR 40; GLUCOSE; SITAGLIPTIN; UNCLASSIFIED DRUG;

AREA UNDER THE CURVE; ARTICLE; DECARBOXYLATION; DRUG ACTIVITY; DRUG CLEARANCE; DRUG HALF LIFE; DRUG HYDROLYSIS; DRUG STRUCTURE; DRUG SYNTHESIS; GLUCOSE BLOOD LEVEL; INSULIN RELEASE; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; ORAL GLUCOSE TOLERANCE TEST;

ADMINISTRATION, ORAL; ANIMALS; BIOLOGICAL AVAILABILITY; BIPHENYL COMPOUNDS; DOSE-RESPONSE RELATIONSHIP, DRUG; MICE; MICE, KNOCKOUT; MOLECULAR STRUCTURE; RECEPTORS, G-PROTEIN-COUPLED; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

RODENTIA;

EID: 84855673463     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.10.118     Document Type: Article

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