메뉴 건너뛰기




Volumn 6, Issue 7, 2015, Pages 722-725

Molecular Property Design: Does Everyone Get It?

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; DRUG DESIGN; DRUG INDUSTRY; DRUG METABOLISM; HUMAN; HYDROGEN BOND; HYDROPHOBICITY; LIPOPHILICITY; MOLECULAR INTERACTION; MOLECULAR WEIGHT; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; SYNTHESIS;

EID: 84938495908     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/acsmedchemlett.5b00157     Document Type: Article
Times cited : (119)

References (15)
  • 1
    • 0023546523 scopus 로고
    • Hydrophobicity and central nervous system agents: on the principle of minimal hydrophobicity in drug design
    • Hansch, C.; Björkroth, J. P.; Leo, A. Hydrophobicity and central nervous system agents: on the principle of minimal hydrophobicity in drug design J. Pharm. Sci. 1987, 76, 663-687
    • (1987) J. Pharm. Sci. , vol.76 , pp. 663-687
    • Hansch, C.1    Björkroth, J.P.2    Leo, A.3
  • 3
    • 35748934487 scopus 로고    scopus 로고
    • The influence of drug-like concepts on decision-making in medicinal chemistry
    • Leeson, P. D.; Springthorpe, B. The influence of drug-like concepts on decision-making in medicinal chemistry Nat. Rev. Drug Discovery 2007, 6, 881-890
    • (2007) Nat. Rev. Drug Discovery , vol.6 , pp. 881-890
    • Leeson, P.D.1    Springthorpe, B.2
  • 4
    • 80053471789 scopus 로고    scopus 로고
    • The influence of the 'organizational factor' on compound quality in drug discovery
    • Leeson, P. D.; St-Gallay, S. A. The influence of the 'organizational factor' on compound quality in drug discovery Nat. Rev. Drug Discovery 2011, 10, 749-765
    • (2011) Nat. Rev. Drug Discovery , vol.10 , pp. 749-765
    • Leeson, P.D.1    St-Gallay, S.A.2
  • 5
    • 79851508525 scopus 로고    scopus 로고
    • Impact of ion class and time on oral drug molecular properties
    • Leeson, P. D.; St-Gallay, S. A.; Wenlock, M. C. Impact of ion class and time on oral drug molecular properties MedChemComm 2011, 2, 91-105
    • (2011) MedChemComm , vol.2 , pp. 91-105
    • Leeson, P.D.1    St-Gallay, S.A.2    Wenlock, M.C.3
  • 6
    • 80052844344 scopus 로고    scopus 로고
    • Getting physical in drug discovery II: the impact of chromatographic hydrophobicity measurements and aromaticity
    • Young, R. J.; Green, D. V.; Luscombe, C. N.; Hill, A. P. Getting physical in drug discovery II: the impact of chromatographic hydrophobicity measurements and aromaticity Drug Discovery Today 2011, 16, 822-830
    • (2011) Drug Discovery Today , vol.16 , pp. 822-830
    • Young, R.J.1    Green, D.V.2    Luscombe, C.N.3    Hill, A.P.4
  • 7
    • 77950560159 scopus 로고    scopus 로고
    • An analysis of the binding efficiencies of drugs and their leads in successful drug discovery programs
    • Perola, E. An analysis of the binding efficiencies of drugs and their leads in successful drug discovery programs J. Med. Chem. 2010, 53, 2986-2997
    • (2010) J. Med. Chem. , vol.53 , pp. 2986-2997
    • Perola, E.1
  • 8
    • 84860690620 scopus 로고    scopus 로고
    • Can the flow of medicines be improved? Fundamental pharmacokinetic and pharmacological principles toward improving Phase II survival
    • Morgan, P.; Van Der Graaf, P. H.; Arrowsmith, J.; Feltner, D. E.; Drummond, K. S.; Wegner, C. D.; Street, S. D. A. Can the flow of medicines be improved? Fundamental pharmacokinetic and pharmacological principles toward improving Phase II survival Drug Discovery Today 2012, 17, 419-424
    • (2012) Drug Discovery Today , vol.17 , pp. 419-424
    • Morgan, P.1    Van Der Graaf, P.H.2    Arrowsmith, J.3    Feltner, D.E.4    Drummond, K.S.5    Wegner, C.D.6    Street, S.D.A.7
  • 12
    • 0031024171 scopus 로고    scopus 로고
    • Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
    • Lipinksi, C. A.; Lombardo, F.; Dominy, B. W.; Feeney, P. J. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings Adv. Drug Delivery Rev. 1997, 23, 3-25
    • (1997) Adv. Drug Delivery Rev. , vol.23 , pp. 3-25
    • Lipinksi, C.A.1    Lombardo, F.2    Dominy, B.W.3    Feeney, P.J.4
  • 13
    • 84871126379 scopus 로고    scopus 로고
    • What can we learn from the evolution of protein-ligand interactions to aid the design of new therapeutics?
    • Higueruelo, A. P.; Schreyer, A. G.; Bickerton, G. R. J.; Blundell, T. L.; Pitt, W. R. What can we learn from the evolution of protein-ligand interactions to aid the design of new therapeutics? PLoS One 2012, 7 (12) e51742
    • (2012) PLoS One , vol.7 , Issue.12
    • Higueruelo, A.P.1    Schreyer, A.G.2    Bickerton, G.R.J.3    Blundell, T.L.4    Pitt, W.R.5
  • 15
    • 80052830823 scopus 로고    scopus 로고
    • How well do medicinal chemists learn from experience?
    • Cheshire, D. R. How well do medicinal chemists learn from experience? Drug Discovery Today 2011, 16, 817-821
    • (2011) Drug Discovery Today , vol.16 , pp. 817-821
    • Cheshire, D.R.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.