Identification of fused-ring alkanoic acids with improved pharmacokinetic profiles that Act as G protein-coupled receptor 40/free fatty acid receptor 1 agonists

Journal of Medicinal Chemistry

Volumn 55, Issue 4, 2012, Pages 1538-1552

  Negoro, Nobuyuki ^a   Sasaki, Shinobu ^a   Ito, Masahiro ^a   Kitamura, Shuji ^a   Tsujihata, Yoshiyuki ^a   Ito, Ryo ^a   Suzuki, Masami ^a   Takeuchi, Koji ^a   Suzuki, Nobuhiro ^a   Miyazaki, Junichi ^a   Santou, Takashi ^a   Odani, Tomoyuki ^a   Kanzaki, Naoyuki ^a   Funami, Miyuki ^a   Tanaka, Toshimasa ^a   Yasuma, Tsuneo ^a   Momose, Yu ^a  

^a TAKEDA PHARMACEUTICAL COMPANY LIMITED   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

3 [4 [(2',6' DIMETHYLBIPHENYL 3 YL)METHOXY] 2 FLUOROPHENYL]PROPANOIC ACID; [6 [[4' (2 ETHOXYETHOXY) 2',6' DIMETHYLBIPHENYL 3 YL]METHOXY] 2,3 DIHYDRO 1 BENZOFURAN 3 YL]ACETIC ACID; AGENTS INTERACTING WITH TRANSMITTER, HORMONE OR DRUG RECEPTORS; ALKANOIC ACID; ANTIDIABETIC AGENT; DIHYDROBENZOFURAN DERIVATIVE; FUSED HETEROCYCLIC RINGS; G PROTEIN COUPLED RECEPTOR 40; G PROTEIN COUPLED RECEPTOR 40 AGONIST; GLUCOSE; INSULIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG EFFICACY; DRUG IDENTIFICATION; DRUG RECEPTOR BINDING; FEMALE; GLUCOSE BLOOD LEVEL; IMPAIRED GLUCOSE TOLERANCE; INSULIN BLOOD LEVEL; LIPOPHILICITY; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; ORAL GLUCOSE TOLERANCE TEST; RAT; SPECIES DIFFERENCE; STRUCTURE ACTIVITY RELATION; TIME TO MAXIMUM PLASMA CONCENTRATION;

ACETATES; ACIDS, ACYCLIC; ANIMALS; BENZOFURANS; CHO CELLS; CRICETINAE; CRICETULUS; FEMALE; GLUCOSE INTOLERANCE; GLUCOSE TOLERANCE TEST; HUMANS; INSULIN; MODELS, MOLECULAR; PROTEIN BINDING; RATS; RATS, WISTAR; RECEPTORS, G-PROTEIN-COUPLED; SPECIES SPECIFICITY;

EID: 84863115309     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm2012968     Document Type: Article

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