메뉴 건너뛰기




Volumn 180, Issue 10, 2015, Pages 67-75

Air force research laboratory integrated omics research

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; DANGEROUS GOODS; HYDROCARBON; JP8 AVIATION FUEL;

EID: 84943526433     PISSN: 00264075     EISSN: 1930613X     Source Type: Journal    
DOI: 10.7205/MILMED-D-15-00051     Document Type: Article
Times cited : (5)

References (54)
  • 2
    • 0032694577 scopus 로고    scopus 로고
    • Metabonomics: Understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data
    • Nicholson JK, Lindon JC, Holmes E: ‘Metabonomics’: understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data. Xenobiotica 1999; 29: 1181-9.
    • (1999) Xenobiotica , vol.29 , pp. 1181-1189
    • Nicholson, J.K.1    Lindon, J.C.2    Holmes, E.3
  • 3
    • 0042338519 scopus 로고    scopus 로고
    • So what’s the deal with metabonomics?
    • Lindon JC, Holmes E, Nicholson JK: So what’s the deal with metabonomics? Anal Chem 2003; 75: 385A-91A.
    • (2003) Anal Chem , vol.75 , pp. 385A-391A
    • Lindon, J.C.1    Holmes, E.2    Nicholson, J.K.3
  • 4
    • 29644443175 scopus 로고    scopus 로고
    • Liquid chromatography-mass spectrometric analysis of urinary metabolites and their pattern recognition for the prediction of drug-induced hepatotoxicity
    • La S, Yoo HH, Kim, D-H: Liquid chromatography-mass spectrometric analysis of urinary metabolites and their pattern recognition for the prediction of drug-induced hepatotoxicity. ChemRes Toxicol 2005; 18: 1887-96.
    • (2005) Chemres Toxicol , vol.18 , pp. 1887-1896
    • La, S.1    Yoo, H.H.2    Kim, D.-H.3
  • 5
    • 20544466649 scopus 로고    scopus 로고
    • Metabonomics in toxicology: A review
    • Robertson DG: Metabonomics in toxicology: a review. Toxicol Sci 2005; 85: 809-22.
    • (2005) Toxicol Sci , vol.85 , pp. 809-822
    • Robertson, D.G.1
  • 7
    • 0345490738 scopus 로고    scopus 로고
    • A 1H NMR-based metabonomic study of urine and plasma samples obtained from healthy human subjects
    • Lenz E, Bright J, Wilson I, Morgan S, Nash A: A 1H NMR-based metabonomic study of urine and plasma samples obtained from healthy human subjects. J Pharm Biomed Anal 2003; 33: 1103-15.
    • (2003) J Pharm Biomed Anal , vol.33 , pp. 1103-1115
    • Lenz, E.1    Bright, J.2    Wilson, I.3    Morgan, S.4    Nash, A.5
  • 8
    • 0036384102 scopus 로고    scopus 로고
    • NMR-based Metabolomics
    • Reo NV: NMR-based Metabolomics. Drug Chem Toxicol 2002; 25: 375-82.
    • (2002) Drug Chem Toxicol , vol.25 , pp. 375-382
    • Reo, N.V.1
  • 9
    • 0034130232 scopus 로고    scopus 로고
    • Chemometric models for toxicity clarification based on NMR spectra of biofluids
    • Holmes E, Nicholls AW, Lindon JC, et al: Chemometric models for toxicity clarification based on NMR spectra of biofluids. Chem Res Toxicol 2000; 13: 471-8.
    • (2000) Chem Res Toxicol , vol.13 , pp. 471-478
    • Holmes, E.1    Nicholls, A.W.2    Lindon, J.C.3
  • 10
    • 0033968994 scopus 로고    scopus 로고
    • Accelerated toxicity screening using NMR and pattern recognition-based methods
    • Holmes E, Shockcor JP: Accelerated toxicity screening using NMR and pattern recognition-based methods. Curr Opin Drug Discovery Dev 2000; 3: 72-8.
    • (2000) Curr Opin Drug Discovery Dev , vol.3 , pp. 72-78
    • Holmes, E.1    Shockcor, J.P.2
  • 11
    • 7344256122 scopus 로고    scopus 로고
    • Development of a model for classification of toxin-induced lesions using 1H NMR spectroscopy of urine combined with pattern recognition
    • Holmes E, Nicholl AW, Lindon JC, et al: Development of a model for classification of toxin-induced lesions using 1H NMR spectroscopy of urine combined with pattern recognition. NMRBiomed 1998; 11: 235-44.
    • (1998) Nmrbiomed , vol.11 , pp. 235-244
    • Holmes, E.1    Nicholl, A.W.2    Lindon, J.C.3
  • 12
    • 18744396052 scopus 로고    scopus 로고
    • Analytical reproducibility in (1)H NMR-basedmetabonomic urinalysis
    • Keun HC, Ebbels TM, Antti H, et al: Analytical reproducibility in (1)H NMR-basedmetabonomic urinalysis. ChemRes Toxicol 2000; 15: 1380-86.
    • (2000) Chemres Toxicol , vol.15 , pp. 1380-1386
    • Keun, H.C.1    Ebbels, T.M.2    Antti, H.3
  • 13
    • 0033795182 scopus 로고    scopus 로고
    • Metabonomics: Evaluation of nuclear magnetic resonance (NMR) and pattern recognition technology for rapid in vivo screening of liver and kidney toxicants
    • Robertson DG, Reily MD, Sigler RE, Wells DF, Paterson DA, Braden TK: Metabonomics: evaluation of nuclear magnetic resonance (NMR) and pattern recognition technology for rapid in vivo screening of liver and kidney toxicants. Toxicol Sci 2000; 57: 326-37.
    • (2000) Toxicol Sci , vol.57 , pp. 326-337
    • Robertson, D.G.1    Reily, M.D.2    Sigler, R.E.3    Wells, D.F.4    Paterson, D.A.5    Braden, T.K.6
  • 14
    • 0036639485 scopus 로고    scopus 로고
    • NMR and pattern recognition studies on liver extracts and intact livers fromrats treated with alpha-naphthylisothiocyanate
    • Waters NJ, Holmes E, Waterfield CJ, Farrant RD, Nicholson JK: NMR and pattern recognition studies on liver extracts and intact livers fromrats treated with alpha-naphthylisothiocyanate. BiochemPharmacol 2002; 64: 67-77.
    • (2002) Biochempharmacol , vol.64 , pp. 67-77
    • Waters, N.J.1    Holmes, E.2    Waterfield, C.J.3    Farrant, R.D.4    Nicholson, J.K.5
  • 16
    • 16244402990 scopus 로고    scopus 로고
    • Metabolomics: Current analytical platforms and methodologies
    • Dunn WB, Ellis DI: Metabolomics: current analytical platforms and methodologies. Trend Anal Chem 2005; 24: 285-94.
    • (2005) Trend Anal Chem , vol.24 , pp. 285-294
    • Dunn, W.B.1    Ellis, D.I.2
  • 17
    • 0016711037 scopus 로고
    • High resolution two dimensional electrophoresis of proteins
    • O’Farrell P: High resolution two dimensional electrophoresis of proteins. J Biol Chem 1975; 250: 4007-21.
    • (1975) J Biol Chem , vol.250 , pp. 4007-4021
    • O’Farrell, P.1
  • 18
    • 84943558595 scopus 로고    scopus 로고
    • Biomarkers of Exposure to Toxic Substances
    • Air Force Research Laboratory Technical Report AFRL-RH-WP-TR-2009-0104. Dayton, OH, Wright-Patterson AFB, Available at, accessed May 22, 2014
    • Shiyanov P, Pitsch R, Qi L, Chen J: Biomarkers of Exposure to Toxic Substances, Vol. 3: Proteomics; Biomarkers to Kidney and Organ Damage. Air Force Research Laboratory Technical Report AFRL-RH-WP-TR-2009-0104. Dayton, OH, Wright-Patterson AFB, 2009. Available at http://www.dtic.mil/dtic/tr/fulltext/u2/a521156.pdf; accessed May 22, 2014.
    • (2009) Proteomics; Biomarkers to Kidney and Organ Damage , vol.3
    • Shiyanov, P.1    Pitsch, R.2    Qi, L.3    Chen, J.4
  • 20
    • 84943530061 scopus 로고    scopus 로고
    • Proteome analysis of human plasma with the ProteomeLab PF 2D system
    • Located at Jaz D Lifesciences. Available at, accessed February 18, 2015
    • Simonian MH, Betgovargez E: Proteome analysis of human plasma with the ProteomeLab PF 2D system. Beckman Coulter Application Information Bulletin A-1963A. 2003. Located at Jaz D Lifesciences. Available at http://www.jazdlifesciences.com/pharmatech/research/Beckman-Coulter-Inc.htm?contentSetId=34692; accessed February 18, 2015.
    • (2003) Beckman Coulter Application Information Bulletin A-1963A
    • Simonian, M.H.1    Betgovargez, E.2
  • 21
    • 31644445293 scopus 로고    scopus 로고
    • Analysis of glioma cell platinum response by metacomparison of two-dimensional chromatographic proteome profiles
    • Billecke C, Malik I, Movsisyan SS, et al: Analysis of glioma cell platinum response by metacomparison of two-dimensional chromatographic proteome profiles. Mol Cell Proteomics 2006; 5: 35-42.
    • (2006) Mol Cell Proteomics , vol.5 , pp. 35-42
    • Billecke, C.1    Malik, I.2    Movsisyan, S.S.3
  • 22
    • 33746566563 scopus 로고    scopus 로고
    • Proteomic analysis of rat plasma by twodimensional liquid chromatography and matrix-assisted laser desorption ionization time-of-flight mass spectrometry
    • Linke T, Ross AC, Harrison EH: Proteomic analysis of rat plasma by twodimensional liquid chromatography and matrix-assisted laser desorption ionization time-of-flight mass spectrometry. J Chromatogr A 2006; 1123(2): 160-9.
    • (2006) J Chromatogr A , vol.1123 , Issue.2 , pp. 160-169
    • Linke, T.1    Ross, A.C.2    Harrison, E.H.3
  • 23
    • 0037176234 scopus 로고    scopus 로고
    • Two-dimensional separations— mass mapping of proteins from human cancer cell lysates
    • Lubman DM, Kachman MT, Wang H, et al: Two-dimensional separations— mass mapping of proteins from human cancer cell lysates. J Chromatogr B 2002; 782: 183-96.
    • (2002) J Chromatogr B , vol.782 , pp. 183-196
    • Lubman, D.M.1    Kachman, M.T.2    Wang, H.3
  • 24
    • 31644437051 scopus 로고    scopus 로고
    • Classification of cancer cell lines using an automated two-dimensional liquid mapping method with hierarchical clustering techniques
    • Wang Y, Wu R, Cho KR, Shedden KA, Barder TJ, Lubman DM: Classification of cancer cell lines using an automated two-dimensional liquid mapping method with hierarchical clustering techniques. Mol Cell Proteomics 2006; 5: 43-52.
    • (2006) Mol Cell Proteomics , vol.5 , pp. 43-52
    • Wang, Y.1    Wu, R.2    Cho, K.R.3    Shedden, K.A.4    Barder, T.J.5    Lubman, D.M.6
  • 25
    • 0037025008 scopus 로고    scopus 로고
    • Three-dimensional protein map according to pI, hydrophobicity and molecular mass
    • Wall DB, Parus SF, Lubman DM: Three-dimensional protein map according to pI, hydrophobicity and molecular mass. J Chromatogr B 2002; 774(1): 53-8.
    • (2002) J Chromatogr B , vol.774 , Issue.1 , pp. 53-58
    • Wall, D.B.1    Parus, S.F.2    Lubman, D.M.3
  • 26
    • 0029685702 scopus 로고    scopus 로고
    • Analytical properties of the nanoelectrospray ion source
    • Wilm M, Mann M: Analytical properties of the nanoelectrospray ion source. Anal Chem 1996; 68: 1-8.
    • (1996) Anal Chem , vol.68 , pp. 1-8
    • Wilm, M.1    Mann, M.2
  • 27
    • 0030026070 scopus 로고    scopus 로고
    • Femtomole sequencing of proteins from polyacrylamide gels by nano-electrospray mass spectrometry
    • Wilm M, Shevchenko A, Houthaeve T, et al: Femtomole sequencing of proteins from polyacrylamide gels by nano-electrospray mass spectrometry. Nature 1996; 379: 466-69.
    • (1996) Nature , vol.379 , pp. 466-469
    • Wilm, M.1    Shevchenko, A.2    Houthaeve, T.3
  • 28
    • 0036583926 scopus 로고    scopus 로고
    • Stable isotope labeling by amino acids in cell culture, SILAC, as a simple and accurate approach to expression proteomics
    • Ong SE, Blagoev B, Kratchmarova I, et al: Stable isotope labeling by amino acids in cell culture, SILAC, as a simple and accurate approach to expression proteomics. Mol Cell Proteomics 2002; 1(5): 376-86.
    • (2002) Mol Cell Proteomics , vol.1 , Issue.5 , pp. 376-386
    • Ong, S.E.1    Blagoev, B.2    Kratchmarova, I.3
  • 29
    • 12444345515 scopus 로고    scopus 로고
    • Tandem mass tags: A novel quantification strategy for comparative analysis of complex protein mixtures by MS/MS
    • Thompson A, Schäfer J, Kuhn K, et al: Tandem mass tags: a novel quantification strategy for comparative analysis of complex protein mixtures by MS/MS. Anal Chem 2003; 75(8): 1895-904.
    • (2003) Anal Chem , vol.75 , Issue.8 , pp. 1895-1904
    • Thompson, A.1    Schäfer, J.2    Kuhn, K.3
  • 30
    • 19944432197 scopus 로고    scopus 로고
    • Multiplexed protein quantitation in Saccharomyces cerevisiae using aminereactive isobaric tagging reagents
    • Ross PL, Huang YN, Marchese JN, et al: Multiplexed protein quantitation in Saccharomyces cerevisiae using aminereactive isobaric tagging reagents. Mol Cell Proteomics 2004; 3(12): 1154-69.
    • (2004) Mol Cell Proteomics , vol.3 , Issue.12 , pp. 1154-1169
    • Ross, P.L.1    Huang, Y.N.2    Marchese, J.N.3
  • 31
    • 33847174067 scopus 로고    scopus 로고
    • Protein labeling by iTRAQ: A new tool for quantitative mass spectrometry in proteome research
    • Wiese S, Reidegeld KA, Meyer HE, Warscheid B: Protein labeling by iTRAQ: a new tool for quantitative mass spectrometry in proteome research. Proteomics 2007; 7(3): 340-50.
    • (2007) Proteomics , vol.7 , Issue.3 , pp. 340-350
    • Wiese, S.1    Reidegeld, K.A.2    Meyer, H.E.3    Warscheid, B.4
  • 33
    • 84897500817 scopus 로고    scopus 로고
    • Combining amine metabolomics and quantitative proteomics of cancer cells using derivatization with isobaric tags
    • Murphy JP, Everley RA, Coloff JL, Gygi SP: Combining amine metabolomics and quantitative proteomics of cancer cells using derivatization with isobaric tags. Anal Chem 2014; 86(7): 3585-93.
    • (2014) Anal Chem , vol.86 , Issue.7 , pp. 3585-3593
    • Murphy, J.P.1    Everley, R.A.2    Coloff, J.L.3    Gygi, S.P.4
  • 35
    • 64249122641 scopus 로고    scopus 로고
    • Subtoxic chlorpyrifos treatment resulted in differential expression of genes implicated in neurological functions and development
    • Stapleton AR, Chan VT: Subtoxic chlorpyrifos treatment resulted in differential expression of genes implicated in neurological functions and development. Arch Toxicol 2009; 83(4): 319-33.
    • (2009) Arch Toxicol , vol.83 , Issue.4 , pp. 319-333
    • Stapleton, A.R.1    Chan, V.T.2
  • 37
    • 68149162196 scopus 로고    scopus 로고
    • D-Serine exposure resulted in gene expression changes implicated in neurodegenerative disorders and neuronal dysfunction in male Fischer 344 rats
    • Davidson ME, Kerepesi LA, Soto A, Chan VT: D-Serine exposure resulted in gene expression changes implicated in neurodegenerative disorders and neuronal dysfunction in male Fischer 344 rats. Arch Toxicol 2009; 83(8): 747-62.
    • (2009) Arch Toxicol , vol.83 , Issue.8 , pp. 747-762
    • Davidson, M.E.1    Kerepesi, L.A.2    Soto, A.3    Chan, V.T.4
  • 38
    • 37249091335 scopus 로고    scopus 로고
    • D-Serine exposure resulted in gene expression changes indicative of activation of fibrogenic pathways and down-regulation of energy metabolism and oxidative stress response
    • Soto A, DelRaso NJ, Schlager JJ, Chan VT: D-Serine exposure resulted in gene expression changes indicative of activation of fibrogenic pathways and down-regulation of energy metabolism and oxidative stress response. Toxicology 2008; 243(1-2): 177-92.
    • (2008) Toxicology , vol.243 , Issue.1-2 , pp. 177-192
    • Soto, A.1    Delraso, N.J.2    Schlager, J.J.3    Chan, V.T.4
  • 39
    • 77951068899 scopus 로고    scopus 로고
    • A pathway and approach to biomarker validation and qualification for osteoarthritis clinical trials
    • Hunter DJ, Losina E, Guermazi A, Burstein D, Lassere MN, Kraus V: A pathway and approach to biomarker validation and qualification for osteoarthritis clinical trials. Curr Drug Targets 2010; 11(5): 536-45.
    • (2010) Curr Drug Targets , vol.11 , Issue.5 , pp. 536-545
    • Hunter, D.J.1    Losina, E.2    Guermazi, A.3    Burstein, D.4    Lassere, M.N.5    Kraus, V.6
  • 40
    • 84867025309 scopus 로고    scopus 로고
    • Validation processes of protein biomarkers in serum—a cross platform comparison
    • Katja Köhler K, Seitz H: Validation processes of protein biomarkers in serum—a cross platform comparison. Sensors 2012; 12: 12710-28.
    • (2012) Sensors , vol.12 , pp. 12710-12728
    • Katja Köhler, K.1    Seitz, H.2
  • 41
  • 43
    • 84943576420 scopus 로고    scopus 로고
    • Biomarkers of Exposure to Toxic Substances
    • Air Force Technical Report AFRL-RH-WP-TR-2010-0143. Dayton, OH, Wright-Patterson AFBAvailable at, accessed June 19, 2014
    • DelRaso N, Mahle D, Rietcheck R, et al: Biomarkers of Exposure to Toxic Substances, Vol. 6: Dose and Time Response of Liver Toxicant. Air Force Technical Report AFRL-RH-WP-TR-2010-0143. Dayton, OH, Wright-Patterson AFB, 2010. Available at http://www.dtic.mil/ dtic/tr/fulltext/u2/a534170.pdf; accessed June 19, 2014.
    • Dose and Time Response of Liver Toxicant , vol.6
    • Delraso, N.1    Mahle, D.2    Rietcheck, R.3
  • 44
    • 84943576420 scopus 로고    scopus 로고
    • Biomarkers of Exposure to Toxic Substances
    • Air Force Technical Report AFRL-RH-WP-TR-2009-0102.Dayton, OH, Wright-Patterson AFB, Available at, accessed December 30, 2014
    • DelRaso N, Mauzy C, Rietcheck R: Biomarkers of Exposure to Toxic Substances, Vol. 1: Global Experimental Design: Biomarker Discovery for Early Prediction of Organ-Selective Toxicity. Air Force Technical Report AFRL-RH-WP-TR-2009-0102.Dayton, OH, Wright-Patterson AFB, 2009. Available at http://www.dtic.mil/dtic/tr/fulltext/u2/a606414.pdf; accessed December 30, 2014.
    • (2009) Global Experimental Design: Biomarker Discovery for Early Prediction of Organ-Selective Toxicity , vol.1
    • Delraso, N.1    Mauzy, C.2    Rietcheck, R.3
  • 45
    • 84943576420 scopus 로고    scopus 로고
    • Biomarkers of Exposure to Toxic Substances
    • Air Force Research Laboratory Technical Report AFRL-RHWP-TR-2009-0105. Dayton, OH, Wright-Patterson AFB, Available at, accessed June 19, 2014
    • DelRaso N, Reitcheck R, Mahle D, et al: Biomarkers of Exposure to Toxic Substances, Vol. 4: Metabonomics Biomarkers to Liver and Organ Damage. Air Force Research Laboratory Technical Report AFRL-RHWP-TR-2009-0105. Dayton, OH, Wright-Patterson AFB, 2009. Available at http://www.dtic.mil/dtic/tr/fulltext/u2/a530977.pdf; accessed June 19, 2014.
    • (2009) Metabonomics Biomarkers to Liver and Organ Damage , vol.4
    • Delraso, N.1    Reitcheck, R.2    Mahle, D.3
  • 46
    • 0034488643 scopus 로고    scopus 로고
    • Exposures to jet fuel and benzene during aircraft fuel tank repair in the US Air Force
    • Carlton GN, Smith LB. Exposures to jet fuel and benzene during aircraft fuel tank repair in the US Air Force. Appl Occup Environ Hyg 2000; 15(6): 485-91.
    • (2000) Appl Occup Environ Hyg , vol.15 , Issue.6 , pp. 485-491
    • Carlton, G.N.1    Smith, L.B.2
  • 47
    • 26644433695 scopus 로고    scopus 로고
    • Dermal exposure to jet fuel (JP-8) in US Air Force personnel
    • Chao YC, Gibson RL, Nylander-French LA. Dermal exposure to jet fuel (JP-8) in US Air Force personnel. Ann Occup Hyg 2005; 49(7): 639-45.
    • (2005) Ann Occup Hyg , vol.49 , Issue.7 , pp. 639-645
    • Chao, Y.C.1    Gibson, R.L.2    Nylander-French, L.A.3
  • 48
    • 0037599489 scopus 로고    scopus 로고
    • National Research Council, National Academy of Sciences, Washington, DC, Available at, accessed February 18, 2015
    • National Research Council. Toxicologic assessment of jet-propulsion fuel 8. National Research Council, National Academy of Sciences, Washington, DC, 2003. Available at http://www.ncbi.nlm.nih.gov/books/NBK207629/; accessed February 18, 2015.
    • (2003) Toxicologic Assessment of Jet-Propulsion Fuel 8
  • 50
    • 4444340013 scopus 로고    scopus 로고
    • Dose-dependent production of urinary naphthols among workers exposed to jet fuel (JP-8)
    • Serdar B, Egeghy PP, Gibson R, Rappaport SM: Dose-dependent production of urinary naphthols among workers exposed to jet fuel (JP-8). Am J Ind Med 2004; 46(3): 234-44.
    • (2004) Am J Ind Med , vol.46 , Issue.3 , pp. 234-244
    • Serdar, B.1    Egeghy, P.P.2    Gibson, R.3    Rappaport, S.M.4
  • 53
    • 33646198860 scopus 로고    scopus 로고
    • Pharmaco-metabonomic phenotyping and personalized drug treatment
    • Clayton TA, Lindon JC, Cloarec O, et al: Pharmaco-metabonomic phenotyping and personalized drug treatment. Nature 2006; 440: 1073-77.
    • (2006) Nature , vol.440 , pp. 1073-1077
    • Clayton, T.A.1    Lindon, J.C.2    Cloarec, O.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.