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Volumn 30, Issue 10, 2015, Pages 1622-1630

Cell cycle control in the kidney

Author keywords

acute kidney injury; chronic kidney disease; crescent; renal fibrosis; renal function

Indexed keywords

CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASE INHIBITOR; CYCLINE; CYCLOPHOSPHAMIDE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; IMMUNOSUPPRESSIVE AGENT; NUTLIN 3; PROTEIN MDM2; PROTEIN P53; RAPAMYCIN; ROSCOVITINE; CELL CYCLE PROTEIN;

EID: 84943374240     PISSN: 09310509     EISSN: 14602385     Source Type: Journal    
DOI: 10.1093/ndt/gfu395     Document Type: Review
Times cited : (79)

References (64)
  • 1
    • 84923910942 scopus 로고    scopus 로고
    • A potential role for mechanical forces in the detachment of podocytes and the progression of ckd
    • Kriz W, Lemley KV. A potential role for mechanical forces in the detachment of podocytes and the progression of CKD. J Am Soc Nephrol 2015; 26: 258-269
    • (2015) J Am Soc Nephrol , vol.26 , pp. 258-269
    • Kriz, W.1    Lemley, K.V.2
  • 3
    • 84255210700 scopus 로고    scopus 로고
    • Molecular definitions of cell death subroutines: Recommendations of the nomenclature committee on cell death 2012
    • Galluzzi L, Vitale I, Abrams JM, et al. Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012. Cell Death Differ 2012; 19: 107-120
    • (2012) Cell Death Differ , vol.19 , pp. 107-120
    • Galluzzi, L.1    Vitale, I.2    Abrams, J.M.3
  • 4
    • 79960957085 scopus 로고    scopus 로고
    • Mitotic catastrophe: A mechanism for avoiding genomic instability
    • Vitale I, Galluzzi L, Castedo M, et al. Mitotic catastrophe: a mechanism for avoiding genomic instability. Nat Rev Mol Cell Biol 2011; 12: 385-392
    • (2011) Nat Rev Mol Cell Biol , vol.12 , pp. 385-392
    • Vitale, I.1    Galluzzi, L.2    Castedo, M.3
  • 6
    • 63749131243 scopus 로고    scopus 로고
    • Kinases that control the cell cycle in response to DNA damage: Chk1, chk2, and mk2
    • Reinhardt HC, Yaffe MB. Kinases that control the cell cycle in response to DNA damage: Chk1, Chk2, and MK2. Curr Opin Cell Biol 2009; 21: 245-255
    • (2009) Curr Opin Cell Biol , vol.21 , pp. 245-255
    • Reinhardt, H.C.1    Yaffe, M.B.2
  • 9
    • 0032553485 scopus 로고    scopus 로고
    • Requirement for p53 and p21 to sustain G2 arrest after DNA damage
    • Bunz F, Dutriaux A, Lengauer C, et al. Requirement for p53 and p21 to sustain G2 arrest after DNA damage. Science 1998; 282: 1497-1501
    • (1998) Science , vol.282 , pp. 1497-1501
    • Bunz, F.1    Dutriaux, A.2    Lengauer, C.3
  • 10
    • 84871300122 scopus 로고    scopus 로고
    • Transforming growth factor beta-1 stimulates profibrotic epithelial signaling to activate pericyte-myofibroblast transition in obstructive kidney fibrosis
    • Wu CF, Chiang WC, Lai CF, et al. Transforming growth factor beta-1 stimulates profibrotic epithelial signaling to activate pericyte-myofibroblast transition in obstructive kidney fibrosis. Am J Pathol 2013; 182: 118-131
    • (2013) Am J Pathol , vol.182 , pp. 118-131
    • Wu, C.F.1    Chiang, W.C.2    Lai, C.F.3
  • 11
    • 0036674617 scopus 로고    scopus 로고
    • Live or let die: The cell's response to p53
    • Vousden KH, Lu X. Live or let die: the cell's response to p53. Nat Rev Cancer 2002; 2: 594-604
    • (2002) Nat Rev Cancer , vol.2 , pp. 594-604
    • Vousden, K.H.1    Lu, X.2
  • 12
    • 2942530310 scopus 로고    scopus 로고
    • Erk and p38 mapk-activated protein kinases: A family of protein kinases with diverse biological functions
    • Roux PP, Blenis J. ERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functions. Microbiol Mol Biol Rev 2004; 68: 320-344
    • (2004) Microbiol Mol Biol Rev , vol.68 , pp. 320-344
    • Roux, P.P.1    Blenis, J.2
  • 13
    • 0028456132 scopus 로고
    • Proliferative activity of intrinsic cell populations in the normal human kidney
    • Nadasdy T, Laszik Z, Blick KE, et al. Proliferative activity of intrinsic cell populations in the normal human kidney. J Am Soc Nephrol 1994; 4: 2032-2039
    • (1994) J Am Soc Nephrol , vol.4 , pp. 2032-2039
    • Nadasdy, T.1    Laszik, Z.2    Blick, K.E.3
  • 14
    • 0031738382 scopus 로고    scopus 로고
    • Cell cycle regulation and differentiation in the human podocyte lineage
    • Nagata M, Nakayama K, Terada Y, et al. Cell cycle regulation and differentiation in the human podocyte lineage. Am J Pathol 1998; 153: 1511-1520
    • (1998) Am J Pathol , vol.153 , pp. 1511-1520
    • Nagata, M.1    Nakayama, K.2    Terada, Y.3
  • 15
    • 0033945550 scopus 로고    scopus 로고
    • Podocyte cell cycle regulation and proliferation in collapsing glomerulopathies
    • Barisoni L, Mokrzycki M, Sablay L, et al. Podocyte cell cycle regulation and proliferation in collapsing glomerulopathies. Kidney Int 2000; 58: 137-143
    • (2000) Kidney Int , vol.58 , pp. 137-143
    • Barisoni, L.1    Mokrzycki, M.2    Sablay, L.3
  • 16
    • 0013979580 scopus 로고
    • The normal urinary excretion rates of renal tubular cells, leucocytes and red blood cells
    • Prescott LF. The normal urinary excretion rates of renal tubular cells, leucocytes and red blood cells. Clin Sci 1966; 31: 425-435
    • (1966) Clin Sci , vol.31 , pp. 425-435
    • Prescott, L.F.1
  • 17
    • 84926618275 scopus 로고    scopus 로고
    • Cell cycle arrest and the evolution of chronic kidney disease from acute kidney injury
    • Canaud G, Bonventre JV. Cell cycle arrest and the evolution of chronic kidney disease from acute kidney injury. Nephrol Dial Transplant 2015; 30: 575-583
    • (2015) Nephrol Dial Transplant , vol.30 , pp. 575-583
    • Canaud, G.1    Bonventre, J.V.2
  • 18
    • 0034004155 scopus 로고    scopus 로고
    • Cell cycle regulatory proteins in renal disease: Role in hypertrophy, proliferation, and apoptosis
    • Shankland SJ, Wolf G. Cell cycle regulatory proteins in renal disease: role in hypertrophy, proliferation, and apoptosis. Am J Physiol Renal Physiol 2000; 278: F515-F529
    • (2000) Am J Physiol Renal Physiol , vol.278 , pp. F515-F529
    • Shankland, S.J.1    Wolf, G.2
  • 19
    • 0031958909 scopus 로고    scopus 로고
    • Expression of the cyclin kinase inhibitor, p27kip1, in developing and mature human kidney
    • Combs HL, Shankland SJ, Setzer SV, et al. Expression of the cyclin kinase inhibitor, p27kip1, in developing and mature human kidney. Kidney Int 1998; 53: 892-896
    • (1998) Kidney Int , vol.53 , pp. 892-896
    • Combs, H.L.1    Shankland, S.J.2    Setzer, S.V.3
  • 20
    • 0032929050 scopus 로고    scopus 로고
    • The dysregulated podocyte phenotype: A novel concept in the pathogenesis of collapsing idiopathic focal segmental glomerulosclerosis and HIV-associated nephropathy
    • Barisoni L, Kriz W, Mundel P, et al. The dysregulated podocyte phenotype: a novel concept in the pathogenesis of collapsing idiopathic focal segmental glomerulosclerosis and HIV-associated nephropathy. J Am Soc Nephrol 1999; 10: 51-61
    • (1999) J Am Soc Nephrol , vol.10 , pp. 51-61
    • Barisoni, L.1    Kriz, W.2    Mundel, P.3
  • 21
    • 0033947637 scopus 로고    scopus 로고
    • HIV-1 induces renal epithelial dedifferentiation in a transgenic model of HIV-associated nephropathy
    • Barisoni L, Bruggeman LA, Mundel P, et al. HIV-1 induces renal epithelial dedifferentiation in a transgenic model of HIV-associated nephropathy. Kidney Int 2000; 58: 173-181
    • (2000) Kidney Int , vol.58 , pp. 173-181
    • Barisoni, L.1    Bruggeman, L.A.2    Mundel, P.3
  • 22
    • 0033864305 scopus 로고    scopus 로고
    • Differential expression of cyclindependent kinase inhibitors in human glomerular disease: Role in podocyte proliferation and maturation
    • Shankland SJ, Eitner F, Hudkins KL, et al. Differential expression of cyclindependent kinase inhibitors in human glomerular disease: role in podocyte proliferation and maturation. Kidney Int 2000; 58: 674-683
    • (2000) Kidney Int , vol.58 , pp. 674-683
    • Shankland, S.J.1    Eitner, F.2    Hudkins, K.L.3
  • 23
    • 84886681074 scopus 로고    scopus 로고
    • New insights into the pathology of podocyte loss: Mitotic catastrophe
    • Liapis H, Romagnani P, Anders HJ. New insights into the pathology of podocyte loss: mitotic catastrophe. Am J Pathol 2013; 183: 1364-1374
    • (2013) Am J Pathol , vol.183 , pp. 1364-1374
    • Liapis, H.1    Romagnani, P.2    Anders, H.J.3
  • 24
    • 77951619699 scopus 로고    scopus 로고
    • Cdk inhibitor p21 is prosurvival in adriamycin-induced podocyte injury, in vitro and in vivo
    • Marshall CB, Krofft RD, Pippin JW, et al. CDK inhibitor p21 is prosurvival in adriamycin-induced podocyte injury, in vitro and in vivo. Am J Physiol Renal Physiol 2010; 298: F1140-F1151
    • (2010) Am J Physiol Renal Physiol , vol.298 , pp. F1140-F1151
    • Marshall, C.B.1    Krofft, R.D.2    Pippin, J.W.3
  • 25
    • 0036144851 scopus 로고    scopus 로고
    • Podocyte injury promotes progressive nephropathy in zucker diabetic fatty rats
    • Hoshi S, Shu Y, Yoshida F, et al. Podocyte injury promotes progressive nephropathy in zucker diabetic fatty rats. Lab Invest 2002; 82: 25-35
    • (2002) Lab Invest , vol.82 , pp. 25-35
    • Hoshi, S.1    Shu, Y.2    Yoshida, F.3
  • 26
    • 0031801448 scopus 로고    scopus 로고
    • The cyclin kinase inhibitor p21waf1, cip1 is increased in experimental diabetic nephropathy: Potential role in glomerular hypertrophy
    • Kuan CJ, al-Douahji M, Shankland SJ. The cyclin kinase inhibitor p21WAF1, CIP1 is increased in experimental diabetic nephropathy: potential role in glomerular hypertrophy. J Am Soc Nephrol 1998; 9: 986-993
    • (1998) J Am Soc Nephrol , vol.9 , pp. 986-993
    • Kuan, C.J.1    Al-Douahji, M.2    Shankland, S.J.3
  • 27
    • 33644876868 scopus 로고    scopus 로고
    • Galectin-9 inhibits glomerular hypertrophy in db/db diabetic mice via cell-cycle-dependent mechanisms
    • Baba M, Wada J, Eguchi J, et al. Galectin-9 inhibits glomerular hypertrophy in db/db diabetic mice via cell-cycle-dependent mechanisms. J Am Soc Nephrol 2005; 16: 3222-3234
    • (2005) J Am Soc Nephrol , vol.16 , pp. 3222-3234
    • Baba, M.1    Wada, J.2    Eguchi, J.3
  • 28
    • 0037371582 scopus 로고    scopus 로고
    • The lack of cyclin kinase inhibitor p27(Kip1) ameliorates progression of diabetic nephropathy
    • Awazu M, Omori S, Ishikura K, et al. The lack of cyclin kinase inhibitor p27(Kip1) ameliorates progression of diabetic nephropathy. J Am Soc Nephrol 2003; 14: 699-708
    • (2003) J Am Soc Nephrol , vol.14 , pp. 699-708
    • Awazu, M.1    Omori, S.2    Ishikura, K.3
  • 29
    • 84878792765 scopus 로고    scopus 로고
    • Podocyte loss involves MDM2-driven mitotic catastrophe
    • Mulay SR, Thomasova D, Ryu M, et al. Podocyte loss involves MDM2-driven mitotic catastrophe. J Pathol 2013; 230: 322-335
    • (2013) J Pathol , vol.230 , pp. 322-335
    • Mulay, S.R.1    Thomasova, D.2    Ryu, M.3
  • 30
    • 0032861063 scopus 로고    scopus 로고
    • Regulation of mesangial cell proliferation
    • Schocklmann HO, Lang S, Sterzel RB. Regulation of mesangial cell proliferation. Kidney Int 1999; 56: 1199-1207
    • (1999) Kidney Int , vol.56 , pp. 1199-1207
    • Schocklmann, H.O.1    Lang, S.2    Sterzel, R.B.3
  • 31
    • 0030781307 scopus 로고    scopus 로고
    • Direct in vivo inhibition of the nuclear cell cycle cascade in experimental mesangial proliferative glomerulonephritis with roscovitine, a novel cyclin-dependent kinase antagonist
    • Pippin JW, Qu Q, Meijer L, et al. Direct in vivo inhibition of the nuclear cell cycle cascade in experimental mesangial proliferative glomerulonephritis with roscovitine, a novel cyclin-dependent kinase antagonist. J Clin Invest 1997; 100: 2512-2520
    • (1997) J Clin Invest , vol.100 , pp. 2512-2520
    • Pippin, J.W.1    Qu, Q.2    Meijer, L.3
  • 32
    • 30644480721 scopus 로고    scopus 로고
    • Cell cycle and glomerular disease: A minireview
    • Marshall CB, Shankland SJ. Cell cycle and glomerular disease: a minireview. Nephron Exp Nephrol 2006; 102: e39-e48
    • (2006) Nephron Exp Nephrol , vol.102 , pp. e39-e48
    • Marshall, C.B.1    Shankland, S.J.2
  • 33
    • 84880607793 scopus 로고    scopus 로고
    • Anti-proliferative actions of Ttype calcium channel inhibition in Thy1 nephritis
    • Cove-Smith A, Mulgrew CJ, Rudyk O, et al. Anti-proliferative actions of Ttype calcium channel inhibition in Thy1 nephritis. Am J Pathol 2013; 183: 391-401
    • (2013) Am J Pathol , vol.183 , pp. 391-401
    • Cove-Smith, A.1    Mulgrew, C.J.2    Rudyk, O.3
  • 34
    • 0030462640 scopus 로고    scopus 로고
    • The p53-independent activation of transcription of p21 waf1/cip1/sdi1 after acute renal failure
    • Megyesi J, Udvarhelyi N, Safirstein RL, et al. The p53-independent activation of transcription of p21 WAF1/CIP1/SDI1 after acute renal failure. Am J Physiol 1996; 271: F1211-F1216
    • (1996) Am J Physiol , vol.271 , pp. F1211-F1216
    • Megyesi, J.1    Udvarhelyi, N.2    Safirstein, R.L.3
  • 35
    • 0032519006 scopus 로고    scopus 로고
    • Induction of p21waf1/cip1/sdi1 in kidney tubule cells affects the course of cisplatin-induced acute renal failure
    • Megyesi J, Safirstein RL, Price PM. Induction of p21WAF1/CIP1/SDI1 in kidney tubule cells affects the course of cisplatin-induced acute renal failure. J Clin Invest 1998; 101: 777-782
    • (1998) J Clin Invest , vol.101 , pp. 777-782
    • Megyesi, J.1    Safirstein, R.L.2    Price, P.M.3
  • 36
    • 33748073102 scopus 로고    scopus 로고
    • Dependence of cisplatin-induced cell death in vitro and in vivo on cyclin-dependent kinase 2
    • Price PM, Yu F, Kaldis P, et al. Dependence of cisplatin-induced cell death in vitro and in vivo on cyclin-dependent kinase 2. J Am Soc Nephrol 2006; 17: 2434-2442
    • (2006) J Am Soc Nephrol , vol.17 , pp. 2434-2442
    • Price, P.M.1    Yu, F.2    Kaldis, P.3
  • 37
    • 84894046460 scopus 로고    scopus 로고
    • CDK4/6 inhibition induces epithelial cell cycle arrest and ameliorates acute kidney injury
    • DiRocco DP, Bisi J, Roberts P, et al. CDK4/6 inhibition induces epithelial cell cycle arrest and ameliorates acute kidney injury. Am J Physiol Renal Physiol 2014; 306: F379-F388
    • (2014) Am J Physiol Renal Physiol , vol.306 , pp. F379-F388
    • DiRocco, D.P.1    Bisi, J.2    Roberts, P.3
  • 38
    • 0001556829 scopus 로고    scopus 로고
    • Renal tubule regeneration after ischemic injury is coupled to the up-regulation and activation of cyclins and cyclin dependent kinases
    • Park SK, Kang MJ, Kim Wet al. Renal tubule regeneration after ischemic injury is coupled to the up-regulation and activation of cyclins and cyclin dependent kinases. Kidney Int 1997; 52: 706-714
    • (1997) Kidney Int , vol.52 , pp. 706-714
    • Park, S.K.1    Kang, M.J.2    Kim, W.3
  • 39
    • 77952174830 scopus 로고    scopus 로고
    • Epithelial cell cycle arrest in G2/M mediates kidney fibrosis after injury
    • Yang L, Besschetnova TY, Brooks CR, et al. Epithelial cell cycle arrest in G2/M mediates kidney fibrosis after injury. Nat Med 2010; 16: 535-543
    • (2010) Nat Med , vol.16 , pp. 535-543
    • Yang, L.1    Besschetnova, T.Y.2    Brooks, C.R.3
  • 40
    • 84906795005 scopus 로고    scopus 로고
    • Hyperglycemia causes cellular senescence via a SGLT2-and p21-dependent pathway in proximal tubules in the early stage of diabetic nephropathy
    • Kitada K, Nakano D, Ohsaki H, et al. Hyperglycemia causes cellular senescence via a SGLT2-and p21-dependent pathway in proximal tubules in the early stage of diabetic nephropathy. J Diabetes Complicat 2014; 28: 604-611
    • (2014) J Diabetes Complicat , vol.28 , pp. 604-611
    • Kitada, K.1    Nakano, D.2    Ohsaki, H.3
  • 41
    • 0032875388 scopus 로고    scopus 로고
    • The lack of a functional p21(waf1/cip1) gene ameliorates progression to chronic renal failure
    • Megyesi J, Price PM, Tamayo E, et al. The lack of a functional p21(WAF1/CIP1) gene ameliorates progression to chronic renal failure. Proc Natl Acad Sci USA 1999; 96: 10830-10835
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 10830-10835
    • Megyesi, J.1    Price, P.M.2    Tamayo, E.3
  • 42
    • 59949101434 scopus 로고    scopus 로고
    • Regeneration of glomerular podocytes by human renal progenitors
    • Ronconi E, Sagrinati C, Angelotti ML, et al. Regeneration of glomerular podocytes by human renal progenitors. J Am Soc Nephrol 2009; 20: 322-332
    • (2009) J Am Soc Nephrol , vol.20 , pp. 322-332
    • Ronconi, E.1    Sagrinati, C.2    Angelotti, M.L.3
  • 43
    • 84899738750 scopus 로고    scopus 로고
    • Unraveling the role of podocyte turnover in glomerular aging and injury
    • Wanner N, Hartleben B, Herbach N, et al. Unraveling the role of podocyte turnover in glomerular aging and injury. J Am Soc Nephrol 2014; 25: 707-716
    • (2014) J Am Soc Nephrol , vol.25 , pp. 707-716
    • Wanner, N.1    Hartleben, B.2    Herbach, N.3
  • 44
    • 72049121911 scopus 로고    scopus 로고
    • Renal progenitor cells contribute to hyperplastic lesions of podocytopathies and crescentic glomerulonephritis
    • Smeets B, Angelotti ML, Rizzo P, et al. Renal progenitor cells contribute to hyperplastic lesions of podocytopathies and crescentic glomerulonephritis. J Am Soc Nephrol 2009; 20: 2593-2603
    • (2009) J Am Soc Nephrol , vol.20 , pp. 2593-2603
    • Smeets, B.1    Angelotti, M.L.2    Rizzo, P.3
  • 45
    • 77957857754 scopus 로고    scopus 로고
    • Notch activation differentially regulates renal progenitors proliferation and differentiation toward the podocyte lineage in glomerular disorders
    • Lasagni L, Ballerini L, Angelotti ML, et al. Notch activation differentially regulates renal progenitors proliferation and differentiation toward the podocyte lineage in glomerular disorders. Stem Cells 2010; 28: 1674-1685
    • (2010) Stem Cells , vol.28 , pp. 1674-1685
    • Lasagni, L.1    Ballerini, L.2    Angelotti, M.L.3
  • 46
    • 0026562550 scopus 로고
    • Inhibition of mesangial cell proliferation and matrix expansion in glomerulonephritis in the rat by antibody to platelet-derived growth factor
    • Johnson RJ, Raines EW, Floege J, et al. Inhibition of mesangial cell proliferation and matrix expansion in glomerulonephritis in the rat by antibody to platelet-derived growth factor. J Exp Med 1992; 175: 1413-1416
    • (1992) J Exp Med , vol.175 , pp. 1413-1416
    • Johnson, R.J.1    Raines, E.W.2    Floege, J.3
  • 47
    • 0030752624 scopus 로고    scopus 로고
    • Extraglomerular origin of the mesangial cell after injury. A new role of the juxtaglomerular apparatus
    • Hugo C, Shankland SJ, Bowen-Pope DF, et al. Extraglomerular origin of the mesangial cell after injury. A new role of the juxtaglomerular apparatus. J Clin Invest 1997; 100: 786-794
    • (1997) J Clin Invest , vol.100 , pp. 786-794
    • Hugo, C.1    Shankland, S.J.2    Bowen-Pope, D.F.3
  • 48
    • 84924184378 scopus 로고    scopus 로고
    • Renin lineage cells repopulate the glomerular mesangium after injury
    • Starke C, Betz H, Hickmann L, et al. Renin lineage cells repopulate the glomerular mesangium after injury. J Am Soc Nephrol 2015; 26: 48-54
    • (2015) J Am Soc Nephrol , vol.26 , pp. 48-54
    • Starke, C.1    Betz, H.2    Hickmann, L.3
  • 49
    • 84871586311 scopus 로고    scopus 로고
    • P53-independent roles of MDM2 in NF-kappaB signaling: Implications for cancer therapy, wound healing, and autoimmune diseases
    • Thomasova D, Mulay SR, Bruns H, et al. p53-independent roles of MDM2 in NF-kappaB signaling: implications for cancer therapy, wound healing, and autoimmune diseases. Neoplasia 2012; 14: 1097-1101
    • (2012) Neoplasia , vol.14 , pp. 1097-1101
    • Thomasova, D.1    Mulay, S.R.2    Bruns, H.3
  • 50
    • 79955028635 scopus 로고    scopus 로고
    • Tight regulation of p53 activity by Mdm2 is required for ureteric bud growth and branching
    • Hilliard S, Aboudehen K, Yao X, et al. Tight regulation of p53 activity by Mdm2 is required for ureteric bud growth and branching. Dev Biol 2011; 353: 354-366
    • (2011) Dev Biol , vol.353 , pp. 354-366
    • Hilliard, S.1    Aboudehen, K.2    Yao, X.3
  • 51
    • 84893740627 scopus 로고    scopus 로고
    • Mdm2 is required for maintenance of the nephrogenic niche
    • Hilliard SA, Yao X, El-Dahr SS. Mdm2 is required for maintenance of the nephrogenic niche. Dev Biol 2014; 387: 1-14
    • (2014) Dev Biol , vol.387 , pp. 1-14
    • Hilliard, S.A.1    Yao, X.2    El-Dahr, S.S.3
  • 52
    • 84904267177 scopus 로고    scopus 로고
    • Tissue-specific and age-dependent effects of global mdm2 loss
    • Zhang Y, Xiong S, Li Q, et al. Tissue-specific and age-dependent effects of global Mdm2 loss. J Pathol 2014; 233: 380-391
    • (2014) J Pathol , vol.233 , pp. 380-391
    • Zhang, Y.1    Xiong, S.2    Li, Q.3
  • 53
    • 80555146731 scopus 로고    scopus 로고
    • Mdm2 promotes systemic lupus erythematosus and lupus nephritis
    • Allam R, Sayyed SG, Kulkarni OP, et al. Mdm2 promotes systemic lupus erythematosus and lupus nephritis. J Am Soc Nephrol 2011; 22: 2016-2027
    • (2011) J Am Soc Nephrol , vol.22 , pp. 2016-2027
    • Allam, R.1    Sayyed, S.G.2    Kulkarni, O.P.3
  • 54
    • 84861668569 scopus 로고    scopus 로고
    • Mdm2 (murine double minute-2) links inflammation and tubular cell healing during acute kidney injury in mice
    • Mulay SR, Thomasova D, Ryu M, et al. MDM2 (murine double minute-2) links inflammation and tubular cell healing during acute kidney injury in mice. Kidney Int 2012; 81: 1199-1211
    • (2012) Kidney Int , vol.81 , pp. 1199-1211
    • Mulay, S.R.1    Thomasova, D.2    Ryu, M.3
  • 55
    • 84884542277 scopus 로고    scopus 로고
    • Nrf2 signalling promotes ex vivo tubular epithelial cell survival and regeneration via murine double minute (mdm)-2
    • Hagemann JH, Thomasova D, Mulay SR, et al. Nrf2 signalling promotes ex vivo tubular epithelial cell survival and regeneration via murine double minute (MDM)-2. Nephrol Dial Transplant 2013; 28: 2028-2037
    • (2013) Nephrol Dial Transplant , vol.28 , pp. 2028-2037
    • Hagemann, J.H.1    Thomasova, D.2    Mulay, S.R.3
  • 57
    • 29244486472 scopus 로고    scopus 로고
    • Inhibition of mTOR signaling with rapamycin attenuates renal hypertrophy in the early diabetic mice
    • Sakaguchi M, Isono M, Isshiki K, et al. Inhibition of mTOR signaling with rapamycin attenuates renal hypertrophy in the early diabetic mice. Biochem Biophys Res Commun 2006; 340: 296-301
    • (2006) Biochem Biophys Res Commun , vol.340 , pp. 296-301
    • Sakaguchi, M.1    Isono, M.2    Isshiki, K.3
  • 58
    • 80052499138 scopus 로고    scopus 로고
    • Inhibiting angiotensin-converting enzyme promotes renal repair by limiting progenitor cell proliferation and restoring the glomerular architecture
    • Benigni A, Morigi M, Rizzo P, et al. Inhibiting angiotensin-converting enzyme promotes renal repair by limiting progenitor cell proliferation and restoring the glomerular architecture. Am J Pathol 2011; 179: 628-638
    • (2011) Am J Pathol , vol.179 , pp. 628-638
    • Benigni, A.1    Morigi, M.2    Rizzo, P.3
  • 59
    • 40049091449 scopus 로고    scopus 로고
    • Cdk/gsk-3 inhibitors as therapeutic agents for parenchymal renal diseases
    • Obligado SH, Ibraghimov-Beskrovnaya O, Zuk A, et al. CDK/GSK-3 inhibitors as therapeutic agents for parenchymal renal diseases. Kidney Int 2008; 73: 684-690
    • (2008) Kidney Int , vol.73 , pp. 684-690
    • Obligado, S.H.1    Ibraghimov-Beskrovnaya, O.2    Zuk, A.3
  • 60
    • 68049136123 scopus 로고    scopus 로고
    • Sandoval RMet al. SiRNA targeted to p53 attenuates ischemic and cisplatin-induced acute kidney injury
    • Molitoris BA, Dagher PC, Sandoval RMet al. siRNA targeted to p53 attenuates ischemic and cisplatin-induced acute kidney injury. J Am Soc Nephrol 2009; 20: 1754-1764
    • (2009) J Am Soc Nephrol , vol.20 , pp. 1754-1764
    • Molitoris, B.A.1    Dagher, P.C.2
  • 61
    • 75149131726 scopus 로고    scopus 로고
    • Activation of p53 promotes renal injury in acute aristolochic acid nephropathy
    • Zhou L, Fu P, Huang XR, et al. Activation of p53 promotes renal injury in acute aristolochic acid nephropathy. J Am Soc Nephrol 2010; 21: 31-41
    • (2010) J Am Soc Nephrol , vol.21 , pp. 31-41
    • Zhou, L.1    Fu, P.2    Huang, X.R.3
  • 62
    • 70350567735 scopus 로고    scopus 로고
    • 20 years studying p53 functions in genetically engineered mice
    • Donehower LA, Lozano G. 20 years studying p53 functions in genetically engineered mice. Nat Rev Cancer 2009; 9: 831-841
    • (2009) Nat Rev Cancer , vol.9 , pp. 831-841
    • Donehower, L.A.1    Lozano, G.2
  • 63
    • 33748670457 scopus 로고    scopus 로고
    • The pathological response to DNA damage does not contribute to p53-mediated tumour suppression
    • Christophorou MA, Ringshausen I, Finch AJ, et al. The pathological response to DNA damage does not contribute to p53-mediated tumour suppression. Nature 2006; 443: 214-217
    • (2006) Nature , vol.443 , pp. 214-217
    • Christophorou, M.A.1    Ringshausen, I.2    Finch, A.J.3
  • 64
    • 0033543728 scopus 로고    scopus 로고
    • A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy
    • Komarov PG, Komarova EA, Kondratov RV, et al. A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy. Science 1999; 285: 1733-1737
    • (1999) Science , vol.285 , pp. 1733-1737
    • Komarov, P.G.1    Komarova, E.A.2    Kondratov, R.V.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.