Mdm2 is required for maintenance of the nephrogenic niche

Developmental Biology

Volumn 387, Issue 1, 2014, Pages 1-14

  Hilliard, Sylvia A ^a   Yao, Xiao ^a   El Dahr, Samir S ^a  

^a TULANE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cap mesenchyme; Mdm2; Metanephric kidney; Nephron progenitor cells; P53

Indexed keywords

AMPHIPHYSIN; CELL PROTEIN; GREEN FLUORESCENT PROTEIN; HISTONE H2AX; OSTEOGENIC PROTEIN 1; PROTEIN CITED1; PROTEIN LHX1; PROTEIN MDM2; PROTEIN P53; PROTEIN SALL1; TRANSCRIPTION FACTOR PAX2; TRANSCRIPTION FACTOR PAX8; UNCLASSIFIED DRUG; WNT4 PROTEIN; CITED1 PROTEIN; MARKER; SALL1 PROTEIN;

ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BMP7 GENE; CELL DIFFERENTIATION; CELL FATE; CELL LINEAGE; CELL PROLIFERATION; CELL RENEWAL; CELL SURVIVAL; CONTROLLED STUDY; DNA DAMAGE; EMBRYO; EYA1 GENE; FEMALE; GENE; GENE EXPRESSION; GENE FUNCTION; IMMUNOFLUORESCENCE; KIDNEY PARENCHYMA; MALE; MDM2 GENE; MOUSE; NEPHRON; NONHUMAN; PAX2 GENE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIX2 GENE; STEM CELL; UPREGULATION; DEVELOPMENTAL GENE; KIDNEY DEVELOPMENT; KIDNEY DYSPLASIA; KIDNEY HYPOPLASIA; KIDNEY PROXIMAL TUBULE; LHX1 GENE; MESENCHYME; NEPHROGENIC NICHE; NEPHRON PROGENITOR CELL; NEWBORN; PAX8 GENE; PERINATAL MORTALITY; STEM CELL NICHE; WNT4 GENE;

MURINAE; MUS;

CAP MESENCHYME; MDM2; METANEPHRIC KIDNEY; NEPHRON PROGENITOR CELLS; P53;

ANIMALS; APOPTOSIS; BONE MORPHOGENETIC PROTEIN 7; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL SURVIVAL; GENOTYPE; GREEN FLUORESCENT PROTEINS; HISTONES; HOMEODOMAIN PROTEINS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LIM-HOMEODOMAIN PROTEINS; MICE; MICE, KNOCKOUT; NEPHRONS; NERVE TISSUE PROTEINS; NUCLEAR PROTEINS; ORGANOGENESIS; PAIRED BOX TRANSCRIPTION FACTORS; PAX2 TRANSCRIPTION FACTOR; PROTEIN TYROSINE PHOSPHATASES; PROTO-ONCOGENE PROTEINS C-MDM2; STEM CELLS; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; TUMOR SUPPRESSOR PROTEIN P53; WNT4 PROTEIN;

EID: 84893740627     PISSN: 00121606     EISSN: 1095564X     Source Type: Journal    
DOI: 10.1016/j.ydbio.2014.01.009     Document Type: Article

References (32)

1. Abbas H.A., Maccio D.R., Coskun S., Jackson J.G., Hazen A.L., Sills T.M., You M.J., Hirschi K.K., Lozano G. Mdm2 is required for survival of hematopoietic stem cells/progenitors via dampening of ROS-induced p53 activity. Cell Stem Cell 2010, 7:606-617.
2. Barak H., Huh S.H., Chen S., Jeanpierre C., Martinovic J., Parisot M., Bole-Feysot C., Nitschke P., Salomon R., Antignac C., Ornitz D.M., Kopan R. FGF9 and FGF20 maintain the stemness of nephron progenitors in mice and man. Dev. Cell 2012, 22:1191-1207.
3. Blank U., Brown A., Adams D.C., Karolak M.J., Oxburgh L. BMP7 promotes proliferation of nephron progenitor cells via a JNK-dependent mechanism. Development 2009, 136:3557-3566.
4. Brown A.C., Adams D., de Caestecker M., Yang X., Friesel R., Oxburgh L. FGF/EGF signaling regulates the renewal of early nephron progenitors during embryonic development. Development 2011, 138:5099-5112.
5. Brown A.C., Muthukrishnan S.D., Guay J.A., Adams D.C., Schafer D.A., Fetting J.L., Oxburgh L. Role for compartmentalization in nephron progenitor differentiation. Proc. Natl. Acad. Sci. U. S. A. 2013, 110:4640-4645.
6. Das A., Tanigawa S., Karner C.M., Xin M., Lum L., Chen C., Olsen E.N., Perantoni A.O., Carroll T.J. Stromal-epithelial crosstalk regulates kidney progenitor cell differentiation. Nat. Cell Biol. 2013, 15:1035-1046.
7. Das B., Bayat-Mokhtari R., Tsui M., Lotfi S., Tsuchida R., Felsher D.W., Yeger H. HIF-2alpha suppresses p53 to enhance the stemness and regenerative potential of human embryonic stem cells. Stem Cells 2012, 30:1685-1695.
8. Denner D.R., Rauchman M. Mi-2/NuRD is required in renal progenitor cells during embryonic kidney development. Dev. Biol. 2013, 375:105-116.
9. Donald S.P., Sun X.Y., Hu C.A., Yu J., Mei J.M., Valle D., Phang J.M. Proline oxidase, encoded by p53-induced gene-6, catalyzes the generation of proline-dependent reactive oxygen species. Cancer Res. 2001, 61:1810-1815.
10. Francoz S., Froment P., Bogaerts S., De Clercq S., Maetens M., Doumont G., Bellefroid E., Marine J.C. Mdm4 and Mdm2 cooperate to inhibit p53 activity in proliferating and quiescent cells in vivo. Proc. Natl. Acad. Sci. U. S. A. 2006, 103:3232-3237.
11. Hendry C., Rumballe B., Moritz K., Little M.H. Defining and redefining the nephron progenitor population. Pediatr. Nephrol. 2011, 26:1395-1406.
12. Hilliard S., Aboudehen K., Yao X., El-Dahr S.S. Tight regulation of p53 activity by Mdm2 is required for ureteric bud growth and branching. Dev. Biol. 2011, 353:354-366.
13. Ito A., Kawaguchi Y., Lai C.H., Kovacs J.J., Higashimoto Y., Appella E., Yao T.P. MDM2-HDAC1-mediated deacetylation of p53 is required for its degradation. EMBO J. 2002, 21:6236-6245.
14. Karner C.M., Das A., Ma Z., Self M., Chen C., Lum L., Oliver G., Carroll T.J. Canonical Wnt9b signaling balances progenitor cell expansion and differentiation during kidney development. Development 2011, 138:1247-1257.
15. Keller G., Zimmer G., Mall G., Ritz E., Amann K. Nephron number in patients with primary hypertension. N. Engl. J. Med. 2003, 348:101-108.
16. Kobayashi A., Valerius M.T., Mugford J.W., Carroll T.J., Self M., Oliver G., McMahon A.P. Six2 defines and regulates a multipotent self-renewing nephron progenitor population throughout mammalian kidney development. Cell Stem Cell 2008, 3:169-181.
17. Li P.F., Dietz R., von Harsdorf R. p53 regulates mitochondrial membrane potential through reactive oxygen species and induces cytochrome c-independent apoptosis blocked by Bcl-2. EMBO J. 1999, 18:6027-6036.
18. Liu G., Terzian T., Xiong S., Van Pelt C.S., Audiffred A., Box N.F., Lozano G. The p53-Mdm2 network in progenitor cell expansion during mouse postnatal development. J. Pathol. 2007, 213:360-368.
19. Mugford J.W., Yu J., Kobayashi A., McMahon A.P. High-resolution gene expression analysis of the developing mouse kidney defines novel cellular compartments within the nephron progenitor population. Dev. Biol. 2009, 333:312-323.
20. Myrie S.B., McKnight L.L., Van Vliet B.N., Bertolo R.F. Low birth weight is associated with reduced nephron number and increased blood pressure in adulthood in a novel spontaneous intrauterine growth-restricted model in Yucatan miniature Swine. Neonatology 2011, 100:380-386.
21. Nishinakamura R., Matsumoto Y., Nakao K., Nakamura K., Sato A., Copeland N.G., Gilbert D.J., Jenkins N.A., Scully S., Lacey D.L., Katsuki M., Asashima M., Yokota T. Murine homolog of SALLI is essential for ureteric bud invasion in kidney development. Development 2001, 128:3105-3115.
22. Oxburgh L., Brown A.C., Fetting J., Hill B. BMP signaling in the nephron progenitor niche. Pediatr. Nephrol. 2011, 26:1491-1497.
23. Pant V., Xiong S., Jackson J.G., Post S.M., Abbas H.A., Quintás-Cardama A., Hamir A.N., Lozano G. The p53-Mdm2 feedback loop protects against DNA damage by inhibiting p53 activity but is dispensable for p53 stability, development, and longevity. Genes Dev. 2013, 27:1857-1867.
24. Park J.S., Valerius M.T., McMahon A.P. Wnt/beta-catenin signaling regulates nephron induction during mouse kidney development. Development 2007, 134:2533-2539.
25. Polyak K., Xia Y., Zweier J.L., Kinzler K.W., Vogelstein B. A model for p53-induced apoptosis. Nature 1997, 389:300-305.
26. Ringshausen I., O'Shea C.C., Finch A.J., Swigart L.B., Evan G.I. Mdm2 is critically and continuously required to suppress lethal p53 activity in vivo. Cancer Cell 2006, 10:501-514.
27. Rumballe B.A., Georgas K.M., Combes A.N., Ju A.L., Gilbert T., Little M.H. Nephron formation adopts a novel spatial topology at cessation of nephrogenesis. Dev. Biol. 2011, 360:110-122.
28. Saifudeen Z., Dipp S., Stefkova J., Yao X., Lookabaugh S., El-Dahr S.S. p53 regulates metanephric development. J. Am. Soc. Nephrol. 2009, 20:2328-2337.
29. Self M., Lagutin O.V., Bowling B., Hendrix J., Cai Y., Dressler G.R., Oliver G. Six2 is required for suppression of nephrogenesis and progenitor renewal in the developing kidney. EMBO J. 2006, 25:5214-5228.
30. Valentin-Vega Y.A., Okano H., Lozano G. The intestinal epithelium compensates for p53-mediated cell death and guarantees organismal survival. Cell Death Differ. 2008, 15:1772-1781.
31. Walker K.A., Bertram J.F. Kidney development: core curriculum 2011. Am. J. Kidney Dis. 2011, 57:948-958.
32. Weber S., Moriniere V., Knuppel T., Charbit M., Dusek J., Ghiggeri G.M., Jankauskiene A., Mir S., Montini G., Peco-Antic A., Wuhl E., Zurowska A.M., Mehls O., Antignac C., Schaefer F., Salomon R. Prevalence of mutations in renal developmental genes in children with renal hypodysplasia: results of the ESCAPE study. J. Am. Soc. Nephrol. 2006, 17:2864-2870.