Inhibiting angiotensin-converting enzyme promotes renal repair by limiting progenitor cell proliferation and restoring the glomerular architecture

American Journal of Pathology

Volumn 179, Issue 2, 2011, Pages 628-638

  Benigni, Ariela ^a   Morigi, Marina ^a   Rizzo, Paola ^a   Gagliardini, Elena ^a   Rota, Cinzia ^a   Abbate, Mauro ^a   Ghezzi, Serena ^a   Remuzzi, Andrea ^a,b   Remuzzi, Giuseppe ^a,c  

^a MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

^b UNIVERSITY OF BERGAMO   (Italy)

^c OSPEDALI RIUNITI   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CCAAT ENHANCER BINDING PROTEIN DELTA; CD24 ANTIGEN; CLAUDIN 1; DIPEPTIDYL CARBOXYPEPTIDASE; LISINOPRIL; NERVE CELL ADHESION MOLECULE; WT1 PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BOWMAN CAPSULE; CELL ACTIVATION; CELL DIFFERENTIATION; CELL MIGRATION; CELL PROLIFERATION; CELL SUBPOPULATION; CONTROLLED STUDY; DOWN REGULATION; ENZYME INHIBITION; GLOMERULOSCLEROSIS; KIDNEY INJURY; KIDNEY TUBULE CELL; MALE; MITOSIS; NONHUMAN; PODOCYTE; PRIORITY JOURNAL; RAT; RENAL PROTECTION; STEM CELL;

ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; ANIMALS; CELL PROLIFERATION; CREATININE; HUMANS; KIDNEY; KIDNEY FAILURE, CHRONIC; KIDNEY GLOMERULUS; MALE; MICROSCOPY, IMMUNOELECTRON; MITOSIS; PODOCYTES; RATS; RATS, WISTAR; STEM CELLS; TIME FACTORS;

EID: 80052499138     PISSN: 00029440     EISSN: 15252191     Source Type: Journal    
DOI: 10.1016/j.ajpath.2011.04.003     Document Type: Article

References (32)

1. P.M. Just, M.C. Riella, E.A. Tschosik, L.L. Noe, S.K. Bhattacharyya, and F. de Charro Economic evaluations of dialysis treatment modalities Health Policy 86 2008 163 180
2. B. Gridelli, and G. Remuzzi Strategies for making more organs available for transplantation N Engl J Med 343 2000 404 410 (Pubitemid 30626124)
3. K.M. Denton, W.P. Anderson, and R. Sinniah Effects of angiotensin II on regional afferent and efferent arteriole dimensions and the glomerular pole Am J Physiol Regul Integr Comp Physiol 279 2000 R629 R638
4. S. Anderson, T.W. Meyer, H.G. Rennke, and B.M. Brenner Control of glomerular hypertension limits glomerular injury in rats with reduced renal mass J Clin Invest 76 1985 612 619 (Pubitemid 15227525)
5. A. Remuzzi, A. Fassi, T. Bertani, N. Perico, and G. Remuzzi ACE inhibition induces regression of proteinuria and halts progression of renal damage in a genetic model of progressive nephropathy Am J Kidney Dis 34 1999 626 632 (Pubitemid 29473047)
6. G. Remuzzi, A. Benigni, and A. Remuzzi Mechanisms of progression and regression of renal lesions of chronic nephropathies and diabetes J Clin Invest 116 2006 288 296 (Pubitemid 43228342)
7. A. Remuzzi, E. Gagliardini, F. Sangalli, M. Bonomelli, M. Piccinelli, A. Benigni, and G. Remuzzi ACE inhibition reduces glomerulosclerosis and regenerates glomerular tissue in a model of progressive renal disease Kidney Int 69 2006 1124 1130
8. J.A. Joles, B. Braam, and M.C. Verhaar ACE inhibition and glomerular repair: restructuring or regeneration? Kidney Int 69 2006 1105 1107
9. J.A. Oliver Adult renal stem cells and renal repair Curr Opin Nephrol Hypertens 13 2004 17 22 (Pubitemid 39069894)
10. D. Macconi, F. Sangalli, M. Bonomelli, S. Conti, L. Condorelli, E. Gagliardini, G. Remuzzi, and A. Remuzzi Podocyte repopulation contributes to regression of glomerular injury induced by ACE inhibition Am J Pathol 174 2009 797 807
11. D. Appel, D.B. Kershaw, B. Smeets, G. Yuan, A. Fuss, B. Frye, M. Elger, W. Kriz, J. Floege, and M.J. Moeller Recruitment of podocytes from glomerular parietal epithelial cells J Am Soc Nephrol 20 2009 333 343
12. C. Sagrinati, G.S. Netti, B. Mazzinghi, E. Lazzeri, F. Liotta, F. Frosali, E. Ronconi, C. Meini, M. Gacci, R. Squecco, M. Carini, L. Gesualdo, F. Francini, E. Maggi, F. Annunziato, L. Lasagni, M. Serio, S. Romagnani, and P. Romagnani Isolation and characterization of multipotent progenitor cells from the Bowman's capsule of adult human kidneys J Am Soc Nephrol 17 2006 2443 2456 (Pubitemid 44300960)
13. E. Ronconi, C. Sagrinati, M.L. Angelotti, E. Lazzeri, B. Mazzinghi, L. Ballerini, E. Parente, F. Becherucci, M. Gacci, M. Carini, E. Maggi, M. Serio, G.B. Vannelli, L. Lasagni, S. Romagnani, and P. Romagnani Regeneration of glomerular podocytes by human renal progenitors J Am Soc Nephrol 20 2009 322 332
14. B. Smeets, M.L. Angelotti, P. Rizzo, H. Dijkman, E. Lazzeri, F. Mooren, L. Ballerini, E. Parente, C. Sagrinati, B. Mazzinghi, E. Ronconi, F. Becherucci, A. Benigni, E. Steenbergen, L. Lasagni, G. Remuzzi, J. Wetzels, and P. Romagnani Renal progenitor cells contribute to hyperplastic lesions of podocytopathies and crescentic glomerulonephritis J Am Soc Nephrol 20 2009 2593 2603
15. A. Remuzzi, S. Puntorieri, C. Battaglia, T. Bertani, and G. Remuzzi Angiotensin converting enzyme inhibition ameliorates glomerular filtration of macromolecules and water and lessens glomerular injury in the rat J Clin Invest 85 1990 541 549 (Pubitemid 20070063)
16. J. Vasiliades Reaction of alkaline sodium picrate with creatinine: i Kinetics and mechanism of formation of the mono-creatinine picric acid complex Clin Chem 22 1976 1664 1671
17. Y. Takano, K. Yamauchi, N. Hiramatsu, A. Kasai, K. Hayakawa, M. Yokouchi, J. Yao, and M. Kitamura Recovery and maintenance of nephrin expression in cultured podocytes and identification of HGF as a repressor of nephrin Am J Physiol Renal Physiol 292 2007 F1573 F1582
18. L. Lasagni, L. Ballerini, M.L. Angelotti, E. Parente, C. Sagrinati, B. Mazzinghi, A. Peired, E. Ronconi, F. Becherucci, D. Bani, M. Gacci, M. Carini, E. Lazzeri, and P. Romagnani Notch activation differentially regulates renal progenitors proliferation and differentiation toward the podocyte lineage in glomerular disorders Stem Cells 28 2010 1674 1685
19. T. Ohse, J.W. Pippin, M.R. Vaughan, P.T. Brinkkoetter, R.D. Krofft, and S.J. Shankland Establishment of conditionally immortalized mouse glomerular parietal epithelial cells in culture J Am Soc Nephrol 19 2008 1879 1890
20. M. Abbate, D. Brown, and J.V. Bonventre Expression of NCAM recapitulates tubulogenic development in kidneys recovering from acute ischemia Am J Physiol 277 1999 F454 F463
21. J.B. Bard, A. Gordon, L. Sharp, and W.I. Sellers Early nephron formation in the developing mouse kidney J Anat 199 2001 385 392 (Pubitemid 32998936)
22. G.A. Challen, G. Martinez, M.J. Davis, D.F. Taylor, M. Crowe, R.D. Teasdale, S.M. Grimmond, and M.H. Little Identifying the molecular phenotype of renal progenitor cells J Am Soc Nephrol 15 2004 2344 2357 (Pubitemid 39159334)
23. G. Swetha, V. Chandra, S. Phadnis, and R. Bhonde Glomerular parietal epithelial cells of adult murine kidney undergo EMT to generate cells with traits of renal progenitors J Cell Mol Med 2009 (In press)
24. V. Barbaro, A. Testa, E. Di Iorio, F. Mavilio, G. Pellegrini, and M. De Luca C/EBPdelta regulates cell cycle and self-renewal of human limbal stem cells J Cell Biol 177 2007 1037 1049 (Pubitemid 46955708)
25. J. O'Rourke, R. Yuan, and J. DeWille CCAAT/enhancer-binding protein-delta (C/EBP-delta) is induced in growth-arrested mouse mammary epithelial cells J Biol Chem 272 1997 6291 6296 (Pubitemid 27118102)
26. Y. Zhang, T. Liu, P. Yan, T. Huang, and J. Dewille Identification and characterization of CCAAT/Enhancer Binding proteindelta (C/EBPdelta) target genes in G0 growth arrested mammary epithelial cells BMC Mol Biol 9 2008 83
27. S. Metsuyanim, O. Harari-Steinberg, E. Buzhor, D. Omer, N. Pode-Shakked, H. Ben-Hur, R. Halperin, D. Schneider, and B. Dekel Expression of stem cell markers in the human fetal kidney PLoS One 4 2009 e6709
28. B. Smeets, S. Uhlig, A. Fuss, F. Mooren, J.F. Wetzels, J. Floege, and M.J. Moeller Tracing the origin of glomerular extracapillary lesions from parietal epithelial cells J Am Soc Nephrol 20 2009 2604 2615
29. P.S. Thorner, M. Ho, V. Eremina, Y. Sado, and S. Quaggin Podocytes contribute to the formation of glomerular crescents J Am Soc Nephrol 19 2008 495 502 (Pubitemid 351355393)
30. J. Bariety, D. Nochy, C. Mandet, C. Jacquot, D. Glotz, and A. Meyrier Podocytes undergo phenotypic changes and express macrophagic-associated markers in idiopathic collapsing glomerulopathy Kidney Int 53 1998 918 925 (Pubitemid 28155664)
31. M.J. Moeller, A. Soofi, I. Hartmann, M. Le Hir, R. Wiggins, W. Kriz, and L.B. Holzman Podocytes populate cellular crescents in a murine model of inflammatory glomerulonephritis J Am Soc Nephrol 15 2004 61 67 (Pubitemid 38020698)
32. M. Le Hir, C. Keller, V. Eschmann, B. Hahnel, H. Hosser, and W. Kriz Podocyte bridges between the tuft and Bowman's capsule: an early event in experimental crescentic glomerulonephritis J Am Soc Nephrol 12 2001 2060 2071 (Pubitemid 32880342)