Ubiquitin ligase Siah2 regulates RevErbα degradation and the mammalian circadian clock

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 40, 2015, Pages 12420-12425

  DeBruyne, Jason P ^a   Baggs, Julie E ^a   Sato, Trey K ^b,c   Hogenesch, John B ^b  

^a MOREHOUSE SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

Circadian clock; RevErb Nr1d1; Siah2; Ubiquitin ligase screen

Indexed keywords

F BOX PROTEIN; PROTEIN; REVERB ALPHA PROTEIN; SIAH2 PROTEIN; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR CLOCK; UBIQUITIN PROTEIN LIGASE; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG; NR1D1 PROTEIN, HUMAN; NUCLEAR PROTEIN; NUCLEAR RECEPTOR NR1D1; SEVEN IN ABSENTIA PROTEINS;

ANIMAL EXPERIMENT; ARTICLE; CIRCADIAN RHYTHM; CONTROLLED STUDY; DNA BINDING; FIBROBLAST; GENE EXPRESSION; GENE INTERACTION; IMMUNOPRECIPITATION; MOLECULAR CLONING; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DEPLETION; PROTEIN INTERACTION; PROTEIN STABILITY; PROTEIN SYNTHESIS; U2OS CELL LINE; UBIQUITINATION; ANIMAL; CELL CULTURE; CELL LINE; CYTOLOGY; FLUORESCENCE MICROSCOPY; GENETICS; HUMAN; MAMMALIAN EMBRYO; METABOLISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; TUMOR CELL LINE; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; CELL LINE; CELL LINE, TUMOR; CELLS, CULTURED; CIRCADIAN CLOCKS; EMBRYO, MAMMALIAN; FIBROBLASTS; GENE EXPRESSION; HUMANS; MICE; MICROSCOPY, FLUORESCENCE; NUCLEAR PROTEINS; NUCLEAR RECEPTOR SUBFAMILY 1, GROUP D, MEMBER 1; PROTEOLYSIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA INTERFERENCE; UBIQUITIN-PROTEIN LIGASES;

EID: 84943327589     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1501204112     Document Type: Article

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