Dual roles of FBXL3 in the mammalian circadian feedback loops are important for period determination and robustness of the clock

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 12, 2013, Pages 4750-4755

  Shi, Guangsen ^a   Xing, Lijuan ^a   Liu, Zhiwei ^a   Qu, Zhipeng ^a   Wu, Xi ^a   Dong, Zhen ^a   Wang, Xiaohan ^a   Gao, Xiang ^a   Huang, Moli ^b   Yan, Jie ^b   Yang, Ling ^b   Liu, Yi ^c   Ptáček, Louis J ^d   Xu, Ying ^a,b  

^a NANJING UNIVERSITY   (China)

^b SOOCHOW UNIVERSITY   (China)

^c UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CRYPTOCHROME 1; F BOX LEUCINE RICH REPEAT PROTEIN 3; F BOX PROTEIN; HISTONE DEACETYLASE 3; RETINOIC ACID RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CIRCADIAN RHYTHM; CONTROLLED STUDY; FEEDBACK SYSTEM; GENE DELETION; GENE EXPRESSION; GENE INTERACTION; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION;

ANIMALS; CIRCADIAN RHYTHM; CRYPTOCHROMES; F-BOX PROTEINS; GENE EXPRESSION REGULATION; GENE PRODUCTS, REV; MICE; MICE, KNOCKOUT; RESPONSE ELEMENTS; THYROID HORMONE RECEPTORS ALPHA;

EID: 84875279589     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1302560110     Document Type: Article

References (36)

1. Hastings MH, Reddy AB, Maywood ES (2003) A clockwork web: Circadian timing in brain and periphery, in health and disease. Nat Rev Neurosci 4(8):649-661.
2. Allada R, Emery P, Takahashi JS, Rosbash M (2001) Stopping time: The genetics of fly and mouse circadian clocks. Annu Rev Neurosci 24:1091-1119.
3. Lowrey PL, Takahashi JS (2004) Mammalian circadian biology: Elucidating genomewide levels of temporal organization. Annu Rev Genomics Hum Genet 5:407-441.
4. Panda S, et al. (2002) Coordinated transcription of key pathways in the mouse by the circadian clock. Cell 109(3):307-320.
5. Reppert SM, Weaver DR (2002) Coordination of circadian timing in mammals. Nature 418(6901):935-941.
6. Sharma VK (2003) Adaptive significance of circadian clocks. Chronobiol Int 20(6):901-919.
7. Schibler U, Naef F (2005) Cellular oscillators: Rhythmic gene expression and metabolism. Curr Opin Cell Biol 17(2):223-229.
8. Preitner N, et al. (2002) The orphan nuclear receptor REV-ERBalpha controls circadian transcription within the positive limb of the mammalian circadian oscillator. Cell 110(2):251-260.
9. Sato TK, et al. (2004) A functional genomics strategy reveals Rora as a component of the mammalian circadian clock. Neuron 43(4):527-537.
10. Liu AC, et al. (2008) Redundant function of REV-ERBalpha and beta and non-essential role for Bmal1 cycling in transcriptional regulation of intracellular circadian rhythms. PLoS Genet 4(2):e1000023.
11. Siepka SM, et al. (2007) Circadian mutant Overtime reveals F-box protein FBXL3 regulation of cryptochrome and period gene expression. Cell 129(5):1011-1023.
12. Godinho SI, et al. (2007) The after-hours mutant reveals a role for Fbxl3 in determining mammalian circadian period. Science 316(5826):897-900.
13. Busino L, et al. (2007) SCFFbxl3 controls the oscillation of the circadian clock by directing the degradation of cryptochrome proteins. Science 316(5826):900-904.
14. Chen R, et al. (2009) Rhythmic PER abundance defines a critical nodal point for negative feedback within the circadian clock mechanism. Mol Cell 36(3):417-430.
15. King DP, et al. (1997) Positional cloning of the mouse circadian clock gene. Cell 89(4): 641-653.
16. Bunger MK, et al. (2000) Mop3 is an essential component of the master circadian pacemaker in mammals. Cell 103(7):1009-1017.
17. Xu Y, et al. (2007) Modeling of a human circadian mutation yields insights into clock regulation by PER2. Cell 128(1):59-70.
18. Thresher RJ, et al. (1998) Role of mouse cryptochrome blue-light photoreceptor in circadian photoresponses. Science 282(5393):1490-1494.
19. Vitaterna MH, et al. (1999) Differential regulation of mammalian period genes and circadian rhythmicity by cryptochromes 1 and 2. Proc Natl Acad Sci USA 96(21):12114-12119.
20. Etchegaray JP, Lee C, Wade PA, Reppert SM (2003) Rhythmic histone acetylation underlies transcription in the mammalian circadian clock. Nature 421(6919):177-182.
21. Boone C, Bussey H, Andrews BJ (2007) Exploring genetic interactions and networks with yeast. Nat Rev Genet 8(6):437-449.
22. Bugge A, et al. (2012) Rev-erba and Rev-erbβ coordinately protect the circadian clock and normal metabolic function. Genes Dev 26(7):657-667.
23. Alenghat T, et al. (2008) Nuclear receptor corepressor and histone deacetylase 3 govern circadian metabolic physiology. Nature 456(7224):997-1000.
24. Yin L, Lazar MA (2005) The orphan nuclear receptor Rev-erbalpha recruits the N-CoR/ histone deacetylase 3 corepressor to regulate the circadian Bmal1 gene. Mol Endocrinol 19(6):1452-1459.
25. Liu C, Li S, Liu T, Borjigin J, Lin JD (2007) Transcriptional coactivator PGC-1alpha integrates the mammalian clock and energy metabolism. Nature 447(7143):477-481.
26. Bae K, et al. (2001) Differential functions of mPer1, mPer2, and mPer3 in the SCN circadian clock. Neuron 30(2):525-536.
27. Wang X, et al. (2010) Interaction of MAGED1 with nuclear receptors affects circadian clock function. EMBO J 29(8):1389-1400.
28. Debruyne JP, et al. (2006) A clock shock: Mouse CLOCK is not required for circadian oscillator function. Neuron 50(3):465-477.
29. Zheng B, et al. (2001) Nonredundant roles of the mPer1 and mPer2 genes in the mammalian circadian clock. Cell 105(5):683-694.
30. Cho H, et al. (2012) Regulation of circadian behaviour and metabolism by REV-ERB-a and REV-ERB-β. Nature 485(7396):123-127.
31. Kume K, et al. (1999) mCRY1 and mCRY2 are essential components of the negative limb of the circadian clock feedback loop. Cell 98(2):193-205.
32. Oster H, Yasui A, van der Horst GT, Albrecht U (2002) Disruption of mCry2 restores circadian rhythmicity in mPer2 mutant mice. Genes Dev 16(20):2633-2638.
33. Ueda HR, et al. (2005) System-level identification of transcriptional circuits underlying mammalian circadian clocks. Nat Genet 37(2):187-192.
34. Ukai-Tadenuma M, et al. (2011) Delay in feedback repression by cryptochrome 1 is required for circadian clock function. Cell 144(2):268-281.
35. Gu X, et al. (2012) The circadian mutation PER2(S662G) is linked to cell cycle progression and tumorigenesis. Cell Death Differ 19(3):397-405.
36. Lee C, Etchegaray JP, Cagampang FR, Loudon AS, Reppert SM (2001) Posttranslational mechanisms regulate the mammalian circadian clock. Cell 107(7):855-867.