The NLRP3 inflammasome and its role in age-related macular degeneration

Advances in Experimental Medicine and Biology

Volumn 854, Issue , 2016, Pages 59-65

  Ildefonso, Cristhian J ^a   Biswal, Manas R ^a   Ahmed, Chulbul M ^a   Lewin, Alfred S ^a  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

Blindness; Complement system proteins; Cytokines; Immune system; Immunity; Inflammasomes; Inflammation; Macular degeneration

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; AMYLOID BETA PROTEIN; CRYOPYRIN; INFLAMMASOME; INTERLEUKIN 18; INTERLEUKIN 1BETA; INTERLEUKIN 6; MACROPHAGE INFLAMMATORY PROTEIN 3ALPHA; MITOGEN ACTIVATED PROTEIN KINASE 3; MYELOID DIFFERENTIATION FACTOR 88; TUMOR NECROSIS FACTOR ALPHA; VASCULOTROPIN; VASCULOTROPIN ANTIBODY; AUTACOID; CARRIER PROTEIN; CYTOKINE; NLRP3 PROTEIN, HUMAN;

AGE RELATED MACULAR DEGENERATION; AGING; AUTOPHAGY; BINDING AFFINITY; CELL ACTIVATION; CELL DEATH; CELL MIGRATION; CYTOKINE RELEASE; DRUG EFFICACY; DRUG RESPONSE; HUMAN; INTERNALIZATION; LYSOSOME; MICROGLIA; NEOVASCULARIZATION (PATHOLOGY); PATHOGENESIS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN TARGETING; ANIMAL; INFLAMMATION; MACULAR DEGENERATION; METABOLISM; RETINA; SIGNAL TRANSDUCTION;

ANIMALS; CARRIER PROTEINS; CYTOKINES; HUMANS; INFLAMMASOMES; INFLAMMATION; INFLAMMATION MEDIATORS; MACULAR DEGENERATION; RETINA; SIGNAL TRANSDUCTION;

EID: 84943303132     PISSN: 00652598     EISSN: 22148019     Source Type: Book Series    
DOI: 10.1007/978-3-319-17121-0_9     Document Type: Chapter

References (34)

1. Anderson OA, Finkelstein A, Shima DT (2013) A2E induces IL-1ß production in retinal pigment epithelial cells via the NLRP3 inflammasome. PLoS ONE 8:e67263
2. Bauernfeind FG, Horvath G, Stutz A et al (2009) Cutting edge: NF-kB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression. J Immunol 183:787-791
3. Camelo S (2014) Potential sources and roles of adaptive immunity in age-related macular degeneration: shall we rename AMD into autoimmune macular disease? Autoimmune Dis 2014:e532487
4. Campbell M, Doyle SL (2013) An eye on the future of inflammasomes and drug development in AMD. J Mol Med 91:1059-1070
5. Campbell DM, Doyle SL, Ozaki E et al (2014) An overview of the involvement of Interleukin-18 in degenerative retinopathies. In: Ash JD, Grimm C, Hollyfield JG et al (eds) Retinal degenerative diseases. Springer, New York, pp 409-415. (Adv Exp Med Biol)
6. Cao L, Wang H, Wang F et al (2013) Aβ-induced senescent retinal pigment epithelial cells create a proinflammatory microenvironment in AMD. Invest Ophthalmol Vis Sci 54:3738-3750
7. Cassel SL, Joly S, Sutterwala FS (2009) The NLRP3 inflammasome: a sensor of immune danger signals. Semin Immunol 21:194-198
8. Crabb JW, Miyagi M, Gu X et al (2002) Drusen proteome analysis: an approach to the etiology of age-related macular degeneration. Proc Natl Acad Sci U S A 99:14682-14687
9. Cruz-Guilloty F, Saeed AM, Duffort S et al (2014) T cells and macrophages responding to oxidative damage cooperate in pathogenesis of a mouse model of age-related macular degeneration. PLoS ONE 9:e88201
10. Dinarello C, Novick D, Kim S et al (2013) Interleukin-18 and IL-18 binding protein. Inflammation 4:289
11. Doyle SL, Campbell M, Ozaki E et al (2012) NLRP3 has a protective role in age-related macular degeneration through the induction of IL-18 by drusen components. Nature Med 18:791-798
12. Doyle SL, Ozaki E, Brennan K et al (2014) IL-18 Attenuates experimental choroidal neovascularization as a potential therapy for wet age-related macular degeneration. Sci Transl Med 6:230ra44-230ra44
13. Dridi S, Hirano Y, Tarallo V et al (2012) ERK1/2 activation is a therapeutic target in age-related macular degeneration. Proc Natl Acad Sci U S A 109:13781-13786
14. Fernandes-Alnemri T, Wu J, Yu J-W et al (2007) The pyroptosome: a supramolecular assembly of ASC dimers mediating inflammatory cell death via caspase-1 activation. Cell Death Differ 14:1590-1604
15. Fletcher EL, Jobling AI, Greferath U et al (2014) Studying age-related macular degeneration using animal models. Optom Vis Sci 91:878-886
16. Johnson LV, Leitner WP, Rivest AJ et al (2002) The Alzheimer's Aβ-peptide is deposited at sites of complement activation in pathologic deposits associated with aging and age-related macular degeneration. Proc Natl Acad Sci U S A 99:11830-11835
17. Kaarniranta K, Sinha D, Blasiak J et al (2013) Autophagy and heterophagy dysregulation leads to retinal pigment epithelium dysfunction and development of age-related macular degeneration. Autophagy 9:973-984
18. Kaneko H, Dridi S, Tarallo V et al (2011) DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration. Nature 471:325-330
19. Kauppinen A, Niskanen H, Suuronen T et al (2012) Oxidative stress activates NLRP3 inflammasomes in ARPE-19 cells-implications for age-related macular degeneration (AMD). Immunol Lett 147
20. Kerur N, Hirano Y, Tarallo V et al (2013) TLR-Independent and P2 × 7-dependent signaling mediate alu RNA-induced NLRP3 inflammasome activation in geographic atrophy. Invest Ophthalmol Vis Sci 54:7395-7401
21. Klein R, Klein BEK (2013) The prevalence of age-related eye diseases and visual impairment in aging: current estimates. Invest Ophthalmol Vis Sci 54:ORSF5-ORSF13
22. Kuida K, Lippke JA, Ku G et al (1995) Altered cytokine export and apoptosis in mice deficient in interleukin-1 beta converting enzyme. Science 267:2000-2003
23. Le HT, Harton JA (2013) Pyrin-and CARD-only proteins as regulators of NLR functions. Mol Innate Immun 4:275
24. Liu RT, Gao J, Cao S et al (2013) Inflammatory mediators induced by Amyloid-Beta in the Retina and RPE in vivo: implications for inflammasome activation in age-related macular degeneration. Invest Ophthalmol Vis Sci 54:2225-2237
25. Ma W, Zhao L, Fontainhas AM et al (2009) Microglia in the mouse retina alter the structure and function of retinal pigmented epithelial cells: a potential cellular interaction relevant to AMD. PLoS ONE 4:e7945
26. Marneros AG (2013) NLRP3 inflammasome blockade inhibits VEGF-A-induced age-related macular degeneration. Cell Rep 4:945-958
27. Miao EA, Rajan JV, Aderem A (2011) Caspase-1-induced pyroptotic cell death. Immunol Rev 243:206-214
28. Mullins RF, Russell SR, Anderson DH et al (2000) Drusen associated with aging and age-related macular degeneration contain proteins common to extracellular deposits associated with atherosclerosis, elastosis, amyloidosis, and dense deposit disease. FASEB J 14:835-846
29. Narayanan R, Butani V, Boyer DS et al (2007) Complement factor H polymorphism in age-related macular degeneration. Ophthalmol 114:1327-1331
30. Shastry BS (2007) Assessment of the contribution of the LOC387715 gene polymorphism in a family with exudative age-related macular degeneration and heterozygous CFH variant (Y402H). J Hum Genet 52:384-387
31. Srinivasula SM, Poyet J-L, Razmara M et al (2002) The PYRIN-CARD protein ASC is an activating adaptor for Caspase-1. J Biol Chem 277:21119-21122
32. Stutz A, Golenbock DT, Latz E (2009) Inflammasomes: too big to miss. J Clin Invest 119:3502-3511
33. Tarallo V, Hirano Y, Gelfand BD et al (2012) DICER1 loss and alu RNA induce age-related macular degeneration via the NLRP3 inflammasome and MyD88. Cell 149:847-859
34. Tseng WA, Thein T, Kinnunen K et al (2013) NLRP3 inflammasome activation in retinal pigment epithelial cells by lysosomal destabilization: implications for age-related macular degeneration. Invest Ophthalmol Vis Sci 54:110-120