Potential sources and roles of adaptive immunity in age-related macular degeneration: Shall we rename AMD into autoimmune macular disease?

Autoimmune Diseases

Volumn 2014, Issue , 2014, Pages

  Camelo, Serge ^a  

^a NONE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 17 ANTIBODY;

ADAPTIVE IMMUNITY; BLOOD RETINA BARRIER; GENETIC ASSOCIATION; HUMAN; INNATE IMMUNITY; MACROPHAGE; MICROGLIA; PATHOGENESIS; PIGMENT EPITHELIUM; RETINA DEGENERATION; RETINA MACULA AGE RELATED DEGENERATION; REVIEW; SUBRETINAL NEOVASCULARIZATION; T LYMPHOCYTE;

EID: 84901323589     PISSN: 20900422     EISSN: 20900430     Source Type: Journal    
DOI: 10.1155/2014/532487     Document Type: Review

References (125)

1. Klein R., Peto T., Bird A., Vannewkirk M. R., The epidemiology of age-related macular degeneration. American Journal of Ophthalmology 2004 137 3 486 495 2-s2.0-1542297335 10.1016/j.ajo.2003.11.069 (Pubitemid 38328641)
2. Holz F. G., Pauleikhoff D., Klein R., Bird A. C., Pathogenesis of lesions in late age-related macular disease. American Journal of Ophthalmology 2004 137 3 504 510 2-s2.0-1542297332 10.1016/j.ajo.2003.11.026 (Pubitemid 38328643)
3. Bonilha V. L., Age and disease-related structural changes in the retinal pigment epithelium. Clinical Ophthalmology 2008 2 2 413 424
4. Kinnunen K., Petrovski G., Moe M. C., Berta A., Kaarniranta K., Molecular mechanisms of retinal pigment epithelium damage and development of age-related macular degeneration. Acta Ophthalmologica 2011 90 299 309 2-s2.0-81555234798 10.1111/j.1755-3768.2011.02179.x
5. Neuner B., Komm A., Wellmann J., Dietzel M., Pauleikhoff D., Walter J., Busch M., Hense H. W., Smoking history and the incidence of age-related macular degeneration-Results from the Muenster Aging and Retina Study (MARS) cohort and systematic review and meta-analysis of observational longitudinal studies. Addictive Behaviors 2009 34 11 938 947 2-s2.0-68149182806 10.1016/j.addbeh.2009. 05.015
6. Hollyfield J. G., Bonilha V. L., Rayborn M. E., Yang X., Shadrach K. G., Lu L., Ufret R. L., Salomon R. G., Perez V. L., Oxidative damage-induced inflammation initiates age-related macular degeneration. Nature Medicine 2008 14 2 194 198 2-s2.0-38949185692 10.1038/nm1709 (Pubitemid 351214555)
7. Hollyfield J. G., Age-related macular degeneration: the molecular link between oxidative damage, tissue-specific inflammation and outer retinal disease: the Proctor lecture. Investigative Ophthalmology and Visual Science 2010 51 3 1276 1281 2-s2.0-77949890579 10.1167/iovs.09-4478
8. Buschini E., Piras A., Nuzzi R., Vercelli A., Age related macular degeneration and drusen: neuroinflammation in the retina. Progress in Neurobiology 2011 95 1 14 25 2-s2.0-79960671469 10.1016/j.pneurobio.2011.05.011
9. Shen J. K., Dong A., Hackett S. F., Bell W. R., Green W. R., Campochiaro P. A., Oxidative damage in age-related macular degeneration. Histology and Histopathology 2007 22 12 1301 1308 2-s2.0-34548592109 (Pubitemid 47470323)
10. Xu H., Chen M., Forrester J. V., Para-inflammation in the aging retina. Progress in Retinal and Eye Research 2009 28 5 348 368 2-s2.0-67651155742 10.1016/j.preteyeres.2009.06.001
11. Ardeljan D., Chan C. C., Aging is not a disease: distinguishing age-related macular degeneration from aging. Progress in Retinal and Eye Research 2013 37 68 89 10.1016/j.preteyeres.2013.07.003
12. Edwards A. O., Ritter R. III, Abel K. J., Manning A., Panhuysen C., Farrer L. A., Complement factor H polymorphism and age-related macular degeneration. Science 2005 308 5720 421 424 2-s2.0-17244379811 10.1126/science.1110189 (Pubitemid 40530082)
13. Haines J. L., Hauser M. A., Schmidt S., Scott W. K., Olson L. M., Gallins P., Spencer K. L., Shu Y. K., Noureddine M., Gilbert J. R., Schnetz-Boutaud N., Agarwal A., Postel E. A., Pericak-Vance M. A., Complement factor H variant increases the risk of age-related macular degeneration. Science 2005 308 5720 419 421 2-s2.0-20244388812 10.1126/science.1110359 (Pubitemid 40530081)
14. Klein R. J., Zeiss C., Chew E. Y., Tsai J. Y., Sackler R. S., Haynes C., Henning A. K., SanGiovanni J. P., Mane S. M., Mayne S. T., Bracken M. B., Ferris F. L., Ott J., Barnstable C., Hoh J., Complement factor H polymorphism in age-related macular degeneration. Science 2005 308 5720 385 389 2-s2.0-20244380171 10.1126/science.1109557 (Pubitemid 40530070)
15. Maller J., George S., Purcell S., Fagerness J., Altshuler D., Daly M. J., Seddon J. M., Common variation in three genes, including a noncoding variant in CFH, strongly influences risk of age-related macular degeneration. Nature Genetics 2006 38 9 1055 1059 2-s2.0-33748309136 10.1038/ng1873 (Pubitemid 44325932)
16. Maller J. B., Fagerness J. A., Reynolds R. C., Neale B. M., Daly M. J., Seddon J. M., Variation in complement factor 3 is associated with risk of age-related macular degeneration. Nature Genetics 2007 39 10 1200 1201 2-s2.0-34748819371 10.1038/ng2131 (Pubitemid 47482689)
17. Heurich M., Martínez-Barricarte R., Francis N. J., Roberts D. L., Rodríguez De Córdoba S., Morgan B. P., Harris C. L., Common polymorphisms in C3, factor B, and factor H collaborate to determine systemic complement activity and disease risk. Proceedings of the National Academy of Sciences of the United States of America 2011 108 21 8761 8766 2-s2.0-79957691055 10.1073/pnas.1019338108
18. Montes T., Tortajada A., Morgan B. P., De Córdoba S. R., Harris C. L., Functional basis of protection against age-related macular degeneration conferred by a common polymorphism in complement factor B. Proceedings of the National Academy of Sciences of the United States of America 2009 106 11 4366 4371 2-s2.0-63449141168 10.1073/pnas.0812584106
19. Fagerness J. A., Maller J. B., Neale B. M., Reynolds R. C., Daly M. J., Seddon J. M., Variation near complement factor I is associated with risk of advanced AMD. European Journal of Human Genetics 2009 17 1 100 104 2-s2.0-57649215855 10.1038/ejhg.2008.140
20. Tuo J., Smith B. C., Bojanowski C. M., Meleth A. D., Gery I., Csaky K. G., Chew E. Y., Chan C. C., The involvement of sequence variation and expression of CX3CR1 in the pathogenesis of age-related macular degeneration. FASEB Journal 2004 18 11 1297 1299 2-s2.0-9444220221 10.1096/fj.04-1862fje (Pubitemid 39561582)
21. Chan C. C., Tuo J., Bojanowski C. M., Csaky K. G., Green W. R., Detection of CX3CR1 single nucleotide polymorphism and expression on archived eyes with age-related macular degeneration. Histology and Histopathology 2005 20 3 857 863 2-s2.0-21644482231 (Pubitemid 40932603)
22. Combadière C., Feumi C., Raoul W., Keller N., Rodéro M., Pézard A., Lavalette S., Houssier M., Jonet L., Picard E., Debré P., Sirinyan M., Deterre P., Ferroukhi T., Cohen S. Y., Chauvaud D., Jeanny J. C., Chemtob S., Behar-Cohen F., Sennlaub F., CX3CR1-dependent subretinal microglia cell accumulation is associated with cardinal features of age-related macular degeneration. Journal of Clinical Investigation 2007 117 10 2920 2928 2-s2.0-34948898131 10.1172/JCI31692 (Pubitemid 47529622)
23. Schaumberg D. A., Rose L., Deangelis M. M., Semba R. D., Hageman G. S., Chasman D. I., Prospective study of common variants in CX3CR1 and risk of macular degeneration: pooled analysis from 5 long-term studies. JAMA Ophthalmology 2014 132 1 84 95 10.1001/jamaophthalmol.2013.5506
24. Penfold P. L., Liew S. C. K., Madigan M. C., Provis J. M., Modulation of major histocompatibility complex class II expression in retinas with age-related macular degeneration. Investigative Ophthalmology and Visual Science 1997 38 10 2125 2133 2-s2.0-0030931699 (Pubitemid 27407531)
25. Gupta N., Brown K. E., Milam A. H., Activated microglia in human retinitis pigmentosa, late-onset retinal degeneration, and age-related macular degeneration. Experimental Eye Research 2003 76 4 463 471 2-s2.0-0037375042 10.1016/S0014-4835(02)00332-9 (Pubitemid 36299058)
26. Sennlaub F., Auvynet C., Calippe B., Lavalette S., Poupel L., Hu S. J., Dominguez E., Camelo S., Levy O., Guyon E., Saederup N., Charo I. F., Rooijen N. V., Nandrot E., Bourges J. L., Behar-Cohen F., Sahel J. A., Guillonneau X., Raoul W., Combadiere C., CCR2 monocytes infiltrate atrophic lesions in age-related macular disease and mediate photoreceptor degeneration in experimental subretinal inflammation in Cx3cr1 deficient mice. EMBO Molecular Medicine 2013 5 11 1775 1793
27. Espinosa-Heidmann D. G., Caicedo A., Hernandez E. P., Csaky K. G., Cousins S. W., Bone marrow-derived progenitor cells contribute to experimental choroidal neovascularization. Investigative Ophthalmology and Visual Science 2003 44 11 4914 4919 2-s2.0-0142231914 10.1167/iovs.03-0371 (Pubitemid 37315309)
28. Espinosa-Heidmann D. G., Suner I. J., Hernandez E. P., Monroy D., Csaky K. G., Cousins S. W., Macrophage depletion diminishes lesion size and severity in experimental choroidal neovascularization. Investigative Ophthalmology and Visual Science 2003 44 8 3586 3592 2-s2.0-0042343858 10.1167/iovs.03-0038 (Pubitemid 36909799)
29. Sakurai E., Anand A., Ambati B. K., Van Rooijen N., Ambati J., Macrophage depletion inhibits experimental choroidal neovascularization. Investigative Ophthalmology and Visual Science 2003 44 8 3578 3585 2-s2.0-0042844768 10.1167/iovs.03-0097 (Pubitemid 36909798)
30. Raoul W., Feumi C., Keller N., Lavalette S., Houssier M., Behar-Cohen F., Combadière C., Sennlaub F., Lipid-bloated subretinal microglial cells are at the origin of drusen appearance in CX3CR1-deficient mice. Ophthalmic Research 2008 40 3-4 115 119 2-s2.0-42449093343 10.1159/000119860 (Pubitemid 351562887)
31. MacHalińska A., Dziedziejko V., Mozolewska-Piotrowska K., Karczewicz D., Wiszniewska B., MacHaliński B., Elevated plasma levels of c3a complement compound in the exudative form of age-related macular degeneration. Ophthalmic Research 2009 42 1 54 59 2-s2.0-66149093071 10.1159/000219686
32. Robman L., Baird P. N., Dimitrov P. N., Richardson A. J., Guymer R. H., C-reactive protein levels and complement factor H polymorphism interaction in age-related macular degeneration and its progression. Ophthalmology 2010 117 10 1982 1988 2-s2.0-77957591829 10.1016/j.ophtha.2010.02.003
33. Mitta V. P., Christen W. G., Glynn R. J., Semba R. D., Ridker P. M., Rimm E. B., Hankinson S. E., Schaumberg D. A., C-reactive protein and the incidence of macular degeneration: pooled analysis of 5 cohorts. JAMA Ophthalmology 2013 131 4 507 513 10.1001/jamaophthalmol.2013.2303
34. Nussenblatt R. B., Ferris F. III, Age-related macular degeneration and the immune response: implications for therapy. American Journal of Ophthalmology 2007 144 4 618 626 2-s2.0-34548718285 10.1016/j.ajo.2007.06.025 (Pubitemid 47429625)
35. Morohoshi K., Goodwin A. M., Ohbayashi M., Ono S. J., Autoimmunity in retinal degeneration: autoimmune retinopathy and age-related macular degeneration. Journal of Autoimmunity 2009 33 3-4 247 254 2-s2.0-71649108317 10.1016/j.jaut.2009.09.003
36. Ambati J., Atkinson J. P., Gelfand B. D., Immunology of age-related macular degeneration. Nature Reviews Immunology 2013 13 438 451 10.1038/nri3459
37. Whitcup S. M., Sodhi A., Atkinson J. P., Holers V. M., Sinha D., Rohrer B., Dick A. D., The role of the immune response in age-related macular degeneration. International Journal of Inflammation 2013 2013 10 348092 10.1155/2013/348092
38. Penfold P. L., Provis J. M., Furby J. H., Gatenby P. A., Billson F. A., Autoantibodies to retinal astrocytes associated with age-related macular degeneration. Graefe's Archive for Clinical and Experimental Ophthalmology 1990 228 3 270 274 2-s2.0-0025321591 10.1007/BF00920033 (Pubitemid 20150313)
39. Patel N., Ohbayashi M., Nugent A. K., Ramchand K., Toda M., Chau K. Y., Bunce C., Webster A., Bird A. C., Ono S. J., Chong V., Circulating anti-retinal antibodies as immune markers in age-related macular degeneration. Immunology 2005 115 3 422 430 2-s2.0-21244450029 10.1111/j.1365-2567.2005.02173.x (Pubitemid 40896040)
40. Chen H., Wu L., Pan S., Wu D. Z., An immunologic study on age-related macular degeneration. Yan Ke Xue Bao 1993 9 3 113 120 2-s2.0-0027666606
41. Gurne D. H., Tso M. O. M., Edward D. P., Ripps H., Antiretinal antibodies in serum of patients with age-related macular degeneration. Ophthalmology 1991 98 5 602 607 2-s2.0-0025736918
42. Joachim S. C., Bruns K., Lackner K. J., Pfeiffer N., Grus F. H., Analysis of IgG antibody patterns against retinal antigens and antibodies to α -crystallin, GFAP, and α -enolase in sera of patients with "wet" age-related macular degeneration. Graefe's Archive for Clinical and Experimental Ophthalmology 2007 245 5 619 626 2-s2.0-34250710768 10.1007/s00417-006-0429-9 (Pubitemid 46951226)
43. Morohoshi K., Ohbayashi M., Patel N., Chong V., Bird A. C., Ono S. J., Identification of anti-retinal antibodies in patients with age-related macular degeneration. Experimental and Molecular Pathology 2012 93 2 193 199 10.1016/j.yexmp.2012.03.007
44. Morohoshi K., Patel N., Ohbayashi M., Chong V., Grossniklaus H. E., Bird A. C., Ono S. J., Serum autoantibody biomarkers for age-related macular degeneration and possible regulators of neovascularization. Experimental and Molecular Pathology 2012 92 1 64 73 2-s2.0-81055139499 10.1016/j.yexmp.2011.09. 017
45. Cherepanoff S., Mitchell P., Wang J. J., Gillies M. C., Retinal autoantibody profile in early age-related macular degeneration: preliminary findings from the Blue Mountains Eye Study. Clinical and Experimental Ophthalmology 2006 34 6 590 595 2-s2.0-33747347186 10.1111/j.1442-9071.2006. 01281.x
46. Gu X., Meer S. G., Miyagi M., Rayborn M. E., Hollyfield J. G., Crabb J. W., Salomon R. G., Carboxyethylpyrrole protein adducts and autoantibodies, biomarkers for age-related macular degeneration. Journal of Biological Chemistry 2003 278 43 42027 42035 2-s2.0-0142242222 10.1074/jbc.M305460200 (Pubitemid 37310467)
47. Crabb J. W., Miyagi M., Gu X., Shadrach K., West K. A., Sakaguchi H., Kamei M., Hasan A., Yan L., Rayborn M. E., Salomon R. G., Hollyfield J. G., Drusen proteome analysis: an approach to the etiology of age-related macular degeneration. Proceedings of the National Academy of Sciences of the United States of America 2002 99 23 14682 14687 2-s2.0-11144258543 10.1073/pnas. 222551899 (Pubitemid 35334544)
48. Ni J., Yuan X., Gu J., Yue X., Gu X., Nagaraj R. H., Crabb J. W., Plasma protein pentosidine and carboxymethyllysine, biomarkers for age-related macular degeneration. Molecular and Cellular Proteomics 2009 8 8 1921 1933 2-s2.0-70350617849 10.1074/mcp.M900127-MCP200
49. Forooghian F., MacDonald I. M., Heckenlively J. R., Héon E., Gordon L. K., Hooks J. J., Detrick B., Nussenblatt R. B., The need for standardization of antiretinal antibody detection and measurement. American Journal of Ophthalmology 2008 146 4 489 495 2-s2.0-51849123587 10.1016/j.ajo.2008.05.046
50. Adamus G., Ren G., Weleber R. G., Autoantibodies against retinal proteins in paraneoplastic and autoimmune retinopathy. BMC Ophthalmology 2004 4 article 5 1 9 2-s2.0-4544288945 10.1186/1471-2415-4-1
51. Ren G., Adamus G., Cellular targets of anti- α -enolase autoantibodies of patients with autoimmune retinopathy. Journal of Autoimmunity 2004 23 2 161 167 2-s2.0-8444233146 10.1016/j.jaut.2004.06.003 (Pubitemid 39485797)
52. Deshka D., Beate P., Reinhild K., Manfred Z., High incidence of antibodies to lens proteins in sera from patients with uveitis. Graefe's Archive for Clinical and Experimental Ophthalmology 2007 245 5 683 688 2-s2.0-34250775134 10.1007/s00417-006-0407-2 (Pubitemid 46951234)
53. Birnbaum G., Kotilinek L., Heat shock or stress proteins and their role as autoantigens in multiple sclerosis. Annals of the New York Academy of Sciences 1997 835 157 167 2-s2.0-0031578753 10.1111/j.1749-6632.1997.tb48627.x (Pubitemid 28046104)
54. Andrié R. P., Bauriedel G., Braun P., Höpp H. W., Nickenig G., Skowasch D., Prevalence of intimal heat shock protein 60 homologues in unstable angina and correlation with anti-heat shock protein antibody titers. Basic Research in Cardiology 2011 106 4 657 665 2-s2.0-79959734440 10.1007/s00395-011-0171-2
55. Boren E., Gershwin M. E., Inflamm-aging: autoimmunity, and the immune-risk phenotype. Autoimmunity Reviews 2004 3 5 401 406 2-s2.0-3342995295 10.1016/j.autrev.2004.03.004 (Pubitemid 38993363)
56. Liang K. P., Gabriel S. E., Autoantibodies: innocent bystander or key player in immunosenescence and atherosclerosis? Journal of Rheumatology 2007 34 6 1203 1207 2-s2.0-34250222517 (Pubitemid 46898097)
57. Scott S. E., Bouhenni R. A., Chomyk A. M., Dunmire J. J., Patil J., Nakamura H., Deepak P., Anti-retinal antibodies in serum of laser-treated rabbits. Investigative Ophthalmology & Visual Science 2012 53 1764 1772 10.1167/iovs.11-7685
58. Adamus G., Machnicki M., Elerding H., Sugden B., Blocker Y. S., Fox D. A., Antibodies to recoverin induce apoptosis of photoreceptor and bipolar cells in vivo. Journal of Autoimmunity 1998 11 5 523 533 2-s2.0-0032192068 10.1006/jaut.1998.0221 (Pubitemid 28520211)
59. Kyger M., Worley A., Adamus G., Autoimmune responses against photoreceptor antigens during retinal degeneration and their role in macrophage recruitment into retinas of RCS rats. Journal of Neuroimmunology 2012 254 91 100
60. Murinello S., Mullins R. F., Lotery A. J., Perry V. H., Teeling J. L., Fcgamma receptor upregulation is associated with immune complex inflammation in the mouse retina and early age-related macular degeneration. Investigative Ophthalmology & Visual Science 2014 55 247 258 10.1167/iovs.13-11821
61. Penfold P., Killingsworth M., Sarks S., An ultrastructural study of the role of leucocytes and fibroblasts in the breakdown of Bruch's membrane. Australian Journal of Ophthalmology 1984 12 1 23 31 2-s2.0-0021187070 (Pubitemid 14056546)
62. Penfold P. L., Killingsworth M. C., Sarks S. H., Senile macular degeneration: the involvement of immunocompetent cells. Graefe's Archive for Clinical and Experimental Ophthalmology 1985 223 2 69 76 2-s2.0-0021846648 (Pubitemid 15051681)
63. Ezzat M. K., Hann C. R., Vuk-Pavlovic S., Pulido J. S., Immune cells in the human choroid. British Journal of Ophthalmology 2008 92 7 976 980 2-s2.0-47049127751 10.1136/bjo.2007.129742 (Pubitemid 351969682)
64. Mo F. M., Proia A. D., Johnson W. H., Cyr D., Lashkari K., Interferon γ -inducible protein-10 (IP-10) and eotaxin as biomarkers in age-related macular degeneration. Investigative Ophthalmology and Visual Science 2010 51 8 4226 4236 2-s2.0-77955864782 10.1167/iovs.09-3910
65. Newman A. M., Gallo N. B., Hancox L. S., Miller N. J., Radeke C. M., Maloney M. A., Cooper J. B., Hageman G. S., Anderson D. H., Johnson L. V., Radeke M. J., Systems-level analysis of age-related macular degeneration reveals global biomarkers and phenotype-specific functional networks. Genome Medicine 2012 4 article 16 2-s2.0-84857316312 10.1186/PREACCEPT-1418491035586234
66. Detrick B., Hooks J. J., Immune regulation in the retina. Immunologic Research 2010 47 1-3 153 161 2-s2.0-77953962770 10.1007/s12026-009-8146-1
67. Chen H., Liu B., Lukas T. J., Neufeld A. H., The aged retinal pigment epithelium/choroid: a potential substratum for the pathogenesis of age-related macular degeneration. PLoS ONE 2008 3 6 2-s2.0-48649088785 10.1371/journal.pone. 0002339 e2339
68. Chen M., Muckersie E., Forrester J. V., Xu H., Immune activation in retinal aging: a gene expression study. Investigative Ophthalmology and Visual Science 2010 51 11 5888 5896 2-s2.0-79953155543 10.1167/iovs.09-5103
69. Collier R. J., Patel Y., Martin E. A., Dembinska O., Hellberg M., Krueger D. S., Kapin M. A., Romano C., Agonists at the serotonin receptor (5-HT1A) protect the retina from severe photo-oxidative stress. Investigative Ophthalmology and Visual Science 2011 52 5 2118 2126 2-s2.0-79956021004 10.1167/iovs.10-6304
70. Lehmann U., Heuss N. D., McPherson S. W., Roehrich H., Gregerson D. S., Dendritic cells are early responders to retinal injury. Neurobiology of Disease 2010 40 1 177 184 2-s2.0-77955842423 10.1016/j.nbd.2010.05.022
71. Goverdhan S. V., Lotery A. J., Howell W. M., HLA and eye disease: a synopsis. International Journal of Immunogenetics 2005 32 6 333 342 2-s2.0-28444437776 10.1111/j.1744-313X.2005.00548.x (Pubitemid 41735570)
72. Faber C., Singh A., Kruger Falk M., Juel H. B., Sorensen T. L., Nissen M. H., Age-related macular degeneration is associated with increased proportion of CD56(+) T cells in peripheral blood. Ophthalmology 2013 120 11 2310 2316 10.1016/j.ophtha.2013.04.014
73. Luger D., Caspi R. R., New perspectives on effector mechanisms in uveitis. Seminars in Immunopathology 2008 30 2 135 143 2-s2.0-42449154999 10.1007/s00281-008-0108-5
74. Caspi R. R., Silver P. B., Luger D., Tang J., Cortes L. M., Pennesi G., Mattapallil M. J., Chan C. C., Mouse models of experimental autoimmune uveitis. Ophthalmic Research 2008 40 3-4 169 174 2-s2.0-42449105777 10.1159/000119871 (Pubitemid 351562898)
75. Luger D., Silver P. B., Tang J., Cua D., Chen Z., Iwakura Y., Bowman E. P., Sgambellone N. M., Chan C. C., Caspi R. R., Either a Th17 or a Th1 effector response can drive autoimmunity: conditions of disease induction affect dominant effector category. Journal of Experimental Medicine 2008 205 4 799 810 2-s2.0-42249084849 10.1084/jem.20071258 (Pubitemid 351549879)
76. Steinman L., A brief history of TH17, the first major revision in the T H1/TH2 hypothesis of T cell-mediated tissue damage. Nature Medicine 2007 13 2 139 145 2-s2.0-33846966636 10.1038/nm1551
77. Ouyang W., Kolls J. K., Zheng Y., The biological functions of T helper 17 cell effector cytokines in inflammation. Immunity 2008 28 4 454 467 2-s2.0-41549135632 10.1016/j.immuni.2008.03.004 (Pubitemid 351471762)
78. Korn T., Bettelli E., Oukka M., Kuchroo V. K., IL-17 and Th17 cells. Annual Review of Immunology 2009 27 485 517 2-s2.0-61949463911 10.1146/annurev.immunol.021908.132710
79. Miossec P., Korn T., Kuchroo V. K., Interleukin-17 and type 17 helper T cells. New England Journal of Medicine 2009 361 9 848 898 2-s2.0-69349093225 10.1056/NEJMra0707449
80. Shin J. I., Bayry J., A role for IL-17 in age-related macular degeneration. Nature Reviews Immunology 2013 13 article 701 10.1038/nri3459-c1
81. Liu B., Wei L., Meyerle C., Tuo J., Sen H. N., Li Z., Chakrabarty S., Agron E., Chan C. C., Klein M. L., Chew E., Ferris F., Nussenblatt R. B., Complement component C5a promotes expression of IL-22 and IL-17 from human T cells and its implication in age-related macular degeneration. Journal of Translational Medicine 2011 9 1, article 111 2-s2.0-79960559299 10.1186/1479-5876-9-111
82. Chan C. C., Shen de F., Cao X., Wang V. M., Wang Y., Tuo J., Expression of IL-17 In eyes of age-related macular degeneration. ARVO, 2011
83. Hasegawa E., Sonoda K. H., Shichita T., Morita R., Sekiya T., Kimura A., Oshima Y., Takeda A., Yoshimura T., Yoshida S., Ishibashi T., Yoshimura A., IL-23-independent induction of IL-17 from gammadeltaT cells and innate lymphoid cells promotes experimental intraocular neovascularization. Journal of Immunology 2013 190 1778 1787 10.4049/jimmunol.1202495
84. Wei L., Liu B., Tuo J., Shen D., Chen P., Li Z., Liu X., Ni J., Dagur P., Sen H. N., Jawad S., Ling D., Park S., Chakrabarty S., Meyerle C., Agron E., Ferris F. L. III, Chew E. Y., McCoy J. P., Blum E., Francis P. J., Klein M. L., Guymer R. H., Baird P. N., Chan C. C., Nussenblatt R. B., Hypomethylation of the IL17RC promoter associates with age-related macular degeneration. Cell Reports 2012 2 5 1151 1158 10.1016/j.celrep.2012.10.013
85. Bernstein B. E., Meissner A., Lander E. S., The mammalian epigenome. Cell 2007 128 4 669 681 2-s2.0-33847032960 10.1016/j.cell.2007.01.033 (Pubitemid 46273573)
86. Smith E., Prasad K. M. R., Butcher M., Dobrian A., Kolls J. K., Ley K., Galkina E., Blockade of interleukin-17A results in reduced atherosclerosis in apolipoprotein E-deficient mice. Circulation 2010 121 15 1746 1755 2-s2.0-77951485998 10.1161/CIRCULATIONAHA.109.924886
87. Sergejeva S., Ivanov S., Lötvall J., Lindén A., Interleukin-17 as a recruitment and survival factor for airway macrophages in allergic airway inflammation. American Journal of Respiratory Cell and Molecular Biology 2005 33 3 248 253 2-s2.0-24344469562 10.1165/rcmb.2004-0213OC (Pubitemid 41254291)
88. Jovanovic D. V., Di Battista J. A., Martel-Pelletier J., Jolicoeur F. C., He Y., Zhang M., Mineau F., Pelletier J. P., IL-17 stimulates the production and expression of proinflammatory cytokines, IL- β and TNF- α by human macrophages. Journal of Immunology 1998 160 7 3513 3521 2-s2.0-0032055597 (Pubitemid 28164746)
89. Gao Q., Jiang Y., Ma T., Zhu F., Gao F., Zhang P., Guo C., Wang Q., Wang X., Ma C., Zhang Y., Chen W., Zhang L., A critical function of Th17 proinflammatory cells in the development of atherosclerotic plaque in mice. Journal of Immunology 2010 185 10 5820 5827 2-s2.0-78650637747 10.4049/jimmunol.1000116
90. Silverpil E., Glader P., Hansson M., Lindén A., Impact of interleukin-17 on macrophage phagocytosis of apoptotic neutrophils and particles. Inflammation 2011 34 1 1 9 2-s2.0-78751644108 10.1007/s10753-010- 9201-8
91. Volin M. V., Shahrara S., Role of TH-17 cells in rheumatic and other autoimmune diseases. Rheumatology 2011 1 article 104 10.4172/2161-1149.1000104
92. Kebir H., Kreymborg K., Ifergan I., Dodelet-Devillers A., Cayrol R., Bernard M., Giuliani F., Arbour N., Becher B., Prat A., Human TH17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation. Nature Medicine 2007 13 10 1173 1175 2-s2.0-34948909646 10.1038/nm1651 (Pubitemid 47530640)
93. Wang D. D., Zhao Y. F., Wang G. Y., Sun B., Kong Q. F., Zhao K., Zhang Y., Wang J. H., Liu Y. M., Mu L. L., Wang D. S., Li H. L., IL-17 potentiates neuronal injury induced by oxygen-glucose deprivation and affects neuronal IL-17 receptor expression. Journal of Neuroimmunology 2009 212 1-2 17 25 2-s2.0-67649848277 10.1016/j.jneuroim.2009.04.007
94. Reynolds A. D., Stone D. K., Hutter J. A. L., Benner E. J., Mosley R. L., Gendelman H. E., Regulatory T cells attenuate Th17 cell-mediated nigrostriatal dopaminergic neurodegeneration in a model of Parkinson's disease. Journal of Immunology 2010 184 5 2261 2271 2-s2.0-77951882307 10.4049/jimmunol.0901852
95. Chen Y., Yang P., Li F., Kijlstra A., The effects of Th17 cytokines on the inflammatory mediator production and barrier function of ARPE-19 cells. PLoS ONE 2011 6 3 2-s2.0-79953305489 10.1371/journal.pone.0018139 e18139
96. Takahashi H., Numasaki M., Lotze M. T., Sasaki H., Interleukin-17 enhances bFGF-, HGF- and VEGF-induced growth of vascular endothelial cells. Immunology Letters 2005 98 2 189 193 2-s2.0-18044377011 10.1016/j.imlet.2004.11. 012 (Pubitemid 40602629)
97. Ryu S., Lee J. H., Kim S. I., IL-17 increased the production of vascular endothelial growth factor in rheumatoid arthritis synoviocytes. Clinical Rheumatology 2006 25 1 16 20 2-s2.0-33645739379 10.1007/s10067-005-1081-1
98. Matzinger P., The danger model: a renewed sense of self. Science 2002 296 5566 301 305 2-s2.0-0037066427 10.1126/science.1071059 (Pubitemid 34303674)
99. Kurien B. T., Scofield R. H., Autoimmunity and oxidatively modified autoantigens. Autoimmunity Reviews 2008 7 7 567 573 2-s2.0-50949098933 10.1016/j.autrev.2008.04.019
100. Moghaddam A. E., Gartlan K. H., Kong L., Sattentau Q. J., Reactive carbonyls are a major Th2-inducing damage-associated molecular pattern generated by oxidative stress. Journal of Immunology 2011 187 4 1626 1633 2-s2.0-80051935634 10.4049/jimmunol.1003906
101. Kurien B. T., Scofield R. H., 4-Hydroxynonenal-modified Ro 60 autoantigen accelerates autoimmunity in experimental animals. Rheumatology 2008 47 10 1587 2-s2.0-52949112323 10.1093/rheumatology/ken300
102. Weismann D., Hartvigsen K., Lauer N., Bennett K. L., Scholl H. P. N., Issa P. C., Cano M., Brandstätter H., Tsimikas S., Skerka C., Superti-Furga G., Handa J. T., Zipfel P. F., Witztum J. L., Binder C. J., Complement factor H binds malondialdehyde epitopes and protects from oxidative stress. Nature 2011 478 7367 76 81 2-s2.0-80053904386 10.1038/nature10449
103. Handa J. T., Verzijl N., Matsunaga H., Aotaki-Keen A., Lutty G. A., Te Koppele J. M., Miyata T., Hjelmeland L. M., Increase in the advanced glycation end product pentosidine in Bruch's membrane with age. Investigative Ophthalmology and Visual Science 1999 40 3 775 779 2-s2.0-0033024626 (Pubitemid 29109458)
104. Hammes H. P., Hoerauf H., Alt A., Schleicher E., Clausen J. T., Bretzel R. G., Laqua H., N(ε)(carboxymethyl)lysin and the AGE receptor RAGE colocalize in age-related macular degeneration. Investigative Ophthalmology and Visual Science 1999 40 8 1855 1859 2-s2.0-0032587144 (Pubitemid 29297167)
105. Wuttge D. M., Bruzelius M., Stemme S., T-cell recognition of lipid peroxidation products breaks tolerance to self proteins. Immunology 1999 98 2 273 279 2-s2.0-0032854884 10.1046/j.1365-2567.1999.00872.x (Pubitemid 29487650)
106. Getts D. R., Chastain E. M., Terry R. L., Miller S. D., Virus infection, antiviral immunity, and autoimmunity. Immunological Reviews 2013 255 197 209 10.1111/imr.12091
107. Enouz S., Carrie L., Merkler D., Bevan M. J., Zehn D., Autoreactive T cells bypass negative selection and respond to self-antigen stimulation during infection. Journal of Experimental Medicine 2012 209 1769 1779 10.1084/jem.20120905
108. Barzilai O., Ram M., Shoenfeld Y., Viral infection can induce the production of autoantibodies. Current Opinion in Rheumatology 2007 19 6 636 643 2-s2.0-34948879087 10.1097/BOR.0b013e3282f0ad25 (Pubitemid 47530886)
109. Streilein J. W., Immunoregulatory mechanisms of the eye. Progress in Retinal and Eye Research 1999 18 3 357 370 2-s2.0-0033039802 10.1016/S1350-9462(98)00022-6 (Pubitemid 29092611)
110. Zinkernagel M. S., McMenamin P. G., Forrester J. V., Degli-Esposti M. A., T cell responses in experimental viral retinitis: mechanisms, peculiarities and implications for gene therapy with viral vectors. Progress in Retinal and Eye Research 2011 30 4 275 284 2-s2.0-79958105726 10.1016/j.preteyeres.2011.04.001
111. Streilein J. W., Dana M. R., Ksander B. R., Immunity causing blindness: five different paths to herpes stromal keratitis. Immunology Today 1997 18 9 443 449 2-s2.0-0030770508 10.1016/S0167-5699(97)01114-6 (Pubitemid 27381987)
112. Caspi R. R., Ocular autoimmunity: the price of privilege? Immunological Reviews 2006 213 1 23 35 2-s2.0-33748745741 10.1111/j.1600-065X.2006.00439.x (Pubitemid 44401491)
113. Blank M., Barzilai O., Shoenfeld Y., Molecular mimicry and auto-immunity. Clinical Reviews in Allergy and Immunology 2007 32 1 111 118 2-s2.0-34247118771 10.1007/s12016-007-0025-8 (Pubitemid 46594581)
114. Cusick M. F., Libbey J. E., Fujinami R. S., Molecular mimicry as a mechanism of autoimmune disease. Clinical Reviews in Allergy and Immunology 2012 42 1 102 111 2-s2.0-84857061618 10.1007/s12016-011-8294-7
115. Fournier E. M., Velez M. G., Leahy K., Swanson C. L., Rubtsov A. V., Torres R. M., Pelanda R., Dual-reactive B cells are autoreactive and highly enriched in the plasmablast and memory B cell subsets of autoimmune mice. Journal of Experimental Medicine 2012 209 1797 1812 10.1084/jem.20120332
116. Hooks J. J., Percopo C., Wang Y., Detrick B., Retina and retinal pigment epithelial cell autoantibodies are produced during murine coronavirus retinopathy. Journal of Immunology 1993 151 6 3381 3389 2-s2.0-0027185997 (Pubitemid 23282651)
117. Kalayoglu M. V., Galvan C., Mahdi O. S., Byrne G. I., Mansour S., Serological association between Chlamydia pneumoniae infection and age-related macular degeneration. Archives of Ophthalmology 2003 121 4 478 482 2-s2.0-0037386730 10.1001/archopht.121.4.478 (Pubitemid 36427634)
118. Miller D. M., Espinosa-Heidmann D. G., Legra J., Dubovy S. R., Sũner I. J., Sedmak D. D., Dix R. D., Cousins S. W., The association of prior cytomegalovirus infection with neovascular age-related macular degeneration. American Journal of Ophthalmology 2004 138 3 323 328 2-s2.0-4444335830 10.1016/j.ajo.2004.03.018 (Pubitemid 39208558)
119. Zhu J., Quyyumi A. A., Norman J. E., Csako G., Waclawiw M. A., Shearer G. M., Epstein S. E., Effects of total pathogen burden on coronary artery disease risk and C-reactive protein levels. American Journal of Cardiology 2000 85 2 140 146 2-s2.0-0033984188 10.1016/S0002-9149(99)00653-0 (Pubitemid 30026092)
120. Sato W., Aranami T., Yamamura T., Cutting edge: human Th17 cells are identified as bearing CCR2+CCR5- phenotype. Journal of Immunology 2007 178 12 7525 7529 2-s2.0-34250196774 (Pubitemid 46898020)
121. Reboldi A., Coisne C., Baumjohann D., Benvenuto F., Bottinelli D., Lira S., Uccelli A., Lanzavecchia A., Engelhardt B., Sallusto F., C-C chemokine receptor 6-regulated entry of TH-17 cells into the CNS through the choroid plexus is required for the initiation of EAE. Nature Immunology 2009 10 5 514 523 2-s2.0-65249175159 10.1038/ni.1716
122. Oo Y. H., Banz V., Kavanagh D., Liaskou E., Withers D. R., Humphreys E., Reynolds G. M., Lee-Turner L., Kalia N., Hubscher G. S., Klenerman P., Eksteen B., Adams D. H., CXCR3-dependent recruitment and CCR6-mediated positioning of Th-17 cells in the inflamed liver. Journal of Hepatology 2012 57 1044 1051 10.1016/j.jhep.2012.07.008
123. Kellner H., Targeting interleukin-17 in patients with active rheumatoid arthritis: rationale and clinical potential. Therapeutic Advances in Musculoskeletal Disease 2012 5 3 141 152 10.1177/1759720X13485328
124. Chew E. Y., Clemons T. E., Agron E., Sperduto R. D., Sangiovanni J. P., Kurinij N., Davis M. D., Long-term effects of vitamins C and E, β -carotene, and zinc on age-related macular degeneration: AREDS report no. 35. Ophthalmology 2013 120 1604 1611 10.1016/j.ophtha.2013.01.021
125. Cruz-Guilloty F., Saeed A. M., Duffort S., Cano M., Ebrahimi K. B., Ballmick A., Tan Y., Wang H., Laird J. M., Salomon R. G., Handa J. T., Perez V. L., T cells and macrophages responding to oxidative damage cooperate in pathogenesis of a mouse model of age-related macular degeneration. PLoS ONE 2014 9 2 e88201 10.1371/journal.pone.0088201