Comparative study on solid self-nanoemulsifying drug delivery and solid dispersion system for enhanced solubility and bioavailability of ezetimibe

International Journal of Nanomedicine

Volumn 10, Issue , 2015, Pages 6147-6159

  Rashid, Rehmana ^a   Kim, Dong Wuk ^a   Yousaf, Abid Mehmood ^a   Mustapha, Omer ^a   Ud Din, Fakhar ^a   Park, Jong Hyuck ^a   Yong, Chul Soon ^b   Oh, Yu Kyoung ^c   Youn, Yu Seok ^d   Kim, Jong Oh ^b   Choi, Han Gon ^a  

^a Hanyang University   (South Korea)

^b Yeungnam University   (South Korea)

^c Seoul National University   (South Korea)

^d Sungkyunkwan University   (South Korea)

Author keywords

Bioavailability; Ezetimibe; Solid dispersion; Solid self nanoemulsifying drug delivery system; Solubility

Indexed keywords

CAPRYOL 90; CREMOPHOR; EZETIMIBE; HYDROXYPROPYLCELLULOSE; POLYSORBATE 80; SILICON DIOXIDE; SURFACTANT; UNCLASSIFIED DRUG; EMULSION; HYPOCHOLESTEROLEMIC AGENT; NANOPARTICLE;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; COMPARATIVE STUDY; DIFFERENTIAL SCANNING CALORIMETRY; DISPERSION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG DELIVERY SYSTEM; DRUG ELIMINATION; DRUG FORMULATION; DRUG HALF LIFE; DRUG SOLUBILITY; INFRARED SPECTROSCOPY; MALE; MAXIMUM PLASMA CONCENTRATION; NANOEMULSION; NONHUMAN; PARTICLE SIZE; PHYSICAL CHEMISTRY; POWDER; RAT; SCANNING ELECTRON MICROSCOPY; SOLID SELF NANOEMULSIFYING DRUG DELIVERY SYSTEM; SOLVENT EVAPORATED SOLID DISPERSION; SPRAY DRYING; SURFACE MODIFIED SOLID DISPERSION; TIME TO MAXIMUM PLASMA CONCENTRATION; X RAY DIFFRACTION; ANIMAL; BIOAVAILABILITY; CHEMISTRY; EMULSION; MEDICINAL CHEMISTRY; ORAL DRUG ADMINISTRATION; PROCEDURES; SOLUBILITY; SPRAGUE DAWLEY RAT; TISSUE DISTRIBUTION;

ADMINISTRATION, ORAL; ANIMALS; ANTICHOLESTEREMIC AGENTS; BIOLOGICAL AVAILABILITY; CALORIMETRY, DIFFERENTIAL SCANNING; CHEMISTRY, PHARMACEUTICAL; DRUG DELIVERY SYSTEMS; EMULSIONS; EZETIMIBE; MALE; MICROSCOPY, ELECTRON, SCANNING; NANOPARTICLES; PARTICLE SIZE; RATS; RATS, SPRAGUE-DAWLEY; SILICON DIOXIDE; SOLUBILITY; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; TISSUE DISTRIBUTION;

EID: 84943186737     PISSN: 11769114     EISSN: 11782013     Source Type: Journal    
DOI: 10.2147/IJN.S91216     Document Type: Article

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