Exemestane loaded self-microemulsifying drug delivery system (SMEDDS): Development and optimization

AAPS PharmSciTech

Volumn 9, Issue 2, 2008, Pages 628-634

  Singh, Ajeet K ^a   Chaurasiya, Akash ^a   Singh, Manish ^a   Upadhyay, Satish C ^a   Mukherjee, Rama ^a   Khar, Roop K ^b  

^a DABUR RESEARCH FOUNDATION   (India)

^b HAMDARD UNIVERSITY   (India)

Author keywords

Aromatase inhibitors; Exemestane; Microemulsion; SMEDDS

Indexed keywords

CREMOPHOR; DIETHYLENE GLYCOL MONOETHYL ETHER; EXEMESTANE; PROPYLENE GLYCOL; ANDROSTANE DERIVATIVE; AROMATASE INHIBITOR; DRUG CARRIER; OIL; SURFACTANT;

ARTICLE; CONTROLLED STUDY; DILUTION; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG SOLUBILITY; DRUG STABILITY; MICROEMULSION; PARTICLE SIZE; PHASE SEPARATION; PROCESS DEVELOPMENT; PROCESS OPTIMIZATION; THERMODYNAMICS; THERMOSTABILITY; TRANSMISSION ELECTRON MICROSCOPY; ZETA POTENTIAL; CHEMISTRY; EMULSION; METHODOLOGY; PHARMACEUTICS; SOLUBILITY; SURFACE PROPERTY; TEMPERATURE;

ANDROSTADIENES; AROMATASE INHIBITORS; CHEMISTRY, PHARMACEUTICAL; DRUG CARRIERS; DRUG COMPOUNDING; DRUG STABILITY; EMULSIONS; MICROSCOPY, ELECTRON, TRANSMISSION; OILS; PARTICLE SIZE; SOLUBILITY; SURFACE PROPERTIES; SURFACE-ACTIVE AGENTS; TECHNOLOGY, PHARMACEUTICAL; TEMPERATURE; THERMODYNAMICS;

EID: 51449124269     PISSN: None     EISSN: 15309932     Source Type: Journal    
DOI: 10.1208/s12249-008-9080-6     Document Type: Article

References (21)

1. J. R. Robinson. Introduction: Semi-solid formulations for oral drug delivery. Bull. Tech.-Gattefosse. 89: 11-13 (1996).
2. B. J. Aungst. Novel formulation strategies for improving oral bioavailability of drugs with poor membrane permeation or presystemic metabolism. J. Pharm. Sci. 82: 979-987 (1993).
3. A. J. Humberstone, and W. N. Charman. Lipid-based vehicles for the oral delivery of poorly water-soluble drugs. Adv. Drug Del. Rev. 25: 103-128 (1997).
4. W. L. Chiou, S. J. Chen, and N. Athanikar. Enhancement of dissolution rates of poorly water-soluble drugs by crystallization in aqueous surface solutions. I. Sulfathiazole, prednisone, and chloramphenicol. J. Pharm. Sci. 65: 1702-1704 (1976).
5. C. W. Pouton. Self-emulsifying drug delivery systems: Assessment of the efficiency of emulsification. Int. J. Pharm. 27: 335-348 (1985).
6. C. W. Pouton. Effects of the inclusion of a model drug on the performance self-emulsifying formulations. J. Pharm. Pharmacol. 37: 1P (1985).
7. C. W. Pouton. Formulation of self-emulsifying drug delivery systems. Adv. Drug Deliv. Rev. 25: 47-58 (1997).
8. T. T. Kararli, T. E. Needham, M. Grifaen, G. Schoenhard, L. J. Ferro, and L. Alcorn. Oral delivery of a rennin inhibitor compound using emulsion formulation. Pharm. Res. 9: 888-893 (1992).
9. R. A. Schwendener, and H. Schott. Lipophilic 1-beta-D-arabinofuranosyl cytosine derivatives in liposomal formulations for oral and parenteral antileukemic therapy in the murine L1210 leukemia model. J. Cancer Res. Clin. Oncol. 122: 723-726 (1996).
10. H. Shen, and M. Zhong. Prepration and evaluation of self-microemulsifying drug delivery systems (SMEDDS) containing atorvastatin. J. Pharm. Pharmacol. 58: 1183-1191 (2006).
11. D. K. Wang, Z. H. Shi, L. Liu, X. Y. Wang, C. X. Zhang, and P. Zhao. Development of Self-microemulsifying drug delivery systems for oral bioavailability enhancement of a-Asarone in beagle dogs. PDA J. Pharm. Sci. Tech. 60 (6):343-349 (2006).
12. P. P. Constantinides. Lipid microemulsion for improving drug dissolution and oral absorption: Physical and biopharmaceutical aspects. Pharm. Res. 12 (11):1561-1572 (1995).
13. P. K. Ghosh, and R. S. R. Murthy. Microemulsions: A potential drug delivery system. Curr. Drug Deliv. 3: 167-180 (2006).
14. P. E. Lonning. Pharmacological profiles of exemestane and formestane, steroidal aromatase inhibitors used for the treatment of post-menopausal breast cancer. Breast Can. Res. Treat. 49: S45-S52 (1998).
15. K. S. Weippl, and P. E. Goss. Prevention of breast cancer using SERMs and aromatase inhibitors. J. Mammary Gland Biol. Neoplasia. 8: 5-18 (2003).
16. M. Dowsett. Theoretical considerations for the ideal aromatase inhibitors. Breast Can. Res. Treat. 49: S39-S44 (1998).
17. Physician Desk Reference. Thomson Healthcare, Montvale, NJ. 60th edition, 2006, pp. 2600-2602.
18. B. K. Kang, J. S. Lee, S. K. Chon, S. Y. Jeong, S. H. Yuk, G. Khang, H. B. Lee, and S. H. Cho. Development of self-microemulsifying drug delivery systems (SMEDDS) for oral bioavailability enhancement of simvastatin in beagle dogs. Int. J. Pharm. 274: 65-73 (2004).
19. T. Lucas, R. Bishara, and R. Seevers. A stability program for the distribution of drug products. Pharma. Tech. 68-71 (2004).
20. T. R. Kommuru, B. Gurley, M. A. Khan, and I. K. Reddy. Self-emulsifying drug delivery systems (SEDDS) of co-enzyme Q10: Formulation development and bioavailability assessment. Int. J. Pharm. 212: 233-246 (2001).
21. P. P. Constantinides, C. M. Lancaster, and J. Marcello. Enhanced intestinal absorption of an RGD peptide from water-in-oil microemulsions of different composition and particle size. J. Control. Release. 34: 109-116 (1995).