Preparation and evaluation of raloxifene-loaded solid dispersion nanoparticle by spray-drying technique without an organic solvent

International Journal of Pharmaceutics

Volumn 443, Issue 1-2, 2013, Pages 50-57

  Tran, Tuan Hiep ^a   Poudel, Bijay K ^a   Marasini, Nirmal ^a   Chi, Sang Cheol ^b   Choi, Han Gon ^c   Yong, Chul Soon ^a   Kim, Jong Oh ^a  

^a Yeungnam University   (South Korea)

^b Sungkyunkwan University   (South Korea)

^c Hanyang University   (South Korea)

Author keywords

Bioavailability; Nanoparticles; Raloxifene; Solubility; Spray drying

Indexed keywords

NANOPARTICLE; POLYSORBATE 20; POVIDONE; RALOXIFENE; WATER;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; DIFFERENTIAL SCANNING CALORIMETRY; DISPERSION; DISSOLUTION; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG ELIMINATION; DRUG FORMULATION; DRUG HALF LIFE; DRUG SCREENING; DRUG SOLUBILITY; DRUG SYNTHESIS; IN VITRO STUDY; MALE; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; PARTICLE SIZE; PH; PHYSICAL CHEMISTRY; PLASMA CONCENTRATION-TIME CURVE; PRIORITY JOURNAL; RAT; SCANNING ELECTRON MICROSCOPY; SPRAY DRYING; TIME TO MAXIMUM PLASMA CONCENTRATION; X RAY DIFFRACTION;

ADMINISTRATION, ORAL; ANIMALS; BIOLOGICAL AVAILABILITY; CALORIMETRY, DIFFERENTIAL SCANNING; DRUG CARRIERS; DRUG COMPOUNDING; EXCIPIENTS; MALE; MOLECULAR STRUCTURE; NANOPARTICLES; PARTICLE SIZE; PHASE TRANSITION; POLYSORBATES; POVIDONE; RALOXIFENE; RATS; RATS, SPRAGUE-DAWLEY; SELECTIVE ESTROGEN RECEPTOR MODULATORS; SOLUBILITY; SOLVENTS; SURFACE PROPERTIES; WATER; X-RAY DIFFRACTION;

EID: 84873046612     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2013.01.013     Document Type: Article

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