Concurrent determination of ezetimibe and its phase-I and II metabolites by HPLC with UV detection: Quantitative application to various in vitro metabolic stability studies and for qualitative estimation in bile

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 853, Issue 1-2, 2007, Pages 88-96

  Basha, Shaik Jafar Sadik ^a   Naveed, Shaik Abdul ^a   Tiwari, Nirbhay Kumar ^a   Shashikumar, Dhanya ^a   Muzeeb, Syed ^a   Kumar, Thammera Ranjith ^a   Kumar, Nyavanandi Vijay ^a   Rao, Nadipalli Prabhakar ^a   Srinivas, Nanduri ^a   Mullangi, Ramesh ^a   Srinivas, Nuggehally R ^a  

^a DR REDDY'S LABORATORIES LTD   (India)

Author keywords

Ezetimibe; Ezetimibe glucuronide; Ezetimibe ketone; Ezetimibe ketone glucuronide; HPLC; Metabolism

Indexed keywords

DEPROTEINIZATION; EZETIMIBE; EZETIMIBE GLUCURONIDES; EZETIMIBE KETONE GLUCURONIDES; EZETIMIBE KETONES;

ACETONITRILE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; KETONES; METABOLITES; METHANOL; SEPARATION;

DRUG PRODUCTS;

ACETONITRILE; DRUG METABOLITE; EZETIMIBE; EZETIMIBE BENZYLIC GLUCURONIDE; EZETIMIBE GLUCURONIDE; EZETIMIBE KETONE; EZETIMIBE KETONE GLUCURONIDE; FORMIC ACID; METHANOL; PERCHLORIC ACID; THEOPHYLLINE; UNCLASSIFIED DRUG; WATER;

ANALYTIC METHOD; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG BILE LEVEL; DRUG STRUCTURE; ELUTION; FLOW RATE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MALE; NONHUMAN; PRIORITY JOURNAL; QUALITATIVE ANALYSIS; QUANTITATIVE ANALYSIS; QUANTITATIVE ASSAY; RAT; SUPERNATANT; ULTRAVIOLET DETECTION; WISTAR RAT;

ANIMALS; AZETIDINES; BILE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; GLUCURONIDES; MALE; MOLECULAR STRUCTURE; RATS; RATS, WISTAR; REPRODUCIBILITY OF RESULTS; SPECTROPHOTOMETRY, ULTRAVIOLET; TANDEM MASS SPECTROMETRY;

EID: 34249991273     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2007.02.053     Document Type: Article

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