메뉴 건너뛰기




Volumn 370, Issue 1680, 2015, Pages

T cell engineering as therapy for cancer and HIV: Our synthetic future

Author keywords

Cancer; Immunotherapy; Synthetic biology

Indexed keywords

BIOLOGY; CANCER; CELLS AND CELL COMPONENTS; DISEASE TREATMENT; GENETIC ENGINEERING; HUMAN IMMUNODEFICIENCY VIRUS; IMMUNE SYSTEM;

EID: 84942930968     PISSN: 09628436     EISSN: 14712970     Source Type: Journal    
DOI: 10.1098/rstb.2014.0374     Document Type: Review
Times cited : (23)

References (78)
  • 1
    • 0036852241 scopus 로고    scopus 로고
    • Cancer immunoediting: From immunosurveillance to tumor escape
    • Dunn GP, Bruce AT, Ikeda H, Old LJ, Schreiber RD. 2002 Cancer immunoediting: from immunosurveillance to tumor escape. Nat. Immunol. 3, 991–998. (doi:10.1038/ni1102-991)
    • (2002) Nat. Immunol , vol.3 , pp. 991-998
    • Dunn, G.P.1    Bruce, A.T.2    Ikeda, H.3    Old, L.J.4    Schreiber, R.D.5
  • 2
    • 4644324025 scopus 로고    scopus 로고
    • Cancer immunotherapy: Moving beyond current vaccines
    • Rosenberg SA, Yang JC, Restifo NP. 2004 Cancer immunotherapy: moving beyond current vaccines. Nat. Med. 10, 909–915. (doi:10.1038/nm1100)
    • (2004) Nat. Med , vol.10 , pp. 909-915
    • Rosenberg, S.A.1    Yang, J.C.2    Restifo, N.P.3
  • 3
    • 84959071443 scopus 로고
    • Quantitative studies on tissue transplantation immunity. II. The origin, strength and duration of actively and adoptively acquired immunity
    • Billingham RE, Brent L, Medawar PB. 1954 Quantitative studies on tissue transplantation immunity. II. The origin, strength and duration of actively and adoptively acquired immunity. Proc. R. Soc. Lond. B 143, 58–80. (doi:10.1098/rspb.1954.0054)
    • (1954) Proc. R. Soc. Lond. B , vol.143 , pp. 58-80
    • Billingham, R.E.1    Brent, L.2    Medawar, P.B.3
  • 4
    • 0001751833 scopus 로고
    • Studies on the immunological response to foreign tumor transplants in the mouse. I. The role of lymph node cells in conferring immunity by adoptive transfer
    • Mitchison NA. 1955 Studies on the immunological response to foreign tumor transplants in the mouse. I. The role of lymph node cells in conferring immunity by adoptive transfer. J. Exp. Med. 102, 157–177. (doi:10.1084/jem.102.2.157)
    • (1955) J. Exp. Med , vol.102 , pp. 157-177
    • Mitchison, N.A.1
  • 5
    • 84856790663 scopus 로고    scopus 로고
    • Synthetic biology: Advancing biological frontiers by building synthetic systems
    • Chen YY, Galloway KE, Smolke CD. 2012 Synthetic biology: advancing biological frontiers by building synthetic systems. Genome Biol. 13, 240. (doi:10.1186/gb-2012-13-2-240)
    • (2012) Genome Biol , vol.13 , pp. 240
    • Chen, Y.Y.1    Galloway, K.E.2    Smolke, C.D.3
  • 6
    • 0024834988 scopus 로고
    • Expression of immunoglobulin-T-cell receptor chimeric molecules as functional receptors with antibody-type specificity
    • Gross G, Waks T, Eshhar Z. 1989 Expression of immunoglobulin-T-cell receptor chimeric molecules as functional receptors with antibody-type specificity. Proc. Natl Acad. Sci. USA 86, 10024–10028. (doi:10.1073/pnas.86.24.10024)
    • (1989) Proc. Natl Acad. Sci. USA , vol.86 , pp. 10024-10028
    • Gross, G.1    Waks, T.2    Eshhar, Z.3
  • 7
    • 0026064305 scopus 로고
    • The cytoplasmic domain of the T cell receptor zeta chain is sufficient to couple to receptor-associated signal transduction pathways
    • Irving BA, Weiss A. 1991 The cytoplasmic domain of the T cell receptor zeta chain is sufficient to couple to receptor-associated signal transduction pathways. Cell 64, 891–901. (doi:10.1016/0092-8674(91)90314-O)
    • (1991) Cell , vol.64 , pp. 891-901
    • Irving, B.A.1    Weiss, A.2
  • 8
    • 84255197842 scopus 로고    scopus 로고
    • Cancer immunotherapy comes of age
    • Mellman I, Coukos G, Dranoff G. 2011 Cancer immunotherapy comes of age. Nature 480, 480–489. (doi:10.1038/nature10673)
    • (2011) Nature , vol.480 , pp. 480-489
    • Mellman, I.1    Coukos, G.2    Dranoff, G.3
  • 9
    • 84871338258 scopus 로고    scopus 로고
    • Different affinity windows for virus and cancerspecific T-cell receptors: Implications for therapeutic strategies
    • Aleksic M, Liddy N, Molloy PE, Pumphrey N, Vuidepot A, Chang K-M, Jakobsen BK. 2012 Different affinity windows for virus and cancerspecific T-cell receptors: implications for therapeutic strategies. Eur. J. Immunol. 42, 3174–3179. (doi:10.1002/eji.201242606)
    • (2012) Eur. J. Immunol , vol.42 , pp. 3174-3179
    • Aleksic, M.1    Liddy, N.2    Molloy, P.E.3    Pumphrey, N.4    Vuidepot, A.5    Chang, K.-M.6    Jakobsen, B.K.7
  • 10
    • 84856845120 scopus 로고    scopus 로고
    • Generation of polyclonal CMVspecific T cells for the adoptive immunotherapy of glioblastoma
    • Ghazi A et al. 2012 Generation of polyclonal CMVspecific T cells for the adoptive immunotherapy of glioblastoma. J. Immunother. 35, 159–168. (doi:10.1097/CJI.0b013e318247642f)
    • (2012) J. Immunother , vol.35 , pp. 159-168
    • Ghazi, A.1
  • 11
    • 79960412239 scopus 로고    scopus 로고
    • Is cytomegalovirus a therapeutic target in glioblastoma?
    • Sampson JH, Mitchell DA. 2011 Is cytomegalovirus a therapeutic target in glioblastoma? Clin. Cancer Res. 17, 4619–4621. (doi:10.1158/1078-0432.CCR-11-0992)
    • (2011) Clin. Cancer Res , vol.17 , pp. 4619-4621
    • Sampson, J.H.1    Mitchell, D.A.2
  • 12
    • 84867744197 scopus 로고    scopus 로고
    • Ex vivo functional analysis, expansion and adoptive transfer of cytomegalovirusspecific T-cells in patients with glioblastoma multiforme
    • Crough T, Beagley L, Smith C, Jones L, Walker DG, Khanna R. 2012 Ex vivo functional analysis, expansion and adoptive transfer of cytomegalovirusspecific T-cells in patients with glioblastoma multiforme. Immunol. Cell Biol. 90, 872–880. (doi:10.1038/icb.2012.19)
    • (2012) Immunol. Cell Biol , vol.90 , pp. 872-880
    • Crough, T.1    Beagley, L.2    Smith, C.3    Jones, L.4    Walker, D.G.5    Khanna, R.6
  • 13
    • 84895487305 scopus 로고    scopus 로고
    • Gene editing of CCR5 in autologous CD4 T-cells of persons infected with HIV
    • Tebas P et al. 2014 Gene editing of CCR5 in autologous CD4 T-cells of persons infected with HIV. N. Engl. J. Med. 370, 901–910. (doi:10.1056/NEJMoa1300662)
    • (2014) N. Engl. J. Med , vol.370 , pp. 901-910
    • Tebas, P.1
  • 14
    • 84890147150 scopus 로고    scopus 로고
    • Exploiting the curative potential of adoptive T-cell therapy for cancer
    • Hinrichs CS, Rosenberg SA. 2014 Exploiting the curative potential of adoptive T-cell therapy for cancer. Immunol. Rev. 257, 56–71. (doi:10.1111/imr.12132)
    • (2014) Immunol. Rev , vol.257 , pp. 56-71
    • Hinrichs, C.S.1    Rosenberg, S.A.2
  • 15
    • 55949125601 scopus 로고    scopus 로고
    • Adoptive cell therapy for patients with metastatic melanoma: Evaluation of intensive myeloablative chemoradiation preparative regimens
    • Dudley ME et al. 2008 Adoptive cell therapy for patients with metastatic melanoma: evaluation of intensive myeloablative chemoradiation preparative regimens. J. Clin. Oncol. 26, 5233–5239. (doi:10.1200/JCO.2008.16.5449)
    • (2008) J. Clin. Oncol , vol.26 , pp. 5233-5239
    • Dudley, M.E.1
  • 16
    • 84890140713 scopus 로고    scopus 로고
    • TCR repertoires of intratumoral T-cell subsets
    • Linnemann C, Mezzadra R, Schumacher TN. 2014 TCR repertoires of intratumoral T-cell subsets. Immunol. Rev. 257, 72–82. (doi:10.1111/imr.12140)
    • (2014) Immunol. Rev , vol.257 , pp. 72-82
    • Linnemann, C.1    Mezzadra, R.2    Schumacher, T.N.3
  • 17
    • 84859399304 scopus 로고    scopus 로고
    • Dissection of T-cell antigen specificity in human melanoma
    • Andersen RS et al. 2012 Dissection of T-cell antigen specificity in human melanoma. Cancer Res. 72, 1642–1650. (doi:10.1158/0008-5472.CAN-11-2614)
    • (2012) Cancer Res , vol.72 , pp. 1642-1650
    • Andersen, R.S.1
  • 18
    • 84880276438 scopus 로고    scopus 로고
    • Mining exomic sequencing data to identify mutated antigens recognized by adoptively transferred tumor-reactive T cells
    • Robbins PF et al. 2013 Mining exomic sequencing data to identify mutated antigens recognized by adoptively transferred tumor-reactive T cells. Nat. Med. 19, 747–752. (doi:10.1038/nm.3161)
    • (2013) Nat. Med , vol.19 , pp. 747-752
    • Robbins, P.F.1
  • 19
    • 84857725402 scopus 로고    scopus 로고
    • Exploiting the mutanome for tumor vaccination
    • Castle JC et al. 2012 Exploiting the mutanome for tumor vaccination. Cancer Res. 72, 1081–1091. (doi:10.1158/0008-5472.CAN-11-3722)
    • (2012) Cancer Res , vol.72 , pp. 1081-1091
    • Castle, J.C.1
  • 20
    • 84862776855 scopus 로고    scopus 로고
    • Cancer exome analysis reveals a T-cell-dependent mechanism of cancer immunoediting
    • Matsushita H et al. 2012 Cancer exome analysis reveals a T-cell-dependent mechanism of cancer immunoediting. Nature 482, 400–404. (doi:10.1038/nature10755)
    • (2012) Nature , vol.482 , pp. 400-404
    • Matsushita, H.1
  • 21
    • 84877669593 scopus 로고    scopus 로고
    • The basic principles of chimeric antigen receptor design
    • Sadelain M, Brentjens R, Riviere I. 2013 The basic principles of chimeric antigen receptor design. Cancer Discov. 3, 388–398. (doi:10.1158/2159-8290.CD-12-0548)
    • (2013) Cancer Discov , vol.3 , pp. 388-398
    • Sadelain, M.1    Brentjens, R.2    Riviere, I.3
  • 22
    • 84890179288 scopus 로고    scopus 로고
    • Of CARs and TRUCKs: Chimeric antigen receptor (CAR) T cells engineered with an inducible cytokine to modulate the tumor stroma
    • Chmielewski M, Hombach AA, Abken H. 2014 Of CARs and TRUCKs: chimeric antigen receptor (CAR) T cells engineered with an inducible cytokine to modulate the tumor stroma. Immunol. Rev. 257, 83–90. (doi:10.1111/imr.12125)
    • (2014) Immunol. Rev , vol.257 , pp. 83-90
    • Chmielewski, M.1    Hombach, A.A.2    Abken, H.3
  • 24
    • 84890239280 scopus 로고    scopus 로고
    • Adoptive immunotherapy for cancer
    • Ruella M, Kalos M. 2014 Adoptive immunotherapy for cancer. Immunol. Rev. 257, 14–38. (doi:10.1111/imr.12136)
    • (2014) Immunol. Rev , vol.257 , pp. 14-38
    • Ruella, M.1    Kalos, M.2
  • 25
    • 84890180201 scopus 로고    scopus 로고
    • Design and implementation of adoptive therapy with chimeric antigen receptor-modified T cells
    • Jensen MC, Riddell SR. 2014 Design and implementation of adoptive therapy with chimeric antigen receptor-modified T cells. Immunol. Rev. 257, 127–144. (doi:10.1111/imr.12139)
    • (2014) Immunol. Rev , vol.257 , pp. 127-144
    • Jensen, M.C.1    Riddell, S.R.2
  • 26
    • 78650969008 scopus 로고    scopus 로고
    • Immune responses to transgene and retroviral vector in patients treated with ex vivo engineered T cells
    • Lamers C et al. 2011 Immune responses to transgene and retroviral vector in patients treated with ex vivo engineered T cells. Blood 117, 72–82. (doi:10.1182/blood-2010-07-294520)
    • (2011) Blood , vol.117 , pp. 72-82
    • Lamers, C.1
  • 28
    • 84858759305 scopus 로고    scopus 로고
    • Tumortargeted T cells modified to secrete IL-12 eradicate systemic tumors without need for prior conditioning
    • Pegram HJ, Lee JC, Hayman EG, Imperato GH, Tedder TF, Sadelain M, Brentjens RJ. 2012 Tumortargeted T cells modified to secrete IL-12 eradicate systemic tumors without need for prior conditioning. Blood 119, 4133–4141. (doi:10.1182/blood-2011-12-400044)
    • (2012) Blood , vol.119 , pp. 4133-4141
    • Pegram, H.J.1    Lee, J.C.2    Hayman, E.G.3    Imperato, G.H.4    Tedder, T.F.5    Sadelain, M.6    Brentjens, R.J.7
  • 29
    • 84882782587 scopus 로고    scopus 로고
    • Cytokine release syndrome after blinatumomab treatment related to abnormal macrophage activation and ameliorated with cytokine directed therapy
    • Teachey DT et al. 2013 Cytokine release syndrome after blinatumomab treatment related to abnormal macrophage activation and ameliorated with cytokine directed therapy. Blood 121, 5154–5157. (doi:10.1182/blood-2013-02-485623)
    • (2013) Blood , vol.121 , pp. 5154-5157
    • Teachey, D.T.1
  • 30
    • 84904097189 scopus 로고    scopus 로고
    • How I treat: Current concepts in the diagnosis and management of cytokine release syndrome
    • Lee DW, Gardner R, Porter DL, Louis CU, Ahmed N, Jensen M, Grupp SA, Mackall CL. 2014 How I treat: current concepts in the diagnosis and management of cytokine release syndrome. Blood 124, 188–195. (doi:10.1182/blood-2014-05-552729)
    • (2014) Blood , vol.124 , pp. 188-195
    • Lee, D.W.1    Gardner, R.2    Porter, D.L.3    Louis, C.U.4    Ahmed, N.5    Jensen, M.6    Grupp, S.A.7    Mackall, C.L.8
  • 31
    • 0033168142 scopus 로고    scopus 로고
    • Efficient transfer of a tumor antigen-reactive TCR to human peripheral blood lymphocytes confers anti-tumor reactivity
    • Clay TM, Custer MC, Sachs J, Hwu P, Rosenberg SA, Nishimura MI. 1999 Efficient transfer of a tumor antigen-reactive TCR to human peripheral blood lymphocytes confers anti-tumor reactivity. J. Immunol. 163, 507–513.
    • (1999) J. Immunol , vol.163 , pp. 507-513
    • Clay, T.M.1    Custer, M.C.2    Sachs, J.3    Hwu, P.4    Rosenberg, S.A.5    Nishimura, M.I.6
  • 32
    • 0033887418 scopus 로고    scopus 로고
    • Transfer of specificity for human immunodeficiency virus type 1 into primary human T lymphocytes by introduction of T-cell receptor genes
    • Cooper LJ, Kalos M, Lewinsohn DA, Riddell SR, Greenberg PD. 2000 Transfer of specificity for human immunodeficiency virus type 1 into primary human T lymphocytes by introduction of T-cell receptor genes. J. Virol. 74, 8207–8212. (doi:10.1128/JVI.74.17.8207-8212.2000)
    • (2000) J. Virol , vol.74 , pp. 8207-8212
    • Cooper, L.J.1    Kalos, M.2    Lewinsohn, D.A.3    Riddell, S.R.4    Greenberg, P.D.5
  • 33
    • 21444445173 scopus 로고    scopus 로고
    • Directed evolution of human T-cell receptors with picomolar affinities by phage display
    • Li Y et al. 2005 Directed evolution of human T-cell receptors with picomolar affinities by phage display. Nat. Biotechnol. 23, 349–354. (doi:10.1038/nbt1070)
    • (2005) Nat. Biotechnol , vol.23 , pp. 349-354
    • Li, Y.1
  • 34
    • 55749084891 scopus 로고    scopus 로고
    • Engineering higher affinity T cell receptors using a T cell display system
    • Chervin AS, Aggen DH, Raseman JM, Kranz DM. 2008 Engineering higher affinity T cell receptors using a T cell display system. J. Immunol. Methods. 339, 175–184. (doi:10.1016/j.jim.2008.09.016)
    • (2008) J. Immunol. Methods , vol.339 , pp. 175-184
    • Chervin, A.S.1    Aggen, D.H.2    Raseman, J.M.3    Kranz, D.M.4
  • 35
    • 64249129650 scopus 로고    scopus 로고
    • Subtle affinity-enhancing mutations in a myelin oligodendrocyte glycoprotein-specific TCR alter specificity and generate new self-reactivity
    • Udyavar A, Alli R, Nguyen P, Baker L, Geiger TL. 2009 Subtle affinity-enhancing mutations in a myelin oligodendrocyte glycoprotein-specific TCR alter specificity and generate new self-reactivity. J. Immunol. 182, 4439–4447. (doi:10.4049/jimmunol.0804377)
    • (2009) J. Immunol , vol.182 , pp. 4439-4447
    • Udyavar, A.1    Alli, R.2    Nguyen, P.3    Baker, L.4    Geiger, T.L.5
  • 36
    • 22744449565 scopus 로고    scopus 로고
    • Cell-based gene therapy experiments in murine experimental autoimmune encephalomyelitis
    • Louie KA, Weiner LP, Du J, Kochounian HH, Fling SP, Wei W, McMillan M. 2005 Cell-based gene therapy experiments in murine experimental autoimmune encephalomyelitis. Gene Ther. 12, 1145–1153. (doi:10.1038/sj.gt.3302503)
    • (2005) Gene Ther , vol.12 , pp. 1145-1153
    • Louie, K.A.1    Weiner, L.P.2    Du, J.3    Kochounian, H.H.4    Fling, S.P.5    Wei, W.6    McMillan, M.7
  • 37
    • 63049108160 scopus 로고    scopus 로고
    • Increasing functional avidity of TCR-redirected T cells by removing defined N-glycosylation sites in the TCR constant domain
    • Kuball J, Hauptrock B, Malina V, Antunes E, Voss RH, Wolfl M, Strong R, Theobald M, Greenberg PD. 2009 Increasing functional avidity of TCR-redirected T cells by removing defined N-glycosylation sites in the TCR constant domain. J. Exp. Med. 206, 463–475. (doi:10.1084/jem.20082487)
    • (2009) J. Exp. Med , vol.206 , pp. 463-475
    • Kuball, J.1    Hauptrock, B.2    Malina, V.3    Antunes, E.4    Voss, R.H.5    Wolfl, M.6    Strong, R.7    Theobald, M.8    Greenberg, P.D.9
  • 38
    • 84873991752 scopus 로고    scopus 로고
    • Cancer regression and neurological toxicity following anti-MAGE-A3 TCR gene therapy
    • Morgan RA et al. 2013 Cancer regression and neurological toxicity following anti-MAGE-A3 TCR gene therapy. J. Immunother. 36, 133–151. (doi:10.1097/CJI.0b013e3182829903)
    • (2013) J. Immunother , vol.36 , pp. 133-151
    • Morgan, R.A.1
  • 39
    • 84880730689 scopus 로고    scopus 로고
    • Cardiovascular toxicity and titin cross-reactivity of affinity enhanced T cells in myeloma and melanoma
    • Linette GP et al. 2013 Cardiovascular toxicity and titin cross-reactivity of affinity enhanced T cells in myeloma and melanoma. Blood 122, 863–871. (doi:10.1182/blood-2013-03-490565)
    • (2013) Blood , vol.122 , pp. 863-871
    • Linette, G.P.1
  • 40
    • 84883866836 scopus 로고    scopus 로고
    • Identification of a titinderived HLA-A1-presented peptide as a crossreactive target for engineered MAGE A3-directed T cells
    • Cameron BJ et al. 2013 Identification of a titinderived HLA-A1-presented peptide as a crossreactive target for engineered MAGE A3-directed T cells. Sci. Transl. Med. 5, 197ra103. (doi:10.1126/scitranslmed.3006034)
    • (2013) Sci. Transl. Med , vol.5
    • Cameron, B.J.1
  • 41
    • 77952236875 scopus 로고    scopus 로고
    • Lethal graft-versus-host disease in mouse models of T cell receptor gene therapy
    • Bendle GM et al. 2010 Lethal graft-versus-host disease in mouse models of T cell receptor gene therapy. Nat. Med. 16, 565–570. (doi:10.1038/nm.2128)
    • (2010) Nat. Med , vol.16 , pp. 565-570
    • Bendle, G.M.1
  • 42
    • 84862496486 scopus 로고    scopus 로고
    • A foundation for universal T-cell based immunotherapy: T cells engineered to express a CD19-specific chimeric-antigen-receptor and eliminate expression of endogenous TCR
    • Torikai H et al. 2012 A foundation for universal T-cell based immunotherapy: T cells engineered to express a CD19-specific chimeric-antigen-receptor and eliminate expression of endogenous TCR. Blood 119, 5697–5705. (doi:10.1182/blood-2012-01-405365)
    • (2012) Blood , vol.119 , pp. 5697-5705
    • Torikai, H.1
  • 43
    • 84860681545 scopus 로고    scopus 로고
    • Editing T cell specificity towards leukemia by zinc finger nucleases and lentiviral gene transfer
    • Provasi E et al. 2012 Editing T cell specificity towards leukemia by zinc finger nucleases and lentiviral gene transfer. Nat. Med. 18, 807–815. (doi:10.1038/nm.2700)
    • (2012) Nat. Med , vol.18 , pp. 807-815
    • Provasi, E.1
  • 44
    • 13344261952 scopus 로고    scopus 로고
    • T-cell mediated rejection of gene-modified HIV-specific cytotoxic T lymphocytes in HIV-infected patients
    • Riddell SR et al. 1996 T-cell mediated rejection of gene-modified HIV-specific cytotoxic T lymphocytes in HIV-infected patients. Nat. Med. 2, 216–223. (doi:10.1038/nm0296-216)
    • (1996) Nat. Med , vol.2 , pp. 216-223
    • Riddell, S.R.1
  • 45
    • 84860718270 scopus 로고    scopus 로고
    • Decade-long safety and function of retroviral-modified chimeric antigen receptor T cells
    • Scholler J et al. 2012 Decade-long safety and function of retroviral-modified chimeric antigen receptor T cells. Sci. Transl. Med. 4, 132R-A153. (doi:10.1126/scitranslmed.3003761)
    • (2012) Sci. Transl. Med , vol.4
    • Scholler, J.1
  • 46
    • 84886769508 scopus 로고    scopus 로고
    • Replication-competent noninduced proviruses in the latent reservoir increase barrier to HIV-1 cure
    • Ho YC et al. 2013 Replication-competent noninduced proviruses in the latent reservoir increase barrier to HIV-1 cure. Cell 155, 540–551. (doi:10.1016/j.cell.2013.09.020)
    • (2013) Cell , vol.155 , pp. 540-551
    • Ho, Y.C.1
  • 47
    • 60549090253 scopus 로고    scopus 로고
    • Long-term control of HIV by CCR5 Delta32/Delta32 stem-cell transplantation
    • Hu¨tter Get al
    • Hu¨tter G et al. 2009 Long-term control of HIV by CCR5 Delta32/Delta32 stem-cell transplantation. N. Engl. J. Med. 360, 692–696. (doi:10.1056/NEJMoa0802905)
    • (2009) N. Engl. J. Med , vol.360 , pp. 692-696
  • 48
    • 36849028631 scopus 로고    scopus 로고
    • Genetic therapies for HIV/AIDS
    • Rossi JJ, June CH, Kohn DB. 2007 Genetic therapies for HIV/AIDS. Nat. Biotechnol. 25, 1444–1454. (doi:10.1038/nbt1367)
    • (2007) Nat. Biotechnol , vol.25 , pp. 1444-1454
    • Rossi, J.J.1    June, C.H.2    Kohn, D.B.3
  • 49
    • 0031573612 scopus 로고    scopus 로고
    • Effects of CD28 costimulation on long term proliferation of CD4 þ T cells in the absence of exogenous feeder cells
    • Levine BL, Bernstein W, Craighead N, Lindsten T, Thompson CB, June CH. 1997 Effects of CD28 costimulation on long term proliferation of CD4 þ T cells in the absence of exogenous feeder cells. J. Immunol. 159, 5921–5930.
    • (1997) J. Immunol , vol.159 , pp. 5921-5930
    • Levine, B.L.1    Bernstein, W.2    Craighead, N.3    Lindsten, T.4    Thompson, C.B.5    June, C.H.6
  • 50
    • 32644451168 scopus 로고    scopus 로고
    • Engagement of CD83 ligand induces prolonged expansion of CD8þ T cells and preferential enrichment for antigen specificity
    • Hirano N et al. 2006 Engagement of CD83 ligand induces prolonged expansion of CD8þ T cells and preferential enrichment for antigen specificity. Blood 107, 1528–1536. (doi:10.1182/blood-2005-05-2073)
    • (2006) Blood , vol.107 , pp. 1528-1536
    • Hirano, N.1
  • 52
    • 84890156404 scopus 로고    scopus 로고
    • Human cell-based artificial antigen-presenting cells for cancer immunotherapy
    • Butler MO, Hirano N. 2014 Human cell-based artificial antigen-presenting cells for cancer immunotherapy. Immunol. Rev. 257, 191–209. (doi:10.1111/imr.12129)
    • (2014) Immunol. Rev , vol.257 , pp. 191-209
    • Butler, M.O.1    Hirano, N.2
  • 53
    • 60849098427 scopus 로고    scopus 로고
    • IL-7 and IL-15 allow the generation of suicide gene-modified alloreactive self-renewing central memory human T lymphocytes
    • Kaneko S et al. 2009 IL-7 and IL-15 allow the generation of suicide gene-modified alloreactive self-renewing central memory human T lymphocytes. Blood 113, 1006–1015. (doi:10.1182/blood-2008-05-156059)
    • (2009) Blood , vol.113 , pp. 1006-1015
    • Kaneko, S.1
  • 54
    • 84890238278 scopus 로고    scopus 로고
    • Rapamycin-resistant effector T-cell therapy
    • Fowler DH. 2014 Rapamycin-resistant effector T-cell therapy. Immunol. Rev. 257, 210–225. (doi:10.1111/imr.12127)
    • (2014) Immunol. Rev , vol.257 , pp. 210-225
    • Fowler, D.H.1
  • 55
    • 84876758617 scopus 로고    scopus 로고
    • Metabolic pathways in immune cell activation and quiescence
    • Pearce EL, Pearce EJ. 2013 Metabolic pathways in immune cell activation and quiescence. Immunity 38, 633–643. (doi:10.1016/j.immuni.2013.04.005)
    • (2013) Immunity , vol.38 , pp. 633-643
    • Pearce, E.L.1    Pearce, E.J.2
  • 56
    • 82955195419 scopus 로고    scopus 로고
    • Combining mTor inhibitors with rapamycin-resistant T cells: A two-pronged approach to tumor elimination
    • Huye LE, Nakazawa Y, Patel MP, Yvon E, Sun J, Savoldo B, Wilson MH, Dotti G, Rooney CM. 2011 Combining mTor inhibitors with rapamycin-resistant T cells: a two-pronged approach to tumor elimination. Mol. Ther. 19, 2239–2248. (doi:10.1038/mt.2011.179)
    • (2011) Mol. Ther , vol.19 , pp. 2239-2248
    • Huye, L.E.1    Nakazawa, Y.2    Patel, M.P.3    Yvon, E.4    Sun, J.5    Savoldo, B.6    Wilson, M.H.7    Dotti, G.8    Rooney, C.M.9
  • 57
    • 84873395620 scopus 로고    scopus 로고
    • Superior T memory stem cell persistence supports long-lived T cell memory
    • Lugli E et al. 2013 Superior T memory stem cell persistence supports long-lived T cell memory. J. Clin. Invest. 123, 594–599. (doi:10.1172/jci66327)
    • (2013) J. Clin. Invest , vol.123 , pp. 594-599
    • Lugli, E.1
  • 58
    • 80053997259 scopus 로고    scopus 로고
    • A human memory T cell subset with stem cell-like properties
    • Gattinoni L et al. 2011 A human memory T cell subset with stem cell-like properties. Nat. Med. 17, 1290–1297. (doi:10.1038/nm.2446)
    • (2011) Nat. Med , vol.17 , pp. 1290-1297
    • Gattinoni, L.1
  • 59
    • 84890236232 scopus 로고    scopus 로고
    • Genetically engineered donor T cells to optimize graft-versus-tumor effects across MHC barriers
    • Ghosh A, Holland AM, van den Brink MR. 2014 Genetically engineered donor T cells to optimize graft-versus-tumor effects across MHC barriers. Immunol. Rev. 257, 226–236. (doi:10.1111/imr.12142)
    • (2014) Immunol. Rev , vol.257 , pp. 226-236
    • Ghosh, A.1    Holland, A.M.2    Van Den Brink, M.R.3
  • 60
    • 33748459567 scopus 로고    scopus 로고
    • Adoptive transfer of T-cell precursors enhances T-cell reconstitution after allogeneic hematopoietic stem cell transplantation
    • Zakrzewski JL et al. 2006 Adoptive transfer of T-cell precursors enhances T-cell reconstitution after allogeneic hematopoietic stem cell transplantation. Nat. Med. 12, 1039–1047. (doi:10.1038/nm1463)
    • (2006) Nat. Med , vol.12 , pp. 1039-1047
    • Zakrzewski, J.L.1
  • 61
    • 33646546302 scopus 로고    scopus 로고
    • Aging of the immune system: How much can the adaptive immune system adapt?
    • Weng NP. 2006 Aging of the immune system: how much can the adaptive immune system adapt?. Immunity 24, 495–499. (doi:10.1016/j.immuni.2006.05.001)
    • (2006) Immunity , vol.24 , pp. 495-499
    • Weng, N.P.1
  • 62
    • 27744450650 scopus 로고    scopus 로고
    • Telomere length of transferred lymphocytes correlates with in vivo persistence and tumor regression in melanoma patients receiving cell transfer therapy
    • Zhou J, Shen X, Huang J, Hodes RJ, Rosenberg SA, Robbins PF. 2005 Telomere length of transferred lymphocytes correlates with in vivo persistence and tumor regression in melanoma patients receiving cell transfer therapy. J. Immunol. 175, 7046–7052. (doi:10.4049/jimmunol.175.10.7046)
    • (2005) J. Immunol , vol.175 , pp. 7046-7052
    • Zhou, J.1    Shen, X.2    Huang, J.3    Hodes, R.J.4    Rosenberg, S.A.5    Robbins, P.F.6
  • 63
    • 0031112350 scopus 로고    scopus 로고
    • Regulation of telomerase RNA template expression in human T lymphocyte development and activation
    • Weng NP, Levine BL, June CH, Hodes RJ. 1997 Regulation of telomerase RNA template expression in human T lymphocyte development and activation. J. Immunol. 158, 3215–3220.
    • (1997) J. Immunol , vol.158 , pp. 3215-3220
    • Weng, N.P.1    Levine, B.L.2    June, C.H.3    Hodes, R.J.4
  • 64
    • 0031463644 scopus 로고    scopus 로고
    • Tales of tails: Regulation of telomere length and telomerase activity during lymphocyte development, differentiation, activation, and aging
    • Weng NP, Palmer LD, Levine BL, Lane HC, June CH, Hodes RJ. 1997 Tales of tails: regulation of telomere length and telomerase activity during lymphocyte development, differentiation, activation, and aging. Immunol. Rev. 160, 43–54. (doi:10.1111/j.1600-065X.1997.tb01026.x)
    • (1997) Immunol. Rev , vol.160 , pp. 43-54
    • Weng, N.P.1    Palmer, L.D.2    Levine, B.L.3    Lane, H.C.4    June, C.H.5    Hodes, R.J.6
  • 65
    • 84877015451 scopus 로고    scopus 로고
    • Allelic exclusion and peripheral reconstitution by TCR transgenic T cells arising from transduced human hematopoietic stem/progenitor cells
    • Giannoni F et al. 2013 Allelic exclusion and peripheral reconstitution by TCR transgenic T cells arising from transduced human hematopoietic stem/progenitor cells. Mol. Ther. 21, 1044–1054. (doi:10.1038/mt.2013.8)
    • (2013) Mol. Ther , vol.21 , pp. 1044-1054
    • Giannoni, F.1
  • 66
    • 84885612102 scopus 로고    scopus 로고
    • Generation of tumortargeted human T lymphocytes from induced pluripotent stem cells for cancer therapy
    • Themeli M, Kloss CC, Ciriello G, Fedorov VD, Perna F, Gonen M, Sadelain M. 2013 Generation of tumortargeted human T lymphocytes from induced pluripotent stem cells for cancer therapy. Nat. Biotechnol. 31, 928–933. (doi:10.1038/nbt.2678)
    • (2013) Nat. Biotechnol , vol.31 , pp. 928-933
    • Themeli, M.1    Kloss, C.C.2    Ciriello, G.3    Fedorov, V.D.4    Perna, F.5    Gonen, M.6    Sadelain, M.7
  • 67
    • 84890192292 scopus 로고    scopus 로고
    • Hematopoietic stem cells for cancer immunotherapy
    • Gschweng E, De Oliveira S, Kohn DB. 2014 Hematopoietic stem cells for cancer immunotherapy. Immunol. Rev. 257, 237–249. (doi:10.1111/imr.12128)
    • (2014) Immunol. Rev , vol.257 , pp. 237-249
    • Gschweng, E.1    De Oliveira, S.2    Kohn, D.B.3
  • 68
    • 84890171728 scopus 로고    scopus 로고
    • Uncoupling T-cell expansion from effector differentiation in cellbased immunotherapy
    • Crompton JG, Sukumar M, Restifo NP. 2014 Uncoupling T-cell expansion from effector differentiation in cellbased immunotherapy. Immunol. Rev. 257, 264–276. (doi:10.1111/imr.12135)
    • (2014) Immunol. Rev , vol.257 , pp. 264-276
    • Crompton, J.G.1    Sukumar, M.2    Restifo, N.P.3
  • 69
    • 51349090473 scopus 로고    scopus 로고
    • Insertional oncogenesis in 4 patients after retrovirus-mediated gene therapy of SCID-X1
    • Hacein-Bey-Abina S et al. 2008 Insertional oncogenesis in 4 patients after retrovirus-mediated gene therapy of SCID-X1. J. Clin. Invest. 118, 3132–3142. (doi:10.1172/JCI35700)
    • (2008) J. Clin. Invest , vol.118 , pp. 3132-3142
    • Hacein-Bey-Abina, S.1
  • 70
    • 0038446699 scopus 로고    scopus 로고
    • Persistence and expression of the adenosine deaminase gene for 12 years and immune reaction to gene transfer components: Long-term results of the first clinical gene therapy trial
    • Muul LM et al. 2003 Persistence and expression of the adenosine deaminase gene for 12 years and immune reaction to gene transfer components: long-term results of the first clinical gene therapy trial. Blood 101, 2563–2569. (doi:10.1182/blood-2002-09-2800)
    • (2003) Blood , vol.101 , pp. 2563-2569
    • Muul, L.M.1
  • 71
    • 34547691354 scopus 로고    scopus 로고
    • Retroviral integration and human gene therapy
    • Bushman FD. 2007 Retroviral integration and human gene therapy. J. Clin. Invest. 117, 2083–2086. (doi:10.1172/JCI32949)
    • (2007) J. Clin. Invest , vol.117 , pp. 2083-2086
    • Bushman, F.D.1
  • 72
    • 84868706467 scopus 로고    scopus 로고
    • T-cell receptor diversity prevents T-cell lymphoma development
    • Newrzela S et al. 2012 T-cell receptor diversity prevents T-cell lymphoma development. Leukemia 26, 2499–2507. (doi:10.1038/leu.2012.142)
    • (2012) Leukemia , vol.26 , pp. 2499-2507
    • Newrzela, S.1
  • 73
    • 0037441766 scopus 로고    scopus 로고
    • Immunologic potential of donor lymphocytes expressing a suicide gene for early immune reconstitution after hematopoietic T-celldepleted stem cell transplantation
    • Marktel S et al. 2003 Immunologic potential of donor lymphocytes expressing a suicide gene for early immune reconstitution after hematopoietic T-celldepleted stem cell transplantation. Blood 101, 1290–1298. (doi:10.1182/blood-2002-08-2351)
    • (2003) Blood , vol.101 , pp. 1290-1298
    • Marktel, S.1
  • 74
    • 80455162464 scopus 로고    scopus 로고
    • Inducible apoptosis as a safety switch for adoptive cell therapy
    • Di Stasi A et al. 2011 Inducible apoptosis as a safety switch for adoptive cell therapy. N. Engl. J. Med. 365, 1673–1683. (doi:10.1056/NEJMoa1106152)
    • (2011) N. Engl. J. Med , vol.365 , pp. 1673-1683
    • Di Stasi, A.1
  • 75
    • 84902654151 scopus 로고    scopus 로고
    • Long-term outcome and immune reconstitution after haploidentical stem cell transplant in recipients of allodepleted-T-cells expressing the inducible caspase-9 safety transgene
    • Zhou X et al. 2014 Long-term outcome and immune reconstitution after haploidentical stem cell transplant in recipients of allodepleted-T-cells expressing the inducible caspase-9 safety transgene. Blood 123, 3896–3905. (doi:10.1182/blood-2014-01-551671)
    • (2014) Blood , vol.123 , pp. 3896-3905
    • Zhou, X.1
  • 76
    • 80051775476 scopus 로고    scopus 로고
    • T cells with chimeric antigen receptors have potent antitumor effects and can establish memory in patients with advanced leukemia
    • Kalos M, Levine BL, Porter DL, Katz S, Grupp SA, Bagg A, June CH. 2011 T cells with chimeric antigen receptors have potent antitumor effects and can establish memory in patients with advanced leukemia. Sci. Transl. Med. 3, 95ra73. (doi:10.1126/scitranslmed.3002842)
    • (2011) Sci. Transl. Med , vol.3
    • Kalos, M.1    Levine, B.L.2    Porter, D.L.3    Katz, S.4    Grupp, S.A.5    Bagg, A.6    June, C.H.7
  • 77
    • 84876325876 scopus 로고    scopus 로고
    • Chimeric antigen receptor-modified T cells for acute lymphoid leukemia
    • Grupp SA et al. 2013 Chimeric antigen receptor-modified T cells for acute lymphoid leukemia. N. Engl. J. Med. 368, 1509–1518. (doi:10.1056/NEJMoa1215134)
    • (2013) N. Engl. J. Med , vol.368 , pp. 1509-1518
    • Grupp, S.A.1
  • 78
    • 84890230340 scopus 로고    scopus 로고
    • The use of endogenous T cells for adoptive transfer
    • Yee C. 2014 The use of endogenous T cells for adoptive transfer. Immunol. Rev. 257, 250–263. (doi:10.1111/imr.12134)
    • (2014) Immunol. Rev , vol.257 , pp. 250-263
    • Yee, C.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.