Effect of intravenous iron on aerobic capacity and iron metabolism in elite athletes

Medicine and Science in Sports and Exercise

Volumn 47, Issue 7, 2015, Pages 1399-1407

  Burden, Richard J ^a   Pollock, Noel ^b   Whyte, Gregory P ^c   Richards, Toby ^d   Moore, Brian ^e   Busbridge, Mark ^f   Srai, Surjit K ^d   Otto, James ^d   Pedlar, Charles R ^a,b,c,d,e  

^a ST MARY'S UNIVERSITY   (United Kingdom)

^b LoughboroughUniversity   (United Kingdom)

^c LIVERPOOL JOHN MOORES UNIVERSITY   (United Kingdom)

^d UNIVERSITY COLLEGE LONDON   (United Kingdom)

^e Atlantic Technological University   (Ireland)

^f IMPERIAL COLLEGE HEALTHCARE NHS TRUST   (United Kingdom)

Author keywords

ENDURANCE; FERRITIN; HEMOGLOBIN; HEPCIDIN; INTERLEUKIN 6; VO2MAX

Indexed keywords

FERRITIN; HEPCIDIN; INTERLEUKIN 6; IRON; TRANSFERRIN;

ATHLETE; BLOOD; CONTROLLED STUDY; DEFICIENCY; DOUBLE BLIND PROCEDURE; EXERCISE; EXERCISE TEST; FEMALE; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; MALE; MEAN CORPUSCULAR VOLUME; METABOLISM; OXYGEN CONSUMPTION; PHYSIOLOGY; RANDOMIZED CONTROLLED TRIAL; RUNNING; YOUNG ADULT;

ATHLETES; DOUBLE-BLIND METHOD; ERYTHROCYTE INDICES; EXERCISE TEST; FEMALE; FERRITINS; HEPCIDINS; HUMANS; INJECTIONS, INTRAVENOUS; INTERLEUKIN-6; IRON; MALE; OXYGEN CONSUMPTION; PHYSICAL EXERTION; RUNNING; TRANSFERRIN; YOUNG ADULT;

EID: 84942823428     PISSN: 01959131     EISSN: 15300315     Source Type: Journal    
DOI: 10.1249/MSS.0000000000000568     Document Type: Article

References (40)

1. Beard J, Tobin B,. Iron status and exercise. Am J Clin Nutr. 2000; 72 (2 Suppl): S594-7.
2. Beguin Y,. Soluble transferrin receptor for the evaluation of erythropoiesis and iron status. Clin Chim Acta. 2003; 329 (1-2): 9-22.
3. Blee T, Goodman C, Dawson B, Stapff A,. The effect of intramuscular iron injections of serum ferritin levels and physical performance in elite netballers. J Sci Med Sport. 1999; 2 (4): 311-21.
4. Borg GA,. Psychophysical basis of perceived exertion. Med Sci Sports Exerc. 1982; 14 (5): 377-81.
5. Busbridge M, Griffiths C, Ashby D, Jayantha A, Sanwaiya A, Chapman RS,. Development of a novel immunoassay for the regulatory peptide hepcidin. Br J Biomed Sci. 2009; 66 (3): 150-7.
6. Feng Q, Migas MC, Waheed A, Britton RS, Fleming RE,. Ferritin upregulates hepatic expression of bone morphogenetic protein 6 and hepcidin in mice. Am J Gastrointest Liver Physiol. 2012; 302: G1397-404.
7. Ganz T,. Hepcidin and iron regulation, 10 years later. Blood. 2011; 117 (17): 4425-33.
8. Garvican LA, Lobigs L, Telford R, Fallon K, Gore CJ,. Haemoglobin mass in an anaemic female endurance runner before and after iron supplementation. Int J Sports Physiol Perform. 2011; 6 (1): 137-40.
9. Garvican LA, Saunders PU, Cardoso T, Intravenous iron supplementation in distance runners with low or suboptimal ferritin. Med Sci Sports Exerc. 2014; 46 (2): 376-85.
10. Gore CJ, Hopkins WG, Burge CM,. Errors of measurement for blood volume parameters: a meta-Analysis. J Appl Physiol (1985). 2005; 99 (5): 1745-58.
11. Hinton PS, Sinclair LM,. Iron supplementation maintains ventilatory threshold and improves energetic efficiency in iron-deficient nonanaemic athletes. Eur J Clin Nutr. 2007; 61 (1): 30-9.
12. Kasapis C, Thompson PD,. The effects of physical activity on serum C-reactive protein and inflammatory markers: a systematic review. J Am Coll Cardiol. 2005; 45 (10): 1563-9.
13. Kell DB, Pretorius E,. Serum ferritin is an important inflammatory disease marker, as it is mainly a leakage product from damaged cells. Metallomics. 2004; 6 (4): 748-73.
14. Laftah AH, Ramesh B, Simpson RJ, Effect of hepcidin on intestinal iron absorption in mice. Blood. 2004; 103 (10): 3940-4.
15. Lin L, Valore EV, Nemeth E, Goodnough JB, Gabayan V, Ganz T,. Iron transferrin regulates hepcidin synthesis in primary hepatocyte culture through hemojuvelin and BMP2/4. Blood. 2007; 110 (6): 2182-9.
16. Martinovic J, Dopsaj V, Kotur-Stevuljevic J, Dopsaj M, Nesic G,. Oxidative stress status in elite female volleyball athletes with depleted iron stores. Br J Sports Med. 2011; 45: 534-5.
17. Nemeth E, Rivera S, Gabayan V, IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin. J Clin Invest. 2004; 113 (9): 1271-6.
18. Nemeth E, Tuttle MS, Powelson J, Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science. 2004; 306 (5704): 2090-3.
19. Newlin MK, Williams S, McNamara T, Tjalsma H, Swinkels DW, Haymes EM,. The effects of acute exercise bouts on hepcidin in women. Int J Sport Nutr Exerc Metab. 2012; 22 (2): 79-88.
20. Nicolas G, Chauvet C, Viatte L, The gene encoding the iron regulatory peptide hepcidin is regulated by anaemia, hypoxia and inflammation. J Clin Invest. 2002; 110 (7): 1037-44.
21. Nielsen P, Gunther U, Durken M, Fischer R, Dullmann J,. Serum ferritin iron in iron overload and liver damage: correlation to body iron stores and diagnostic relevance. J Lab Clin Med. 2000; 135 (5): 413-8.
22. Papillard-Marechal S, Sznajder M, Hurtado-Nedelec M, Iron metabolism in patients with anorexia nervosa: elevated serum hepcidin concentrations in the absence of inflammation. Am J Clin Nutr. 2012; 95 (3): 548-54.
23. Pedlar CR, Whyte GP, Burden RJ, Moore B, Horgan G, Pollock N,. A case study of an iron-deficient female Olympic 15000 m runner. Int J Sports Physiol Perform. 2013; 8 (6): 696-8.
24. Peeling P, Blee T, Goodman C, Effect of iron injections on aerobic-exercise performance of iron-depleted female athletes. Int J Sport Nutr Exerc Metab. 2007; 17 (3): 221-31.
25. Peeling P, Dawson B, Goodman C, Effects of exercise on hepcidin response and iron metabolism during recovery. Int J Sport Nutr Exerc Metab. 2009; 19 (6): 583-97.
26. Peeling P, Sim M, Badenhorst CE, Iron status and the acute post-exercise hepcidin response in athletes. PLoS One. 2014; 9 (3): 1-6.
27. Piperno A, Gamlimerti S, Mariani R, Modulation of hepcidin production during the hypoxia-induced erythropoiesis in humans in vivo: data from the HIGHCARE project. Blood. 2011; 117 (10): 2953-9.
28. Prommer N, Sottas P, Schoch C, Schumacher YO, Schmidt W,. Total haemoglobin mass-A new parameter to detect blood doping? Med Sci Sports Exerc. 2008; 40 (12): 2112-8.
29. Radjen L, Radjen G, Zivotic-Vanovic M, Radakovic S,. Effect of iron supplementation on maximal oxygen uptake in female athletes [in Serbian]. Vojnosanit Pregl. 2011; 68 (2): 130-5.
30. 2 uptake between the on- And off-Transients of moderate- And high-intensity exercise in humans. J Physiol. 2002; 541 (3): 991-1002.
31. Schmidt W, Prommer N,. The optimised CO-rebreathing method: a new tool to determine total haemoglobin mass routinely. Eur J Appl Physiol. 2005; 95 (5-6): 486-95.
32. 2max. Exerc Sport Sci Rev. 2010; 38 (2): 68-75.
33. Sim M, Dawson B, Landers G, Effect of exercise modality and intensity on postexercise interleukin-6 and hepcidin levels. Int J Sport Nutr Exerc Metab. 2013; 23: 178-86.
34. Sim M, Dawson B, Landers G, Trinder D, Peeling P,. Iron regulation in athletes: exploring the menstrual cycle and effects of different exercise modalities on hepcidin production. Int J Sport Nutr Exerc Metab. 2014; 24 (2): 177-87.
35. Suominen P, Punnonen K, Rajamaki A, Irjala K,. Serum transferrin receptor and transferrin receptor-ferritin index identify healthy subjects with subclinical iron deficits. Blood. 1998; 92 (8): 2934-9.
36. Talbot NP, Lakhal S, Smith TG, Regulation of hepcidin expression at high altitude. Blood. 2012; 119 (3): 857-60.
37. Telford RD, Sly GJ, Hahn AG, Cunningham RB, Bryant C, Smith JA,. Footstrike is the major cause of hemolysis during running. J Appl Physiol (1985). 2003; 94 (1): 38-42.
38. Usyal S, Armutcu F, Aydogan T, Akin K, Ikizek M, Yigitoglu MR,. Some inflammatory cytokine levels, iron metabolism and oxidant stress markers in subjects with nonalcoholic steatohepatitis. Clin Biochem. 2011; 44 (17-18): 1375-9.
39. Vaiksaar S, Jurimae J, Maestu J, No effect of menstrual cycle phase and oral contraceptive use on endurance performance in rowers. J Strength Cond Res. 2011; 25 (6): 1571-8.
40. Zhu YI, Haas JD,. Altered metabolic response of iron-depleted nonanaemic women during a 15-km time trial. J Appl Physiol (1985). 1998; 84 (5): 1768-17.