Impact of alterations in total hemoglobin mass on VO2max

Exercise and Sport Sciences Reviews

Volumn 38, Issue 2, 2010, Pages 68-75

  Schmidt, Walter ^a   Prommer, Nicole ^a  

^a UNIVERSITY OF BAYREUTH   (Germany)

Author keywords

Altitude; Blood manipulation; Blood volume; Cardiac output; Hemoglobin concentration; Training

Indexed keywords

HEMOGLOBIN; RECOMBINANT ERYTHROPOIETIN;

ADAPTATION; ALTITUDE; ANOXIA; ARTICLE; BLOOD VOLUME; DOPING; HEMATOCRIT; HUMAN; OXYGEN CONSUMPTION; PATHOPHYSIOLOGY; PHYSICAL EDUCATION; PHYSIOLOGY;

ADAPTATION, PHYSIOLOGICAL; ALTITUDE; ANOXIA; BLOOD VOLUME; DOPING IN SPORTS; ERYTHROPOIETIN, RECOMBINANT; HEMATOCRIT; HEMOGLOBINS; HUMANS; OXYGEN CONSUMPTION; PHYSICAL EDUCATION AND TRAINING;

EID: 77950220931     PISSN: 00916331     EISSN: None     Source Type: Journal    
DOI: 10.1097/JES.0b013e3181d4957a     Document Type: Article

References (35)

1. Beall CM. Two routes to functional adaptation: Tibetan and Andean high-altitude natives. Proc. Natl. Acad. Sci. U. S. A. 2007; 104:8655-60.
2. Böning D, Maassen N. Mechanisms of doping with erythropoietin. Dtsch. Ztschr. Sportmed. 2008; 59(7-8):175-7.
3. Böning D, Rojas J, Serrato M, et al. Hemoglobin mass and physical training in male and female residents of moderate altitude. Int. J. Sports Med. 2002; 23:79-80.
4. Burge CM, Skinner SL. Determination of hemoglobin mass and blood volume with CO: evaluation and application of a method. J. Appl. Physiol. 1995; 79(2):623-31.
5. Damsgaard R, Munch T, Mørkeberg J, Mortensen SP, González-Alonso J. Effects of blood withdrawal and reinfusion on biomarkers of erythropoiesis in humans: implications for anti-doping strategies. Haematologica. 2006; 91:1006-8.
6. Ekblom B. Effect of physical training on oxygen transport system in man. Acta. Physiol. Scand. 1969; S:1-45.
7. Friedmann-Bette B. Classical altitude training. Scand. J. Med. Sci. Sports 2008; 18(Suppl. 1):11-20.
8. Ge R-L, Witkowski S, Zhang Y, et al. Determinants of erythropoietin release in response to short-term hypobaric hypoxia. J. Appl. Phys. 2002; 92:2361-7.
9. 2maxand haemoglobin mass of trained athletes during high intensity training. Int. J. Sports Med. 1997; 18:477-82.
10. Gore CJ, Hopkins WG. Counterpoint: positive effects of intermittent hypoxia (live high:train low) on exercise performance are not mediated primarily by augmented red cell volume. J. Appl. Physiol. 2005; 99(5): 2055-7.
11. Gore CJ, Hopkins WG, Burge CM. Errors of measurement for blood volume parameters: a meta-analysis. J. Appl. Physiol. 2005; 99: 1745-58.
12. Heinicke K, Prommer N, Cajigal J, Viola T, Behn C, Schmidt W. Longterm exposure to intermittent hypoxia results in increased hemoglobin mass, reduced plasma volume, and elevated erythropoietin plasma levels in man. Eur. J. Appl. Physiol. 2003; 88:535-43.
13. Heinicke K, Wolfahrt B, Winchenbach P, et al. Blood volume and hemoglobin mass in elite athletes of different disciplines. Int. J. Sports Med. 2001; 22:504-12.
14. Horwitz L, Lindenfeld J. Effects of enhanced ventricular filling on cardiac pump performance in exercising dogs. J. Appl. Physiol. 1985; 59(6):1886-90.
15. Kanstrup IL, Ekblom B. Blood volume and hemoglobin concentration as determinants of maximal aerobic power. Med. Sci. Sports Exerc. 1984; 16(3):256-62.
16. 2max:what do we know, and what do we still need to know? J. Physiol. 2008; 586(1):25-34.
17. Levine BD, Stray-Gundersen J. Point: positive effects of intermittent hypoxia (live high:train low) on exercise performance are mediated primarily by augmented red cell volume. J. Appl. Physiol. 2005; 99(5): 2053-5.
18. Lundby C, Thomsen JJ, Boushel R, et al. Erythropoietin treatment elevates haemoglobin concentration by increasing red cell volume and depressing plasma volume. J. Physiol. 2007; 578(1):309-14.
19. 2max with no history of training is primarily due to high blood volume. Med. Sci. Sports Exerc. 2002; 34(6):966-71.
20. Morkeberg JS, Belhage B, Damsgaard R. Changes in blood values in elite cyclist. Int. J. Sports Med. 2009; 30(2):130-8.
21. Parisotto R, Gore CJ, Emslie KR, et al. A novel method utilizing markers of altered erythropoiesis for the detection of recombinant human erythropoietin abuse in athletes. Haematologica 2000; 85(6):564-72.
22. Prommer N, Heckel A, Schmidt W. Timeframe to detect blood withdrawal associated with autologous blood doping. Med. Sci. Sports Exerc. 2007; 39(5 Suppl):S3.
23. 2max. High Alt. Med. Biol. 2007; 8(3):225-35.
24. Prommer N, Sottas P-E, Schoch C, Schumacher YO, Schmidt W. Total hemoglobin massVa new parameter to detect blood doping. Med. Sci. Sports Exerc. 2008; 40(12):2112-8.
25. Rowell LB. Ideas about control of skeletal and cardiac muscle blood flow (1876-2003): cycles of revision and new vision. J. Appl. Physiol. 2004; 97(1):384-92.
26. Sawka MN, Young AJ, Pandolf KB, Dennis RC, Valeri CR. Erythrocyte, plasma and blood volume of healthy young men. Med. Sci. Sports Exerc. 1992; 24:447-53.
27. Schmidt W, Eckardt KU, Hilgendorf A, Strauch S, Bauer C. Effects of maximal and submaximal exercise under normoxic and hypoxic conditions on serum erythropoietin level. Int. J. Sports Med. 1991; 12(5): 457-61.
28. Schmidt W, Heinicke K. Screening of total hemoglobin mass in triathletes and professional cyclists. Dtsch. Ztschr. Sportmed. 2008; 59(6): 16-22.
29. Schmidt W, Heinicke K, Rojas J, et al. Blood volume and hemoglobin mass in endurance athletes from moderate altitude. Med. Sci. Sports Exerc. 2002; 34(12):1934-40.
30. Schmidt W, Prommer N. The optimised CO-rebreathing method: a new tool to determine total haemoglobin mass routinely. Eur. J. Appl. Physiol. 2005; 95:486-95.
31. Schmidt W, Prommer N. Effects of various training modalities on blood volume. Scand. J. Med. Sci. Sports 2008; 18(Suppl. 1):57-69.
32. Schmidt WF, Doerfler C, Wachsmuth N, et al. Influence of body mass, body composition, and performance state on total hemoglobin mass. Med. Sci. Sports Exerc. 2009; 41(5):541.
33. 2max. Exerc. Sport Sci. Rev. 2000; 28(1):10-4.
34. Warburton DE, Haykowski MJ, Quinney HA, et al. Blood volume expansion and cardiorespiratory function: effects of training modality. Med. Sci. Sports Exerc. 2004; 36:991-1000.
35. 2max at high altitude. J. Appl. Physiol. 1996; 81(1):252-9.