A novel infant milk formula concept: Mimicking the human milk fat globule structure

Colloids and Surfaces B: Biointerfaces

Volumn 136, Issue , 2015, Pages 329-339

  Gallier, Sophie ^a   Vocking, Karin ^b   Post, Jan Andries ^b   Van De Heijning, Bert ^a   Acton, Dennis ^a   Van Der Beek, Eline M ^c   Van Baalen, Ton ^a  

^a Nutricia Nederland   (Netherlands)

^b UTRECHT UNIVERSITY   (Netherlands)

^c Danone Research Centre for Specialised Nutrition   (Singapore)

Author keywords

Human milk fat globule; Infant milk formula; Milk fat globule membrane; Milk phospholipids; Transmission electron microscopy

Indexed keywords

BIOLOGICAL MEMBRANES; CHOLESTEROL; ELECTRON MICROSCOPY; HIGH RESOLUTION TRANSMISSION ELECTRON MICROSCOPY; LIPIDS; METABOLISM; OILS AND FATS; PHOSPHOLIPIDS; PROTEINS; SCANNING ELECTRON MICROSCOPY; TRANSMISSION ELECTRON MICROSCOPY;

BIOLOGICAL FUNCTIONS; CONFOCAL LASER SCANNING MICROSCOPY; HUMAN MILK; INFANT MILK FORMULA; INTERFACIAL COMPOSITION; MILK FAT GLOBULES; PHOSPHOLIPID MEMBRANE; PHOSPHOLIPID-COATING;

DROPS;

CHOLESTEROL; FAT DROPLET; FLUORESCENT DYE; GLYCOPROTEIN; MILK FAT; PHOSPHOLIPID; PROTEIN; GLYCOLIPID; MILK FAT GLOBULE;

ARTICLE; ARTIFICIAL MILK; BREAST MILK; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; CYTOPLASM; EXOSOME; HUMAN; LIPID ANALYSIS; LIPID COMPOSITION; NUTRIENT CONTENT; PARTICLE SIZE; PRIORITY JOURNAL; TRANSMISSION ELECTRON MICROSCOPY; CHEMICAL STRUCTURE; CHEMISTRY;

GLYCOLIPIDS; GLYCOPROTEINS; HUMANS; INFANT FORMULA; MICROSCOPY, ELECTRON, TRANSMISSION; MILK, HUMAN; MOLECULAR STRUCTURE; PARTICLE SIZE;

EID: 84942804213     PISSN: 09277765     EISSN: 18734367     Source Type: Journal    
DOI: 10.1016/j.colsurfb.2015.09.024     Document Type: Article

References (51)

1. Keenan T.W., Mather I.H. Milk fat globule membrane. Encyclopedia of Dairy Sciences 2002, 1568-1576. Academic Press, London. J.W.F. In, H. Roginski, P.F. Fox (Eds.).
2. Langley-Evans S.C. Nutrition in early life and the programming of adult disease: a review. J. Hum. Nutr. Diet. 2014, 28:1-14.
3. Le Huërou-Luron I., Blat S., Boudry G. Breast- v. formula-feeding: impacts on the digestive tract and immediate and long-term health effects. Nutr. Res. Rev. 2010, 23:23-36.
4. Gallier S., Gragson D., Jimenez-Flores R., Everett D. Using confocal laser scanning microscopy to probe the milk fat globule membrane and associated proteins. J. Agric. Food Chem. 2010, 58:4250-4257.
5. Lopez C., Ménard O. Human milk fat globules: polar lipid composition and in situ structural investigations revealing the heterogeneous distribution of proteins and the lateral segregation of sphingomyelin in the biological membrane. Colloids Surf. B: Biointerfaces 2011, 83:29-41.
6. Michalski M.C., Briard V., Michel F., Tasson F., Poulain P. Size distribution of fat globules in human colostrum, breast milk, and infant formula. J. Dairy Sci. 2005, 88:1927-1940.
7. Hamosh M., Bitman J., Wood D.L., Hamosh P., Mehta N.R. Lipids in milk and the first steps in their digestion. Pediatrics 1985, 75:146-150.
8. Bitman J., Wood D.L., Mehta N.R., Hamosh P., Hamosh M. Comparison of the phospholipid-composition of breast-milk from mothers of term and preterm infants during lactation. Am. J. Clin. Nutr. 1984, 40:1103-1119.
9. Hamosh M., Peterson J.A., Henderson T.R., Scallan C.D., Kiwan R., Ceriani R.L., Armand M., Mehta N.R., Hamosh P. Protective function of human milk: the milk fat globule. Semin. Perinatol. 1999, 23:242-249.
10. Gallier S., Laubscher A., Jiménez-Flores R. Chapter 4-the milk fat globule membrane: structure, methodology for its study, and functionality. Food Structures, Digestion and Health 2014, 107-142. Academic Press, San Diego. M. Boland, M. Golding, H. Singh (Eds.).
11. Spitsberg V.L. Bovine milk fat globule membrane as a potential nutraceutical. J. Dairy Sci. 2005, 88:2289-2294.
12. Dewettinck K., Rombaut R., Thienpont N., Le T.T., Messens K., Van Camp J. Nutritional and technological aspects of milk fat globule membrane material. Int. Dairy J. 2008, 18:436-457.
13. van Aken G.A. Relating food emulsion structure and composition to the way it is processed in the gastrointestinal tract and physiological responses: what are the opportunities?. Food Biophys. 2010, 5:258-283.
14. Armand M., Pasquier B., Andre M., Borel P., Senft M., Peyrot J., Salducci J., Portugal H., Jaussan V., Lairon D. Digestion and absorption of 2 fat emulsions with different droplet sizes in the human digestive tract. Am. J. Clin. Nutr. 1999, 70:1096-1106.
15. Bourlieu C., Ménard O., De La Chevasnerie A., Sams L., Rousseau F., Madec M.N., Robert B., Deglaire A., Pezennec S., Bouhallab S., Carrière F., Dupont D. The structure of infant formulas impacts their lipolysis, proteolysis and disintegration during in vitro gastric digestion. Food Chem. 2015, 182:224-235.
16. Armand M., Hamosh M., Mehta N.R., Angelus P.A., Philpott J.R., Henderson T.R., Dwyer N.K., Lairon D., Hamosh P. Effect of human milk or formula on gastric function and fat digestion in the premature infant. Pediatr. Res. 1996, 40:429-437.
17. J. Van den Brenk, K.C. Van Dijke, A.M.L. Van der Steen, R.C.J. Moonen, A. Van Baalen, Process for preparing infant formula, Netherlands (2013).
18. Oosting A., Kegler D., Wopereis H.J., Teller I.C., Van De Heijning B.J.M., Verkade H.J., Van Der Beek E.M. Size and phospholipid coating of lipid droplets in the diet of young mice modify body fat accumulation in adulthood. Pediatr. Res. 2012, 72:362-369.
19. Oosting A., Van Vlies N., Kegler D., Schipper L., Abrahamse-Berkeveld M., Ringler S., Verkade H.J., Van Der Beek E.M. Effect of dietary lipid structure in early postnatal life on mouse adipose tissue development and function in adulthood. Br. J. Nutr. 2014, 111:215-226.
20. Gallier S., Gordon K.C., Singh H. Chemical and structural characterisation of almond oil bodies and bovine milk fat globules. Food Chem. 2012, 132:1996-2006.
21. Gallier S., Zhu X.Q., Rutherfurd S.M., Ye A., Moughan P.J., Singh H. In vivo digestion of bovine milk fat globules: effect of processing and interfacial structural changes. II. Upper digestive tract digestion. Food Chem. 2013, 141:3215-3223.
22. Bourlieu C., Michalski M.-C. Structure-function relationship of the milk fat globule. Curr. Opin. Clin. Nutr. Metab. Care 2015, 18:118-127.
23. Huston G.E., Patton S. Factors related to the formation of cytoplasmic crescents on milk fat globules. J. Dairy Sci. 1990, 73:2061-2066.
24. Evers J.M., Haverkamp R.G., Holroyd S.E., Jameson G.B., Mackenzie D.D.S., McCarthy O.J. Heterogeneity of milk fat globule membrane structure and composition as observed using fluorescence microscopy techniques. Int. Dairy J. 2008, 18:1081-1089.
25. Horisberger M., Rosset J., Vonlanthen M. Location of glycoproteins on milk fat globule membrane by scanning and transmission electron microscopy, using lectin-labelled gold granules. Exp. Cell Res. 1977, 109:361-369.
26. Severs N.J., Robenek H. Detection of microdomains in biomembranes. An appraisal of recent developments in freeze-fracture cytochemistry. Biochim. Biophys. Acta (BBA) - Rev. Biomembr. 1983, 737:373-408.
27. Martin W. Electron microscopic localization of cholesterol in bovine milk fat globules. Food Microstruct. 1989, 8:3-9.
28. Mani O., Körner M., Ontsouka C.E., Sorensen M.T., Sejrsen K., Bruckmaier R.M., Albrecht C. Identification of ABCA1 and ABCG1 in milk fat globules and mammary cells-implications for milk cholesterol secretion. J. Dairy Sci. 2011, 94:1265-1276.
29. Rueda R. The role of complex lipids in attaining metabolic health. Curr. Cardiovasc. Risk Rep. 2014, 8:1-8.
30. Noh S.K., Koo S.I. Milk sphingomyelin is more effective than egg sphingomyelin in inhibiting intestinal absorption of cholesterol and fat in rats. J. Nutr. 2004, 134:2611-2616.
31. Bayley T.M., Alasmi M., Thorkelson T., Jones P.J.H., Corcoran J., Krug-Wispe S., Tsang R.C. Longer term effects of early dietary cholesterol level on synthesis and circulating cholesterol concentrations in human infants. Metabolism 2002, 51:25-33.
32. Uauy R., Mize C.E., Castillo-Duran C. Fat intake during childhood: metabolic responses and effects on growth. Am. J. Clin. Nutr. 2000, 72:1354S-1360S.
33. Wooding F.B.P. Structure of milk fat globule membrane. J. Ultrastruct. Res. 1971, 37:388-400.
34. Kalab M. Electron microscopy of foods. Physical Properties of Foods 1983, 43-104. AVI Publishing Company, Inc., Westport, CT. M. Peleg, E.B. Bagley (Eds.).
35. Patton S., Keenan T.W. The milk fat globule membrane. Biochim. Biophys. Acta (BBA) - Rev. Biomembr. 1975, 415:273-309.
36. Argov-Argaman N., Smilowitz J.T., Bricarello D.A., Barboza M., Lerno L., Froehlich J.W., Lee H., Zivkovic A.M., Lemay D.G., Freeman S., Lebrilla C.B., Parikh A.N., German J.B. Lactosomes: structural and compositional classification of unique nanometer-sized protein lipid particles of human milk. J. Agric. Food Chem. 2010, 58:11234-11242.
37. Admyre C., Johansson S.M., Qazi K.R., Filén J.J., Lahesmaa R., Norman M., Neve E.P.A., Scheynius A., Gabrielsson S. Exosomes with immune modulatory features are present in human breast milk. J. Immunol. 2007, 179:1969-1978.
38. Keenan T.W., Dylewski D.P. Intracellular origin of milk lipid globules and the nature and structure of the milk fat globule membrane. Advanced Dairy Chemistry: Lipids 1995, 89-130. Chapman Hall, London. P.F. Fox (Ed.).
39. Vlassov A.V., Magdaleno S., Setterquist R., Conrad R. Exosomes: current knowledge of their composition, biological functions, and diagnostic and therapeutic potentials. Biochim. Biophys. Acta (BBA) - Gen. Subj. 2012, 1820:940-948.
40. Lemay D.G., Hovey R.C., Hartono S.R., Hinde K., Smilowitz J.T., Ventimiglia F., Schmidt K.A., Lee J.W.S., Islas-Trejo A., Silva P.I., Korf I., Medrano J.F., Barry P.A., German J.B. Sequencing the transcriptome of milk production: milk trumps mammary tissue. BMC Genomics 2013, 14.
41. Morin P., Jimenez-Flores R., Pouliot Y. Effect of processing on the composition and microstructure of buttermilk and its milk fat globule membranes. Int. Dairy J. 2007, 17:1179-1187.
42. Vanderghem C., Bodson P., Danthine S., Paquot M., Deroanne C., Blecker C. Milk fat globule membrane and buttermilks: from composition to valorization. Biotechnol. Agron. Soc. Environ. 2010, 14:485-500.
43. Corredig M., Dalgleish D.G. Isolates from industrial buttermilk: emulsifying properties of materials derived from the milk fat globule membrane. J. Agric. Food Chem. 1997, 45:4595-4600.
44. Corredig M., Dalgleish D.G. Characterization of the interface of an oil-in-water emulsion stabilized by milk fat globule membrane material. J. Dairy Res. 1998, 65:465-477.
45. Waninge R., Walstra P., Bastiaans J., Nieuwenhuijse H., Nylander T., Paulsson M., Bergenståhl B. Competitive adsorption between beta-casein or beta-lactoglobulin and model milk membrane lipids at oil-water interfaces. J. Agric. Food Chem. 2005, 53:716-724.
46. Dickinson E. Flocculation of protein-stabilized oil-in-water emulsions. Colloids Surf. B: Biointerfaces 2010, 81:130-140.
47. Murphy E.G., Roos Y.H., Hogan S.A., Maher P.G., Flynn C.G., Fenelon M.A. Physical stability of infant milk formula made with selectively hydrolysed whey proteins. Int. Dairy J. 2015, 40:39-46.
48. Gallier S., Gragson D., Jimenez-Flores R., Everett D.W. Surface characterization of bovine milk phospholipid mono layers by langmuir isotherms and microscopic techniques. J. Agric. Food Chem. 2010, 58:12275-12285.
49. Abrahamse E., Minekus M., van Aken G.A., van de Heijning B., Knol J., Bartke N., Oozeer R., van der Beek E.M., Ludwig T. Development of the digestive system-experimental challenges and approaches of infant lipid digestion. Food Dig. 2012, 3:63-77.
50. Gallier S., Cui J., Olson T.D., Rutherfurd S.M., Ye A., Moughan P.J., Singh H. In vivo digestion of bovine milk fat globules: effect of processing and interfacial structural changes. I. Gastric digestion. Food Chem. 2013, 141:3273-3281.
51. Lecomte M., Bourlieu C., Meugnier E., Penhoat A., Cheillan D., Pineau G., Loizon E., Trauchessec M., Claude M., Ménard O., Géloën A., Laugerette F., Michalski M.-C. Milk polar lipids affect in vitro digestive lipolysis and postprandial lipid metabolism in mice. J. Nutr. 2015, 145:1770-1777.