Invited review: Bovine milk fat globule membrane as a potential nutraceutical

Journal of Dairy Science

Volumn 88, Issue 7, 2005, Pages 2289-2294

  Spitsberg, V L ^a  

^a BioVita Technologies   (Israel)

Author keywords

Bovine milk fat globule membrane; Cholesterolemia; Milk anticancer protein; Phospholipid

Indexed keywords

BOVINAE; ESCHERICHIA COLI; HELICOBACTER PYLORI;

EID: 22944439068     PISSN: 00220302     EISSN: None     Source Type: Journal    
DOI: 10.3168/jds.S0022-0302(05)72906-4     Document Type: Review

References (58)

1. Adachi, I., H.-X. Liu, I. Horikoshi, N. Ueno, and H. Sato. 1993. Possibility of lymphatic absorption of epidermal growth factor from intestine. Yakugaku Zasshi 113:256-263. (In Japanese)
2. Astaire, J. C., R. Ward, J. B. German, and R. Jimenez-Flores. 2003. Concentration of polar MFGM lipids from buttermilk by microfiltration and supercritical fluid extraction. J. Dairy Sci. 86:2297-2307.
3. Banga, A. K. 1995. Oral delivery of peptide and protein drugs. Pages 217-244 in Therapeutic peptides and proteins. Formulation, processing and delivery systems. Technomic Publishing Co., Lancaster, PA.
4. Bansal, M., and D. Medina. 1993. Expression of fatty acid binding proteins in the developing mouse mammary gland. Biochem. Biophys. Res. Commun. 191:61-69.
5. Berra, B., I. Colombo, E. Sottocornola, and A. Giacosa. 2002. Dietary sphingolipids in colorectal cancer prevention. Eur. J. Cancer 1:193-197.
6. Cover, T. L., and M. J. Blaser. 1992. Helicobacter pylori and gastroduodenal disease. Annu. Rev. Med. 43:135-145.
7. Daniels, M. J., Y. Wang, M. Lee, and A. R. Venkitaraman. 2004. Abnormal cytokinesis in cells deficient in the breast cancer susceptibility protein BRCA2. Science 306:876-879.
8. Ernst, P. 1999. Review article: The role of inflammation in the pathogenesis of gastric cancer. Aliment. Pharmacol. Ther. 13(Suppl. 1):13-18.
9. Franke, F. F., H. W. Held, G. Grund, S. Winter, C. Freudenstein, E. Schmidt, E.-D. Jarasch, and T. W. Kennan. 1981. Antibodies to the major insoluble milk fat globule membrane-associated protein: Specific location in apical region of lactating epithelial cells. J. Cell Biol. 89:485-494.
10. Goldfarb, M. 1997. Two-dimensional electrophoretic analysis of human milk-fat globule membrane proteins with attention to apolipoprotein E patterns. Electrophoresis 18:511-515.
11. Greenwalt, D. E., R. H. Lipsky, C. F. Ockenhouse, H. Ikeda, N. N. Tandon, and G. A. Jamieson. 1992. Membrane glycoprotein CD36: A review of its role(s) in adherence, signal transduction, and transfusion medicine. Blood 80:1105-1115.
12. Grosse, R., and P. Langen. 1990. Mammary-derived growth inhibitor. Pages 249-265 in Handbook of experimental pharmacology. Vol. 96. M. B. Sporn, and A. B. Roberts, ed. Springer-Verlag, Berlin, Germany.
13. Guggenmos, J., A. S. Schubari, S. Ogg, M. Anderson, T. Olsson, I. H. Mather, and C. Linington. 2004. Antibody cross-reactivity between myelin oligodendrocyte glycoprotein and the milk butyrophilin in multiple sclerosis. J. Immunol. 172:661-668.
14. Hancock, J. T., V. Salisbury, M. C. Ovejero-Boglione, R. Cherry, C. Hoare, R. Eisenthal, and R. Harrison. 2002. Antimicrobial properties of milk: Dependence on presence of xanthine oxidase and nitrite. Antimicrob. Agents Chemother. 46:3308-3310.
15. Heid, H. W., M. Schnolzer, and T. W. Keenan. 1996. Adipocyte differentiation-related protein is secreted into milk as a constituent of milk lipid globule membrane. Biochem. J. 320:1025-1030.
16. Hertervig, E., A. Nilsson, Y. Cheng, and R. D. Duan. 2003. Purified intestinal alkaline sphingomyelinase inhibits proliferation without inducing apoptosis in HT-29 colon carcinoma cells. J. Cancer Res. Clin. Oncol. 129:577-582.
17. Hirmo, S., S. Kelm, and M. Iwersen. 1998. Inhibition of Helicobacter pylori sialic- acid-specific haemagglutination by human gastrointestinal mucins and milk glycoproteins. FEMS Immunol. Med. Microbiol. 20:275-281.
18. Horrocks, L. A., and A. A. Farooqui. 2004. Docosahexaenoic acid in the diets: Its importance in main and restoration of neural membrane function. Prostaglandins Leukot. Essent. Fatty Acids 70:351-372.
19. Howard, A. N., and J. Marks. 1979. Effect of milk products on serum-cholesterol. Lancet 2:957.
20. Ito, O., K. Hotta, Y. Goso, K. Ishihara, T. Sugun, M. Morita, T. Wadstrom, and K. Schauer. 1993. Milk fat globule membrane substances inhibit mouse intestinal beta-glucuronidase. J. Food Sci. 58:753-755.
21. Ito, O., S. Kamata, M. Hayashi, Y. Suzuki, T. Sakou, and S. Motoyoshi. 1992. Inhibitory effect of cream and milk fat globule membrane on hypercholesterolemia in the rat. Anim. Sci. Technol. (Japan) 63:1022-1027.
22. Jensen, S. K., and K. N. Nielsen. 1996. Tocopherols, retinol, beta-carotene and fatty acids in fat globule membrane and fat globule core in cows' milk. J. Dairy Res. 63:565-574.
23. Kanno, C. 1990. Secretory membranes of the lactating mammary gland. Protoplasma 159:184-208.
24. Keenan, T. W., E. M. Powell, M. Sasaki, W. N. Eigle, and W. W. Franke. 1977. Membranes of mammary gland. XIV. Isolation and partial characterization of a high molecular weight glycoprotein fraction from bovine milk fat globule membrane. Cytobiologie 15:96-115.
25. Kilara, A., and D. Panyam. 2003. Peptides from milk proteins and their properties. Crit. Rev. Food Sci. Nutr. 43:607-633.
26. Krum, S. A., J. E. Womack, and T. F. Lane. 2003. Bovine BRCA1 shows classic responses to genotoxic stress but low in vitro transcriptional activation activity. Oncogene 22:6032-6044.
27. Lemonnier, L. A., D. L. Dillehay, M. J. Vespremi, J. Abrams, E. Brody, and E. M. Schmelz. 2003. Sphingomyelin in the suppression of colon tumors: Prevention versus intervention. Arch. Biochem. Biophys. 419:129-138.
28. Lindmark-Mansson, H., and B. Akesson. 2000. Antioxidative factors in milk. Br. J. Nutr. 84(Suppl.):S103-S110.
29. Macardle, P. J., Z. Chen, C. Y. Shih, C. M. Huang, H. Weedon, Q. Sun, A. F. Lopez, and H. Zola. 1996. Characterization of human leucocytes bearing the IL-3 receptor. Cell. Immunol. 168:59-68.
30. Mana, P., M. Goodyear, C. Bernard, R. Tomioka, M. Freire-Garabal, and D. Linares. 2004. Tolerance induction by molecular mimicry: Prevention and suppression of experimental autoimmune encephalomyelitis with the milk protein butyrophilin. Int. Immunol. 16:489-499.
31. Manke, L. A., D. M. Lowery, A. Nguyen, and M. B. Yaffe. 2003. BRCT repeats as phosphopeptide modules involved in protein targeting. Science 302:636-639.
32. Martin, H. M., J. T. Hancock, V. Salisbury, and R. Harrison. 2004. Role of xanthine oxidoreductase as an antimicrobial agent. Infect. Immun. 72:4933-4939.
33. Mather, I. H. 2000. A review and proposed nomenclature for major proteins of the milk-fat globule membrane. J. Dairy Sci. 83:203-247.
34. Mather, I. H., and T. W. Keenan. 1998. Origin and secretion of milk lipids. J. Mammary Gland Biol. Neoplasia 3:259-273.
35. McDaniel, M. A., S. F. Maier, and G. O. Einstein. 2003. "Brain-specific" nutrients: A memory cure? Nutrition 19:955-956.
36. Moss, M., and D. Freed. 2003, The cow and the coronary: Epidemiology, biochemistry and immunology. Int. J. Cardiol. 87:203-216.
37. Noh, S. K., and S. L. Koo. 2004. Milk sphingomyelin is more effective than egg sphingomyelin in inhibiting intestinal absorption of cholesterol and fat in rats. J. Nutr. 134:2611-2616.
38. Oshida, K., T. Shimizu, M. Takase, Y. Tamura, T. Shimizu, and Y. Yamashiro. 2003. Effect of dietary sphingomyelin on central nervous system myelination in developing rats. Pediatr. Res. 53:580-592.
39. Parodi, P. W. 2001. Cows' milk components with anti-cancer potential. Aust. J. Dairy Technol. 56:65-73.
40. Riccio, P. 2004. The proteins of the milk fat globule membrane in the balance. Trends Food Sci. Technol. 15:458-461.
41. Rodriguez, M., X. Yu, J. Chen, and Z. Songyang. 2003. Phosphopeptide binding specificities of BRCA1 COOH terminal (BRCT) domains. J. Biol. Chem. 278:52914-52918.
42. Sato, H., H. X. Liu, I. Adachi, M. Ueno, M. Lemaire, and I. Horikoshi. 1994. Enhancement of the intestinal absorption of a cyclosporine derivative fat globule membrane. Biopharm. Bull. 17:1526-1528.
43. Sfeir, Z., A. Ibrahimi, E. Amri, P. Grimaldi, and N. Abumrad. 1997. Regulation of FAT/CD36 gene expression: Further evidence in support of a role of the protein in fatty acid binding/transport. Prostaglandins Leukot. Essent. Fatty Acids 57:17-21.
44. Spitsberg, V. L., E. Matitashvili, and R. C. Gorewit. 1995. Association of fatty acid binding protein and glycoprotein CD36 in the bovine mammary gland. Eur. J. Biochem. 230:872-878.
45. Spitsberg, V. L., and R. C. Gorewit. 2002. Isolation, purification and characterization of fatty-acid-binding protein from milk fat globule membrane: Effect of bovine growth hormone treatment. Pak. J. Nutr. 1:43-48.
46. Spitsberg, V. L., and R. C. Gorewit. 1997a. Anti-cancer proteins found in milk. CALS News, Vol. 3(5). Cornell University, Ithaca, NY.
47. Spitsberg, V. L., and R. C. Gorewit. 1997b. Breast ovarian cancer susceptibility protein (BRCA1) in milk, tissue and cells. J. Dairy Sci. 80(Suppl. 1):60.
48. Spitsberg, V. L., and R. C. Gorewit. 1997c. In vitro phosphorylated bovine milk fat globule membrane proteins. J. Nutr. Biochem. 8:181-189.
49. Spitsberg, V. L., and R. C. Gorewit. 1998. Solubilization and purification of xanthine oxidase from bovine milk fat globule membrane. Protein Expr. Purif. 13:229-234.
50. Sprong, R. C., M. F. E. Hulstein, and R. van der Meer. 2002. Bovine milk fat components inhibit food-born pathogens. Int. Dairy J. 12:209-215.
51. Stefferl, A., A. Schubari, M. Storch, A. Amini, I. Mather, H. Lassm, and C. Linington. 2000. Butyrophilin, a milk protein, modulates the encephalitogenic T cell response to myelin oligoddendrocyte glycoprotein in experimental autoimmune encephalomyelitis. J. Immunol. 165:2859-2865.
52. Tassone, P., F. Tuccillo, P. Bonelli, M. C. Turco, L. Cecco, M. Cerra, H. M. Bond, V. Barbieri, and S. D. Venuta. 1998. CD36 is rapidly and transiently upregulated on phytohemagglutinin (PHA)-stimulated peripheral blood lymphocytes analysis by a new monoclonal antibody. Tissue Antigens 51:671-675.
53. Vesper, H., E. M. Schmel, M. N. Nikolova-Karakashian, D. L. Dillehay, D. V. Lynch, and A. H. Merrill, Jr. 1999. Sphingolipids in food and the emerging importance of sphingolipids to nutrition. J. Nutr. 129:1239-1250.
54. Vissak, C., D. Lemery, L. Le Corre, P. Fustier, P. Dechelotte, J. C. Maurizis, Y. G. Bignon, and D. J. Bernard-Gallon. 2002. Presence of BRCA1 and BRCA2 proteins in human fat globules after delivery. Biochim. Biophys. Acta 1586:50-56.
55. Vorbach, C., S. Alistair, and M. R. Capecchi. 2002. The housekeeping gene xanthine oxidoreductase is necessary for milk fat droplet enveloping and secretion: Gene sharing in the lactating mammary gland. Genes Dev. 16:3223-3235.
56. Wang, X., S. Hirmo, R. Millen, and T. Wadstrom. 2001. Inhibition of Helicobacter pylori infection by bovine milk glycoconjugates in a BALB/cA mouse model. FEMS Immunol. Med. Microbiol. 20:275-281.
57. Warensjo, E., J. H. Jansson, L. Berglund, K. Boman, B. Ahren, L. Weinehall, B. Lindahl, G. Hallmans, and B. Vessby. 2004. Estimated intake of milk fat is negatively associated with cardiovascular risk factors and does not increase the risk of a first acute myocardial infarction. A prospective case-control study. Br. J. Nutr. 91:635-642.
58. Whanger, P. D. 2004. Selenium and the relationship to cancer: An up-date dagger. Br. J. Nutr. 91:11-28.