Generation and Application of Ovarian Steroidogenic Cell Lines

The Ovary: Second Edition

Volumn , Issue , 2004, Pages 389-409

  Amsterdam, Abraham ^a   Sasson, R ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

[No Author keywords available]

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EID: 84942768614     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-012444562-8/50023-9     Document Type: Chapter

References (206)

1. Amsterdam A., Rotmensch S. Structure-function relationships during granulosa cell differentiation. Endocr. Rev. 1987, 8:309-337.
2. Amsterdam A., Rotmensch S., Ben-Ze'ev A. Structure-function relationships in the differentiating granulosa cell. Prog. Clin. Biol. Res. 1989, 296:121-130.
3. Amsterdam A., Rotmensch S., Ben-Ze'ev A. Coordinated regulation of morphological and biochemical differentiation in a steroidogenic cell: The granulosa cell model. Trends Biochem. Sci. 1989, 14:377-382.
4. Amsterdam A., Koch Y., Lieberman M.E., Lindner H.R. Distribution of binding sites for human chorionic gonadotropin in the preovulatory follicle of the rat. J. Cell. Biol. 1975, 67:894-900.
5. Lindner H.R., Amsterdam A., Salomon Y., et al. Intraovarian factors in ovulation: Determinants of follicular response to gonadotrophins. J. Reprod. Fertil. 1977, 51:215-235.
6. Amsterdam A., Plehn-Dujowich D., Suh B.S. Structure-function relationships during differentiation of normal and oncogene-transformed granulosa cells. Biol. Reprod. 1992, 46:513-522.
7. Hsueh A.J., Adashi E.Y., Jones P.B., Welsh T.H. Hormonal regulation of the differentiation of cultured ovarian granulosa cells. Endocr. Rev. 1984, 5:76-127.
8. Amsterdam A., Kohen F., Nimrod A., Lindner H.R. Lateral mobility and internalization of hormone receptors to human chorionic gonadotropin in cultured rat granulosa cells. Adv. Exp. Med. Biol. 1979, 112:69-75.
9. Amsterdam A., Berkowitz A., Nimrod A., Kohen F. Aggregation of luteinizing hormone receptors in granulosa cells: A possible mechanism of desensitization to the hormone. Proc. Natl. Acad. Sci. USA 1980, 77:3440-3444.
10. Amsterdam A., Knecht M., Catt K.J. Hormonal regulation of cytodifferentiation and intercellular communication in cultured granulosa cells. Proc. Natl. Acad. Sci. USA 1981, 78:3000-3004.
11. Furman A., Rotmensch S., Dor J., et al. Culture of human granulosa cells from an in vitro fertilization program: Effects of extracellular matrix on morphology and cyclic adenosine 3',5' monophosphate production. Fertil. Steril. 1986, 46:514-517.
12. Ben-Ze'ev A., Amsterdam A. Regulation of cytoskeletal proteins involved in cell contact formation during differentiation of granulosa cells on extracellular matrix. Proc. Natl. Acad. Sci. USA 1986, 83:2894-2898.
13. Aharoni D., Meiri I., Atzmon R., Vlodavsky I., Amsterdam A. Differential effect of components of the extracellular matrix on differentiation and apoptosis. Curr. Biol. 1997, 7:43-51.
14. Amsterdam A., Rotmensch S., Furman A., Venter E.A., Vlodavsky I. Synergistic effect of human chorionic gonadotropin and extracellular matrix on in vitro differentiation of human granulosa cells: Progesterone production and gap junction formation. Endocrinology 1989, 124:1956-1964.
15. Amsterdam A., Keren-Tal I., Dantes A., Matityahou A., Plehn-Dujowich D. Generation of ovarian steroidogenic cell lines. The Ovary 1993, 487-500. Academic Press, New York. 1st ed. E.Y. Adashi, P.C.K. Leung (Eds.).
16. Lie B.L., Leung E., Leung P.C., Auersperg N. Long-term growth and steroidogenic potential of human granulosa-lutein cells immortalized with SV40 large T antigen. Mol. Cell. Endocrinol. 1996, 120:169-176.
17. Auersperg N., Wong A.S., Choi K.C., Kang S.K., Leung P.C. Ovarian surface epithelium: Biology, endocrinology, and pathology. Endocr. Rev. 2001, 22:255-288.
18. Suh B.S., Eisenbach L., Amsterdam A. Adenosine 3',5'-monophosphate suppresses metastatic spread in nude mice of steroidogenic rat granulosa cells transformed by simian virus-40 and Ha-ras oncogene. Endocrinology 1992, 131:526-532.
19. Suh B.S., Amsterdam A. Establishment of highly steroidogenic granulosa cell lines by cotransfection with SV40 and Ha-ras oncogene: Induction of steroidogenesis by cyclic adenosine 3'-5'-monophosphate and its suppression by phorbol ester. Endocrinology 1990, 127:2489-2500.
20. Hanukoglu I., Suh B.S., Himmelhoch S., Amsterdam A. Induction and mitochondrial localization of cytochrome P450scc system enzymes in normal and transformed ovarian granulosa cells. J. Cell. Biol. 1990, 111:1373-1381.
21. Amsterdam A., Zauberman A., Meir G., Pinhasi-Kimhi O., Suh B.S., Oren M. Cotransfection of granulosa cells with simian virus 40 and Ha-RAS oncogene generates stable lines capable of induced steroidogenesis. Proc. Natl. Acad. Sci. USA 1988, 85:7582-7586.
22. Michalovitz D., Amsterdam A., Oren M. Interactions between SV40 and cellular oncogenes in the transformation of primary rat cells. Curr. Top. Microbiol. Immunol. 1989, 144:63-75.
23. Keren-Tal I., Suh B.S., Dantes A., Lindner S., Oren M., Amsterdam A. Involvement of p53 expression in cAMP-mediated apoptosis in immortalized granulosa cells. Exp. Cell. Res. 1995, 218:283-295.
24. Hosokawa K., Aharoni D., Dantes A., et al. Modulation of Mdm2 expression and p53-induced apoptosis in immortalized human ovarian granulosa cells. Endocrinology 1998, 139:4688-4700.
25. Tajima K., Hosokawa K., Yoshida Y., et al. Establishment of FSH-responsive cell lines by transfection of pre-ovulatory human granulosa cells with mutated p53 (p53val135) and Ha-ras genes. Mol. Hum. Reprod. 2002, 8:48-57.
26. Lie B.L., Leung E., Leung P.C., Auersperg N. Long-term growth and steroidogenic potential of human granulosa-lutein cells immortalized with SV40 large T antigen. Mol. Cell. Endocrinol. 1996, 120:169-176.
27. Rainey W.H., Sawetawan C., Shay J.W., et al. Transformation of human granulosa cells with the E6 and E7 regions of human papillomavirus. J. Clin. Endocrinol. Metab. 1994, 78:705-710.
28. Nishi Y., Yanase T., Mu Y., et al. Establishment and characterization of a steroidogenic human granulosalike tumor cell line, KGN, that expresses functional follicle-stimulating hormone receptor. Endocrinology 2001, 142:437-445.
29. Gudermann T., Birnbaumer M., Birnbaumer L. Evidence for dual coupling of the murine luteinizing hormone receptor to adenylyl cyclase and phosphoinositide breakdown and Ca2+ mobilization. Studies with the cloned murine luteinizing hormone receptor expressed in L cells. J. Biol. Chem. 1992, 267:4479-4488.
30. Hipkin R.W., Sanchez-Yague J., Ascoli M. Agonist-induced phosphorylation of the luteinizing hormone/chorionic gonadotropin receptor expressed in a stably transfected cell line. Mol. Endocrinol. 1993, 7:823-832.
31. Minegishi T., Igarashi S., Nakamura K., et al. Functional expression of the recombinant human FSH receptor. J. Endocrinol. 1994, 141:369-375.
32. Quintana J., Hipkin R.W., Sanchez-Yague J., Ascoli M. Follitropin (FSH) and a phorbol ester stimulate the phosphorylation of the FSH receptor in intact cells. J. Biol. Chem. 1994, 269:8772-8779.
33. Bernath V.A., Muro A.F., Vitullo A.D., Bley M.A., Baranao J.L., Kornblihtt A.R. Cyclic AMP inhibits fibronectin gene expression in a newly developed granulosa cell line by a mechanism that suppresses cAMP-responsive element-dependent transcriptional activation. J. Biol. Chem. 1990, 265:18219-18226.
34. Stein L.S., Stoica G., Tilley R., Burghardt R.C. Rat ovarian granulosa cell culture: A model system for the study of cell-cell communication during multistep transformation. Cancer Res. 1991, 51:696-706.
35. Briers T.W., van de Voorde A., Vanderstichele H. Characterization of immortalized mouse granulosa cell lines. In Vitro Cell. Dev. Biol. Anim. 1993, 29A:847-854.
36. Vanderstichele H., Delaey B., de Winter J., et al. Secretion of steroids, growth factors, and cytokines by immortalized mouse granulosa cell lines. Biol. Reprod. 1994, 50:1190-1202.
37. McFarland K.C., Sprengel R., Phillips H.S., et al. Lutropin-choriogonadotropin receptor: An unusual member of the G protein-coupled receptor family. Science. 1989, 245:494-499.
38. Sprengel R., Braun T., Nikolics K., Segaloff D.L., Seeburg P.H. The testicular receptor for follicle stimulating hormone: Structure and functional expression of cloned cDNA. Mol. Endocrinol. 1990, 4:525-530.
39. Suh B.S., Sprengel R., Keren-Tal I., Himmelhoch S., Amsterdam A. Introduction of a gonadotropin receptor expression plasmid into immortalized granulosa cells leads to reconstitution of hormone-dependent steroidogenesis. J. Cell. Biol. 1992, 119:439-450.
40. Keren-Tal I., Dantes A., Sprengel R., Amsterdam A. Establishment of steroidogenic granulosa cell lines expressing follicle stimulating hormone receptors. Mol. Cell. Endocrinol. 1993, 95:R1-R10.
41. Selvaraj N., Dantes A., Limor R., Golander A., Amsterdam A. Establishment of an in vitro bioassay and radio receptor assay for LH/hCG in human sera using immortalized granulosa cells transfected with LH/hCG receptor. Endocrine 1996, 5:275-283.
42. Kananen K., Markkula M., Rainio E., Su J.G., Hsueh A.J., Huhtaniemi I.T. Gonadal tumorigenesis in transgenic mice bearing the mouse inhibin alpha-subunit promoter/simian virus T-antigen fusion gene: Characterization of ovarian tumors and establishment of gonadotropinresponsive granulosa cell lines. Mol. Endocrinol. 1995, 9:616-627.
43. Gore-Langton R., Armstrong D. Follicular steroidogenesis and its control. The Physiology of Reproduction 1994, 571-627. Raven Press, New York. E. Knobil, J.D. Neill (Eds.).
44. Smyth C.D., Miro F., Whitelaw P.F., Howles C.M., Hillier S.G. Ovarian thecal/interstitial androgen synthesis is enhanced by a follicle-stimulating hormonestimulated paracrine mechanism. Endocrinology 1993, 133:1532-1538.
45. Smyth C.D., Miro F., Howles C.M., Hillier S.G. Effect of luteinizing hormone on follicle stimulating hormone-activated paracrine signalling in rat ovary. Hum. Reprod. 1995, 10:33-39.
46. Hsueh A.J., Dahl K.D., Vaughan J., et al. Heterodimers and homodimers of inhibin subunits have different paracrine action in the modulation of luteinizing hormone-stimulated androgen biosynthesis. Proc. Natl. Acad. Sci. USA 1987, 84:5082-5086.
47. Nahum R., Thong K.J., Hillier S.G. Metabolic regulation of androgen production by human thecal cells in vitro. Hum. Reprod. 1995, 10:75-81.
48. Hillier S., Miro F., Mather J., Thong K. Comparison of the effects of inhibin-A and inhibin-B on androgen production by human theca cells. FSH Action and Intraovarian Regulation 1997, 137-144. The Parthenon Publishing Group, New York. B.C.J.M. Fauser (Ed.).
49. Solovyeva E.V., Hayashi M., Margi K., et al. Growth differentiation factor-9 stimulates rat theca-interstitial cell androgen biosynthesis. Biol. Reprod. 2000, 63:1214-1218.
50. Yoshida Y., Hosokawa K., Dantes A., Kotsuji F., Kleinman H.K., Amsterdam A. Role of laminin in ovarian cancer tumor growth and metastasis via regulation of Mdm2 and Bcl-2 expression. Int. J. Oncol. 2001, 18:913-921.
51. Pan J., Roskelley C.D., Luu-The V., Rojiani M., Auersperg N. Reversal of divergent differentiation by ras oncogene-mediated transformation. Cancer Res. 1992, 52:4269-4272.
52. Pan J., Roskelley C.D., Auersperg N. Influence of cell type on the steroidogenic potential and basal cyclic AMP levels of ras-oncogene-transformed rat cells. Differentiation 1995, 58:321-328.
53. Richards J.S. Hormonal control of gene expression in the ovary. Endocr. Rev. 1994, 15:725-751.
54. Omura T., Morohashi K. Gene regulation of steroidogenesis. J. Steroid. Biochem. Mol. Biol. 1995, 53:19-25.
55. Stocco D.M., Clark B.J. Regulation of the acute production of steroids in steroidogenic cells. Endocr. Rev. 1996, 17:221-244.
56. Amsterdam A., Hanukoglu I., Suh B., et al. Oncogene-transformed granulosa cells as a model system for the study of steroidogenic processes. J. Steroid. Biochem. Mol. Biol. 1992, 43:875-884.
57. Amsterdam A., Suh B.S. An inducible functional peripheral benzodiazepine receptor in mitochondria of steroidogenic granulosa cells. Endocrinology 1991, 129:503-510.
58. Amsterdam A., Selvaraj N. Control of differentiation, transformation, and apoptosis in granulosa cells by oncogenes, oncoviruses, and tumor suppressor genes. Endocr. Rev. 1997, 18:435-461.
59. Honda S., Morohashi K., Omura T. Novel cAMP regulatory elements in the promoter region of bovine P-450(11 beta) gene. J. Biochem. (Tokyo) 1990, 108:1042-1049.
60. Rice D.A., Mouw A.R., Bogerd A.M., Parker K.L. A shared promoter element regulates the expression of three steroidogenic enzymes. Mol. Endocrinol. 1991, 5:1552-1561.
61. Morohashi K., Honda S., Inomata Y., Handa H., Omura T. A common trans-acting factor, Ad4-binding protein, to the promoters of steroidogenic P-450s. J. Biol. Chem. 1992, 267:17913-17919.
62. Nomura M., Morohashi K., Kirita S., et al. Three forms of rat CYP11B genes: 11 beta-hydroxylase gene, aldosterone synthase gene, and a novel gene. J. Biochem. (Tokyo) 1993, 113:144-152.
63. Lynch J.P., Lala D.S., Peluso J.J., Luo W., Parker K.L., White B.A. Steroidogenic factor 1, an orphan nuclear receptor, regulates the expression of the rat aromatase gene in gonadal tissues. Mol. Endocrinol. 1993, 7:776-786.
64. Fitzpatrick S.L., Richards J.S. Cis-acting elements of the rat aromatase promoter required for cyclic adenosine 3',5'-monophosphate induction in ovarian granulosa cells and constitutive expression in R2C Leydig cells. Mol. Endocrinol. 1993, 7:341-354.
65. Clemens J.W., Lala D.S., Parker K.L., Richards J.S. Steroidogenic factor-1 binding and transcriptional activity of the cholesterol side-chain cleavage promoter in rat granulosa cells. Endocrinology 1994, 134:1499-1508.
66. Michael M.D., Kilgore M.W., Morohashi K., Simpson E.R. Ad4BP/SF-1 regulates cyclic AMP-induced transcription from the proximal promoter (PII) of the human aromatase P450 (CYP19) gene in the ovary. J. Biol. Chem. 1995, 270:13561-13566.
67. Lala D.S., Rice D.A., Parker K.L. Steroidogenic factor I, a key regulator of steroidogenic enzyme expression, is the mouse homolog of fushi tarazu-factor I. Mol. Endocrinol. 1992, 6:1249-1258.
68. Honda S., Morohashi K., Nomura M., Takeya H., Kitajima M., Omura T. Ad4BP-regulating steroidogenic P-450 gene is a member of steroid hormone receptor superfamily. J. Biol. Chem. 1993, 269:7494-7502.
69. Evans R.M. The steroid and thyroid hormone receptor superfamily. Science 1988, 240:889-895.
70. Ikeda Y., Lala D.S., Luo X., Kim E., Moisan M.P., Parker K.L. Characterization of the mouse FTZ-F1 gene, which encodes a key regulator of steroid hydroxylase gene expression. Mol. Endocrinol. 1993, 7:852-860.
71. Morohashi K., Iida H., Nomura M., et al. Functional difference between Ad4BP and ELP, and their distributions in steroidogenic tissues. Mol. Endocrinol. 1994, 8:643-653.
72. Hatano O., Takayama K., Imai T., et al. Sexdependent expression of a transcription factor, Ad4BP, regulating steroidogenic P-450 genes in the gonads during prenatal and postnatal rat development. Development 1994, 120:2787-2797.
73. Breckwoldt M., Selvaraj N., Aharoni D., et al. Expression of Ad4-BP/cytochrome P450 side chain cleavage enzyme and induction of cell death in long-term cultures of human granulosa cells. Mol. Hum. Reprod. 1996, 2:391-400.
74. Luo X., Ikeda Y., Parker K.L. The cell-specific nuclear receptor steroidogenic factor 1 plays multiple roles in reproductive function. Philos. Trans. R. Soc. Lond. B. Biol. Sci. 1995, 350:279-283.
75. Shen W.H., Moore C.C., Ikeda Y., Parker K.L., Ingraham H.A. Nuclear receptor steroidogenic factor 1 regulates the mullerian inhibiting substance gene: A link to the sex determination cascade. Cell 1994, 77:651-661.
76. Nomura M., Bartsch S., Nawata H., Omura T., Morohashi K. An E box element is required for the expression of the ad4bp gene, a mammalian homologue of ftz-fl gene, which is essential for adrenal and gonadal development. J. Biol. Chem. 1995, 270:7453-7461.
77. Keren-Tal I., Dantes A., Plehn-Dujowich D., Amsterdam A. Association of Ad4BP/SF-1 transcription factor with steroidogenic activity in oncogene-transformed granulosa cells. Mol. Cell. Endocrinol. 1997, 127:49-57.
78. Yamamoto R., Kallen C.B., Babalola G.O., Rennert H., Billheimer J.T., Strauss J.F. Cloning and expression of a cDNA encoding human sterol carrier protein 2. Proc. Natl. Acad. Sci. USA 1991, 88:463-467.
79. Seedorf U., Assmann G. Cloning, expression, and nucleotide sequence of rat liver sterol carrier protein 2 cDNAs. J. Biol. Chem. 1991, 266:630-636.
80. Rennert H., Amsterdam A., Billheimer J.T., Strauss J.F. Regulated expression of sterol carrier protein 2 in the ovary: A key role for cyclic AMP. Biochemistry 1991, 30:11280-11285.
81. Anholt R.R., Pedersen P.L., De Souza E.B., Snyder S.H. The peripheral-type benzodiazepine receptor. Localization to the mitochondrial outer membrane. J. Biol. Chem. 1986, 261:576-583.
82. Yanagibashi K., Ohno Y., Nakamichi N., et al. Peripheral-type benzodiazepine receptors are involved in the regulation of cholesterol side chain cleavage in adrenocortical mitochondria. J. Biochem. (Tokyo) 1989, 106:1026-1029.
83. Mukhin A.G., Papadopoulos V., Costa E., Krueger K.E. Mitochondrial benzodiazepine receptors regulate steroid biosynthesis. Proc. Natl. Acad. Sci. USA 1989, 86:9813-9816.
84. Papadopoulos V., Mukhin A.G., Costa E., Krueger K.E. The peripheral-type benzodiazepine receptor is functionally linked to Leydig cell steroidogenesis. J. Biol. Chem. 1990, 265:3772-3779.
85. Fares F., Bar-Ami S., Brandes J.M., Gavish M. Changes in the density of peripheral benzodiazepine binding sites in genital organs of the female rat during the oestrous cycle. J. Reprod. Fertil. 1988, 83:619-625.
86. Katz Y., Ben-Baruch G., Kloog Y., Menczer J., Gavish M. Increased density of peripheral benzodiazepine-binding sites in ovarian carcinomas as compared with benign ovarian tumours and normal ovaries. Clin. Sci. (Lond.) 1990, 78:155-158.
87. Selvaraj N., Israeli D., Amsterdam A. Partial sequencing of the rat steroidogenic acute regulatory protein message from immortalized granulosa cells: Regulation by gonadotropins and isoproterenol. Mol. Cell. Endocrinol. 1996, 123:171-177.
88. Simpson E.R. Cholesterol side-chain cleavage, cytochrome P450, and the control of steroidogenesis. Mol. Cell. Endocrinol. 1979, 13:213-227.
89. Miller W.L. Molecular biology of steroid hormone synthesis. Endocr. Rev. 1988, 9:295-318.
90. Mitani F., Shimizu T., Ueno R., et al. Cytochrome P-45011 beta and P-450scc in adrenal cortex: Zonal distribution and intramitochondrial localization by the horseradish peroxidase-labeled antibody method. J. Histochem. Cytochem. 1982, 30:1066-1074.
91. Farkash Y., Timberg R., Orly J. Preparation of antiserum to rat cytochrome P-450 cholesterol side chain cleavage, and its use for ultrastructural localization of the immunoreactive enzyme by protein A-gold technique. Endocrinology 1986, 118:1353-1365.
92. Crivello J.F., Jefcoate C.R. Intracellular movement of cholesterol in rat adrenal cells. Kinetics and effects of inhibitors. J. Biol. Chem. 1980, 255:8144-8151.
93. Jefcoate C.R., DiBartolomeis M.J., Williams C.A., McNamara B.C. ACTH regulation of cholesterol movement in isolated adrenal cells. J. Steroid. Biochem. 1987, 27:721-729.
94. Arthur J.R., Boyd G.S. The effect of inhibitors of protein synthesis on cholesterol side-chain cleavage in the mitochondria of luteinized rat ovaries. Eur. J. Biochem. 1974, 49:117-127.
95. Krueger R.J., Orme-Johnson N.R. Acute adrenocorticotropic hormone stimulation of adrenal corticosteroidogenesis. Discovery of a rapidly induced protein. J. Biol. Chem. 1983, 258:10159-10167.
96. Epstein L.F., Orme-Johnson N.R. Acute action of luteinizing hormone on mouse Leydig cells: Accumulation of mitochondrial phosphoproteins and stimulation of testosterone synthesis. Mol. Cell. Endocrinol. 1991, 81:113-126.
97. Stocco D.M., Chen W. Presence of identical mitochondrial proteins in unstimulated constitutive steroid-producing R2C rat Leydig tumor and stimulated nonconstitutive steroid-producing MA-10 mouse Leydig tumor cells. Endocrinology 1991, 128:1918-1926.
98. Stevens V.L., Xu T., Lambeth J.D. Cholesterol trafficking in steroidogenic cells. Reversible cycloheximide-dependent accumulation of cholesterol in a pre-steroidogenic pool. Eur. J. Biochem. 1993, 216:557-563.
99. Alberta J.A., Epstein L.F., Pon L.A., Orme-Johnson N.R. Mitochondrial localization of a phosphoprotein that rapidly accumulates in adrenal cortex cells exposed to adrenocorticotropic hormone or to cAMP. J. Biol. Chem. 1989, 264:2368-2372.
100. Elliott M.E., Goodfriend T.L., Jefcoate C.R. Bovine adrenal glomerulosa and fasciculata cells exhibit 28.5-kilodalton proteins sensitive to angiotensin, other agonists, and atrial natriuretic peptide. Endocrinology 1993, 133:1669-1677.
101. Pon L.A., Orme-Johnson N.R. Acute stimulation of steroidogenesis in corpus luteum and adrenal cortex by peptide hormones. Rapid induction of a similar protein in both tissues. J. Biol. Chem. 1986, 261:6594-6599.
102. Stocco D.M., Sodeman T.C. The 30-kDa mitochondrial proteins induced by hormone stimulation in MA-10 mouse Leydig tumor cells are processed from larger precursors. J. Biol. Chem. 1991, 266:19731-19738.
103. Epstein L.F., Orme-Johnson N.R. Regulation of steroid hormone biosynthesis. Identification of precursors of a phosphoprotein targeted to the mitochondrion in stimulated rat adrenal cortex cells. J. Biol. Chem. 1991, 266:19739-19745.
104. Stocco D.M., Clark B.J. The requirement of phosphorylation on a threonine residue in the acute regulation of steroidogenesis in MA-10 mouse Leydig cells. J. Steroid. Biochem. Mol. Biol. 1993, 46:337-347.
105. Clark B.J., Wells J., King S.R., Stocco D.M. The purification, cloning, and expression of a novel luteinizing hormone-induced mitochondrial protein in MA-10 mouse Leydig tumor cells. Characterization of the steroidogenic acute regulatory protein (StAR). J. Biol. Chem. 1994, 269:28314-28322.
106. Sugawara T., Holt J.A., Driscoll D., et al. Human steroidogenic acute regulatory protein: Functional activity in COS-1 cells, tissue-specific expression, and mapping of the structural gene to 8p11.2 and a pseudogene to chromosome 13. Proc. Natl. Acad. Sci. USA 1995, 92:4778-4782.
107. Lin D., Sugawara T., Strauss J.F., et al. Role of steroidogenic acute regulatory protein in adrenal and gonadal steroidogenesis. Science 1995, 267:1828-1831.
108. Stocco D.M., Clark B.J. The role of the steroidogenic acute regulatory protein in steroidogenesis. Steroids 1997, 62:29-36.
109. Selvaraj N., Dantes A., Amsterdam A. Establishment and characterization of steroidogenic granulosa cells expressing beta(2)-adrenergic receptor: Regulation of adrenodoxin and steroidogenic acute regulatory protein by adrenergic agents. Mol. Cell. Endocrinol. 2000, 168:53-63.
110. Arakane F., Kallen C.B., Watari H., et al. The mechanism of action of steroidogenic acute regulatory protein (StAR). StAR acts on the outside of mitochondria to stimulate steroidogenesis. J. Biol. Chem. 1998, 273:16339-16345.
111. Strauss J.F., Kallen C.B., Christenson L.K., et al. The steroidogenic acute regulatory protein (StAR): A window into the complexities of intracellular cholesterol trafficking. Rec. Prog. Hormone Res. 1999, 54:369-394. discussion 394-395.
112. Orian A., Gonen H., Bercovich B., et al. SCF(beta)(-TrCP) ubiquitin ligase-mediated processing of NF-kappaB p105 requires phosphorylation of its C-terminus by IkappaB kinase. EMBO J. 2000, 19:2580-2591.
113. Oren M. Regulation of the p53 tumor suppressor protein. J. Biol. Chem. 1999, 274:36031-36034.
114. Bercovich Z., Kahana C. Involvement of the 20S proteasome in the degradation of ornithine decarboxylase. Eur. J. Biochem. 1993, 213:205-210.
115. Leibovitz D., Koch Y., Fridkin M., et al. Archaebacterial and eukaryotic proteasomes prefer different sites in cleaving gonadotropin-releasing hormone. J. Biol. Chem. 1995, 270:11029-11032.
116. Sutovsky P., Moreno R.D., Ramalho-Santos J., Dominko T., Simerly C., Schatten G. Ubiquitinated sperm mitochondria, selective proteolysis, and the regulation of mitochondrial inheritance in mammalian embryos. Biol. Reprod. 2000, 63:582-590.
117. Tajima K., Babich S., Yoshida Y., Dantes A., Strauss J.F., Amsterdam A. The proteasome inhibitor MG132 promotes accumulation of the steroidogenic acute regulatory protein (StAR) and steroidogenesis. FEBS Lett. 2001, 490:59-64.
118. Amsterdam A., Gold R.S., Hosokawa K., et al. Crosstalk among multiple signaling pathways controlling ovarian cell death. Trends Endocrinol. Metab. 1999, 10:255-262.
119. Hosokawa K., Dantes A., Schere-Levy C., et al. Induction of Ad4BP/SF-1, steroidogenic acute regulatory protein, and cytochrome P450scc enzyme system expression in newly established human granulosa cell lines. Endocrinology 1998, 139:4679-4687.
120. Sasson R., Tajima K., Amsterdam A. Glucocorticoids protect against apoptosis induced by serum deprivation, cyclic adenosine 3',5'-monophosphate and p53 activation in immortalized human granulosa cells: Involvement of Bcl-2. Endocrinology 2001, 142:802-811.
121. Adashi E.Y., Jones P.B., Hsueh A.J. Synergistic effect of glucocorticoids on the stimulation of progesterone production by follicle-stimulating hormone in cultured rat granulosa cells. Endocrinology 1981, 109:1888-1894.
122. Sasson R., Winder N., Kees S., Amsterdam A. Induction of apoptosis in granulosa cells by TNF alpha and its attenuation by glucocorticoids involve modulation of Bcl-2. Biochem. Biophys. Res. Commun. 2002, 294:51-59.
123. Huang T.J., Shirley Li P. Dexamethasone inhibits luteinizing hormone-induced synthesis of steroidogenic acute regulatory protein in cultured rat preovulatory follicles. Biol. Reprod. 2001, 64:163-170.
124. Barkan D., Jia H., Dantes A., Vardimon L., Amsterdam A., Rubinstein M. Leptin modulates the glucocorticoid-induced ovarian steroidogenesis. Endocrinology 1999, 140:1731-1738.
125. Spicer L.J., Francisco C.C. The adipose obese gene product, leptin: Evidence of a direct inhibitory role in ovarian function. Endocrinology 1997, 138:3374-3379.
126. Zachow R.J., Magoffin D.A. Direct intraovarian effects of leptin: Impairment of the synergistic action of insulin-like growth factor-I on follicle-stimulating hormone-dependent estradiol-17 beta production by rat ovarian granulosa cells. Endocrinology 1997, 138:847-850.
127. Karlsson C., Lindell K., Svensson E., et al. Expression of functional leptin receptors in the human ovary. J. Clin. Endocrinol. Metab. 1997, 82:4144-4148.
128. Seger R., Hanoch T., Rosenberg R., et al. The ERK signaling cascade inhibits gonadotropin-stimulated steroidogenesis. J. Biol. Chem. 2001, 276:13957-13964.
129. Santana P., Llanes L., Hernandez I., et al. Ceramide mediates tumor necrosis factor effects on P450-aromatase activity in cultured granulosa cells. Endocrinology 1995, 136:2345-2348.
130. Adashi E.Y., Resnick C.E., Packman J.N., Hurwitz A., Payne D.W. Cytokine-mediated regulation of ovarian function: Tumor necrosis factor alpha inhibits gonadotropin-supported progesterone accumulation by differentiating and luteinized murine granulosa cells. Am. J. Obstet. Gynecol. 1990, 162:889-896. discussion 896-899.
131. Spicer L.J. Tumor necrosis factor-alpha (TNF-alpha) inhibits steroidogenesis of bovine ovarian granulosa and thecal cells in vitro. Involvement of TNF-alpha receptors. Endocrine 1998, 8:109-115.
132. Fukuoka M., Yasuda K., Taii S., Mori T. Synergistic actions of cytokines and growth factors in enhancing porcine granulosa cell growth. Endocrinol. Jpn. 1992, 39:277-288.
133. Roby K.F., Terranova P.F. Effects of tumor necrosis factor-alpha in vitro on steroidogenesis of healthy and atretic follicles of the rat: Theca as a target. Endocrinology 1990, 126:2711-2718.
134. Chen Y.J., Feng Q., Liu Y.X. Expression of the steroidogenic acute regulatory protein and luteinizing hormone receptor and their regulation by tumor necrosis factor alpha in rat corpora lutea. Biol. Reprod. 1999, 60:419-427.
135. Amsterdam A., Nimrod A., Lamprecht S.A., Burstein Y., Lindner H.R. Internalization and degradation of receptor-bound hCG in granulosa cell cultures. Am. J. Physiol. 1979, 236:E129-E138.
136. Ezra E., Salomon Y. Mechanism of desensitization of adenylate cyclase by lutropin. Impaired introduction of GTP into the regulatory site. J. Biol. Chem. 1981, 256:5377-5382.
137. Ekstrom R.C., Hunzicker-Dunn M. Comparison of the luteinizing hormone-sensitive adenylyl cyclase of the pig ovarian follicle and corpus luteum and its susceptibility to in vitro hormone-dependent desensitization. Endocrinology 1990, 126:1191-1198.
138. Keren-Tal I., Dantes A., Amsterdam A. Activation of FSH-responsive adenylate cyclase by staurosporine: Role for protein phosphorylation in gonadotropin receptor desensitization. Mol. Cell. Endocrinol. 1996, 116:39-48.
139. Selvaraj N., Amsterdam A. Modulation of FSH receptor phosphorylation correlates with hormone-induced coupling to the adenylate cyclase system. Endocrine 1997, 6:179-185.
140. Seger R., Krebs E.G. The MAPK signaling cascade. FASEB J. 1995, 9:726-735.
141. Amsterdam A., Tajima K., Frajese V., Seger R. Analysis of signal transduction stimulated by gonadotropins in granulosa cells. Mol. Cell Endocrinol. 2003, 202(1-2):77-80.
142. Tajima K., Dantes A., Yao Z., Sorokina K., Kotsuji F., Seger R., Amsterdam A. Down-regulation of steroidogenic response to gonadotropins in human and rat preovulatory granulosa cells involves mitogen-activated protein kinase activation and modulation of DAX-1 and steroidogenic factor-1. J. Clin. Endocrinol. Metab. 2003, 88(5):2288-2289.
143. Das S., Maizels E.T., DeManno D., St.Clair E., Adam S.A., Hunzicker-Dunn M. A stimulatory role of cyclic adenosine 3',5'-monophosphate in follicle-stimulating hormone-activated mitogen-activated protein kinase signaling pathway in rat ovarian granulosa cells. Endocrinology 1996, 137:967-974.
144. Gutkind J.S. Cell growth control by G protein-coupled receptors: From signal transduction to signal integration. Oncogene 1998, 17:1331-1342.
145. Naor Z., Benard O., Seger R. Activation of MAPK cascades by G-protein-coupled receptors: The case of gonadotropin-releasing hormone receptor. Trends Endocrinol. Metab. 2000, 11:91-99.
146. Lalli E., Melner M.H., Stocco D.M., Sassone-Corsi P. DAX-1 blocks steroid production at multiple levels. Endocrinology 1998, 139:4237-4243.
147. Granot Z., Geiss-Friedlander R., Melamed-Book N., Eimerl S., Timberg R., Weiss A.M., Hales K.H., Hales D.B., Stocco D.M., Orly J. Proteolysis of normal and mutated steroidogenic acute regulatory (StAR) proteins in the mitochondria: the fale of unmanted proteins. Mol. Endocrinol. 2003, (in press).
148. Zeleznik A.J., Somers J.P. Regulation of the primate corpus luteum: Cellular and molecular perspectives. Trends Endocrinol. Metab. 1999, 10:189-193.
149. McGee E.A., Perlas E., LaPolt P.S., Tsafriri A., Hsueh A.J. Follicle-stimulating hormone enhances the development of preantral follicles in juvenile rats. Biol. Reprod. 1997, 57:990-998.
150. Goodenough D.A., Goliger J.A., Paul D.L. Connexins, connexons, and intercellular communication. Annu. Rev. Biochem. 1996, 65:475-502.
151. Simon A.M., Goodenough D.A., Li E., Paul D.L. Female infertility in mice lacking connexin 37. Nature 1997, 385:525-529.
152. Grazul-Bilska A.T., Reynolds L.P., Redmer D.A. Gap junctions in the ovaries. Biol. Reprod. 1997, 57:947-957.
153. Khan-Dawood F.S., Yang J., Dawood M.Y. Expression of gap junction protein connexin-43 in the human and baboon (Papio anubis) corpus luteum. J. Clin. Endocrinol. Metab. 1996, 81:835-842.
154. Juneja S.C., Barr K.J., Enders G.C., Kidder G.M. Defects in the germ line and gonads of mice lacking connexin 43. Biol. Reprod. 1999, 60:1263-1270.
155. Wiesen J.F., Midgley A.R. Changes in expression of connexin 43 gap junction messenger ribonucleic acid and protein during ovarian follicular growth. Endocrinology 1993, 133:741-746.
156. Granot I., Dekel N. Cell-to-cell communication in the ovarian follicle: Developmental and hormonal regulation of the expression of connexin 43. Hum. Reprod. 1998, 13(Suppl 4):85-97.
157. Mayerhofer A., Garfield R.E. Immunocytochemical analysis of the expression of gap junction protein connexin 43 in the rat ovary. Mol. Reprod. Dev. 1995, 41:331-338.
158. Huet C., Monget P., Pisselet C., Hennequet C., Locatelli A., Monniaux D. Chronology of events accompanying follicular atresia in hypophysectomized ewes. Changes in levels of steroidogenic enzymes, connexin 43, insulin-like growth factor II/mannose 6 phosphate receptor, extracellular matrix components, and matrix metalloproteinases. Biol. Reprod. 1998, 58:175-185.
159. Granot I., Dekel N. Developmental expression and regulation of the gap junction protein and transcript in rat ovaries. Mol. Reprod. Dev. 1997, 47:231-239.
160. Sommersberg B., Bulling A., Salzer U., et al. Gap junction communication and connexin 43 gene expression in a rat granulosa cell line: Regulation by follicle-stimulating hormone. Biol. Reprod. 2000, 63:1661-1668.
161. Sasson R., Amsterdam A. Stimulation of apoptosis in human granulosa cells from in vitro fertilization patients and its prevention by dexamethasone: Involvement of cell contact and bcl-2 expression. J. Clin. Endocrinol. Metab. 2002, 87:3441-3451.
162. Amsterdam A., Josephs R., Lieberman M.E., Lindner H.R. Organization of intramembrane particles in freeze-cleaved gap junctions of rat graafian follicles: Optical-diffraction analysis. J. Cell. Sci. 1976, 21:93-105.
163. Sommersberg B., Bulling A., Salzer U., et al. Gap junction communication and connexin 43 gene expression in a rat granulosa cell line: Regulation by follicle-stimulating hormone. Biol. Reprod. 2000, 63:1661-1668.
164. Risek B., Klier F.G., Phillips A., Hahn D.W., Gilula N.B. Gap junction regulation in the uterus and ovaries of immature rats by estrogen and progesterone. J. Cell. Sci. 1995, 108:1017-1032.
165. Sasson R., Shinder V., Dantes A., Land A, Amsterdam A. Activation of multiple signal transduction pathways by glucocorticoids: protection of ovarian follicular cells against apoptosis. Biochem. Biophys. Res. Comm. 2003, (in press).
166. Aharoni D., Dantes A., Oren M., Amsterdam A. cAMP-mediated signals as determinants for apoptosis in primary granulosa cells. Exp. Cell. Res. 1995, 218:271-282.
167. Hillier S.G., Tetsuka M. An anti-inflammatory role for glucocorticoids in the ovaries?. J. Reprod. Immunol. 1998, 39:21-27.
168. Andersen C.Y., Hornnes P. Intrafollicular concentrations of free cortisol close to follicular rupture. Hum. Reprod. 1994, 9:1944-1949.
169. Escher G., Galli I., Vishwanath B.S., Frey B.M., Frey F.J. Tumor necrosis factor alpha and interleukin 1beta enhance the cortisone/cortisol shuttle. J. Exp. Med. 1997, 186:189-198.
170. Tetsuka M., Haines L.C., Milne M., Simpson G.E., Hillier S.G. Regulation of 11beta-hydroxysteroid dehydrogenase type 1 gene expression by LH and interleukin-1beta in cultured rat granulosa cells. J. Endocrinol. 1999, 163:417-423.
171. Yong P.Y., Thong K.J., Andrew R., Walker B.R., Hillier S.G. Development-related increase in cortisol biosynthesis by human granulosa cells. J. Clin. Endocrinol. Metab. 2000, 85:4728-4733.
172. Werb Z. Biochemical actions of glucocorticoids on macrophages in culture. Specific inhibition of elastase, collagenase, and plasminogen activator secretion and effects on other metabolic functions. J. Exp. Med. 1978, 147:1695-1712.
173. Orth D., Kovacs W., Debold C. The adrenal gland. Textbook of Endocrinology 1992, 89-620. WB Saunders Company, London. 8th ed. J.D. Wilson, D.W. Foster (Eds.).
174. Amsterdam A., Tajima K., Sasson R. Cell-specific regulation of apoptosis by glucocorticoids: Implication to their anti-inflammatory action. Biochem. Pharmacol. 2002, 64:843.
175. Kaipia A., Chun S.Y., Eisenhauer K., Hsueh A.J. Tumor necrosis factor-alpha and its second messenger, ceramide, stimulate apoptosis in cultured ovarian follicles. Endocrinology 1996, 137:4864-4870.
176. Quirk S.M., Porter D.A., Huber S.C., Cowan R.G. Potentiation of Fas-mediated apoptosis of murine granulosa cells by interferon-gamma, tumor necrosis factor-alpha, and cycloheximide. Endocrinology 1998, 139:4860-4869.
177. Matsubara H., Ikuta K., Ozaki Y., et al. Gonadotropins and cytokines affect luteal function through control of apoptosis in human luteinized granulosa cells. J. Clin. Endocrinol. Metab. 2000, 85:1620-1626.
178. Witty J.P., Bridgham J.T., Johnson A.L. Induction of apoptotic cell death in hen granulosa cells by ceramide. Endocrinology 1996, 137:5269-5277.
179. Grell M., Becke F.M., Wajant H., Mannel D.N., Scheurich P. TNF receptor type 2 mediates thymocyte proliferation independently of TNF receptor type 1. Eur. J. Immunol. 1998, 28:257-263.
180. Grell M., Wajant H., Zimmermann G., Scheurich P. The type 1 receptor (CD120a) is the high-affinity receptor for soluble tumor necrosis factor. Proc. Natl. Acad. Sci. USA 1998, 95:570-575.
181. Roby K.F., Terranova P.F. Effects of tumor necrosis factor-alpha in vitro on steroidogenesis of healthy and atretic follicles of the rat: Theca as a target. Endocrinology 1990, 126:2711-2718.
182. Sakumoto R., Murakami S., Kishi H., Iga K., Okano A., Okuda K. Tumor necrosis factor-alpha and its receptor in the corpus luteum of pregnant cows. Mol. Reprod. Dev. 2000, 55:406-411.
183. Bridgham J.T., Johnson A.L. Expression and regulation of Fas antigen and tumor necrosis factor receptor type I in hen granulosa cells. Biol. Reprod. 2001, 65:733-739.
184. Braw R.H., Bar-Ami S., Tsafriri A. Effect of hypophysectomy on atresia of rat preovulatory follicles. Biol. Reprod. 1981, 25:989-996.
185. Gross A., Jockel J., Wei M.C., Korsmeyer S.J. Enforced dimerization of BAX results in its translocation, mitochondrial dysfunction and apoptosis. EMBO J. 1998, 17:3878-3885.
186. Pitzer F., Dantes A., Fuchs T., Baumeister W., Amsterdam A. Removal of proteasomes from the nucleus and their accumulation in apoptotic blebs during programmed cell death. FEBS Lett. 1996, 394:47-50.
187. Kothakota S., Azuma T., Reinhard C., et al. Caspase-3-generated fragment of gelsolin: Effector of morphological change in apoptosis. Science 1997, 278:294-298.
188. Kwiatkowski D.J. Functions of gelsolin: Motility, signaling, apoptosis, cancer. Curr. Opin. Cell. Biol. 1999, 11:103-108.
189. Shukovski L., Keren-Tal I., Dantes A., Amsterdam A. Regulation of follistatin messenger ribonucleic acid in steroidogenic rat granulosa cell lines. Endocrinology 1995, 136:2889-2895.
190. Lindsell C.E., Misra V., Murphy B.D. Regulation of follistatin gene expression in the ovary and in primary cultures of porcine granulosa cells. J. Reprod. Fertil. 1994, 100:591-597.
191. Miyanaga K., Shimasaki S. Structural and functional characterization of the rat follistatin (activin-binding protein) gene promoter. Mol. Cell. Endocrinol. 1993, 92:99-109.
192. Shimon I., Rubinek T., Bar-Hava I., et al. Ovarian hyperstimulation without elevated serum estradiol associated with pure follicle-stimulating hormone-secreting pituitary adenoma. J. Clin. Endocrinol. Metab. 2001, 86:3635-3640.
193. Amsterdam A. Novel genes regulated by gonadotropins in granulosa cells: New perspectives on their physiological functions. Mol. Cell. Endocrinol. 2003, 202:133-137.
194. Grosse J., Bulling A., Brucker C., et al. Synaptosome-associated protein of 25 kilodaltons in oocytes and steroid-producing cells of rat and human ovary: Molecular analysis and regulation by gonadotropins. Biol. Reprod. 2000, 63:643-650.
195. Sasson, R., Dantes, A., Tajma, K., Amsterdam, A. Novel genes modulated by FSH in normal and immortalized FSH-responsive cells: new insights into the mechanism of FSH action. FASEB J. 17(10), 1256-1266.
196. Masumoto N., Ikebuchi Y., Matsuoka T., Tasaka K., Miyake A., Murata Y. Involvement of SNAP-25 in TRH-induced exocytosis in pituitary GH4Cl cells. J. Endocrinol. 1997, 153:R5-R10.
197. Hohne-Zell B., Gratzl M. Adrenal chromaffin cells contain functionally different SNAP-25 monomers and SNAP-25/syntaxin heterodimers. FEBS Lett. 1996, 394:109-116.
198. Hohne-Zell B., Galler A., Schepp W., Gratzl M., Prinz C. Functional importance of synaptobrevin and SNAP-25 during exocytosis of histamine by rat gastric enterochromaffin-like cells. Endocrinology 1997, 138:5518-5526.
199. Sadoul K., Lang J., Montecucco C., et al. SNAP-25 is expressed in islets of Langerhans and is involved in insulin release. J. Cell. Biol. 1995, 128:1019-1028.
200. Fritz S., Wessler I., Breitling R., et al. Expression of muscarinic receptor types in the primate ovary and evidence for nonneuronal acetylcholine synthesis. J. Clin. Endocrinol. Metab. 2001, 86:349-354.
201. Fritz S., Grunert R., Stocco D.M., Hales D.B., Mayerhofer A. StAR protein is increased by muscarinic receptor activation in human luteinized granulosa cells. Mol. Cell. Endocrinol. 2001, 171:49-51.
202. Peluso J.J. Putative mechanism through which N-cadherin-mediated cell contact maintains calcium homeostasis and thereby prevents ovarian cells from undergoing apoptosis. Biochem. Pharmacol. 1997, 54:847-853.
203. Aharoni D., Dantes A., Amsterdam A. Cross-talk between adenylate cyclase activation and tyrosine phosphorylation leads to modulation of the actin cytoskeleton and to acute progesterone secretion in ovarian granulosa cells. Endocrinology 1993, 133:1426-1436.
204. Amsterdam A., Dantes A., Liscovitch M. Role of phospholipase-D and phosphatidic acid in mediating gonadotropin-releasing hormone-induced inhibition of preantral granulosa cell differentiation. Endocrinology 1994, 135:1205-1211.
205. Furman A., Rotmensch S., Kohen F., Mashiach S., Amsterdam A. Regulation of rat granulosa cell differentiation by extracellular matrix produced by bovine corneal endothelial cells. Endocrinology 1986, 118:1878-1885.
206. Amsterdam A., Aharoni D. Plasticity of cell organization during differentiation of normal and oncogene transformed granulosa cells. Microsc. Res. Tech. 1994, 27:108-124.