Modulation of Mdm2 expression and p53-induced apoptosis in immortalized human ovarian granulosa cells

Endocrinology

Volumn 139, Issue 11, 1998, Pages 4688-4700

  Hosokawa, Kumiko ^a,c   Aharoni, Dorit ^a   Dantes, Ada ^a   Shaulian, Eitan ^a   Schere levy, Carolina ^a   Atzmon, Ruth ^b   Kotsuji, Fumikazu ^c   Oren, Moshe ^a   Vlodavsky, Israel ^b   Amsterdam, Abraham ^a,d  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^b HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

^c UNIVERSITY OF FUKUI   (Japan)

^d Dept Molec Endocrinol Cancer Res ^*

Author keywords

[No Author keywords available]

Indexed keywords

BASIC FIBROBLAST GROWTH FACTOR; CYCLIC AMP; FORSKOLIN; PROTEIN P53;

APOPTOSIS; ARTICLE; EXTRACELLULAR MATRIX; GENE EXPRESSION; GRANULOSA CELL; HUMAN; HUMAN CELL; ONCOGENE H RAS; OVARY CELL; PRIORITY JOURNAL; STEROIDOGENESIS; TEMPERATURE SENSITIVE MUTANT; TUMOR SUPPRESSOR GENE;

EID: 7844228772     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.139.11.6280     Document Type: Article

References (70)

1. Amsterdam A, Plehn-Dujowich D, Suh BS 1992 Structure-function relationships during differentiation of normal and oncogene transformed granulosa cells. Biol Reprod 46:513-522
2. Amsterdam A, Rotmensch S 1987 Structure-function relationships during granulosa cell differentiation. Endocr Rev 8:309-337
3. Amsterdam A, Rotmensch S, Ben-Ze'ev A 1989 Coordinated regulation of morphological and biochemical differentiation in a steroidogenic cell: the granulosa cell model. Trends Biochem Sci 14:377-382
4. Lefkowitz RJ 1993 G protein-coupled receptor kinases. Cell 74:409-412
5. Johnson GL, Dhanasedaron N 1989 The G protein family and their interaction with receptors. Endocr Rev 10:317-331
6. Hsueh AJW, LaPolt PS 1992 Molecular basis of gonadotropin receptor regulation. Trends Endocrinol Metab 3:164-170
7. Berridge MV, Tan AS, Hilton CJ 1993 Cyclic adenosine monophosphate promotes cell survival and retards apoptosis in a factor dependent bone marrow-derived cell line. Exp Hematol 21:267-276
8. Duprez E, Gjersten BT, Bernard O, Lanotte M, Doskeland SO 1993 Antiapoptotic effect of heterozygously expressed mutant RI (Ala336-Asp) subunit of cAMP kinase I in a rat leukemia cell line. J Biol Chem 268:8332-8340
9. McConkey DJ, Orrenius S, Jondal M 1990 Agents that elevate cAMP stimulate DNA fragmentation in thymocytes. J Immunol 145:1227-1230
10. Aharoni D, Dantes A, Oren M, Amsterdam A 1995 c-AMP mediated signals as determinants for apoptosis in primary granulosa cells. Exp Cell Res 218:271-282
11. Amsterdam A, Selvaraj N 1997 Control of differentiation, transformation, and apoptosis in granulosa cells by oncogenes, oncoviruses, and tumor suppressor genes. Endocr Rev 18:435-461
12. Lue X, Ikeda Y, Parker KL 1994 A cell-specific nuclear receptor is essential for adrenal and gonadal development and sexual differentiation. Cell 77:481-490
13. Richards JS 1994 Hormonal control of gene expression in the ovary. Endocr Rev 15:725-751
14. Stocco DM, Clark BJ 1996 Regulation of the acute production of steroids in steroidogenic cells. Endocr Rev 17:221-244
15. Keren-Tal I, Suh BS, Dantes A, Lindner S, Oren M, Amsterdam A 1995 Involvement of p53 expression in cAMP mediated apoptosis in immortalized granulosa cells. Exp Cell Res 218:283-295
16. Folkman J, Klagsburn M 1987 Angiogenic factors. Science 235:442-447
17. Rifkin DB, Moscatelli D 1989 Recent developments in the cell biology of basic fibroblast factor. J Cell Biol 109:1-6
18. Rogelj S, Weinsberg RA, Fanning P, Klagsbrun M 1988 Basic fibroblast growth factor fused to a signal transforms cells. Nature 331:173-175
19. Yayon A, Klagsbrun M 1990 Autocrine transformation by chimeric signal peptide-basic fibroblast factor: reversal by suramin. Proc Natl Acad Sci USA 87:5346-5350
20. Coughlin SR, Barr PJ, Cousens LS, Fretto LJ, Williams LT 1988 Acidic and basic fibroblast growth factors stimulate tyrosine kinase activity in vivo. J Biol Chem 263:988-993
21. Bellot F, Crumley G, Kaplow JM, Schlessinger J, Jaye M, Dionne CA 1991 Ligand-induced transphosphorylation between different FGF receptors. EMBO J 10:2849-2954
22. Aharoni D, Meiri I, Atzmon R, Vlodavsky I, Amsterdam A 1997 Differential effect of components of the extracellular matrix on differentiation and apoptosis. Curr Biol 7:43-51
23. Fuks Z, Persaud RS, Alfieri A, McLoughlin M, Ehleiter D, Schwartz JL, Seddon AP, Cordon-Cardo C, Haimovitz FA 1994 Basic fibroblast growth factor protects endothelial cells against radiation-induced programmed cell death in vitro and in vivo. Cancer Res 54:2582-2590
24. Gottlieb T, Oren M 1996 p53 in growth control and neoplasia. Biochem Biophys Acta 1287:77-102
25. Ko LJ, Prives C 1996 p53:puzzle and paradigm. Genes Dev 10:1054-1072
26. Levine AJ 1997 p53, the cellular gatekeeper for growth and division. Cell 88:323-331
27. Oren M 1994 Relationship of p53 to the control of apoptotic cell death. Semin Cancer Biol 5:221-227
28. Hsueh AJW, Billig H, Tsafriri A 1994 Ovarian follicle atresia: a hormonally controlled apoptotic process. Endocr Rev 15:707-724
29. Tilly JL 1996 Apoptosis and ovarian function. Rev Reprod 1:162-172
30. Tilly JL, Tilly KI, Kenton LM, Johnson AL 1995 Expression of members of the Bcl-2 gene family in the immature rat ovary: equine chorionic gonadotropin-mediated inhibition of granulosa cell apoptosis is associated with decreased Bax and constitutive Bcl-2 and Bcl-xlong messenger ribonucleic acid levels. Endocrinology 136:232-241
31. Miyashita T, Reed JC 1995 Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. Cell 80:293-299
32. Barak Y, Juven T, Haffner R, Oren M 1993 mdm2 expression is induced by wild type-p53 activity. EMBO J 12:461-468
33. Juven T, Barak Y, Zauberman A, George DL, Oren M 1993 Wild type p53 can mediate sequence-specific transactivation of an internal promoter within the mdm2 gene. Oncogene 8:3411-3416
34. Wu X, Bayle JH, Olson D, Levine AJ 1993 The p53-mdm-2 autoregulatory feedback loop. Genes Dev 7:1126-1132
35. Olson DC, Marechal V, Momand J, Chen JD, Romocki C, Levine AJ 1993 Identification and characterization of multiple mdm-2 proteins and mdm-2-p53 protein complexes. Oncogene 8:2353-2360
36. Chen JD, Lin JY, Levine AJ 1995 Regulation of transcription functions of the p53 tumor suppressor by the mdm-2 oncogene. Mol Med 1:142-152
37. Haines DS, Landers JE, Engel LJ, George DL 1994 Physical and functional interaction between wild-type p53 and mdm2 proteins. Mol Cell Biol 14:1171-1178
38. Haupt Y, Maya R, Kazaz A, Oren M 1997 Mdm2 promotes the rapid degradation of p53. Nature 387:296-299
39. Kubbutat MHG, Jones SN, Vousden KH 1997 Regulation of p53 stability by Mdm2. Nature 387:299-303
40. Momand J, Zambetti GP, Olson DC, George DL, Levine AJ 1992 The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation. Cell 69:1237-1245
41. Oliner JD, Pietenpol JA, Thiagalingam S, Gvuris J, Kinzler KW, Vogelstein B 1993 Oncoprotein MDM2 conceals the activation domain of tumour suppressor-p53. Nature 362:857-860
42. Zauberman A, Barak Y, Ragimov N, Levy N, Oren M 1993 Sequence-specific DNA binding by p53: identification of target sites and lack of binding to p53-MDM2 complexes. EMBO J 12:2799-2808
43. Momand J, Zambetti GP 1997 Mdm-2: "big brother" of p53. J Cell Biochem 64:343-352
44. Picksley SM, Lane DP 1993 The p53-mdm2 autoregulatory feedback loop - a paradigm for the regulation of growth control by p53? BioEssays 15:689-690
45. Chen CY, Oliner JD, Zhan QM, Fornace AJ, Vogelstein B, Kastan MB 1994 Interactions between p53 and MDM2 in a mammalian cell cycle checkpoint pathway. Proc Natl Acad Sci USA 91:2684-2688
46. Chen JD, Wu X, Lin JY, Levine AJ 1996 mdm-2 inhibits the G1 arrest and apoptosis functions of the p53 tumor suppressor protein. Mol Cell Biol 16:2445-2452
47. Haupt Y, Barak Y, Oren M 1996 Cell type-specific inhibition of p53-mediated apoptosis by mdm2. EMBO J 15:1596-1606
48. Shaulian E, Resnitzky D, Shifman O, Blandino G, Amsterdam A, Yayon A, and Oren M 1997 Induction of Mdm2 and enhancement of cell survival by bFGF. Oncogene 15:2717-2725
49. Hosokawa K, Dantes A, Schere-Levy C, Barash A, Kotsuji F, Vlodavsky I, and Amsterdam A 1998 Induction of Ad4BP/SF-1, StAR and cytochrome P450scc enzyme system expression in newly established human granulosa cell lines. 139:4679-4687
50. Rogelj S, Klagsbrun M, Atzmon R, Kurokawa M, Haimovitz A, Fuks Z, Vlodavsky I 1989 Basic fibroblast growth factor is an extracellular matrix component required for supporting the proliferation of vascular endothelial cells and the differentiation of PC12 cells. J Cell Biol 109:823-831
51. Kramer HR, and Vogel KG 1984 Selective degradation of basement membrane macromolecules by metastatic cells. J Natl Cancer Inst 72:889-899
52. Kohen F, Bauminger S, and Lindner HR 1975 Preparation of antigenic steroid-protein conjugate. In: Cameron EHD, Hillier SG, Griffiths K (eds) Steroid Immunoassay. Alpha Omega Publishing Ltd., Cardiff, Wales, 11-23
53. Bradford MM 1976 A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principles of protein-dye binding. Anal Biochem 72:248-254
54. Hanukoglu I, Suh BS, Himmelhoch S, Amsterdam A 1990 Induction and mitochondrial localization of cytochrome P450scc system enzymes in normal and transformed ovarian granulosa cells. J Cell Biol 111:1973-1981
55. Suh BS, Amsterdam A 1990 Establishment of highly steroidogenic granulosa cell lines by cotransfection with SV40 and Ha-ras oncogene: induction of steroidogenesis by cyclic adenosine 3′-5′-monophosphate and its suppression by phorbol ester. Endocrinology 127:2489-2500
56. Michalovitz D, Halevy O, Oren M 1990 Conditional inhibition of transformation and of cell proliferation by a temperature-sensitive mutant of p53. Cell 62:671-680
57. Yonish-Rouach E, Resnitzky D, Lotem J, Sachs L, Kimchi A, Oren M 1991 Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6. Nature 352:345-347
58. Ruoslahti E, Yamaguchi Y 1991 Proteoglycans as modulators of growth factor activities. Cell 64:867-869
59. Vlodavsky I, Bar-Shavit R, Korner G, Fuks Z 1993 Extracellular matrix-bound growth factors, enzymes and plasma proteins. In: Rohrbach DH, Timpl R (eds) Basement Membranes: Cellular and Molecular Aspects. Academic Press Inc, Orlando, pp 327-343
60. El-Deiry WS, Tokino T, Velculescu VE, Levy DB, Parsons R, Trent JM, Lin D, Mercer WE, Kinzler KW, Vogelstein B 1993 WAF1, a potential mediator of p53 tumor suppression. Cell 75:817-825
61. Breckwoldt M, Selvaraj N, Aharoni D, Barash A, Segal I, Insler V, Amsterdam A 1996 Expression of Ad4BP/cytochrome P450 side chain cleavage enzyme and induction of cell death in long term cultures of human granulosa cells. Mol Hum Reprod 2:391-400
62. Polyak K, Xia Y, Zweier JL, Kinzler KW, Vogelstein B 1997 A model for p53-induced apoptosis. Nature 389:300-305
63. Pitzer F, Dantes A, Fuchs T, Baumeister W, Amsterdam A 1996 Removal of proteasomes from the nucleus and their accumulation in apoptotic blebs during programmed cell death. FEBS Lett 394:47-50
64. Bogoyevitch MA, Glennon PE, Andersson MB, Clerk A, Lazou A, Marshall CJ, Parker PJ, Sugden PH 1994 Endothelin-1 and fibroblast growth factors stimulate the mitogen-activated protein kinase signaling cascade in cardiac myocytes. The potential role of the cascade in the integration of two signaling pathways leading to myocyte hypertrophy. J Biol Chem 269:1110-1119
65. Creuzet C, Loeb J, Barbin G 1995 Fibroblast growth factors stimulate protein tyrosine phosphorylation and mitogen-activated protein kinase activity in primary cultures of hippocampal neurons. J Neurochem 64:1541-1547
66. Amsterdam A, Rotmensch S, Furman A, Venter EA, Vlodavsky I 1989 Synergistic effect of human chorionic gonadotropin and extracellular matrix on in vitro differentiation of human granulosa cells: progesterone production and gap junction formation. Endocrinology 124:1956-1964
67. Furman A, Rotmensch S, Kohen F, Mashiach S, Amsterdam A 1986 Regulation of rat granulosa cell differentiation by extracellular matrix produced by bovine corneal endothelial cells. Endocrinology 118:1878-1885
68. Martin SJ, O'Brien GA, Nishioka WK, McGahon AJ, Mahboubi A, Saido TC, Green DR 1995 Proteolysis of fodrin (non-erythroid spectrin) during apoptosis. J Biol Chem 270:6425-6428
69. Kothakota S, Azuma T, Reinhard C, Klippel A, Tang J, Chu K, McGarry TJ, Kirschner MW, Koths K, Kwiatkowski DJ, Williams LT 1997 Caspase-3-generated fragment of gelsolin: effector of morphological change in apoptosis. Science 278:294-298
70. Amsterdam A, Aharoni D 1994 Plasticity of cell organization during differentiation of normal and oncogene transformed granulosa cells. Micros Res Tech 27:108-124