Unravelling the complexity of COPD by microRNAs: It's a small world after all

European Respiratory Journal

Volumn 46, Issue 3, 2015, Pages 807-818

  Osei, Emmanuel T ^a   Florez Sampedro, Laura ^a   Timens, Wim ^a   Postma, Dirkje S ^a   Heijink, Irene H ^a   Brandsma, Corry Anke ^a  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

MICRORNA; MICRORNA 150; MICRORNA 181C; MICRORNA 181D; MICRORNA 18A 3P; MICRORNA 211; MICRORNA 221; MICRORNA 302D; MICRORNA 30A 3P; MICRORNA 30C; MICRORNA 30E 3P; MICRORNA 30E 5P; MICRORNA 483 3P; MICRORNA 520E; MICRORNA 638; MICRORNA 92A; MICRORNA LET 7C; MICRORNA LET 7D; MICRORNA LET 7E; MICRORNA LET 7F; UNCLASSIFIED DRUG;

ARTICLE; CHRONIC OBSTRUCTIVE LUNG DISEASE; CYTOKINE PRODUCTION; DISEASE ASSOCIATION; EMPHYSEMA; ENVIRONMENTAL EXPOSURE; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; GENE TARGETING; HUMAN; IMMUNE RESPONSE; LUNG FUNCTION; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; RISK FACTOR; RNA PROCESSING; SMOKING; TISSUE REPAIR; ADULT; ADVERSE EFFECTS; AGED; ANIMAL; DISEASE COURSE; DRUG EFFECTS; FEMALE; GENETICS; MALE; MIDDLE AGED; MOLECULARLY TARGETED THERAPY; PATHOPHYSIOLOGY; PROCEDURES; PROGNOSIS; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; REAL TIME POLYMERASE CHAIN REACTION; RISK ASSESSMENT;

ADULT; AGED; ANIMALS; DISEASE PROGRESSION; FEMALE; GENE EXPRESSION REGULATION; HUMANS; MALE; MICRORNAS; MIDDLE AGED; MOLECULAR TARGETED THERAPY; PROGNOSIS; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; REAL-TIME POLYMERASE CHAIN REACTION; RISK ASSESSMENT; SMOKING;

EID: 84942766278     PISSN: 09031936     EISSN: 13993003     Source Type: Journal    
DOI: 10.1183/13993003.02139-2014     Document Type: Article

References (69)

1. Decramer M, Janssens W, Miravitlles M. Chronic obstructive pulmonary disease. Lancet 2012; 379: 1341-1351.
2. World Health Organization. Burden of COPD. www.who.int/respiratory/copd/burden/en/ Date last accessed: October 7, 2014.
3. Heijink IH, de Bruin HG, van den Berge M, et al. Role of aberrant WNT signalling in the airway epithelial response to cigarette smoke in chronic obstructive pulmonary disease. Thorax 2013; 68: 709-716.
4. Pouwels SD, Heijink IH, ten Hacken NH, et al. DAMPs activating innate and adaptive immune responses in COPD. Mucosal Immunol 2014; 7: 215-226.
5. Hogg JC, Timens W. The pathology of chronic obstructive pulmonary disease. Annu Rev Pathol 2009; 4: 435-459.
6. Pottier N, Cauffiez C, Perrais M, et al. FibromiRs: translating molecular discoveries into new anti-fibrotic drugs. Trends Pharmacol Sci 2014; 35: 119-126.
7. Angulo M, Lecuona E, Sznajder JI. Role of microRNAs in lung disease. Arch Bronconeumol 2012; 48: 325-330.
8. miRBase. Search results for "mammalian". www.mirbase.org/cgi-bin/query.pl?terms=mammalian&submit=Search Date last updated: June 26, 2014. Date last accessed: March 18, 2015.
9. Kozomara A, Griffiths-Jones S. miRBase: annotating high confidence microRNAs using deep sequencing data. Nucleic Acids Res 2014; 42: D68-D73.
10. Kuhn DE, Martin MM, Feldman DS, et al. Experimental validation of miRNA targets. Methods 2008; 44: 47-54.
11. Swierczynski S, Klieser E, Illig R, et al. Histone deacetylation meets miRNA: epigenetics and post-transcriptional regulation in cancer and chronic diseases. Expert Opin Biol Ther 2015; 15: 651-664.
12. Lujambio A, Ropero S, Ballestar E, et al. Genetic unmasking of an epigenetically silenced microRNA in human cancer cells. Cancer Res 2007; 67: 1424-1429.
13. Lujambio A, Calin GA, Villanueva A, et al. A microRNA DNA methylation signature for human cancer metastasis. Proc Natl Acad Sci USA 2008; 105: 13556-13561.
14. Akbas F, Coskunpinar E, Aynaci E, et al. Analysis of serum micro-RNAs as potential biomarker in chronic obstructive pulmonary disease. Exp Lung Res 2012; 38: 286-294.
15. Janssen HL, Reesink HW, Lawitz EJ, et al. Treatment of HCV infection by targeting microRNA. N Engl J Med 2013; 368: 1685-1694.
16. Hassan F, Nuovo GJ, Crawford M, et al. MiR-101 and miR-144 regulate the expression of the CFTR chloride channel in the lung. PLoS One 2012; 7: e50837.
17. Zhao Y, Xu Y, Li Y, et al. NF-κB-mediated inflammation leading to EMT via miR-200c is involved in cell transformation induced by cigarette smoke extract. Toxicol Sci 2013; 135: 265-276.
18. Oldenburger A, van Basten B, Kooistra W, et al. Interaction between Epac1 and miRNA-7 in airway smooth muscle cells. Naunyn Schmiedebergs Arch Pharmacol 2014; 387: 795-797.
19. Izzotti A, Calin GA, Arrigo P, et al. Downregulation of microRNA expression in the lungs of rats exposed to cigarette smoke. FASEB J 2009; 23: 806-812.
20. Halappanavar S, Nikota J, Wu D, et al. IL-1 receptor regulates microRNA-135b expression in a negative feedback mechanism during cigarette smoke-induced inflammation. J Immunol 2013; 190: 3679-3686.
21. Xie L, Wu M, Lin H, et al. An increased ratio of serum miR-21 to miR-181a levels is associated with the early pathogenic process of chronic obstructive pulmonary disease in asymptomatic heavy smokers. Mol Biosyst 2014; 10: 1072-1081.
22. Van Pottelberge GR, Mestdagh P, Bracke KR, et al. MicroRNA expression in induced sputum of smokers and patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2011; 183: 898-906.
23. Graff JW, Powers LS, Dickson AM, et al. Cigarette smoking decreases global microRNA expression in human alveolar macrophages. PLoS One 2012; 7: e44066.
24. Schembri F, Sridhar S, Perdomo C, et al. MicroRNAs as modulators of smoking-induced gene expression changes in human airway epithelium. Proc Natl Acad Sci USA 2009; 106: 2319-2324.
25. Izzotti A, Larghero P, Longobardi M, et al. Dose-responsiveness and persistence of microRNA expression alterations induced by cigarette smoke in mouse lung. Mutat Res 2011; 717: 9-16.
26. Soeda S, Ohyashiki JH, Ohtsuki K, et al. Clinical relevance of plasma miR-106b levels in patients with chronic obstructive pulmonary disease. Int J Mol Med 2013; 31: 533-539.
27. Leidinger P, Keller A, Borries A, et al. Specific peripheral miRNA profiles for distinguishing lung cancer from COPD. Lung Cancer 2011; 74: 41-47.
28. Molina-Pinelo S, Pastor MD, Suarez R, et al. MicroRNA clusters: dysregulation in lung adenocarcinoma and COPD. Eur Respir J 2014; 43: 1740-1749.
29. Ezzie ME, Crawford M, Cho JH, et al. Gene expression networks in COPD: microRNA and mRNA regulation. Thorax 2012; 67: 122-131.
30. Chatila WM, Criner GJ, Hancock WW, et al. Blunted expression of miR-199a-5p in regulatory T cells of patients with chronic obstructive pulmonary disease compared to unaffected smokers. Clin Exp Immunol 2014; 177: 341-352.
31. Lewis A, Riddoch-Contreras J, Natanek SA, et al. Downregulation of the serum response factor/miR-1 axis in the quadriceps of patients with COPD. Thorax 2012; 67: 26-34.
32. Mizuno S, Bogaard HJ, Gomez-Arroyo J, et al. MicroRNA-199a-5p is associated with hypoxia-inducible factor-1a expression in lungs from patients with COPD. Chest 2012; 142: 663-672.
33. 2 in chronic obstructive pulmonary disease fibroblasts. Am J Respir Crit Care Med 2010; 182: 1020-1029.
34. Christenson SA, Brandsma CA, Campbell JD, et al. miR-638 regulates gene expression networks associated with emphysematous lung destruction. Genome Med 2013; 5: 114.
35. Savarimuthu Francis SM, Davidson MR, Tan ME, et al. MicroRNA-34c is associated with emphysema severity and modulates SERPINE1 expression. BMC Genomics 2014; 15: 88.
36. Rab A, Rowe SM, Raju SV, et al. Cigarette smoke and CFTR: implications in the pathogenesis of COPD. Am J Physiol Lung Cell Mol Physiol 2013; 305: L530-L541.
37. Bracken CP, Gregory PA, Kolesnikoff N, et al. A double-negative feedback loop between ZEB1-SIP1 and the microRNA-200 family regulates epithelial-mesenchymal transition. Cancer Res 2008; 68: 7846-7854.
38. Gregory PA, Bert AG, Paterson EL, et al. The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1. Nat Cell Biol 2008; 10: 593-601.
39. Milara J, Peiró T, Serrano A, et al. Epithelial to mesenchymal transition is increased in patients with COPD and induced by cigarette smoke. Thorax 2013; 68: 410-420.
40. Sohal SS, Walters EH. Role of epithelial mesenchymal transition (EMT) in chronic obstructive pulmonary disease (COPD). Respir Res 2013; 14: 120.
41. Oldenburger A, Roscioni SS, Jansen E, et al. Anti-inflammatory role of the cAMP effectors Epac and PKA: implications in chronic obstructive pulmonary disease. PLoS One 2012; 7: e31574.
42. Rippo MR, Olivieri F, Monsurrò V, et al. MitomiRs in human inflamm-aging: a hypothesis involving miR-181a, miR-34a and miR-146a. Exp Gerontol 2014; 56: 154-163.
43. Demedts IK, Morel-Montero A, Lebecque S, et al. Elevated MMP-12 protein levels in induced sputum from patients with COPD. Thorax 2006; 61: 196-201.
44. Trojanek JB, Cobos-Correa A, Diemer S, et al. Airway mucus obstruction triggers macrophage activation and matrix metalloproteinase 12-dependent emphysema. Am J Respir Cell Mol Biol 2014; 51: 709-720.
45. Bossé Y, Postma DS, Sin DD, et al. Molecular signature of smoking in human lung tissues. Cancer Res 2012; 72: 3753-3763.
46. Zandvoort A, Postma DS, Jonker MR, et al. Smad gene expression in pulmonary fibroblasts: indications for defective ECM repair in COPD. Respir Res 2008; 9: 83.
47. Lu L, Ma J, Wang X, et al. Synergistic effect of TGF-β superfamily members on the induction of Foxp3+ Treg. Eur J Immunol 2010; 40: 142-152.
48. 2 and matrix metalloproteinase-2 correlate with the severity of airflow limitation in stable COPD. Respirology 2008; 13: 1014-1021.
49. Zago M, Rico de Souza A, Hecht E, et al. The NF-KB family member RelB regulates microRNA miR-146a to suppress cigarette smoke-induced COX-2 protein expression in lung fibroblasts. Toxicol Lett 2014; 226: 107-116.
50. Taganov KD, Boldin MP, Chang KJ, et al. NF-κB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses. Proc Natl Acad Sci USA 2006; 103: 12481-12486.
51. Perry MM, Moschos SA, Williams AE, et al. Rapid changes in microRNA-146a expression negatively regulate the IL-1β-induced inflammatory response in human lung alveolar epithelial cells. J Immunol 2008; 180: 5689-5698.
52. Bhaumik D, Scott GK, Schokrpur S, et al. MicroRNAs miR-146a/b negatively modulate the senescence-associated inflammatory mediators IL-6 and IL-8. Aging 2009; 1: 402-411.
53. Guo Z, Gu Y, Wang C, et al. Enforced expression of miR-125b attenuates LPS-induced acute lung injury. Immunol Lett 2014; 162: 18-26.
54. Manoharan P, Basford JE, Pilcher-Roberts R, et al. Reduced levels of microRNAs miR-124a and miR-150 are associated with increased proinflammatory mediator expression in Krüppel-like factor 2 (KLF2)-deficient macrophages. J Biol Chem 2014; 289: 31638-31646.
55. Xie W, Li M, Xu N, et al. MiR-181a regulates inflammation responses in monocytes and macrophages. PLoS One 2013; 8: e58639.
56. Galicia JC, Naqvi AR, Ko CC, et al. MiRNA-181a regulates Toll-like receptor agonist-induced inflammatory response in human fibroblasts. Genes Immun 2014; 15: 333-337.
57. Philippe L, Alsaleh G, Pichot A, et al. MiR-20a regulates ASK1 expression and TLR4-dependent cytokine release in rheumatoid fibroblast-like synoviocytes. Ann Rheum Dis 2013; 72: 1071-1079.
58. Campbell JD, McDonough JE, Zeskind JE, et al. A gene expression signature of emphysema-related lung destruction and its reversal by the tripeptide GHK. Genome Med 2012; 4: 67.
59. Noordhoek JA, Postma DS, Chong LL, et al. Different modulation of decorin production by lung fibroblasts from patients with mild and severe emphysema. COPD 2005; 2: 17-25.
60. Tan KS, Choi H, Jiang X, et al. Micro-RNAs in regenerating lungs: an integrative systems biology analysis of murine influenza pneumonia. BMC Genomics 2014; 15: 587.
61. Liu G, Friggeri A, Yang Y, et al. miR-21 mediates fibrogenic activation of pulmonary fibroblasts and lung fibrosis. J Exp Med 2010; 207: 1589-1597.
62. Huleihel L, Ben-Yehudah A, Milosevic J, et al. Let-7d microRNA affects mesenchymal phenotypic properties of lung fibroblasts. Am J Physiol Lung Cell Mol Physiol 2014; 306: L534-L542.
63. Yang S, Cui H, Xie N, et al. miR-145 regulates myofibroblast differentiation and lung fibrosis. FASEB J 2013; 27: 2382-2391.
64. Yang T, Liang Y, Lin Q, et al. miR-29 mediates TGFβ1-induced extracellular matrix synthesis through activation of PI3K-AKT pathway in human lung fibroblasts. J Cell Biochem 2013; 114: 1336-1342.
65. Bader AG, Brown D, Winkler M. The promise of microRNA replacement therapy. Cancer Res 2010; 70: 7027-7030.
66. Henry JC, Azevedo-Pouly AC, Schmittgen TD. MicroRNA replacement therapy for cancer. Pharm Res 2011; 28: 3030-3042.
67. Trang P, Wiggins JF, Daige CL, et al. Systemic delivery of tumor suppressor microRNA mimics using a neutral lipid emulsion inhibits lung tumors in mice. Mol Ther 2011; 19: 1116-1122.
68. Wiggins JF, Ruffino L, Kelnar K, et al. Development of a lung cancer therapeutic based on the tumor suppressor microRNA-34. Cancer Res 2010; 70: 5923-5930.
69. H2-mediated allergen-induced eosinophilic inflammation in the lung. J Allergy Clin Immunol 2014; 133: 1429-1438.