Airway mucus obstruction triggers macrophage activation and matrix metalloproteinase 12-dependent emphysema

American Journal of Respiratory Cell and Molecular Biology

Volumn 51, Issue 5, 2014, Pages 709-720

  Trojanek, Joanna B ^a   Cobos Correa, Amanda ^a,c   Diemer, Stefanie ^a   Kormann, Michael ^d   Schubert, Susanne C ^a   Zhou Suckow, Zhe ^a,b   Agrawal, Raman ^a,b   Duerr, Julia ^a,b   Wagner, Claudius J ^a,b   Schatterny, Jolanthe ^a,b   Hirtz, Stephanie ^a,b   Sommerburg, Olaf ^a,b   Hartl, Dominik ^d   Schultz, Carsten ^a,b,c   Mall, Marcus A ^a,b  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b German Center for Lung Research   (Germany)

^c EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

^d UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

Airway surface liquid; Chronic obstructive pulmonary disease; Cystic fibrosis; Inflammation; Mucus

Indexed keywords

MACROPHAGE ELASTASE; STAT6 PROTEIN; STAT6 PROTEIN, MOUSE;

AIRWAY OBSTRUCTION; ANIMAL; CHRONIC OBSTRUCTIVE LUNG DISEASE; CYSTIC FIBROSIS; DEHYDRATION; GENETICS; GENOMICS; IMMUNOLOGY; KNOCKOUT MOUSE; LUNG ALVEOLUS MACROPHAGE; LUNG EMPHYSEMA; LUNG LAVAGE; MACROPHAGE ACTIVATION; METABOLISM; MUCUS; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM;

AIRWAY OBSTRUCTION; ANIMALS; BRONCHOALVEOLAR LAVAGE FLUID; CYSTIC FIBROSIS; DEHYDRATION; GENOMICS; MACROPHAGE ACTIVATION; MACROPHAGES, ALVEOLAR; MATRIX METALLOPROTEINASE 12; MICE, KNOCKOUT; MUCUS; POLYMORPHISM, SINGLE NUCLEOTIDE; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; PULMONARY EMPHYSEMA; SIGNAL TRANSDUCTION; STAT6 TRANSCRIPTION FACTOR;

EID: 84914143169     PISSN: 10441549     EISSN: 15354989     Source Type: Journal    
DOI: 10.1165/rcmb.2013-0407OC     Document Type: Article

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